José Ignacio Aguirre

Ignacio Aguirre Portrait

Assistant Professor

Department of Physiological Sciences
PO Box 100144
1333 Center Drive
Gainesville, FL 32610-0144
FAX: 352-392-5145


  • Residency, University of Florida, Animal Care Services, College of Medicine, 2012
  • Postdoctoral Research Fellow, University of Arkansas for Medical Sciences, Division of Endocrinology and Metabolism, College of Medicine, 2005
  • PhD, Universidad Nacional de La Plata, Facultad de Ciencias Veterinarias, 2002
  • Diplomat, Imperial College of Science, Technology and Medicine, Department of Histochemistry, 1998
  • Master in Vet. Pathology, University of London, Royal Veterinary College, 1997
  • Diplomat, University of Tokyo, Department of Agriculture, 1992
  • DVM, Universidad Nacional de La Plata, Facultad de Ciencias Veterinarias, 1989

 Honors and Awards

  • UF Excellence Award for Assistant Professors, 2016
  • Diplomate of the American College of Laboratory Animal Medicine (DACLAM), 2013
  • President’s Poster Competition Award. ASBMR, 34th annual meeting, Minneapolis, MN, 2012
  • Young Investigator Travel Grant. ASBMR, 33th annual meeting. San Diego, CA, 2011
  • Burroughs Wellcome Fund Postdoctoral Travel Award. National Veterinary Scholars Symposium, Orlando, FL, 2011
  • Young Investigator Award. The International Society of Bone Morphometry (ISBM), XIth Congress of the ISBM, Zell Am See, Austria, 2009
  • Young Investigator Travel Grant 2007. ASBMR, 29th annual meeting, Honolulu, HI, 2007
  • Juan de la Cierva Award, Spanish Ministry of Education and Science. Barcelona, Spain, 2005
  • Young Investigator Award. The American Society of Bone and Mineral Research (ASBMR),2005
  • Alice L. Jee Memorial Young Investigator Award. The 34th International Sun Valley Workshop on Skeletal Tissue Biology, Sun Valley, ID, 2004
  • Reentry Grant Award for Postgraduate Students. The Antorchas Foundation, Buenos Aires, Argentina, 2000
  • Biorad. Ltd. Co. Assistantship to support Diploma of The Imperial College in Pathology, Department of Histochemistry, Hammersmith Campus, Imperial College of Science, Technology and Medicine, London, United Kingdom, 1997
  • Laboratory Animals LTD grant. London, United Kingdom, 1996
  • Graduate Scholarship Award. International Cooperation Agency, Argentinean Ministry of Education, Buenos Aires, Argentina, 1996
  • Award for Advanced Studies in the United Kingdom. The British Council and the British Embassy, London, United Kingdom, 1996
  • Graduate Scholarship Award. Japanese International Cooperation Agency (JICA), Tokyo, Japan, 1991

Research Interests

Skeletal effects of bisphosphonates and bone anabolic agents/drugs for the prevention and treatment of local osteopenias (e.g., jaw) and postmenopausal osteoporosis. Pathophysiology of osteonecrosis of the jaw (ARONJ), and other side effects of antiresorptive drugs. Small animal models of periodontitis. Extended half-life of RANK Ligand antagonists for preclinical testing of osteoporosis treatments in small animals. Comparative medicine.

Recent Publications

  1. Aguirre J.I.; Akhter M.; Kimmel D.; Pingel J.; Xia X.; Williams A.; Jorgensen M.; Edmonds K.; Lee J.; Reinhard M.; Battles A.; Kesavalu L.; Wronski T.J. Enhanced Alveolar Bone Loss in a Model of Non-Invasive Periodontitis in Rice Rats. Oral Dis. 18(5):459-468, 2012.
  2. Aguirre J.I.; Akhter M.; Kimmel D.; Pingel J.; Xia X.; Williams A.; Jorgensen M.; Kesavalu L.; Wronski T.J. Oncologic Doses of Zoledronic Acid Induce Osteonecrosis of the Jaw-Like Lesions in Rice Rats (Oryzomys palustris) with Periodontitis. J. Bone Mineral Res 27(10):2130-2143, 2012.
  3. Yarrow, J.F.; Conover, C.F.; Beggs, L.A.; Beck, D.T.; Otzel, D.; Baelez, A.; Combs, S.M.; Miller, J. R.; Ye, F.; Aguirre, J.I.; Neuville, K.G.; Williams, A.A.; Conrad, B.P.; Gregory, C.M.; Wronski, T.J.; Bose, P.K.; Borst, S.E. Testosterone Dose-Dependently Prevents Bone and Muscle Loss in Rodents Following Spinal Cord Injury. Journal of Neurotrauma 31(9):834-845, 2014.
  4. Aguirre, J.I.; Edmonds, K.; Zamora, B; Pingel, J.; Thomas, L.; Cancel, D.; Schneider, L.; Reinhard, M.K.; Battles, A.H.; Akhter, M.P.; Kimmel, D.B.; Wronski, T. J. Marsh rice rat (Oryzomys palustris) under laboratory conditions: breeding, rearing, veterinary care and hematologic findings in a small animal model for periodontitis. JAALAS. (Accepted; May, 2014).

Additional publications

  1. Aguirre, J.I.; Buttery, L.; O´shaughnessy, M.; Afzal, F.; Fernandez de Marticorena, I.; Hukkanen, M.; Huang, P.; MacIntyre, I.; Polak, J. Endothelial Nitric Oxide Synthase Gene-Deficient Mice Demonstrate Marked Retardation in Postnatal Bone Formation, Reduced Bone Volume, and Defects in Osteoblast Maturation and Activity. Am. J. Pathol. (USA) 158(1): 247-257, 2001.
  2. Chen, J.; Plotkin, L.; Aguirre, J.I.; Han L.; Peng H.; Kousteni S.; Bellido, T.; Manolagas, S. Transient Versus Sustained Activation and Nuclear Accumulation of ERKs Underlie the Anti-versus the Pro-apoptotic Effects of Estrogens on Osteoblasts/Osteocytes and Osteoclasts. J. Biol. Chem. (USA) 280(6):4632-4638, 2005.
  3. Plotkin, L.; Aguirre, J.I.; Kousteni, S.; Manolagas, S.C.; Bellido, T. Bisphosphonates and Estrogens Inhibit Osteocyte Apoptosis Via Distinct Molecular Mechanisms Downstream of ERK Activation. J. Biol. Chem. (USA) 280:7317-7325, 2005.
  4. Plotkin, L.; Mathov, I.; Aguirre, J.I.; Manolagas, S.C.; Bellido, T. Mechanical Stimulus Prevent Osteocytes Apoptosis Through an Integrin/SRC/ERK Signalsome Localized in Caveolae. Am. J. Physiol.- Cell Physiology (USA) 289: C633-C643, 2005.
  5. Aguirre, J.I.; Plotkin, L.I.; Stewart, S.A.; Weinstein, R.S.; Parfitt, A.M.; Manolagas, S.C.; Bellido.T. Osteocyte Apoptosis Precedes Osteoclastic Bone Resorption and The Loss of Bone Mineral and Strength Induced by Unloading in Mice. J. Bone Mineral Res (USA) 21 (4): 605-615, 2006.
  6. Aguirre, J.I.; Leal M.E., Rivera, M.F.; Vanegas, S.M.; Wronski, T.J. Effects of Basic Fibroblast Growth Factor and a Prostaglandin E2 Receptor Subtype 4 Agonist on Osteoblastogenesis and Adipogenesis in Aged Ovariectomized Rats. J. Bone Mineral Res (USA) 22 (6): 877-888, 2007.
  7. Aslanidi, G.; Kroutov, V.; Philipsberg, G.; Lamb, K.; Campbell-Thompson, M.; Walter, G.; Kurenov, S.; Aguirre, J.I.; Keller, P.; Hankenson, K.; MacDougald, O.; Zolotukhin, S. Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats. Am. J. Physiol.- Endocrinology and Metabolism (USA) 293 (3) E726-E736, 2007.
  8. Aguirre, J.I.; Plotkin, L.I.; Gortazar, A.R.; Martin Millan, M., O’brien C.A.; Manolagas, S.C.; Bellido.T. A Novel Ligand-independent Function of The Estrogen Receptor Is Essential for Osteocyte and Osteoblast Mechanotransduction. J. Biol. Chem. 282 (35) 25501-25508, 2007.
  9. Leal, M.E.; Holliday, S.; Aguirre, J.I.; Wronski, T.J. In Vitro and in Vivo Evidence for Stimulation of Bone Resorption by and EP4 Receptor Agonist and Basic Fibroblast Growth Factor: Implications for their Efficacy as Bone Anabolic Agents. Bone 44(2) 266-274, 2009.
  10. Aguirre, J.I.; Altman, M.K.; Vanegas, S.M.; Franz, S.E.; Bassit A.C.; Wronski, T.J. Effects of alendronate on bone healing after tooth extraction in rats. Oral Dis. 16(7):674-685, 2010.
  11. Ma Y.L.; Zeng, Q.Q.; Porras, L.L.; Harvey, A.; Moore, T.L.; Shelbourn, T.L.; Dalsky G.P.; Wronski, T.J.; Aguirre, J.I.; Bryant, H.U.; Sato, M. Teriparatide [rhPTH (1-34)], but not strontium ranelate, demonstrated bone anabolic efficacy in mature, osteopenic, ovariectomized rats. Endocrinology 152(5) 1767-78, 2011.

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