Aaron Mickle

Aaron Mickle

Assistant Professor

Department: Department of Physiological Sciences
Business Phone: (352) 294-4016
Business Email: amickle@ufl.edu

About Aaron Mickle

Aaron Mickle is an Assistant Professor in the Department of Physiological Sciences, in the college of Veterinary Medicine at the University of Florida. He received my PhD in pharmacology from the University of Iowa under the mentorship of Dr. DP Mohapatra studying nociceptor sensitization in the context of metastasized cancer pain. He completed his postdoc at Washington University in Saint Louis with Dr. Robert Gereau, were he collaborated with material, electrical and biomedical engineers to develop closed-loop optogenetic based neuromodulatory technologies. His current research focuses on incorporating multiple techniques at the system and cellular level to answer questions related to mechanisms of visceral pain and function.


Essay Contest Winner for Urodynamic and Neurourology Research
2019 · Diokno-Lapides
42nd Annual O’Leary Prize Neuroscience Award Finalist
2019 · Washington University
Young Investigator Travel Award
2018 · American Pain Society
Thatch Award – Poster Finalist
2018 · Washington University Neuroscience Retreat
Department of Anesthesiology Academic Evening – Best Postdoctoral Researcher Abstract, 2018
2018 · Washington University
Thach Award – Poster Finalist
2017 · Washington University Neuroscience Retreat
NIH F32 NRSA Postdoctoral Fellowship
2017 · National Institutes of Health
Research Scholar Award
2017 · Urology Care Foundation
Postdoctoral Fellowship
2016 · McDonnell Center for Cellular/Molecular Neurobiology
Department of Pharmacology Retreat Best Graduate Student Poster Award
2014 · University of Iowa
NIH F31 NRSA Graduate Student Fellowship
2012 · National Institutes of Health
NIH T32 Institutional NRSA Graduate student Fellowship
2011 · National Institutes of Health
Undergraduate Research Grant
2007 · University of Wisconsin – La Crosse

Research Profile

Development of technology to study visceral diseases and refine current/develop new analgesic technologies – Our lab works closely with material, chemical and electrical engineers to develop new tools to study the nervous system with the end goal using these tools to study the changes that occur in these systems during and after the development of chronic pain, as well as the hopeful end goal of implementing these strategies in patients.

Urothelial cell-to-sensory afferent signaling in bladder pain and function – Urothelial cells, the endothelial cells that line the bladder wall, were classically thought to function as a passive barrier. However, evidence collected over the last decade has shown them to be a much more active component of bladder physiology and pathophysiology. The fact that urothelial cells express many different types of sensory receptors, ion channels, signaling peptides and neurotransmitters, along with their close proximity to nerve fibers suggest that they could communicate and/or receive input from neuronal cells. Our lab is using innovative techniques to isolate these signaling mechanisms to specific cell types with the goal of understanding how these cells communicate under normal physiologic conditions as well as how the signaling may be altered under disease conditions.

The role of immune cell signaling in interstitial cystitis/ bladder pain syndrome (IC/BPS) pain – IC/BPS is idiopathic in nature, however over the past two decades mounting evidence suggests alterations to the innate immune response may play a role in the symptomology and progression of the disease. Our lab aims to study the involvement of different immune cells in pain and bladder dysfunction associated with models of IC/BPS

Open Researcher and Contributor ID (ORCID)



Characterization of a method to study urodynamics and bladder nociception in male and female mice
LUTS: Lower Urinary Tract Symptoms. [DOI] 10.1111/luts.12365.
Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves
Science Advances. 5(7) [DOI] 10.1126/sciadv.aaw5296. [PMID] 31281895.
A wireless closed-loop system for optogenetic peripheral neuromodulation.
Nature. 565(7739):361-365 [DOI] 10.1038/s41586-018-0823-6. [PMID] 30602791.
A bright future? Optogenetics in the periphery for pain research and therapy.
Pain. 159 Suppl 1:S65-S73 [DOI] 10.1097/j.pain.0000000000001329. [PMID] 30113949.
Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(32):7032-7057 [DOI] 10.1523/JNEUROSCI.3542-17.2018. [PMID] 29976627.
Macrophage angiotensin II type 2 receptor triggers neuropathic pain.
Proceedings of the National Academy of Sciences of the United States of America. 115(34):E8057-E8066 [DOI] 10.1073/pnas.1721815115. [PMID] 30082378.
Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics.
Small (Weinheim an der Bergstrasse, Germany). 14(4) [DOI] 10.1002/smll.201702479. [PMID] 29215787.
Natural Wax for Transient Electronics
Advanced Functional Materials. 28(32) [DOI] 10.1002/adfm.201801819.
Parathyroid hormone-related peptide activates and modulates TRPV1 channel in human DRG neurons.
European journal of pain (London, England). 22(9):1685-1690 [DOI] 10.1002/ejp.1251. [PMID] 29797679.
Parathyroid Hormone-Related Peptide Elicits Peripheral TRPV1-dependent Mechanical Hypersensitivity.
Frontiers in cellular neuroscience. 12 [DOI] 10.3389/fncel.2018.00038. [PMID] 29497363.
Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics.
Neuron. 93(3):509-521.e3 [DOI] 10.1016/j.neuron.2016.12.031. [PMID] 28132830.
Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics.
Pain. 158(11):2108-2116 [DOI] 10.1097/j.pain.0000000000000968. [PMID] 28700536.
Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain
Scientific Reports. 7(1) [DOI] 10.1038/s41598-017-16129-3. [PMID] 29158567.
Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies.
Pharmaceuticals (Basel, Switzerland). 9(4) [PMID] 27854251.
View on: PubMed
Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics.
Proceedings of the National Academy of Sciences of the United States of America. 113(50):E8169-E8177 [PMID] 27911798.
View on: PubMed
Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking.
Pain. 156(9):1620-1636 [DOI] 10.1097/j.pain.0000000000000224. [PMID] 25970319.
Interference with peroxisome proliferator-activated receptor-γ in vascular smooth muscle causes baroreflex impairment and autonomic dysfunction.
Hypertension (Dallas, Tex. : 1979). 64(3):590-6 [DOI] 10.1161/HYPERTENSIONAHA.114.03553. [PMID] 24914194.
NMDA receptor mediates chronic visceral pain induced by neonatal noxious somatic stimulation.
European journal of pharmacology. 744:28-35 [DOI] 10.1016/j.ejphar.2014.09.034. [PMID] 25281204.
Visceral analgesic effect of 5-HT(4) receptor agonist in rats involves the rostroventral medulla (RVM).
Neuropharmacology. 79:345-58 [DOI] 10.1016/j.neuropharm.2013.12.006. [PMID] 24334068.
Distinct modifications in Kv2.1 channel via chemokine receptor CXCR4 regulate neuronal survival-death dynamics.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(49):17725-39 [DOI] 10.1523/JNEUROSCI.3029-12.2012. [PMID] 23223293.
Pronociceptive effect of 5-HT(1A) receptor agonist on visceral pain involves spinal N-methyl-D-aspartate (NMDA) receptor.
Neuroscience. 219:243-54 [DOI] 10.1016/j.neuroscience.2012.05.030. [PMID] 22626644.
The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gβγ-dependent modulation of TRPV1 channel.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(35):11942-55 [DOI] 10.1523/JNEUROSCI.1330-12.2012. [PMID] 22933780.
Neonatal cystitis-induced colonic hypersensitivity in adult rats: a model of viscero-visceral convergence.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 23(7):683-e281 [DOI] 10.1111/j.1365-2982.2011.01724.x. [PMID] 21592255.
Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process.
Pain. 149(3):555-564 [DOI] 10.1016/j.pain.2010.03.030. [PMID] 20413219.
Altered mechanosensitive properties of vagal afferent fibers innervating the stomach following gastric surgery in rats.
Neuroscience. 162(4):1299-306 [DOI] 10.1016/j.neuroscience.2009.05.042. [PMID] 19477237.
Unifying shading and texture through an active observer.
Proceedings of the Royal Society of London. Series B, Biological sciences. 238(1290):25-37 [PMID] 2574467.
View on: PubMed


Postdoctoral Fellow
2019 · Washington University in Saint Louis
PhD – Pharmacology
2014 · University of Iowa
BS – Biology
2007 · University of Wisconsin – Lacrosse

Teaching Profile

Courses Taught
VME6932 Seminar in Physiological Sciences
VEM5110 Animal Systems 1
VME6937L VMS Graduate Seminar Series

Contact Details

(352) 294-4016

University of Florida


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