Charles H Vite

Charles H Vite,

Professor And Chair, Small Animal Clinical Sciences

Department: Small Animal Clinical Sciences
Business Phone: (352) 294-4504
Business Email: charlesvite@ufl.edu

About Charles H Vite

Dr. Charles Vite, Professor and Chair of the Department of Small Animal Clinical Sciences, moved from the University of Pennsylvania to the University of Florida in October 2023. A board-certified veterinary neurologist, Dr. Vite has a research focus to improve the characterization and treatment of hereditary neurodegenerative diseases. His laboratory develops and evaluates experimental therapies including gene therapy, cell-based therapy, and pharmacotherapy and develops and validates ante-mortem biochemical and magnetic resonance markers of disease severity and progression.

Accomplishments

Chair and Professor (with tenure)
2023-Current · Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida
Professor (with tenure), Section of Neurology and Neurosurgery
2018-2023 · Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania
Associate Professor (with tenure), Section of Neurology
2012-2018 · Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania
Assistant Professor, Section of Neurology
2004-2012 · Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania

Board Certifications

  • Diplomate
    ACVIM (Neurology)

Clinical Profile

Medical neurology

Areas of Interest
  • Epilepsy
  • Niemann-Pick disease

Research Profile

The focus of my lab is to improve the characterization and treatment of neurodegenerative diseases by studying naturally occurring large animal models of human diseases. My lab develops and evaluates experimental therapies including gene therapy, cell-based therapy, and pharmacotherapy in canine and feline models, and develops and validates ante mortem biochemical and magnetic resonance markers of disease severity and progression. My emphasis is to build bridges between biomedical sciences, government, pharmaceutical industries, and the FDA in order to bring new therapies to patients.

Open Researcher and Contributor ID (ORCID)

0000-0001-6625-5266

Publications

2023
A Homozygous MAN2B1 Missense Mutation in a Doberman Pinscher Dog with Neurodegeneration, Cytoplasmic Vacuoles, Autofluorescent Storage Granules, and an α-Mannosidase Deficiency.
Genes. 14(9) [DOI] 10.3390/genes14091746. [PMID] 37761886.
2023
Biodistribution of Adeno-Associated Virus Gene Therapy Following Cerebrospinal Fluid-Directed Administration.
Human gene therapy. 34(3-4):94-111 [DOI] 10.1089/hum.2022.163. [PMID] 36606687.
2022
Efficacy and Safety of a Krabbe Disease Gene Therapy.
Human gene therapy. 33(9-10):499-517 [DOI] 10.1089/hum.2021.245. [PMID] 35333110.
2021
Low incidence of hepatocellular carcinoma in mice and cats treated with systemic adeno-associated viral vectors.
Molecular therapy. Methods & clinical development. 20:247-257 [DOI] 10.1016/j.omtm.2020.11.015. [PMID] 33473358.
2021
Meningeal B Cell Clusters Correlate with Submeningeal Pathology in a Natural Model of Multiple Sclerosis.
Journal of immunology (Baltimore, Md. : 1950). 207(1):44-54 [DOI] 10.4049/jimmunol.2000514. [PMID] 34162727.
2020
Application of N-palmitoyl-O-phosphocholineserine for diagnosis and assessment of response to treatment in Niemann-Pick type C disease.
Molecular genetics and metabolism. 129(4):292-302 [DOI] 10.1016/j.ymgme.2020.01.007. [PMID] 32033912.
2020
Cerebrospinal fluid and serum glycosphingolipid biomarkers in canine globoid cell leukodystrophy (Krabbe Disease).
Molecular and cellular neurosciences. 102 [DOI] 10.1016/j.mcn.2019.103451. [PMID] 31794880.
2020
Global CNS correction in a large brain model of human alpha-mannosidosis by intravascular gene therapy.
Brain : a journal of neurology. 143(7):2058-2072 [DOI] 10.1093/brain/awaa161. [PMID] 32671406.
2020
Krabbe disease successfully treated via monotherapy of intrathecal gene therapy.
The Journal of clinical investigation. 130(9):4906-4920 [DOI] 10.1172/JCI133953. [PMID] 32773406.
2020
Pharmacokinetics and distribution of 2-hydroxypropyl-β-cyclodextrin following a single intrathecal dose to cats.
Journal of inherited metabolic disease. 43(3):618-634 [DOI] 10.1002/jimd.12189. [PMID] 31707730.
2019
Large animal models contribute to the development of therapies for central and peripheral nervous system dysfunction in patients with lysosomal storage diseases.
Human molecular genetics. 28(R1):R119-R131 [DOI] 10.1093/hmg/ddz127. [PMID] 31384936.
2019
N-acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease.
Journal of lipid research. 60(8):1410-1424 [DOI] 10.1194/jlr.RA119000157. [PMID] 31201291.
2018
A cross-species approach to disorders affecting brain and behaviour.
Nature reviews. Neurology. 14(11):677-686 [DOI] 10.1038/s41582-018-0074-z. [PMID] 30287906.
2018
AAVrh10 Gene Therapy Ameliorates Central and Peripheral Nervous System Disease in Canine Globoid Cell Leukodystrophy (Krabbe Disease).
Human gene therapy. 29(7):785-801 [DOI] 10.1089/hum.2017.151. [PMID] 29316812.
2018
Evaluation of Intrathecal Routes of Administration for Adeno-Associated Viral Vectors in Large Animals.
Human gene therapy. 29(1):15-24 [DOI] 10.1089/hum.2017.026. [PMID] 28806897.
2018
LC3 Immunostaining in the Inferior Olivary Nuclei of Cats With Niemann-Pick Disease Type C1 Is Associated With Patterned Purkinje Cell Loss.
Journal of neuropathology and experimental neurology. 77(3):229-245 [DOI] 10.1093/jnen/nlx119. [PMID] 29346563.
2018
Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages.
The neuroradiology journal. 31(2):168-176 [DOI] 10.1177/1971400917733431. [PMID] 29350082.
2017
Canine and Feline Models of Human Genetic Diseases and Their Contributions to Advancing Clinical Therapies
.
The Yale journal of biology and medicine. 90(3):417-431 [PMID] 28955181.
2017
Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1-2 trial.
Lancet (London, England). 390(10104):1758-1768 [DOI] 10.1016/S0140-6736(17)31465-4. [PMID] 28803710.
2017
Novel region of interest interrogation technique for diffusion tensor imaging analysis in the canine brain.
The neuroradiology journal. 30(4):339-346 [DOI] 10.1177/1971400917709629. [PMID] 28627967.
2016
Cerebrospinal Fluid Calbindin D Concentration as a Biomarker of Cerebellar Disease Progression in Niemann-Pick Type C1 Disease.
The Journal of pharmacology and experimental therapeutics. 358(2):254-61 [DOI] 10.1124/jpet.116.232975. [PMID] 27307499.
2016
Clinical Improvement of Alpha-mannosidosis Cat Following a Single Cisterna Magna Infusion of AAV1.
Molecular therapy : the journal of the American Society of Gene Therapy. 24(1):26-33 [DOI] 10.1038/mt.2015.168. [PMID] 26354342.
2016
Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe’s disease).
Journal of neuroscience research. 94(11):1007-17 [DOI] 10.1002/jnr.23838. [PMID] 27638585.
2016
Correction: Forecasting Seizures Using Bivariate Intracranial EEG Measures and SVM in Naturally Occurring Canine Epilepsy.
PloS one. 11(5) [DOI] 10.1371/journal.pone.0156476. [PMID] 27227650.
2016
Crowdsourcing reproducible seizure forecasting in human and canine epilepsy.
Brain : a journal of neurology. 139(Pt 6):1713-22 [DOI] 10.1093/brain/aww045. [PMID] 27034258.
2016
Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease.
PloS one. 11(3) [DOI] 10.1371/journal.pone.0152007. [PMID] 27019000.
2016
Diffusion tensor imaging analysis of the brain in the canine model of Krabbe disease.
The neuroradiology journal. 29(6):417-424 [PMID] 27677296.
2016
Diffusion Tensor Imaging for Assessing Brain Gray and White Matter Abnormalities in a Feline Model of α-Mannosidosis.
Journal of neuropathology and experimental neurology. 75(1):35-43 [PMID] 26671987.
2016
Ebola virus mediated infectivity is restricted in canine and feline cells.
Veterinary microbiology. 182:102-7 [DOI] 10.1016/j.vetmic.2015.11.011. [PMID] 26711035.
2016
Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII.
Molecular therapy : the journal of the American Society of Gene Therapy. 24(2):206-216 [DOI] 10.1038/mt.2015.189. [PMID] 26447927.
2016
Fostering collaborative research for rare genetic disease: the example of niemann-pick type C disease.
Orphanet journal of rare diseases. 11(1) [PMID] 27903269.
2016
Insights into the Pathogenesis and Treatment of Krabbe Disease.
Pediatric endocrinology reviews : PER. 13 Suppl 1:689-96 [PMID] 27491217.
2016
Mining continuous intracranial EEG in focal canine epilepsy: Relating interictal bursts to seizure onsets.
Epilepsia. 57(1):89-98 [DOI] 10.1111/epi.13249. [PMID] 26608448.
2016
Temporal behavior of seizures and interictal bursts in prolonged intracranial recordings from epileptic canines.
Epilepsia. 57(12):1949-1957 [DOI] 10.1111/epi.13591. [PMID] 27807850.
2015
A review of gene therapy in canine and feline models of lysosomal storage disorders.
Human gene therapy. Clinical development. 26(1):27-37 [DOI] 10.1089/humc.2015.002. [PMID] 25671613.
2015
Canine status epilepticus treated with fosphenytoin: A proof of principle study.
Epilepsia. 56(6):882-7 [DOI] 10.1111/epi.12994. [PMID] 25953073.
2015
Diffusion tensor imaging and myelin composition analysis reveal abnormal myelination in corpus callosum of canine mucopolysaccharidosis I.
Experimental neurology. 273:1-10 [DOI] 10.1016/j.expneurol.2015.07.021. [PMID] 26222335.
2015
Forecasting Seizures Using Intracranial EEG Measures and SVM in Naturally Occurring Canine Epilepsy.
PloS one. 10(8) [DOI] 10.1371/journal.pone.0133900. [PMID] 26241907.
2015
Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease.
Science translational medicine. 7(276) [DOI] 10.1126/scitranslmed.3010101. [PMID] 25717099.
2015
Mechanism of neuromuscular dysfunction in Krabbe disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(4):1606-16 [DOI] 10.1523/JNEUROSCI.2431-14.2015. [PMID] 25632136.
2014
Adeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain.
Gene therapy. 21(1):28-36 [DOI] 10.1038/gt.2013.54. [PMID] 24131981.
2014
Aging in the canine and feline brain.
The Veterinary clinics of North America. Small animal practice. 44(6):1113-29 [DOI] 10.1016/j.cvsm.2014.07.008. [PMID] 25441628.
2014
Cholesterol homeostatic responses provide biomarkers for monitoring treatment for the neurodegenerative disease Niemann-Pick C1 (NPC1).
Human molecular genetics. 23(22):6022-33 [DOI] 10.1093/hmg/ddu331. [PMID] 24964810.
2014
Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease.
Current topics in medicinal chemistry. 14(3):330-9 [PMID] 24283970.
2014
Corrective GUSB transfer to the canine mucopolysaccharidosis VII brain.
Molecular therapy : the journal of the American Society of Gene Therapy. 22(4):762-73 [DOI] 10.1038/mt.2013.283. [PMID] 24343103.
2014
Forecasting seizures in dogs with naturally occurring epilepsy.
PloS one. 9(1) [DOI] 10.1371/journal.pone.0081920. [PMID] 24416133.
2014
Oligodendrocyte loss during the disease course in a canine model of the lysosomal storage disease fucosidosis.
Journal of neuropathology and experimental neurology. 73(6):536-47 [DOI] 10.1097/NEN.0000000000000075. [PMID] 24806306.
2014
Quantitative, noninvasive, in vivo longitudinal monitoring of gene expression in the brain by co-AAV transduction with a PET reporter gene.
Molecular therapy. Methods & clinical development. 1 [DOI] 10.1038/mtm.2014.16. [PMID] 26015960.
2014
Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magna.
Molecular therapy. Methods & clinical development. 1 [DOI] 10.1038/mtm.2014.51. [PMID] 26052519.
2013
Electrodiagnostic testing and histopathologic changes confirm peripheral nervous system myelin abnormalities in the feline model of niemann-pick disease type C.
Journal of neuropathology and experimental neurology. 72(3):256-62 [DOI] 10.1097/NEN.0b013e318286587f. [PMID] 23399903.
2013
Feasibility study of a caregiver seizure alert system in canine epilepsy.
Epilepsy research. 106(3):456-60 [DOI] 10.1016/j.eplepsyres.2013.06.007. [PMID] 23962794.
2013
Features of brain MRI in dogs with treated and untreated mucopolysaccharidosis type I.
Comparative medicine. 63(2):163-73 [PMID] 23582423.
2013
Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling.
Journal of lipid research. 54(10):2800-14 [DOI] 10.1194/jlr.M040618. [PMID] 23881911.
2013
Postmortem evaluation of 435 cases of intracranial neoplasia in dogs and relationship of neoplasm with breed, age, and body weight.
Journal of veterinary internal medicine. 27(5):1143-52 [DOI] 10.1111/jvim.12136. [PMID] 23865437.
2013
Pulmonary abnormalities in animal models due to Niemann-Pick type C1 (NPC1) or C2 (NPC2) disease.
PloS one. 8(7) [DOI] 10.1371/journal.pone.0067084. [PMID] 23843985.
2012
A digital atlas of the dog brain.
PloS one. 7(12) [DOI] 10.1371/journal.pone.0052140. [PMID] 23284904.
2012
Amyloid-β metabolism in Niemann-Pick C disease models and patients.
Metabolic brain disease. 27(4):573-85 [DOI] 10.1007/s11011-012-9332-8. [PMID] 22935999.
2012
An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluid.
Journal of mass spectrometry : JMS. 47(5):591-603 [DOI] 10.1002/jms.2987. [PMID] 22576872.
2012
Identification of the rostral migratory stream in the canine and feline brain.
PloS one. 7(5) [DOI] 10.1371/journal.pone.0036016. [PMID] 22606243.
2012
Miglustat improves purkinje cell survival and alters microglial phenotype in feline Niemann-Pick disease type C.
Journal of neuropathology and experimental neurology. 71(5):434-48 [DOI] 10.1097/NEN.0b013e31825414a6. [PMID] 22487861.
2011
A novel implanted device to wirelessly record and analyze continuous intracranial canine EEG.
Epilepsy research. 96(1-2):116-22 [DOI] 10.1016/j.eplepsyres.2011.05.011. [PMID] 21676591.
2011
BAER testing in a dog with bilateral external ear canal atresia.
Journal of the American Animal Hospital Association. 47(5):370-4 [DOI] 10.5326/JAAHA-MS-5545. [PMID] 21852512.
2011
Biodistribution and pharmacodynamics of recombinant human alpha-L-iduronidase (rhIDU) in mucopolysaccharidosis type I-affected cats following multiple intrathecal administrations.
Molecular genetics and metabolism. 103(3):268-74 [DOI] 10.1016/j.ymgme.2011.03.011. [PMID] 21482164.
2011
Comparative magnetic resonance imaging findings between gliomas and presumed cerebrovascular accidents in dogs.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 52(1):33-40 [PMID] 21322385.
2011
Correlating magnetic resonance findings with neuropathology and clinical signs in dogs and cats.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 52(1 Suppl 1):S23-31 [DOI] 10.1111/j.1740-8261.2010.01782.x. [PMID] 21392153.
2011
Evaluation of the electroencephalogram in young cats.
American journal of veterinary research. 72(3):391-7 [DOI] 10.2460/ajvr.72.3.391. [PMID] 21355743.
2010
2-hydroxypropyl-beta-cyclodextrin raises hearing threshold in normal cats and in cats with Niemann-Pick type C disease.
Pediatric research. 68(1):52-6 [PMID] 20357695.
2010
Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease.
Science translational medicine. 2(56) [DOI] 10.1126/scitranslmed.3001417. [PMID] 21048217.
2010
Early versus late treatment of spinal cord compression with long-term intrathecal enzyme replacement therapy in canine mucopolysaccharidosis type I.
Molecular genetics and metabolism. 101(2-3):115-22 [DOI] 10.1016/j.ymgme.2010.06.020. [PMID] 20655780.
2010
Magnetic resonance spectroscopy of the occipital cortex and the cerebellar vermis distinguishes individual cats affected with alpha-mannosidosis from normal cats.
NMR in biomedicine. 23(1):74-9 [DOI] 10.1002/nbm.1430. [PMID] 19743435.
2010
Replacing the enzyme alpha-L-iduronidase at birth ameliorates symptoms in the brain and periphery of dogs with mucopolysaccharidosis type I.
Science translational medicine. 2(60) [DOI] 10.1126/scitranslmed.3001380. [PMID] 21123810.
2009
In utero transplantation of monocytic cells in cats with alpha-mannosidosis.
Transplantation. 88(3):323-9 [DOI] 10.1097/TP.0b013e3181b0d264. [PMID] 19667933.
2009
Polymicrogyria in standard poodles.
Journal of veterinary internal medicine. 23(4):871-4 [DOI] 10.1111/j.1939-1676.2009.0338.x. [PMID] 19566852.
2008
Apparent diffusion coefficient reveals gray and white matter disease, and T2 mapping detects white matter disease in the brain in feline alpha-mannosidosis.
AJNR. American journal of neuroradiology. 29(2):308-13 [PMID] 17974615.
2008
Clinical peripheral neuropathy associated with diabetes mellitus in 3 dogs.
The Canadian veterinary journal = La revue veterinaire canadienne. 49(6):583-6 [PMID] 18624068.
2008
Clinical, electrophysiological, and serum biochemical measures of progressive neurological and hepatic dysfunction in feline Niemann-Pick type C disease.
Pediatric research. 64(5):544-9 [DOI] 10.1203/PDR.0b013e318184d2ce. [PMID] 18614965.
2008
CT-guided stereotactic brain biopsy using the Kopf stereotactic system.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 49(5):438-43 [PMID] 18833950.
2008
Tumors affecting the spinal cord of cats: 85 cases (1980-2005).
Journal of the American Veterinary Medical Association. 232(2):237-43 [DOI] 10.2460/javma.232.2.237. [PMID] 18275391.
2007
Bone marrow transplantation for feline mucopolysaccharidosis I.
Molecular genetics and metabolism. 91(3):239-50 [PMID] 17482862.
2007
Correction of clinical manifestations of canine mucopolysaccharidosis I with neonatal retroviral vector gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy. 15(8):1423-31 [PMID] 17519893.
2006
Expression in blood cells may contribute to biochemical and pathological improvements after neonatal intravenous gene therapy for mucopolysaccharidosis VII in dogs.
Molecular genetics and metabolism. 87(1):8-21 [PMID] 16275036.
2006
Ventricular pneumocephalus and septic meningoencephalitis secondary to dorsal rhinotomy and nasal polypectomy in a dog.
Journal of the American Veterinary Medical Association. 229(2):240-5 [PMID] 16842045.
2005
Central nervous system dysfunction associated with Rocky Mountain spotted fever infection in five dogs.
Journal of the American Animal Hospital Association. 41(4):259-66 [PMID] 15995164.
2005
Effective gene therapy for an inherited CNS disease in a large animal model.
Annals of neurology. 57(3):355-64 [PMID] 15732095.
2005
Signs of neurologic dysfunction in dogs with central versus peripheral vestibular disease.
Journal of the American Veterinary Medical Association. 227(4):570-4 [PMID] 16117064.
2004
Gene therapy for lysosomal storage diseases: the lessons and promise of animal models.
The journal of gene medicine. 6(5):481-506 [PMID] 15133760.
2004
Magnetic resonance imaging features of feline intracranial neoplasia: retrospective analysis of 46 cats.
Journal of veterinary internal medicine. 18(2):176-89 [PMID] 15058768.
2004
Prevalence of diseases of the spinal cord of cats.
Journal of veterinary internal medicine. 18(6):851-8 [PMID] 15638269.
2003
Adeno-associated virus vector-mediated transduction in the cat brain.
Gene therapy. 10(22):1874-81 [PMID] 14502216.
2003
Feline intracranial neoplasia: retrospective review of 160 cases (1985-2001).
Journal of veterinary internal medicine. 17(6):850-9 [PMID] 14658723.
2003
Intravascular lymphoma involving the central and peripheral nervous systems in a dog.
Journal of the American Animal Hospital Association. 39(1):90-6 [PMID] 12549621.
2003
Intraventricular brain injection of adeno-associated virus type 1 (AAV1) in neonatal mice results in complementary patterns of neuronal transduction to AAV2 and total long-term correction of storage lesions in the brains of beta-glucuronidase-deficient mice.
Journal of virology. 77(12):7034-40 [PMID] 12768022.
2002
Myotonia and disorders of altered muscle cell membrane excitability.
The Veterinary clinics of North America. Small animal practice. 32(1):169-87, vii [PMID] 11785728.
2002
Results of cerebrospinal fluid analysis, neurologic examination findings, and age at the onset of seizures as predictors for results of magnetic resonance imaging of the brain in dogs examined because of seizures: 115 cases (1992-2000).
Journal of the American Veterinary Medical Association. 220(6):781-4 [PMID] 11918271.
2001
Magnetization transfer imaging of the canine brain: a review.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 42(1):5-8 [PMID] 11245238.
2000
A modified bilateral transfrontal sinus approach to the canine frontal lobe and olfactory bulb: surgical technique and five cases.
Journal of the American Animal Hospital Association. 36(1):43-50 [PMID] 10667405.
2000
Investigating demyelination in the brain in a canine model of globoid cell leukodystrophy (Krabbe disease) using magnetization transfer contrast: preliminary results.
Journal of computer assisted tomography. 24(2):316-21 [PMID] 10752900.
2000
Neurosurgical emergencies.
The Veterinary clinics of North America. Small animal practice. 30(3):617-44, vii [PMID] 10853279.
1999
A missense mutation in canine C1C-1 causes recessive myotonia congenita in the dog.
FEBS letters. 456(1):54-8 [PMID] 10452529.
1999
Congenital myotonic myopathy in the miniature schnauzer: an autosomal recessive trait.
The Journal of heredity. 90(5):578-80 [PMID] 10544501.
1999
Globoid cell leukodystrophy in cairn and West Highland white terriers.
The Journal of heredity. 90(1):138-42 [PMID] 9987921.
1999
Severe neurologic sequelae in a dog after treatment of hypoadrenal crisis.
Journal of the American Veterinary Medical Association. 215(2):222-5, 210 [PMID] 10416476.
1998
A case of canine central nervous system cryptococcosis: management with fluconazole.
Journal of the American Animal Hospital Association. 34(2):145-51 [PMID] 9507427.
1998
Acute fulminating myasthenia gravis in five dogs.
Journal of the American Veterinary Medical Association. 212(6):830-4 [PMID] 9530421.
1998
MRI and electrophysiological abnormalities in a case of canine globoid cell leucodystrophy.
The Journal of small animal practice. 39(8):401-5 [PMID] 9741878.
1998
Myotonic myopathy in a miniature Schnauzer: case report and data suggesting abnormal chloride conductance across the muscle membrane.
Journal of veterinary internal medicine. 12(5):394-7 [PMID] 9773418.
1997
Quantification of cerebral ventricular volume in English bulldogs.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 38(6):437-43 [PMID] 9402710.
1995
A retrospective evaluation of 51 cases of peripheral nerve sheath tumors in the dog.
Journal of the American Animal Hospital Association. 31(4):349-59 [PMID] 7552669.
1990
Comments on a multiple-choice ethics examination.
Journal of the American Veterinary Medical Association. 197(8) [PMID] 2243044.

Grants

Dec 2023 ACTIVE
Support of the NPC1 cat colony for future preclinical trials
Role: Principal Investigator
Funding: UNIV OF NOTRE DAME

Education

PhD (cell and molecular biology)
1999-2003 · University of Pennsylvania
DVM
1986-1990 · Purdue University
BS
1982-1986 · Cornell University

Contact Details

Phones:
Business:
(352) 294-4504
Emails:
Administrative Specialist II:
Stephanie R Tyler
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Business Mailing:
2015 SW 16TH AVE
GAINESVILLE FL 32608
Business Street:
PO Box 100126
GAINESVILLE FL 32610