Emerging Pathogens Institute, Department of Infectious Diseases & Immunology
2055 Mowry Road, Rm 375
Gainesville, FL 32611
Learn about our work by visiting the lab’s website. You can also learn about the CDC Southeastern Center of Excellence in Vector Borne Diseases, including news and upcoming events related to the Center, by visiting their homepage.
- PhD, Microbiology & Immunology, University of Maryland School of Medicine, 2004
- MPhil, Vector Biology, Yale University, 2002
- MPH, Infectious Disease Epidemiology/Global Health, Yale University, 1998
Honors, Awards, and Professional Activities
- Director, CDC Southeastern Regional Center of Excellence in Vector Borne Diseases: Gateway Program, The University of Florida, Gainesville, FL 2016-present
- Editorial Board, PLoS Neglected Tropical Diseases
- Advisory Board, United States Military Malaria Vaccine Program
- Host-Pathogen Working Group, NIH-funded MaHPIC program of Emory University, Atlanta, GA.
- Faculty, Developing Excellence in Leadership and Genetic Training for Malaria Elimination in Sub-Saharan Africa (DELTAS) Training Program, Wellcome Trust, UK, 2015-present
- Human Frontiers Science Program (Strasbourg, France) Young Investigators Award, 2012
Much of Dr. Dinglasan’s research has focused on finding a vaccine that will prevent malaria transmission. As part of this effort, Dinglasan has focused specifically on ways in which interactions between the human malaria parasites Plasmodium falciparum and P. vivax and the Anopheles mosquito midgut can be better understood to disrupt the transmission of these pathogens to humans. To better study these interactions, he is interested in the application of mass spectrometry toward the molecular and cellular analysis of critical transition steps during malaria parasite transmission. He has also studied how nanoparticle technology can contribute to the development of vaccine and drug delivery systems.
His interest in preventing the spread of malaria has led him to study the developmental biology of the malaria parasite – concentrating on the parasite’s sexual stage. This stage of the parasite’s life cycle does not actually cause disease in humans, so it has not been studied as thoroughly as the erythrocytic stages, where the parasite infects red blood cells and causes disease.
Dinglasan’s lab also has an interest in both supplementing and innovating the current arsenal of anti-malarial treatments. By investigating pathways of infection and disease development, his team hopes to find natural product compounds with potential as drug scaffolds for new anti-malaria drugs. Dinglasan’s lab hopes to preempt eventual drug resistance by focusing on novel biochemical pathways in the parasite that can be targeted by natural product compounds. Combining these approaches allows the lab to target multiple aspects of the pathway from transmission to disease.
- Naturally acquired immunity against immature Plasmodium falciparum gametocytes.
- Ribosomal/nucleolar stress induction regulates tert-Butyl hydroperoxide (tBHP) mediated oxidative stress in Anopheles gambiae midguts.
- The Selection of a Hepatocyte Cell Line Susceptible to Plasmodium falciparum Sporozoite Invasion That Is Associated With Expression of Glypican-3.
- Homologs of Human Dengue-Resistance Genes, FKBP1B and ATCAY, Confer Antiviral Resistance in Aedes aegypti Mosquitoes.
Additional publications here