Aaron Mickle

Aaron Mickle,

Assistant Professor

Department: Department of Physiological Sciences
Business Phone: (352) 294-4016
Business Email: amickle@ufl.edu

About Aaron Mickle

Aaron Mickle is an Assistant Professor in the Department of Physiological Sciences, in the College of Veterinary Medicine at the University of Florida. His current research focuses on incorporating multiple techniques at the system and cellular level to answer questions related to mechanisms of bladder sensory function and pain.

Related Links:

Teaching Profile

Courses Taught
2020
VME6932 Seminar in Physiological Sciences
2020-2021
VEM5110 Animal Systems 1
2021-2023
VME6937L VMS Graduate Seminar Series

Research Profile

Development of technology to study visceral diseases and refine current/develop new analgesic technologies – Our lab works closely with material, chemical and electrical engineers to develop new tools to study the nervous system with the end goal using these tools to study the changes that occur in these systems during and after the development of chronic pain, as well as the hopeful end goal of implementing these strategies in patients.

Urothelial cell-to-sensory afferent signaling in bladder pain and function – Urothelial cells, the endothelial cells that line the bladder wall, were classically thought to function as a passive barrier. However, evidence collected over the last decade has shown them to be a much more active component of bladder physiology and pathophysiology. The fact that urothelial cells express many different types of sensory receptors, ion channels, signaling peptides and neurotransmitters, along with their close proximity to nerve fibers suggest that they could communicate and/or receive input from neuronal cells. Our lab is using innovative techniques to isolate these signaling mechanisms to specific cell types with the goal of understanding how these cells communicate under normal physiologic conditions as well as how the signaling may be altered under disease conditions.

The role of immune cell signaling in interstitial cystitis/ bladder pain syndrome (IC/BPS) pain – IC/BPS is idiopathic in nature, however over the past two decades mounting evidence suggests alterations to the innate immune response may play a role in the symptomology and progression of the disease. Our lab aims to study the involvement of different immune cells in pain and bladder dysfunction associated with models of IC/BPS

Open Researcher and Contributor ID (ORCID)

0000-0002-6454-8038

Publications

2022
Open source timed pressure control hardware and software for delivery of air mediated distensions in animal models.
HardwareX. [DOI] 10.1016/j.ohx.2022.e00271. [PMID] 35509929.
2022
Role of Src kinase in regulating protein kinase C mediated phosphorylation of TRPV1
European Journal of Pain. [DOI] 10.1002/ejp.2017.
2021
Characterization of a method to study urodynamics and bladder nociception in male and female mice
LUTS: Lower Urinary Tract Symptoms. [DOI] 10.1111/luts.12365. [PMID] 33202486.
2019
A wireless closed-loop system for optogenetic peripheral neuromodulation.
Nature. [DOI] 10.1038/s41586-018-0823-6. [PMID] 30602791.
2019
Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves
Science Advances. [DOI] 10.1126/sciadv.aaw5296. [PMID] 31281895.
2018
A bright future? Optogenetics in the periphery for pain research and therapy.
Pain. [DOI] 10.1097/j.pain.0000000000001329. [PMID] 30113949.
2018
Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience. [DOI] 10.1523/JNEUROSCI.3542-17.2018.
2018
Macrophage angiotensin II type 2 receptor triggers neuropathic pain.
Proceedings of the National Academy of Sciences of the United States of America. [DOI] 10.1073/pnas.1721815115. [PMID] 30082378.
2018
Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics.
Small (Weinheim an der Bergstrasse, Germany). [DOI] 10.1002/smll.201702479. [PMID] 29215787.
2018
Natural Wax for Transient Electronics
Advanced Functional Materials. [DOI] 10.1002/adfm.201801819.
2018
Parathyroid hormone-related peptide activates and modulates TRPV1 channel in human DRG neurons.
European journal of pain (London, England). [DOI] 10.1002/ejp.1251. [PMID] 29797679.
2018
Parathyroid Hormone-Related Peptide Elicits Peripheral TRPV1-dependent Mechanical Hypersensitivity.
Frontiers in cellular neuroscience. [DOI] 10.3389/fncel.2018.00038. [PMID] 29497363.
2017
Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics.
Neuron. [DOI] 10.1016/j.neuron.2016.12.031. [PMID] 28132830.
2017
Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics.
Pain. [DOI] 10.1097/j.pain.0000000000000968. [PMID] 28700536.
2017
Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain
Scientific Reports. [DOI] 10.1038/s41598-017-16129-3. [PMID] 29158567.
2016
Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies.
Pharmaceuticals (Basel, Switzerland). [PMID] 27854251.
2016
Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics.
Proceedings of the National Academy of Sciences of the United States of America. [PMID] 27911798.
2015
Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking.
Pain. [DOI] 10.1097/j.pain.0000000000000224. [PMID] 25970319.
2015
Sensory TRP channels: the key transducers of nociception and pain.
Progress in molecular biology and translational science. [DOI] 10.1016/bs.pmbts.2015.01.002. [PMID] 25744671.
2014
Interference with peroxisome proliferator-activated receptor-γ in vascular smooth muscle causes baroreflex impairment and autonomic dysfunction.
Hypertension (Dallas, Tex. : 1979). [DOI] 10.1161/HYPERTENSIONAHA.114.03553. [PMID] 24914194.
2014
NMDA receptor mediates chronic visceral pain induced by neonatal noxious somatic stimulation.
European journal of pharmacology. [DOI] 10.1016/j.ejphar.2014.09.034. [PMID] 25281204.
2014
Visceral analgesic effect of 5-HT(4) receptor agonist in rats involves the rostroventral medulla (RVM).
Neuropharmacology. [DOI] 10.1016/j.neuropharm.2013.12.006. [PMID] 24334068.
2012
Distinct modifications in Kv2.1 channel via chemokine receptor CXCR4 regulate neuronal survival-death dynamics.
The Journal of neuroscience : the official journal of the Society for Neuroscience. [DOI] 10.1523/JNEUROSCI.3029-12.2012. [PMID] 23223293.
2012
Pronociceptive effect of 5-HT(1A) receptor agonist on visceral pain involves spinal N-methyl-D-aspartate (NMDA) receptor.
Neuroscience. [DOI] 10.1016/j.neuroscience.2012.05.030. [PMID] 22626644.
2012
The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gβγ-dependent modulation of TRPV1 channel.
The Journal of neuroscience : the official journal of the Society for Neuroscience. [DOI] 10.1523/JNEUROSCI.1330-12.2012. [PMID] 22933780.
2011
Neonatal cystitis-induced colonic hypersensitivity in adult rats: a model of viscero-visceral convergence.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. [DOI] 10.1111/j.1365-2982.2011.01724.x. [PMID] 21592255.
2010
Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process.
Pain. [DOI] 10.1016/j.pain.2010.03.030. [PMID] 20413219.
2009
Altered mechanosensitive properties of vagal afferent fibers innervating the stomach following gastric surgery in rats.
Neuroscience. [DOI] 10.1016/j.neuroscience.2009.05.042. [PMID] 19477237.
Open source timed pressure control hardware and software for delivery of air mediated distensions in animal models
. [DOI] 10.1101/2021.03.15.435466.

Grants

Jul 2022 ACTIVE
Development of an optogenetic-based strategy for controlling the external urethral sphincter
Role: Other
Funding: AMER UROLOGICAL ASSOCIATION FOUNDATION
Feb 2022 ACTIVE
Urothelial Cell to Sensory Neuron Signaling in Bladder Pain.
Role: Principal Investigator
Funding: RITA ALLEN FOUNDATION via COMMUNITY FOUNDATION OF NEW JERSEY
Apr 2021 ACTIVE
An optogenetic-based control paradigm for neuromodulation of bladder function following spinal cord injury
Role: Principal Investigator
Funding: NATL INST OF HLTH NIBIB

Contact Details

Phones:
Business:
(352) 294-4016
Emails:
Business:
amickle@ufl.edu
Addresses:
Business Mailing:
PO Box 100144
GAINESVILLE FL 32610