Aaron Mickle

Aaron Mickle

Assistant Professor

Department: Department of Physiological Sciences
Business Phone: (352) 294-4016
Business Email: amickle@ufl.edu

About Aaron Mickle

Aaron Mickle is an Assistant Professor in the Department of Physiological Sciences, in the college of Veterinary Medicine at the University of Florida. He received my PhD in pharmacology from the University of Iowa under the mentorship of Dr. DP Mohapatra studying nociceptor sensitization in the context of metastasized cancer pain. He completed his postdoc at Washington University in Saint Louis with Dr. Robert Gereau, were he collaborated with material, electrical and biomedical engineers to develop closed-loop optogenetic based neuromodulatory technologies. His current research focuses on incorporating multiple techniques at the system and cellular level to answer questions related to mechanisms of visceral pain and function.

Accomplishments

Essay Contest Winner for Urodynamic and Neurourology Research
2019 · Diokno-Lapides
42nd Annual O’Leary Prize Neuroscience Award Finalist
2019 · Washington University
Young Investigator Travel Award
2018 · American Pain Society
Thatch Award – Poster Finalist
2018 · Washington University Neuroscience Retreat
Department of Anesthesiology Academic Evening – Best Postdoctoral Researcher Abstract, 2018
2018 · Washington University
Thach Award – Poster Finalist
2017 · Washington University Neuroscience Retreat
NIH F32 NRSA Postdoctoral Fellowship
2017 · National Institutes of Health
Research Scholar Award
2017 · Urology Care Foundation
Postdoctoral Fellowship
2016 · McDonnell Center for Cellular/Molecular Neurobiology
Department of Pharmacology Retreat Best Graduate Student Poster Award
2014 · University of Iowa
NIH F31 NRSA Graduate Student Fellowship
2012 · National Institutes of Health
NIH T32 Institutional NRSA Graduate student Fellowship
2011 · National Institutes of Health
Undergraduate Research Grant
2007 · University of Wisconsin – La Crosse

Research Profile

Development of technology to study visceral diseases and refine current/develop new analgesic technologies – Our lab works closely with material, chemical and electrical engineers to develop new tools to study the nervous system with the end goal using these tools to study the changes that occur in these systems during and after the development of chronic pain, as well as the hopeful end goal of implementing these strategies in patients.

Urothelial cell-to-sensory afferent signaling in bladder pain and function – Urothelial cells, the endothelial cells that line the bladder wall, were classically thought to function as a passive barrier. However, evidence collected over the last decade has shown them to be a much more active component of bladder physiology and pathophysiology. The fact that urothelial cells express many different types of sensory receptors, ion channels, signaling peptides and neurotransmitters, along with their close proximity to nerve fibers suggest that they could communicate and/or receive input from neuronal cells. Our lab is using innovative techniques to isolate these signaling mechanisms to specific cell types with the goal of understanding how these cells communicate under normal physiologic conditions as well as how the signaling may be altered under disease conditions.

The role of immune cell signaling in interstitial cystitis/ bladder pain syndrome (IC/BPS) pain – IC/BPS is idiopathic in nature, however over the past two decades mounting evidence suggests alterations to the innate immune response may play a role in the symptomology and progression of the disease. Our lab aims to study the involvement of different immune cells in pain and bladder dysfunction associated with models of IC/BPS

Open Researcher and Contributor ID (ORCID)

0000-0002-6454-8038

Education

Postdoctoral Fellow
2019 · Washington University in Saint Louis
PhD – Pharmacology
2014 · University of Iowa
BS – Biology
2007 · University of Wisconsin – Lacrosse

Contact Details

Phones:
Business:
(352) 294-4016
Emails:
Business:
amickle@ufl.edu

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