Thomas Vickroy

Thomas Vickroy,

Professor Emeritus

Department: VM-DEAN
Business Phone: (352) 294-4036
Business Email: vickroy@ufl.edu

Accomplishments

Distinguished Alumnus Award, Graduate School of Biomedical Sciences
2017 · University of Texas Medical Branch
Invited speaker
2013 · International Workshop for Harmonization of Minor Use/Minor Species Veterinary Drugs in Food Animals
Clinical Sciences Teacher of the Year Award
2006 · UF College of Veterinary Medicine
Teacher of the Year Award (Class of 1996)
1998 · UF College of Veterinary Medicine
Teaching Improvement Program Award
1994 · UF College of Veterinary Medicine
C.E. Cornelius Outstanding Young Investigator Award
1991 · UF College of Veterinary Medicine

Research Profile

–Drug residues in animal-derived and plant-based human food products

–Pharmacokinetics of drugs in food-producing animals

–Disease impacts on drug pharmacokinetics in food-producing animal species

Publications

2020
Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and swine.
Journal of veterinary pharmacology and therapeutics. 43(5):385-420 [DOI] 10.1111/jvp.12861. [PMID] 32270548.
2020
Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part II: Chicken and turkey.
Journal of veterinary pharmacology and therapeutics. [DOI] 10.1111/jvp.12931. [PMID] 33289178.
2019
Extralabel drug use in wildlife and game animals.
Journal of the American Veterinary Medical Association. 255(5):555-568 [DOI] 10.2460/javma.255.5.555. [PMID] 31429657.
2019
Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats.
Acta physiologica (Oxford, England). 226(2) [DOI] 10.1111/apha.13256. [PMID] 30656835.
2019
In vitro and in vivo Synergistic Effects of Florfenicol and Thiamphenicol in Combination Against Swine Actinobacillus pleuropneumoniae and Pasteurella multocida.
Frontiers in microbiology. 10 [DOI] 10.3389/fmicb.2019.02430. [PMID] 31749775.
2019
Integration of Food Animal Residue Avoidance Databank (FARAD) empirical methods for drug withdrawal interval determination with a mechanistic population-based interactive physiologically based pharmacokinetic (iPBPK) modeling platform: example for flunixin meglumine administration.
Archives of toxicology. 93(7):1865-1880 [DOI] 10.1007/s00204-019-02464-z. [PMID] 31025081.
2018
Consequences of fipronil exposure in egg-laying hens.
Journal of the American Veterinary Medical Association. 253(1):57-60 [DOI] 10.2460/javma.253.1.57. [PMID] 29911954.
2018
Extralabel drug use in small ruminants.
Journal of the American Veterinary Medical Association. 253(8):1001-1009 [DOI] 10.2460/javma.253.8.1001. [PMID] 30272520.
2018
Increased Abundance of Lactobacillales in the Colon of Beta-Adrenergic Receptor Knock Out Mouse Is Associated With Increased Gut Bacterial Production of Short Chain Fatty Acids and Reduced IL17 Expression in Circulating CD4+ Immune Cells.
Frontiers in physiology. 9 [DOI] 10.3389/fphys.2018.01593. [PMID] 30483153.
2017
Assessment of veterinary drugs in plants using pharmacokinetic approaches: The absorption, distribution and elimination of tetracycline and sulfamethoxazole in ephemeral vegetables.
PloS one. 12(8) [DOI] 10.1371/journal.pone.0183087. [PMID] 28797073.
2017
Avoiding violative flunixin meglumine residues in cattle and swine.
Journal of the American Veterinary Medical Association. 250(2):182-189 [DOI] 10.2460/javma.250.2.182. [PMID] 28058945.
2017
Considerations for extralabel drug use in calves.
Journal of the American Veterinary Medical Association. 250(11):1275-1282 [DOI] 10.2460/javma.250.11.1275. [PMID] 28509644.
2017
Effect of lidocaine on inflammation in equine jejunum subjected to manipulation only and remote to intestinal segments subjected to ischemia.
American journal of veterinary research. 78(8):977-989 [DOI] 10.2460/ajvr.78.8.977. [PMID] 28738006.
2017
Guide to FARAD resources: historical and future perspectives.
Journal of the American Veterinary Medical Association. 250(10):1131-1139 [DOI] 10.2460/javma.250.10.1131. [PMID] 28467745.
2017
Pharmacokinetics of ceftiofur sodium in equine pregnancy.
Journal of veterinary pharmacology and therapeutics. 40(6):656-662 [DOI] 10.1111/jvp.12399. [PMID] 28317126.
2017
Plasma pharmacokinetics and tissue depletion of cyromazine and its metabolite melamine following oral administration in laying chickens.
Journal of veterinary pharmacology and therapeutics. 40(5):459-467 [DOI] 10.1111/jvp.12379. [PMID] 27900792.
2017
Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon.
Frontiers in physiology. 8 [DOI] 10.3389/fphys.2017.00220. [PMID] 28446880.
2016
Detection of undeclared animal by-products in commercial canine canned foods: Comparative analyses by ELISA and PCR-RFLP coupled with slab gel electrophoresis or capillary gel electrophoresis.
Journal of the science of food and agriculture. 96(5):1659-65 [DOI] 10.1002/jsfa.7268. [PMID] 25996551.
2016
Residue concerns following exposure of livestock to oil and petroleum products.
Journal of the American Veterinary Medical Association. 248(2):145-6 [PMID] 27108460.
View on: PubMed
2015
Disposition of ampicillin trihydrate in plasma, uterine tissue, lochial fluid, and milk of postpartum dairy cattle.
Journal of veterinary pharmacology and therapeutics. 38(4):330-5 [DOI] 10.1111/jvp.12178. [PMID] 25376083.
2015
Egg residue considerations during the treatment of backyard poultry.
Journal of the American Veterinary Medical Association. 247(12):1388-95 [DOI] 10.2460/javma.247.12.1388. [PMID] 26642132.
2014
Levetiracetam rectal administration in healthy dogs.
Journal of veterinary internal medicine. 28(2):504-9 [DOI] 10.1111/jvim.12269. [PMID] 24417468.
2014
Pharmacokinetics and pharmacodynamics of glycopyrrolate following a continuous-rate infusion in the horse.
Journal of veterinary pharmacology and therapeutics. 37(2):133-44 [DOI] 10.1111/jvp.12074. [PMID] 23902283.
2014
Safety of fenbendazole in Chinese ring-necked pheasants (Phasianus colchicus).
Avian diseases. 58(1):8-15 [PMID] 24758107.
View on: PubMed
2013
Disposition of desfuroylceftiofur acetamide in serum, placental tissue, fetal fluids, and fetal tissues after administration of ceftiofur crystalline free acid (CCFA) to pony mares with placentitis.
Journal of veterinary pharmacology and therapeutics. 36(1):59-67 [DOI] 10.1111/j.1365-2885.2012.01392.x. [PMID] 22449008.
2013
Effects of new sampling protocols on procaine penicillin G withdrawal intervals for cattle.
Journal of the American Veterinary Medical Association. 243(10):1408-12 [DOI] 10.2460/javma.243.10.1408. [PMID] 24171369.
2012
Improved nonaqueous capillary electrophoresis for tetracyclines at subparts per billion level.
Electrophoresis. 33(11):1679-82 [DOI] 10.1002/elps.201100485. [PMID] 22887082.
2012
Liquid chromatography incorporating ultraviolet and electrochemical analyses for dual detection of zeranol and zearalenone metabolites in mouldy grains.
Journal of the science of food and agriculture. 92(6):1230-7 [DOI] 10.1002/jsfa.4687. [PMID] 22012692.
2010
Treatment efficacy of trimethoprim sulfamethoxazole, pentoxifylline and altrenogest in experimentally induced equine placentitis.
Theriogenology. 74(3):402-12 [DOI] 10.1016/j.theriogenology.2010.02.023. [PMID] 20416936.
2008
Caffeine-induced hyperactivity in the horse: comparisons of drug and metabolite concentrations in blood and cerebrospinal fluid.
Journal of veterinary pharmacology and therapeutics. 31(2):156-66 [DOI] 10.1111/j.1365-2885.2008.00942.x. [PMID] 18307508.
2007
Capsaicin exposure elicits complex airway defensive motor patterns in normal humans in a concentration-dependent manner.
Pulmonary pharmacology & therapeutics. 20(4):423-32 [PMID] 17236796.
View on: PubMed
2007
Fast differentiation of meats from fifteen animal species by liquid chromatography with electrochemical detection using copper nanoparticle plated electrodes.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 846(1-2):230-9 [PMID] 17008137.
View on: PubMed
2007
The effect of codeine on the Urge-to-Cough response to inhaled capsaicin.
Pulmonary pharmacology & therapeutics. 20(4):338-46 [PMID] 17292647.
View on: PubMed
2006
Continuous monitoring of penicillin G and gentamicin in allantoic fluid of pregnant pony mares by in vivo microdialysis.
Equine veterinary journal. 38(6):520-5 [PMID] 17124841.
View on: PubMed
2006
Pharmacokinetics of clarithromycin and concentrations in body fluids and bronchoalveolar cells of foals.
American journal of veterinary research. 67(10):1681-6 [PMID] 17014316.
View on: PubMed
2005
Pharmacokinetics and pharmacodynamics of pantoprazole in clinically normal neonatal foals.
Equine veterinary journal. 37(4):336-41 [PMID] 16028623.
View on: PubMed
2003
Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues.
American journal of veterinary research. 64(2):216-24 [PMID] 12602592.
View on: PubMed
2002
In vivo monitoring of amino acids by direct sampling of brain extracellular fluid at ultralow flow rates and capillary electrophoresis.
Journal of neuroscience methods. 114(1):39-49 [PMID] 11850038.
View on: PubMed
2001
Continuous measurement of caffeine and two metabolites in blood and skeletal muscle of unrestrained adult horses by semi-automated in vivo microdialysis.
Journal of veterinary pharmacology and therapeutics. 24(6):405-14 [PMID] 11903871.
View on: PubMed
1999
Chronic ethanol exposure increases 3H-GABA release in rat hippocampus by presynaptic muscarinic receptor modulation.
Alcoholism, clinical and experimental research. 23(10):1587-95 [PMID] 10549989.
View on: PubMed
1999
Rapid determination of aspartate enantiomers in tissue samples by microdialysis coupled on-line with capillary electrophoresis.
Analytical chemistry. 71(13):2379-84 [PMID] 10405606.
View on: PubMed
1999
Reversible activation of glutamate transport in rat brain glia by protein kinase C and an okadaic acid-sensitive phosphoprotein phosphatase.
Neurochemical research. 24(8):1017-25 [PMID] 10478941.
View on: PubMed
1998
Development and use of an enzyme-linked immunosorbent assay to monitor serum and urine acepromazine concentrations in thoroghbreds, and possible changes associated with exercise.
American journal of veterinary research. 59(5):593-7 [PMID] 9582962.
View on: PubMed
1998
Evidence for neuronal origin and metabotropic receptor-mediated regulation of extracellular glutamate and aspartate in rat striatum in vivo following electrical stimulation of the prefrontal cortex.
Journal of neurochemistry. 70(2):617-25 [PMID] 9453555.
View on: PubMed
1998
Selective loss of phorbol-12,13-dibutyrate-facilitated L-glutamate transport in forebrain neurons of aged rats.
The journals of gerontology. Series A, Biological sciences and medical sciences. 53(6):B449-51 [PMID] 9823742.
View on: PubMed
1998
Simultaneous isolation of glial and neuronal fractions from rat brain homogenates: comparison of high-affinity L-glutamate transport properties.
Neurochemical research. 23(1):103-13 [PMID] 9482274.
View on: PubMed
1997
High temporal resolution monitoring of glutamate and aspartate in vivo using microdialysis on-line with capillary electrophoresis with laser-induced fluorescence detection.
Analytical chemistry. 69(22):4560-5 [PMID] 9375517.
View on: PubMed
1997
Neurochemical basis of disruption of hippocampal long term potentiation by chronic alcohol exposure.
Frontiers in bioscience : a journal and virtual library. 2:d309-16 [PMID] 9206984.
View on: PubMed
1995
Inhibition of nitric oxide synthase activity in cerebral cortical synaptosomes by nitric oxide donors: evidence for feedback autoregulation.
Neurochemical research. 20(3):299-304 [PMID] 7541898.
View on: PubMed
1995
Regulation of stimulus-dependent hippocampal acetylcholine release by okadaic acid-sensitive phosphoprotein phosphatases.
Neuroscience letters. 191(3):200-4 [PMID] 7644146.
View on: PubMed
1994
Irreversible blockade of high-affinity choline uptake in rat brain by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ).
Biochemical pharmacology. 48(6):1281-7 [PMID] 7945422.
View on: PubMed
1993
Absence of receptor reserve at hippocampal muscarinic autoreceptors which inhibit stimulus-dependent acetylcholine release.
The Journal of pharmacology and experimental therapeutics. 267(3):1198-204 [PMID] 8263780.
View on: PubMed
1993
Presynaptic cholinergic actions by the putative cognitive enhancing agent DuP 996.
The Journal of pharmacology and experimental therapeutics. 264(2):910-7 [PMID] 8382283.
View on: PubMed
1992
Pharmacological heterogeneity among calcium channels that subserve acetylcholine release in vertebrate forebrain.
Neuropharmacology. 31(3):307-9 [PMID] 1321360.
View on: PubMed
1991
Calcium- and barium-activated acetylcholine synthesis and release from isolated nerve terminals. Do divalent cations alter membrane potential?
Annals of the New York Academy of Sciences. 635:446-9 [PMID] 1741600.
View on: PubMed
1991
Characterization of divalent cation-induced [3H]acetylcholine release from EGTA-treated rat hippocampal synaptosomes.
Neurochemical research. 16(10):1175-85 [PMID] 1795760.
View on: PubMed
1991
Neurobiochemical evidence for calcium-induced depolarization of EGTA-pretreated hippocampal synaptosomes.
Brain research. 540(1-2):335-9 [PMID] 1905174.
View on: PubMed
1990
Anatomical and pharmacological heterogeneity of D-[3H]aspartate binding sites.
European journal of pharmacology. 185(1):119-21 [PMID] 2171958.
View on: PubMed
1989
Dissociation between muscarinic receptor-mediated inhibition of adenylate cyclase and autoreceptor inhibition of [3H] acetylcholine release in rat hippocampus.
The Journal of pharmacology and experimental therapeutics. 251(3):1039-44 [PMID] 2557410.
View on: PubMed
1989
Pharmacological and mechanistic studies of cholecystokinin-facilitated [3H]dopamine efflux from rat nucleus accumbens.
Neuropeptides. 13(1):43-50 [PMID] 2466220.
View on: PubMed
1989
The effects of cholecystokinin (CCK-8) on dopamine-containing nerve terminals in the caudate nucleus and nucleus accumbens of the anesthetized rat: an in vivo electrochemical study.
Brain research. 499(1):157-63 [PMID] 2804664.
View on: PubMed
1988
Evidence that type A CCK receptors facilitate dopamine efflux in rat brain.
European journal of pharmacology. 152(3):371-2 [PMID] 3220112.
View on: PubMed
1986
Muscarinic cholinergic ligand binding to intact mouse pituitary tumor cells (AtT-20/D16-16) coupling with two biochemical effectors: adenylate cyclase and phosphatidylinositol turnover.
The Journal of pharmacology and experimental therapeutics. 236(3):653-61 [PMID] 3005550.
View on: PubMed
1985
Autoradiographic localization of muscarinic agonist binding sites in the rat central nervous system with (+)-cis-[3H]methyldioxolane.
Brain research. 325(1-2):340-4 [PMID] 3838491.
View on: PubMed
1985
Effects of bilateral ibotenate-induced lesions of the nucleus basalis magnocellularis upon selective cholinergic biochemical markers in the rat anterior cerebral cortex.
Brain research. 346(2):387-91 [PMID] 3840399.
View on: PubMed
1985
Functional and biochemical basis for multiple muscarinic acetylcholine receptors.
Progress in neuro-psychopharmacology & biological psychiatry. 9(5-6):569-74 [PMID] 3841401.
View on: PubMed
1985
Quantitative light microscopic autoradiography of [3H]hemicholinium-3 binding sites in the rat central nervous system: a novel biochemical marker for mapping the distribution of cholinergic nerve terminals.
Brain research. 329(1-2):368-73 [PMID] 3978459.
View on: PubMed
1985
Regional differences in ethylcholine mustard aziridinium ion (AF64A)-induced deficits in presynaptic cholinergic markers for the rat central nervous system.
The Journal of pharmacology and experimental therapeutics. 235(3):577-82 [PMID] 3841155.
View on: PubMed
1984
Agonist binding to multiple muscarinic receptors.
Federation proceedings. 43(13):2785-90 [PMID] 6383872.
View on: PubMed
1984
Differential regulation of putative M1/M2 muscarinic receptors: implications for different receptor-effector coupling mechanisms.
Advances in experimental medicine and biology. 175:99-114 [PMID] 6208760.
View on: PubMed
1984
Pharmacological differences between the high-affinity muscarinic agonist binding states of the rat heart and cerebral cortex labeled with (+)-[3H]cismethyldioxolane.
The Journal of pharmacology and experimental therapeutics. 229(3):747-55 [PMID] 6202869.
View on: PubMed
1984
Reduced density of sodium-dependent [3H]hemicholinium-3 binding sites in the anterior cerebral cortex of rats following chemical destruction of the nucleus basalis magnocellularis.
European journal of pharmacology. 102(2):369-70 [PMID] 6479222.
View on: PubMed
1984
Sodium-dependent high-affinity binding of [3H]hemicholinium-3 in the rat brain: a potentially selective marker for presynaptic cholinergic sites.
Life sciences. 35(23):2335-43 [PMID] 6503616.
View on: PubMed
1983
Differential regulation of high-affinity agonist binding to muscarinic sites in the rat heart, cerebellum, and cerebral cortex.
Biochemical and biophysical research communications. 116(1):284-90 [PMID] 6639662.
View on: PubMed
1983
Effects of phencyclidine on the release and synthesis of newly formed dopamine.
Neuropharmacology. 22(7):839-42 [PMID] 6137782.
View on: PubMed
1982
Similar dopamine-releasing effects of phencyclidine and nonamphetamine stimulants in striatal slices.
The Journal of pharmacology and experimental therapeutics. 223(3):669-74 [PMID] 6128403.
View on: PubMed
1981
Stimulation of synaptosomal tyrosine hydroxylation by phencyclidine in vitro.
European journal of pharmacology. 71(4):463-73 [PMID] 7250199.
View on: PubMed
1980
In vivo administration of phencyclidine inhibits 3H-dopamine accumulation by rat brain striatal slices.
Substance and alcohol actions/misuse. 1(4):351-4 [PMID] 7302787.
View on: PubMed
1980
Phencyclidine-induced stimulation of synaptosomal tyrosine hydroxylase activity [proceedings].
Psychopharmacology bulletin. 16(4):73-6 [PMID] 6109354.
View on: PubMed
1979
The conversion of [3H] tryptophan to 5-[3H] hydroxytryptamine in mouse brain following depletion of phenylalanine and tyrosine.
Journal of neurochemistry. 33(5):1075-81 [PMID] 501355.
View on: PubMed
1977
TPN and Mn-isocitrate protect isocitrate dehydrogenase against inactivation but increase the number of modified sulfhydryl groups.
Biochemical and biophysical research communications. 77(2):457-63 [PMID] 20091.
View on: PubMed

Grants

May 2020 – Jul 2020
CPPEC 121: Enhancement of Sea Turtle Stranding Response Capacity in Florida (FL)
Role: Principal Investigator
Funding: FL FISH AND WILDLIFE CONSERVATION COMM
Sep 2017 – Dec 2018
Food Animal Residue Avoidance databank (FARAD) Program: University of Florida Component
Role: Principal Investigator
Funding: US DEPT OF AG NATL INST OF FOOD AND AG
Sep 2016 – Apr 2018
Food Animal Residue Avoidance Depletion (FARAD) Program
Role: Principal Investigator
Funding: US DEPT OF AG NATL INST OF FOOD AND AG
Sep 2015 – Aug 2018
Food Animal Residue Avoidance Databank (FARAD) Program: University of Florida
Role: Principal Investigator
Funding: US DEPT OF AG NATL INST OF FOOD AND AG
Aug 2014 – Jul 2016
Food Animal Residue Avoidance Databank (FARAD) Program: University of Florida Component
Role: Principal Investigator
Funding: US DEPT OF AG NATL INST OF FOOD AND AG

Education

Post-Ph.D., NIH / American Heart Association Postdoctoral Fellow, Departments of Pharmacology and Cardiology
1982-1985 · University of Arizona, Tucson, AZ
Ph.D., Department of Pharmacology & Toxicology,
1977-1982 · University of Texas Medical Branch, Galveston, TX
B.S., Biophysics & Biochemistry
1973-1977 · Pennsylvania State University, State College, PA

Teaching Profile

Courses Taught
2016-2017
VEM5200 Pnt Care Clin Skill 1
2006-2007,2009-2016
VEM5171 Vet Pharmacology
2014
VEM5110 Animal Systems 1
2011
VEM5289 Lg An Clin Pharmacol
2011
VEM5286 Vet Clin Pharmacology
2007-2010
VEM5892 Adv Clk Spec Projects
2009
VME6650 Principles of Mammalian Pharmacology
2006
VEM5288 Sm An Clin Pharmacol

Contact Details

Phones:
Business:
(352) 294-4036
Emails:
Business:
vickroy@ufl.edu