Ammon B Peck

Ammon B Peck,


Business Phone: 722 77 39 12
Business Email:

Teaching Profile

Courses Taught
GMS7980 Research for Doctoral Dissertation
VME6505 Autoimmunity
DEN5120C Physiology
GMS6140 Principles of Immunology
GMS7003 Respon Conduct Biomed
DEN6128 Host Defense
GMS6030 Autoimmunity
IDH4905 Individual Work

Research Profile

Currently, three areas of active research are being maintained.

Autoimmune diabetes research: First research endeavors in this area involved application of a novel bone marrow transplantation procedure involving in vitro-grown hematopoietic stem cells to produce bone marrow chimerics between diabetes susceptible and diabetes resistant laboratory mice. Demonstrated that autoimmune diseases are prevented by altering the genetics of the bone marrow, and warned of the ability to transfer autoimmune diseases to recipients through bone marrow transplantation. (Both situations are now recognized as possible complications in human autoimmune diabetes.) More recently, our research has focused on the neogenesis of the endocrine pancreas. Our discoveries may represent the first time a complete organ has been regenerated in vitro from single stem cells, a process that has been accorded world-wide attention. First, presented at the 1995 American Diabetes Association, the 5th International Diabetes Workshop, and a special session of the 5th International Pancreas and Islet Transplantation Association meeting, this research has been covered by CNN, AP, and the BBC. Discussions have been initiated at both the University of Florida and Karolinska Institutet to look at the feasibility of using these in vitro-generated islets for implantation into diabetic patients.

Autoimmune xerostomia & xerophthalmia: This work, carried out in collaboration with Dr. Michael Humphreys-Beher (Department of Oral Biology, College of Dentistry), led to the first award to the University of Florida (1995-1997) from the National Institutes of Health under the Women’s Health Supplemental Grant program. Our work has resulted in the NOD mouse model becoming recognized as “the most appropriate animal model of the human disease, Sjögren’s syndrome”. In 1996, Christopher Robinson, a graduate student in the laboratory working on this project, won the prestigious Hatton Research Award given to the best scientific research by a predoctoral student in the area of dental research by the American Dental Association. Recent work has identified autoantibody reactive with the muscarinic M3 acetylcholine receptor as the probable cause of onset of autoimmune exocrinopathy, opening a whole new area for both diagnosis and intervention therapy.

Hyperoxaluria: Research in this area has demonstrated the importance of the gut-associated bacterium, Oxalobacter formigenes, in regulating the homeostasis of oxalate in both animals and humans. This work has received international media attention, including a special interview and presentation in 1994 on the BBC, later broadcast to seventy-six countries worldwide. This work also received special note by the Mother Teresa Society in 1995. Recently, our research has led to the development of a new designer drug, OxControlTM, that is currently entering clinical trials for the prevention of enteric hyperoxaluria in patients with a variety of conditions (i.e., cystic fibrosis patients, IBS patients and individuals with recurrent kidney stone disease).


Marginal Zone B (MZB) Cells: Comparison of the Initial Identification of Immune Activity Leading to Dacryoadenitis and Sialadenitis in Experimental Sjögren’s Syndrome.
International journal of molecular sciences. 24(15) [DOI] 10.3390/ijms241512209. [PMID] 37569583.
A MZB Cell Activation Profile Present in the Lacrimal Glands of Sjögren’s Syndrome-Susceptible C57BL/6.NOD-Aec1Aec2 Mice Defined by Global RNA Transcriptomic Analyses.
International journal of molecular sciences. 23(11) [DOI] 10.3390/ijms23116106. [PMID] 35682784.
A Temporal Comparative RNA Transcriptome Profile of the Annexin Gene Family in the Salivary versus Lacrimal Glands of the Sjögren’s Syndrome-Susceptible C57BL/6.NOD-Aec1Aec2 Mouse.
International journal of molecular sciences. 23(19) [DOI] 10.3390/ijms231911709. [PMID] 36233010.
Early Covert Appearance of Marginal Zone B Cells in Salivary Glands of Sjögren’s Syndrome-Susceptible Mice: Initiators of Subsequent Overt Clinical Disease.
International journal of molecular sciences. 22(4) [DOI] 10.3390/ijms22041919. [PMID] 33671965.
Upregulated Chemokine and Rho-GTPase Genes Define Immune Cell Emigration into Salivary Glands of Sjögren’s Syndrome-Susceptible C57BL/6.NOD-Aec1Aec2 Mice.
International journal of molecular sciences. 22(13) [DOI] 10.3390/ijms22137176. [PMID] 34281229.
Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset.
Journal of immunology research. 2019 [DOI] 10.1155/2019/4813795. [PMID] 31214622.
Sjogren’s syndrome: An update on disease pathogenesis, clinical manifestations and treatment.
Clinical immunology (Orlando, Fla.). 203:81-121 [DOI] 10.1016/j.clim.2019.04.009. [PMID] 31022578.
What can Sjögren’s syndrome-like disease in mice contribute to human Sjögren’s syndrome?
Clinical immunology (Orlando, Fla.). 182:14-23 [DOI] 10.1016/j.clim.2017.05.001. [PMID] 28478104.
Involvement of renin-angiotensin-aldosterone system in calcium oxalate crystal induced activation of NADPH oxidase and renal cell injury.
World journal of urology. 34(1):89-95 [DOI] 10.1007/s00345-015-1563-y. [PMID] 25981400.
Multiple Roles for B-Lymphocytes in Sjogren’s Syndrome.
Journal of clinical medicine. 5(10) [PMID] 27740602.
Oxalate-degrading microorganisms or oxalate-degrading enzymes: which is the future therapy for enzymatic dissolution of calcium-oxalate uroliths in recurrent stone disease?
Urolithiasis. 44(1):45-50 [DOI] 10.1007/s00240-015-0845-6. [PMID] 26645869.
Activation of the NLRP3 inflammasome in association with calcium oxalate crystal induced reactive oxygen species in kidneys.
The Journal of urology. 193(5):1684-91 [DOI] 10.1016/j.juro.2014.11.093. [PMID] 25437532.
Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice.
Genetics & epigenetics. 7:5-17 [DOI] 10.4137/GEG.S29696. [PMID] 26512207.
Th17 Cells: the Culprit for Sexual Dimorphism in Sjogren’s Syndrome
Scandinavian Journal of Immunology. 81(5)
Regulation of macromolecular modulators of urinary stone formation by reactive oxygen species: transcriptional study in an animal model of hyperoxaluria.
American journal of physiology. Renal physiology. 306(11):F1285-95 [DOI] 10.1152/ajprenal.00057.2014. [PMID] 24598804.
NADPH oxidase as a therapeutic target for oxalate induced injury in kidneys.
Oxidative medicine and cellular longevity. 2013 [DOI] 10.1155/2013/462361. [PMID] 23840917.
Rapid oxalate determination in blood and synthetic urine using a newly developed oxometer.
Journal of endourology. 27(2):145-8 [DOI] 10.1089/end.2012.0438. [PMID] 22973856.
The important role of T cells and receptor expression in Sjögren’s syndrome.
Scandinavian journal of immunology. 78(2):157-66 [DOI] 10.1111/sji.12079. [PMID] 23679844.
The Interferon-Signature of Sjögren’s Syndrome: How Unique Biomarkers Can Identify Underlying Inflammatory and Immunopathological Mechanisms of Specific Diseases.
Frontiers in immunology. 4 [DOI] 10.3389/fimmu.2013.00142. [PMID] 23847613.
Transcriptional landscapes of emerging autoimmunity: transient aberrations in the targeted tissue’s extracellular milieu precede immune responses in Sjögren’s syndrome.
Arthritis research & therapy. 15(5) [DOI] 10.1186/ar4362. [PMID] 24286337.
Type I interferon receptor deficiency prevents murine Sjogren’s syndrome.
Journal of dental research. 92(5):444-9 [DOI] 10.1177/0022034513483315. [PMID] 23533183.
Apocynin-treatment reverses hyperoxaluria induced changes in NADPH oxidase system expression in rat kidneys: a transcriptional study.
PloS one. 7(10) [DOI] 10.1371/journal.pone.0047738. [PMID] 23091645.
B-cell tolerance defects in the B6.Aec1/2 mouse model of Sjögren’s syndrome.
Journal of clinical immunology. 32(3):551-64 [DOI] 10.1007/s10875-012-9663-6. [PMID] 22350147.
Gene therapy using IL-27 ameliorates Sjögren’s syndrome-like autoimmune exocrinopathy.
Arthritis research & therapy. 14(4) [DOI] 10.1186/ar3925. [PMID] 22827855.
Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren’s syndrome.
Arthritis research & therapy. 14(1) [DOI] 10.1186/ar3753. [PMID] 22369699.
Systems analysis of primary Sjögren’s syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model.
Arthritis research & therapy. 14(6) [DOI] 10.1186/ar4081. [PMID] 23116360.
Transcriptome analysis of the interferon-signature defining the autoimmune process of Sjögren’s syndrome.
Scandinavian journal of immunology. 76(3):237-45 [DOI] 10.1111/j.1365-3083.2012.02749.x. [PMID] 22703193.
Enzymatic dissolution of calcium and struvite crystals: in vitro evaluation of biochemical requirements.
Urology. 78(3):721.e13-721.e17 [DOI] 10.1016/j.urology.2011.04.046. [PMID] 21741690.
Gene expression profiling of early-phase Sjögren’s syndrome in C57BL/6.NOD-Aec1Aec2 mice identifies focal adhesion maturation associated with infiltrating leukocytes.
Investigative ophthalmology & visual science. 52(8):5647-55 [DOI] 10.1167/iovs.11-7652. [PMID] 21666236.
IL17: potential therapeutic target in Sjögren’s syndrome using adenovirus-mediated gene transfer.
Laboratory investigation; a journal of technical methods and pathology. 91(1):54-62 [DOI] 10.1038/labinvest.2010.164. [PMID] 20856230.
Phenotypic diversity of peripheral blood plasma cells in primary Sjögren’s syndrome.
Scandinavian journal of immunology. 73(1):18-28 [DOI] 10.1111/j.1365-3083.2010.02475.x. [PMID] 21128999.
Sjögren’s syndrome: studying the disease in mice.
Arthritis research & therapy. 13(3) [DOI] 10.1186/ar3313. [PMID] 21672284.
The current concept of T (h) 17 cells and their expanding role in systemic lupus erythematosus.
Arthritis. 2011 [DOI] 10.1155/2011/810649. [PMID] 22164330.
Pathogenic effect of interleukin-17A in induction of Sjögren’s syndrome-like disease using adenovirus-mediated gene transfer.
Arthritis research & therapy. 12(6) [DOI] 10.1186/ar3207. [PMID] 21182786.
Autoimmunity: limited progress for the patient, despite decades of research.
Scandinavian journal of immunology. 70(5):411-4 [DOI] 10.1111/j.1365-3083.2009.02318.x. [PMID] 19874544.
Differential gene expression in the salivary gland during development and onset of xerostomia in Sjögren’s syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse.
Arthritis research & therapy. 11(2) [DOI] 10.1186/ar2676. [PMID] 19379516.
Differential gene expressions in the lacrimal gland during development and onset of keratoconjunctivitis sicca in Sjögren’s syndrome (SJS)-like disease of the C57BL/6.NOD-Aec1Aec2 mouse.
Experimental eye research. 88(3):398-409 [DOI] 10.1016/j.exer.2008.10.006. [PMID] 19103199.
Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren’s syndrome before disease onset.
Immunology and cell biology. 87(1):81-90 [DOI] 10.1038/icb.2008.70. [PMID] 18936772.
Unraveling the Pathophysiology of Sjogren Syndrome-Associated Dry Eye Disease
The ocular surface. 7:11-27
Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease.
The ocular surface. 7(1):11-27 [PMID] 19214349.
Characterization of intraocular immunopathology following intracameral inoculation with alloantigen.
Molecular vision. 14:615-24 [PMID] 18385797.
Identification of possible candidate genes regulating Sjögren’s syndrome-associated autoimmunity: a potential role for TNFSF4 in autoimmune exocrinopathy.
Arthritis research & therapy. 10(6) [DOI] 10.1186/ar2560. [PMID] 19032782.
Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren’s syndrome: findings in humans and mice.
Arthritis and rheumatism. 58(3):734-43 [DOI] 10.1002/art.23214. [PMID] 18311793.
The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens.
Molecular vision. 14:2435-42 [PMID] 19104677.
Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition.
The American journal of pathology. 171(4):1224-36 [PMID] 17823290.
Development of Sjogren’s syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3.
Journal of immunology (Baltimore, Md. : 1950). 179(4):2318-29 [PMID] 17675493.
IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren’s syndrome-like disease of the nonobese diabetic mouse.
Journal of immunology (Baltimore, Md. : 1950). 179(1):382-90 [PMID] 17579059.
Sjögren’s syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies.
Frontiers in bioscience : a journal and virtual library. 12:1767-89 [PMID] 17127420.
Early pathogenic events associated with Sjögren’s syndrome (SjS)-like disease of the NOD mouse using microarray analysis.
Laboratory investigation; a journal of technical methods and pathology. 86(12):1243-60 [PMID] 17075579.
Muscarinic acetylcholine type-3 receptor desensitization due to chronic exposure to Sjögren’s syndrome-associated autoantibodies.
The Journal of rheumatology. 33(2):296-306 [PMID] 16465661.
Oxalobacter sp. reduces urinary oxalate excretion by promoting enteric oxalate secretion.
Kidney international. 69(4):691-8 [PMID] 16518326.
Role of complement and B lymphocytes in Sjögren’s syndrome-like autoimmune exocrinopathy of NOD.B10-H2b mice.
Molecular immunology. 43(9):1332-9 [PMID] 16221495.
Sjögren’s syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease.
Journal of autoimmunity. 26(2):90-103 [PMID] 16413168.
Sjögren’s syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus.
Scandinavian journal of immunology. 64(3):295-307 [PMID] 16918699.
A dual role for interferon-gamma in the pathogenesis of Sjogren’s syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse.
Scandinavian journal of immunology. 60(6):552-65 [PMID] 15584966.
Animal models to study adult stem cell-derived, in vitro-generated islet implantation.
ILAR journal. 45(3):259-67 [PMID] 15229373.
Characterization and heterologous expression of the oxalyl coenzyme A decarboxylase gene from Bifidobacterium lactis.
Applied and environmental microbiology. 70(9):5066-73 [PMID] 15345383.
Colonization of the neonatal rat intestinal tract from environmental exposure to the anaerobic bacterium Oxalobacter formigenes.
Journal of medical microbiology. 53(Pt 3):249-254 [DOI] 10.1099/jmm.0.05418-0. [PMID] 14970252.
Detection of anti-type 3 muscarinic acetylcholine receptor autoantibodies in the sera of Sjögren’s syndrome patients by use of a transfected cell line assay.
Arthritis and rheumatism. 50(8):2615-21 [PMID] 15334476.
In vitro-generation of surrogate islets from adult stem cells.
Transplant immunology. 12(3-4):259-72 [PMID] 15157920.
Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization.
Nature medicine. 8(6):607-12 [PMID] 12042812.
Expression of osteopontin in rat kidneys: induction during ethylene glycol induced calcium oxalate nephrolithiasis.
The Journal of urology. 168(3):1173-81 [PMID] 12187263.
Generation of islets of Langerhans from adult pancreatic stem cells.
Journal of hepato-biliary-pancreatic surgery. 9(6):704-9 [PMID] 12658404.
IDD3 and IDD5 alleles from nod mice mediate Sjögren’s syndrome-like autoimmunity.
Advances in experimental medicine and biology. 506(Pt B):1035-9 [PMID] 12614028.
Immunogenetics of autoimmune exocrinopathy in the nod mouse: more than meets the eye.
Advances in experimental medicine and biology. 506(Pt B):999-1007 [PMID] 12614023.
In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells.
Proceedings of the National Academy of Sciences of the United States of America. 99(12):8078-83 [PMID] 12048252.
Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 13(1):5-16 [PMID] 12097234.
Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren’s syndrome) on a healthy murine background.
Arthritis and rheumatism. 46(5):1390-8 [PMID] 12115247.
Use of in vitro-generated, stem cell-derived islets to cure type 1 diabetes: how close are we?
Annals of the New York Academy of Sciences. 958:59-68 [PMID] 12021084.
Abnormal organogenesis in salivary gland development may initiate adult onset of autoimmune exocrinopathy.
Experimental and clinical immunogenetics. 18(3):143-60 [PMID] 11549844.
Differential absorption and distribution of epidermal growth factor and insulin-like growth factor in diabetic NOD mice.
Journal of diabetes and its complications. 15(2):103-11 [PMID] 11274907.
Elevated proapoptotic Bax and caspase 3 activation in the NOD.scid model of Sjögren’s syndrome.
Arthritis and rheumatism. 44(3):693-702 [PMID] 11263785.
IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sjögren’s syndrome.
Scandinavian journal of immunology. 54(1-2):133-40 [PMID] 11439159.
Pancreatic stem cells: a therapeutic agent that may offer the best approach for curing type 1 diabetes.
Pediatric diabetes. 2(4):195-202 [PMID] 15016187.
Pancreatic stem cells: building blocks for a better surrogate islet to treat type 1 diabetes.
Annals of medicine. 33(3):186-92 [PMID] 11370772.
Polarized expression of G protein-coupled receptors and an all-or-none discharge of Ca2+ pools at initiation sites of [Ca2+]i waves in polarized exocrine cells.
The Journal of biological chemistry. 276(47):44146-56 [PMID] 11553617.
Rapid reversal of hyperoxaluria in a rat model after probiotic administration of Oxalobacter formigenes.
The Journal of urology. 166(4):1487-91 [PMID] 11547118.
Sjögren’s syndrome: immunological response underlying the disease.
Archivum immunologiae et therapiae experimentalis. 49(5):353-60 [PMID] 11798133.
Aberrant proteolytic digestion of biglycan and decorin by saliva and exocrine gland lysates from the NOD mouse model for autoimmune exocrinopathy.
Clinical and experimental rheumatology. 18(2):233-40 [PMID] 10812497.
Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren’s syndrome-like autoimmune exocrinopathy.
The Journal of rheumatology. 27(8):1896-904 [PMID] 10955330.
Evidence for antimuscarinic acetylcholine receptor antibody-mediated secretory dysfunction in nod mice.
Arthritis and rheumatism. 43(10):2297-306 [PMID] 11037890.
Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells.
Nature medicine. 6(3):278-82 [PMID] 10700229.
Salivary EGF levels reduced in diabetic patients.
Journal of diabetes and its complications. 14(3):140-5 [PMID] 10989322.
An alternative perspective to the immune response in autoimmune exocrinopathy: induction of functional quiescence rather than destructive autoaggression.
Scandinavian journal of immunology. 49(1):7-10 [PMID] 10023850.
Direct correlation between hyperoxaluria/oxalate stone disease and the absence of the gastrointestinal tract-dwelling bacterium Oxalobacter formigenes: possible prevention by gut recolonization or enzyme replacement therapy.
Journal of the American Society of Nephrology : JASN. 10 Suppl 14:S334-40 [PMID] 10541258.
Direct quantification of the enteric bacterium Oxalobacter formigenes in human fecal samples by quantitative competitive-template PCR.
Journal of clinical microbiology. 37(5):1503-9 [PMID] 10203513.
Expression of bikunin mRNA in renal epithelial cells after oxalate exposure.
The Journal of urology. 162(4):1480-6 [PMID] 10492241.
New concepts for the development of autoimmune exocrinopathy derived from studies with the NOD mouse model.
Archives of oral biology. 44 Suppl 1:S21-5 [PMID] 10414851.
Temporal changes in mRNA expression for bikunin in the kidneys of rats during calcium oxalate nephrolithiasis.
Journal of the American Society of Nephrology : JASN. 10(5):986-96 [PMID] 10232684.
The role of apoptosis in the initiation of the autoimmune response in Sjögren’s syndrome.
Clinical and experimental immunology. 116(3):383-7 [PMID] 10361223.
A novel NOD-derived murine model of primary Sjögren’s syndrome.
Arthritis and rheumatism. 41(1):150-6 [PMID] 9433880.
Aberrant expression and potential function for parotid secretory protein (PSP) in the NOD (non-obese diabetic) mouse.
Advances in experimental medicine and biology. 438:925-30 [PMID] 9634989.
Absence of Oxalobacter formigenes in cystic fibrosis patients: a risk factor for hyperoxaluria.
Lancet (London, England). 352(9133):1026-9 [PMID] 9759746.
Characterization of the changing lymphocyte populations and cytokine expression in the exocrine tissues of autoimmune NOD mice.
Autoimmunity. 27(1):29-44 [PMID] 9482205.
Excessive synthesis of matrix metalloproteinases in exocrine tissues of NOD mouse models for Sjögren’s syndrome.
The Journal of rheumatology. 25(12):2371-80 [PMID] 9858432.
Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid mice.
Clinical and experimental rheumatology. 16(6):675-81 [PMID] 9844759.
Infiltrating lymphocyte populations and cytokine production in the salivary and lacrimal glands of autoimmune NOD mice.
Advances in experimental medicine and biology. 438:493-7 [PMID] 9634926.
Salivary gland changes in the NOD mouse model for Sjögren’s syndrome: is there a non-immune genetic trigger?
European journal of morphology. 36 Suppl:247-51 [PMID] 9825931.
Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjögren’s syndrome.
Proceedings of the National Academy of Sciences of the United States of America. 95(13):7538-43 [PMID] 9636185.
DNA sequencing and expression of the formyl coenzyme A transferase gene, frc, from Oxalobacter formigenes.
Journal of bacteriology. 179(10):3378-81 [PMID] 9150242.
Elevated levels of cysteine protease activity in saliva and salivary glands of the nonobese diabetic (NOD) mouse model for Sjögren syndrome.
Proceedings of the National Academy of Sciences of the United States of America. 94(11):5767-71 [PMID] 9159148.
Identification and classification of Oxalobacter formigenes strains by using oligonucleotide probes and primers.
Journal of clinical microbiology. 35(2):350-3 [PMID] 9003594.
In vitro-generation of islets in long-term cultures of pluripotent stem cells from adult mouse pancreas.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 29(6):271-7 [PMID] 9230348.
PSP expression in murine lacrimal glands and function as a bacteria binding protein in exocrine secretions.
The American journal of physiology. 272(4 Pt 1):G863-71 [PMID] 9142919.
A gene map of the human genome.
Science (New York, N.Y.). 274(5287):540-6 [PMID] 8849440.
Autoimmune diabetes-prone NOD mice express the Lyt2 alpha (Lyt2.1) and Lyt3 alpha (Lyt3.1) alleles of CD8.
Immunogenetics. 43(1-2):6-12 [PMID] 8537123.
Competitive RNA templates for detection and quantitation of growth factors, cytokines, extracellular matrix components and matrix metalloproteinases by RT-PCR.
BioTechniques. 20(4):670-4 [PMID] 8800688.
Experimental and clinical allogeneic heart transplant rejection: correlations between histology and immune reactivity detected by cytokine messenger RNA.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 15(8):778-89 [PMID] 8878760.
Genetically programmed development of salivary gland abnormalities in the NOD (nonobese diabetic)-scid mouse in the absence of detectable lymphocytic infiltration: a potential trigger for sialoadenitis of NOD mice.
Clinical immunology and immunopathology. 79(1):50-9 [PMID] 8612351.
Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice.
The Journal of pharmacology and experimental therapeutics. 279(2):790-4 [PMID] 8930185.
Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.
The Journal of clinical investigation. 95(2):628-34 [PMID] 7860747.
Molecular cloning, DNA sequence, and gene expression of the oxalyl-coenzyme A decarboxylase gene, oxc, from the bacterium Oxalobacter formigenes.
Journal of bacteriology. 176(8):2468-72 [PMID] 8157618.
Antioxidant enzyme activities in IDD-prone and IDD-resistant mice: a comparative study.
Free radical biology & medicine. 14(4):409-20 [PMID] 8468025.
Insulin-dependent diabetes in the NOD mouse model. I. Detection and characterization of autoantibody bound to the surface of pancreatic beta cells prior to development of the insulitis lesion in prediabetic NOD mice.
Autoimmunity. 15(2):123-35 [PMID] 8218837.
Insulin-dependent diabetes in the NOD mouse model. II. Beta cell destruction in autoimmune diabetes is a TH2 and not a TH1 mediated event.
Autoimmunity. 15(2):113-22 [PMID] 8105989.
Cloning and expression of the oxalyl-CoA decarboxylase gene from the bacterium, Oxalobacter formigenes: prospects for gene therapy to control Ca-oxalate kidney stone formation.
American journal of kidney diseases : the official journal of the National Kidney Foundation. 17(4):381-5 [PMID] 2008903.
Pertussigen treatment retards, but fails to prevent, the development of type I, insulin-dependent diabetes mellitus (IDDM) in NOD mice.
Autoimmunity. 9(4):311-7 [PMID] 1954311.
Flow cytometric enumeration of mononuclear cell populations infiltrating the islets of Langerhans in prediabetic NOD mice: development of a model of autoimmune insulitis for type I diabetes.
Regional immunology. 3(6):305-17 [PMID] 2132756.
Reciprocal allogeneic bone marrow transplantation between NOD mice and diabetes-nonsusceptible mice associated with transfer and prevention of autoimmune diabetes.
Diabetes. 38(7):894-901 [PMID] 2661286.
A comment on H-2-restricted T cell recognition of Mls determinants: a question of perspective.
Journal of immunogenetics. 15(1-3):77-85 [PMID] 2466908.
Gene transfer into hematopoietic progenitor cells mediated by an adeno-associated virus vector.
Virology. 162(2):483-6 [PMID] 2829430.
Nonresponsiveness to Mlsd in F1 hybrid mice carrying Mlsa and Mlsc genes.
Journal of immunology (Baltimore, Md. : 1950). 139(2):321-5 [PMID] 2955035.
Production of 35 H-2 homozygous strains from wild mice.
Immunogenetics. 26(1-2):115-9 [PMID] 2956187.
Successful semiallogeneic and allogeneic bone marrow reconstitution of lethally irradiated adult mice mediated by neonatal spleen cells.
Transplantation. 44(5):614-20 [PMID] 2961109.
Characteristics of a T lymphocyte-enhancing Ab-specific monoclonal antibody. I. Genetic specificity and preferential enhancement of allogeneic reactions.
Immunogenetics. 23(5):284-91 [PMID] 2423449.
Naturally occurring, spleen-associated suppressor activity of the newborn mouse. Biochemical and functional identification of three monokines secreted by newborn suppressor-inducer monocytes.
Scandinavian journal of immunology. 23(1):35-44 [PMID] 2939550.
A novel anti-Ia monoclonal antibody which specifically enhances the corresponding T cell alloreactivity.
Journal of immunology (Baltimore, Md. : 1950). 133(5):2360-4 [PMID] 6332845.
Changes in the Ir gene controlled response phenotypes in mice of the Ap and Ak family of alleles expressing naturally occurring variant molecules.
Journal of immunology (Baltimore, Md. : 1950). 133(3):1410-6 [PMID] 6205082.
Naturally occurring spleen-associated suppressor activity of the newborn mouse. Requirement for two genetic restrictions in suppression of lethal graft-versus-host disease by newborn spleen cells.
Scandinavian journal of immunology. 20(1):81-91 [PMID] 6463591.
Functional reactivities of lymphocytes primed in murine graft-versus-host reactions.
Transplantation. 35(1):84-90 [PMID] 6218667.
Heterogeneity of an anti-H-2 I-A response as determined by cloned T cell reactivity.
Journal of immunology (Baltimore, Md. : 1950). 130(5):2067-70 [PMID] 6220077.
Isolation and identification of the naturally occurring, newborn spleen-associated suppressor cells. A mixed monocyte/mast cell population with separable suppressor activities.
Scandinavian journal of immunology. 17(5):443-53 [PMID] 6222470.
Lack of shared lymphocyte-stimulating determinants between H-2I and HLA-D/DR using mouse primed lymphocyte typing cells.
Human immunology. 7(2):105-15 [PMID] 6190790.
Lethal murine graft-versus-host disease in the absence of detectable cytotoxic T lymphocytes.
Transplantation. 36(3):281-9 [PMID] 6604351.
Variant class II molecules from H-2 haplotypes in wild mouse populations: functional characteristics of closely related class II gene products.
Journal of immunology (Baltimore, Md. : 1950). 131(5):2432-9 [PMID] 6415169.
Cellular and genetic restrictions in the immunoregulatory activity of alpha-fetoprotein. III. Role of the MLC-stimulating cell population in alpha-fetoprotein-induced suppression of T cell-mediated cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950). 128(3):1134-40 [PMID] 6173421.
Receptor specificity, functional characteristics, and cell-surface phenotype of a highly selected anti-I-Ab-specific, long-term T-cell line.
Immunogenetics. 12(5-6):525-40 [PMID] 6971252.
The mouse primed lymphocyte typing (mPLT)test. II. Detection of variant H-2 K and D molecules in the typing analysis of the class I-associated lymphocyte-stimulating (LS) determinants, using the B10.W lines.
Scandinavian journal of immunology. 13(5):453-60 [PMID] 6171866.
T-lymphocyte recognition of the I-EC gene products (Ia) requires concomitant recognition of I-AB gene products.
Scandinavian journal of immunology. 11(2):235-9 [PMID] 9537050.
The mouse-primed lymphocyte typing test. III. Dissociation of T lymphocyte-stimulating determinants and antibody-defined specificities of the I region-associated Ia antigens.
Journal of immunology (Baltimore, Md. : 1950). 125(3):1978-86 [PMID] 6157729.
Non-T cell nature of the naturally occurring, spleen-associated suppressor cells present in the newborn mouse.
European journal of immunology. 9(9):737-46 [PMID] 159828.
Cellular and genetic restrictions in the immunoregulatory activity of alpha-fetoprotein. I. Selective inhibition of anti-Ia-associated proliferative reactions.
The Journal of experimental medicine. 147(3):667-83 [PMID] 75940.
Cellular and genetic restrictions in the immunoregulatory activity of alpha-fetoprotein. II. Alpha-fetoprotein-induced suppression of cytotoxic T lymphocyte development.
The Journal of experimental medicine. 148(2):360-72 [PMID] 81256.
Environmental and genetic control of T cell activation in vitro: a study using isolated alloantigen-activated T cell clones.
Immunological reviews. 35:146-80 [PMID] 142745.
Secondary in vitro responses of T lymphocytes to non-H-2 alloantigens self-H-2-restricted responses induced in heterologous serum are not dependent on primary-stimulating non-H-2 alloantigens.
The Journal of experimental medicine. 145(4):802-18 [PMID] 300775.
T lymphocyte responses to Mls locus antigens involve recognition of H-2 I region gene products.
Nature. 266(5605):840-2 [PMID] 141007.
Early re-stimulation of MLC: differential effects by MLs-locus and H-2 locus products [proceedings].
Folia biologica. 22(6):429-31 [PMID] 137137.
Specificity in T cell mediated lympholysis: identical genetic control of the proliferative and effector phases of allogeneic and xenogeneic reactions.
Transplantation reviews. 29:189-221 [PMID] 58457.
Mouse cell-mediated lympholysis assay in serum-free and mouse serum-supplemented media: culture conditions and genetic factors.
Scandinavian journal of immunology. 4(1):53-62 [PMID] 49078.
Specificity of cell-mediated lympholysis for public and private H-2 determinants.
Scandinavian journal of immunology. 4(5-6):541-53 [PMID] 52182.
Differential recognition by thymocytes of H-2 and non H-2 alloantigens.
Nature. 252(5483):507-8 [PMID] 4279342.
A miniaturized mouse mixed leukocyte culture in serum-free and mouse serum supplemented media.
Journal of immunological methods. 3(2):147-63 [PMID] 4271080.
Cellular reactivities associated with theta-antigen disparity.
Transplantation proceedings. 5(4):1611-3 [PMID] 4272820.
Immune responses in vitro. 3. Enhancement of the mouse mixed lymphocyte interaction by isologous and homologous sera.
European journal of immunology. 3(7):385-92 [PMID] 4271347.
Immune responses in vitro. 8. Mixed leukocyte culture reactivity induced by theta antigen.
Transplantation. 16(4):339-42 [PMID] 4270410.
Immune responses in vitro. II. Mixed leukocyte interaction in a protein-free medium.
European journal of immunology. 3(7):379-85 [PMID] 4271346.
Immune responses in vitro. IV. A comparison of the protein-free and mouse serum-supplemented mouse mixed lymphocyte interaction assays.
European journal of immunology. 3(8):516-9 [PMID] 4271076.
Immune responses in vitro. VII. Differentiation of H-2 and non-H-2 alloantigens of the mouse by a dual mixed leukocyte culture.
Transplantation. 16(4):331-8 [PMID] 4270409.


Doctor of Philosophy in Medical Microbiology
1972 · University of Wisconsin
Bachelor of Science in Bacteriology
1968 · Syracuse University

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