Ammon B Peck

Ammon B Peck

PROFESSOR

Department: Department of Infectious Diseases & Immunology
Business Phone: (352) 294-4211
Business Email: peck@ufl.edu

Research Profile

Currently, three areas of active research are being maintained.

Autoimmune diabetes research: First research endeavors in this area involved application of a novel bone marrow transplantation procedure involving in vitro-grown hematopoietic stem cells to produce bone marrow chimerics between diabetes susceptible and diabetes resistant laboratory mice. Demonstrated that autoimmune diseases are prevented by altering the genetics of the bone marrow, and warned of the ability to transfer autoimmune diseases to recipients through bone marrow transplantation. (Both situations are now recognized as possible complications in human autoimmune diabetes.) More recently, our research has focused on the neogenesis of the endocrine pancreas. Our discoveries may represent the first time a complete organ has been regenerated in vitro from single stem cells, a process that has been accorded world-wide attention. First, presented at the 1995 American Diabetes Association, the 5th International Diabetes Workshop, and a special session of the 5th International Pancreas and Islet Transplantation Association meeting, this research has been covered by CNN, AP, and the BBC. Discussions have been initiated at both the University of Florida and Karolinska Institutet to look at the feasibility of using these in vitro-generated islets for implantation into diabetic patients.

Autoimmune xerostomia & xerophthalmia: This work, carried out in collaboration with Dr. Michael Humphreys-Beher (Department of Oral Biology, College of Dentistry), led to the first award to the University of Florida (1995-1997) from the National Institutes of Health under the Women’s Health Supplemental Grant program. Our work has resulted in the NOD mouse model becoming recognized as “the most appropriate animal model of the human disease, Sjögren’s syndrome”. In 1996, Christopher Robinson, a graduate student in the laboratory working on this project, won the prestigious Hatton Research Award given to the best scientific research by a predoctoral student in the area of dental research by the American Dental Association. Recent work has identified autoantibody reactive with the muscarinic M3 acetylcholine receptor as the probable cause of onset of autoimmune exocrinopathy, opening a whole new area for both diagnosis and intervention therapy.

Hyperoxaluria: Research in this area has demonstrated the importance of the gut-associated bacterium, Oxalobacter formigenes, in regulating the homeostasis of oxalate in both animals and humans. This work has received international media attention, including a special interview and presentation in 1994 on the BBC, later broadcast to seventy-six countries worldwide. This work also received special note by the Mother Teresa Society in 1995. Recently, our research has led to the development of a new designer drug, OxControlTM, that is currently entering clinical trials for the prevention of enteric hyperoxaluria in patients with a variety of conditions (i.e., cystic fibrosis patients, IBS patients and individuals with recurrent kidney stone disease).

Publications

2019
Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset.
Journal of immunology research. 2019 [DOI] 10.1155/2019/4813795. [PMID] 31214622.
2019
Sjogren’s syndrome: An update on disease pathogenesis, clinical manifestations and treatment.
Clinical immunology (Orlando, Fla.). 203:81-121 [DOI] 10.1016/j.clim.2019.04.009. [PMID] 31022578.
2017
What can Sjögren’s syndrome-like disease in mice contribute to human Sjögren’s syndrome?
Clinical immunology (Orlando, Fla.). 182:14-23 [DOI] 10.1016/j.clim.2017.05.001. [PMID] 28478104.
2016
Oxalate-degrading microorganisms or oxalate-degrading enzymes: which is the future therapy for enzymatic dissolution of calcium-oxalate uroliths in recurrent stone disease?
Urolithiasis. 44(1):45-50 [DOI] 10.1007/s00240-015-0845-6. [PMID] 26645869.
2016
Involvement of renin-angiotensin-aldosterone system in calcium oxalate crystal induced activation of NADPH oxidase and renal cell injury.
World journal of urology. 34(1):89-95 [DOI] 10.1007/s00345-015-1563-y. [PMID] 25981400.
2016
Multiple Roles for B-Lymphocytes in Sjogren’s Syndrome.
Journal of clinical medicine. 5(10) [PMID] 27740602.
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2015
Activation of the NLRP3 inflammasome in association with calcium oxalate crystal induced reactive oxygen species in kidneys.
The Journal of urology. 193(5):1684-91 [DOI] 10.1016/j.juro.2014.11.093. [PMID] 25437532.
2015
Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice.
Genetics & epigenetics. 7:5-17 [DOI] 10.4137/GEG.S29696. [PMID] 26512207.
2015
Th17 Cells: the Culprit for Sexual Dimorphism in Sjogren’s Syndrome
Scandinavian Journal of Immunology. 81(5)
2014
Regulation of macromolecular modulators of urinary stone formation by reactive oxygen species: transcriptional study in an animal model of hyperoxaluria.
American journal of physiology. Renal physiology. 306(11):F1285-95 [DOI] 10.1152/ajprenal.00057.2014. [PMID] 24598804.
2013
NADPH oxidase as a therapeutic target for oxalate induced injury in kidneys.
Oxidative medicine and cellular longevity. 2013 [DOI] 10.1155/2013/462361. [PMID] 23840917.
2013
Rapid oxalate determination in blood and synthetic urine using a newly developed oxometer.
Journal of endourology. 27(2):145-8 [DOI] 10.1089/end.2012.0438. [PMID] 22973856.
2013
The important role of T cells and receptor expression in Sjögren’s syndrome.
Scandinavian journal of immunology. 78(2):157-66 [DOI] 10.1111/sji.12079. [PMID] 23679844.
2013
The Interferon-Signature of Sjögren’s Syndrome: How Unique Biomarkers Can Identify Underlying Inflammatory and Immunopathological Mechanisms of Specific Diseases.
Frontiers in immunology. 4 [DOI] 10.3389/fimmu.2013.00142. [PMID] 23847613.
2013
Transcriptional landscapes of emerging autoimmunity: transient aberrations in the targeted tissue’s extracellular milieu precede immune responses in Sjögren’s syndrome.
Arthritis research & therapy. 15(5) [DOI] 10.1186/ar4362. [PMID] 24286337.
2013
Type I interferon receptor deficiency prevents murine Sjogren’s syndrome.
Journal of dental research. 92(5):444-9 [DOI] 10.1177/0022034513483315. [PMID] 23533183.
2012
Systems analysis of primary Sjögren’s syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model.
Arthritis research & therapy. 14(6) [DOI] 10.1186/ar4081. [PMID] 23116360.
2012
Gene therapy using IL-27 ameliorates Sjögren’s syndrome-like autoimmune exocrinopathy.
Arthritis research & therapy. 14(4) [DOI] 10.1186/ar3925. [PMID] 22827855.
2012
Transcriptome analysis of the interferon-signature defining the autoimmune process of Sjögren’s syndrome.
Scandinavian journal of immunology. 76(3):237-45 [DOI] 10.1111/j.1365-3083.2012.02749.x. [PMID] 22703193.
2012
B-cell tolerance defects in the B6.Aec1/2 mouse model of Sjögren’s syndrome.
Journal of clinical immunology. 32(3):551-64 [DOI] 10.1007/s10875-012-9663-6. [PMID] 22350147.
2012
Apocynin-treatment reverses hyperoxaluria induced changes in NADPH oxidase system expression in rat kidneys: a transcriptional study.
PloS one. 7(10) [DOI] 10.1371/journal.pone.0047738. [PMID] 23091645.
2012
Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren’s syndrome.
Arthritis research & therapy. 14(1) [DOI] 10.1186/ar3753. [PMID] 22369699.
2011
Gene expression profiling of early-phase Sjögren’s syndrome in C57BL/6.NOD-Aec1Aec2 mice identifies focal adhesion maturation associated with infiltrating leukocytes.
Investigative ophthalmology & visual science. 52(8):5647-55 [DOI] 10.1167/iovs.11-7652. [PMID] 21666236.
2011
IL17: potential therapeutic target in Sjögren’s syndrome using adenovirus-mediated gene transfer.
Laboratory investigation; a journal of technical methods and pathology. 91(1):54-62 [DOI] 10.1038/labinvest.2010.164. [PMID] 20856230.
2011
Phenotypic diversity of peripheral blood plasma cells in primary Sjögren’s syndrome.
Scandinavian journal of immunology. 73(1):18-28 [DOI] 10.1111/j.1365-3083.2010.02475.x. [PMID] 21128999.
2011
Sjögren’s syndrome: studying the disease in mice.
Arthritis research & therapy. 13(3) [DOI] 10.1186/ar3313. [PMID] 21672284.
2011
The current concept of T (h) 17 cells and their expanding role in systemic lupus erythematosus.
Arthritis. 2011 [DOI] 10.1155/2011/810649. [PMID] 22164330.
2011
Enzymatic dissolution of calcium and struvite crystals: in vitro evaluation of biochemical requirements.
Urology. 78(3):721.e13-721.e17 [DOI] 10.1016/j.urology.2011.04.046. [PMID] 21741690.
2010
Pathogenic effect of interleukin-17A in induction of Sjögren’s syndrome-like disease using adenovirus-mediated gene transfer.
Arthritis research & therapy. 12(6) [DOI] 10.1186/ar3207. [PMID] 21182786.
2009
Autoimmunity: limited progress for the patient, despite decades of research.
Scandinavian journal of immunology. 70(5):411-4 [DOI] 10.1111/j.1365-3083.2009.02318.x. [PMID] 19874544.
2009
Differential gene expression in the salivary gland during development and onset of xerostomia in Sjögren’s syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse.
Arthritis research & therapy. 11(2) [DOI] 10.1186/ar2676. [PMID] 19379516.
2009
Differential gene expressions in the lacrimal gland during development and onset of keratoconjunctivitis sicca in Sjögren’s syndrome (SJS)-like disease of the C57BL/6.NOD-Aec1Aec2 mouse.
Experimental eye research. 88(3):398-409 [DOI] 10.1016/j.exer.2008.10.006. [PMID] 19103199.
2009
Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren’s syndrome before disease onset.
Immunology and cell biology. 87(1):81-90 [DOI] 10.1038/icb.2008.70. [PMID] 18936772.
2009
Unraveling the Pathophysiology of Sjogren Syndrome-Associated Dry Eye Disease
The ocular surface. 7:11-27
2009
Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease.
The ocular surface. 7(1):11-27 [PMID] 19214349.
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2008
The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens.
Molecular vision. 14:2435-42 [PMID] 19104677.
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2008
Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren’s syndrome: findings in humans and mice.
Arthritis and rheumatism. 58(3):734-43 [DOI] 10.1002/art.23214. [PMID] 18311793.
2008
Characterization of intraocular immunopathology following intracameral inoculation with alloantigen.
Molecular vision. 14:615-24 [PMID] 18385797.
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2008
Identification of possible candidate genes regulating Sjögren’s syndrome-associated autoimmunity: a potential role for TNFSF4 in autoimmune exocrinopathy.
Arthritis research & therapy. 10(6) [DOI] 10.1186/ar2560. [PMID] 19032782.
2007
Development of Sjogren’s syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3.
Journal of immunology (Baltimore, Md. : 1950). 179(4):2318-29 [PMID] 17675493.
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2007
IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren’s syndrome-like disease of the nonobese diabetic mouse.
Journal of immunology (Baltimore, Md. : 1950). 179(1):382-90 [PMID] 17579059.
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2007
Sjögren’s syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies.
Frontiers in bioscience : a journal and virtual library. 12:1767-89 [PMID] 17127420.
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2007
Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition.
The American journal of pathology. 171(4):1224-36 [PMID] 17823290.
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2006
Early pathogenic events associated with Sjögren’s syndrome (SjS)-like disease of the NOD mouse using microarray analysis.
Laboratory investigation; a journal of technical methods and pathology. 86(12):1243-60 [PMID] 17075579.
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2006
Muscarinic acetylcholine type-3 receptor desensitization due to chronic exposure to Sjögren’s syndrome-associated autoantibodies.
The Journal of rheumatology. 33(2):296-306 [PMID] 16465661.
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2006
Oxalobacter sp. reduces urinary oxalate excretion by promoting enteric oxalate secretion.
Kidney international. 69(4):691-8 [PMID] 16518326.
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2006
Role of complement and B lymphocytes in Sjögren’s syndrome-like autoimmune exocrinopathy of NOD.B10-H2b mice.
Molecular immunology. 43(9):1332-9 [PMID] 16221495.
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2006
Sjögren’s syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease.
Journal of autoimmunity. 26(2):90-103 [PMID] 16413168.
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2006
Sjögren’s syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus.
Scandinavian journal of immunology. 64(3):295-307 [PMID] 16918699.
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2004
In vitro-generation of surrogate islets from adult stem cells.
Transplant immunology. 12(3-4):259-72 [PMID] 15157920.
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2004
Detection of anti-type 3 muscarinic acetylcholine receptor autoantibodies in the sera of Sjögren’s syndrome patients by use of a transfected cell line assay.
Arthritis and rheumatism. 50(8):2615-21 [PMID] 15334476.
View on: PubMed
2004
Colonization of the neonatal rat intestinal tract from environmental exposure to the anaerobic bacterium Oxalobacter formigenes.
Journal of medical microbiology. 53(Pt 3):249-254 [DOI] 10.1099/jmm.0.05418-0. [PMID] 14970252.
2004
A dual role for interferon-gamma in the pathogenesis of Sjogren’s syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse.
Scandinavian journal of immunology. 60(6):552-65 [PMID] 15584966.
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2004
Animal models to study adult stem cell-derived, in vitro-generated islet implantation.
ILAR journal. 45(3):259-67 [PMID] 15229373.
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2004
Characterization and heterologous expression of the oxalyl coenzyme A decarboxylase gene from Bifidobacterium lactis.
Applied and environmental microbiology. 70(9):5066-73 [PMID] 15345383.
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2002
Use of in vitro-generated, stem cell-derived islets to cure type 1 diabetes: how close are we?
Annals of the New York Academy of Sciences. 958:59-68 [PMID] 12021084.
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2002
Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 13(1):5-16 [PMID] 12097234.
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2002
Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren’s syndrome) on a healthy murine background.
Arthritis and rheumatism. 46(5):1390-8 [PMID] 12115247.
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2002
In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells.
Proceedings of the National Academy of Sciences of the United States of America. 99(12):8078-83 [PMID] 12048252.
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2002
Expression of osteopontin in rat kidneys: induction during ethylene glycol induced calcium oxalate nephrolithiasis.
The Journal of urology. 168(3):1173-81 [PMID] 12187263.
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2002
IDD3 and IDD5 alleles from nod mice mediate Sjögren’s syndrome-like autoimmunity.
Advances in experimental medicine and biology. 506(Pt B):1035-9 [PMID] 12614028.
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2002
Generation of islets of Langerhans from adult pancreatic stem cells.
Journal of hepato-biliary-pancreatic surgery. 9(6):704-9 [PMID] 12658404.
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2002
Immunogenetics of autoimmune exocrinopathy in the nod mouse: more than meets the eye.
Advances in experimental medicine and biology. 506(Pt B):999-1007 [PMID] 12614023.
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2002
Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization.
Nature medicine. 8(6):607-12 [PMID] 12042812.
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2001
Polarized expression of G protein-coupled receptors and an all-or-none discharge of Ca2+ pools at initiation sites of [Ca2+]i waves in polarized exocrine cells.
The Journal of biological chemistry. 276(47):44146-56 [PMID] 11553617.
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2001
Abnormal organogenesis in salivary gland development may initiate adult onset of autoimmune exocrinopathy.
Experimental and clinical immunogenetics. 18(3):143-60 [PMID] 11549844.
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2001
Amphipathic variable region heavy chain peptides derived from monoclonal human Wegener’s anti-PR3 antibodies stimulate lymphocytes from patients with Wegener’s granulomatosis and microscopic polyangiitis.
Clinical and experimental immunology. 125(2):323-31 [PMID] 11529926.
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2001
Differential absorption and distribution of epidermal growth factor and insulin-like growth factor in diabetic NOD mice.
Journal of diabetes and its complications. 15(2):103-11 [PMID] 11274907.
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2001
Elevated proapoptotic Bax and caspase 3 activation in the NOD.scid model of Sjögren’s syndrome.
Arthritis and rheumatism. 44(3):693-702 [PMID] 11263785.
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2001
IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sjögren’s syndrome.
Scandinavian journal of immunology. 54(1-2):133-40 [PMID] 11439159.
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2001
Pancreatic stem cells: a therapeutic agent that may offer the best approach for curing type 1 diabetes.
Pediatric diabetes. 2(4):195-202 [PMID] 15016187.
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2001
Pancreatic stem cells: building blocks for a better surrogate islet to treat type 1 diabetes.
Annals of medicine. 33(3):186-92 [PMID] 11370772.
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2001
Rapid reversal of hyperoxaluria in a rat model after probiotic administration of Oxalobacter formigenes.
The Journal of urology. 166(4):1487-91 [PMID] 11547118.
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2001
Sjögren’s syndrome: immunological response underlying the disease.
Archivum immunologiae et therapiae experimentalis. 49(5):353-60 [PMID] 11798133.
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2001
Reduced oral wound healing in the NOD mouse model for type 1 autoimmune diabetes and its reversal by epidermal growth factor supplementation.
Diabetes. 50(9):2100-4 [PMID] 11522677.
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2000
Aberrant proteolytic digestion of biglycan and decorin by saliva and exocrine gland lysates from the NOD mouse model for autoimmune exocrinopathy.
Clinical and experimental rheumatology. 18(2):233-40 [PMID] 10812497.
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2000
Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren’s syndrome-like autoimmune exocrinopathy.
The Journal of rheumatology. 27(8):1896-904 [PMID] 10955330.
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2000
Evidence for antimuscarinic acetylcholine receptor antibody-mediated secretory dysfunction in nod mice.
Arthritis and rheumatism. 43(10):2297-306 [PMID] 11037890.
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2000
Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells.
Nature medicine. 6(3):278-82 [PMID] 10700229.
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2000
Salivary EGF levels reduced in diabetic patients.
Journal of diabetes and its complications. 14(3):140-5 [PMID] 10989322.
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1999
The role of apoptosis in the initiation of the autoimmune response in Sjögren’s syndrome.
Clinical and experimental immunology. 116(3):383-7 [PMID] 10361223.
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1999
Temporal changes in mRNA expression for bikunin in the kidneys of rats during calcium oxalate nephrolithiasis.
Journal of the American Society of Nephrology : JASN. 10(5):986-96 [PMID] 10232684.
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1999
New concepts for the development of autoimmune exocrinopathy derived from studies with the NOD mouse model.
Archives of oral biology. 44 Suppl 1:S21-5 [PMID] 10414851.
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1999
Direct quantification of the enteric bacterium Oxalobacter formigenes in human fecal samples by quantitative competitive-template PCR.
Journal of clinical microbiology. 37(5):1503-9 [PMID] 10203513.
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1999
Direct correlation between hyperoxaluria/oxalate stone disease and the absence of the gastrointestinal tract-dwelling bacterium Oxalobacter formigenes: possible prevention by gut recolonization or enzyme replacement therapy.
Journal of the American Society of Nephrology : JASN. 10 Suppl 14:S334-40 [PMID] 10541258.
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1999
An alternative perspective to the immune response in autoimmune exocrinopathy: induction of functional quiescence rather than destructive autoaggression.
Scandinavian journal of immunology. 49(1):7-10 [PMID] 10023850.
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1999
Expression of bikunin mRNA in renal epithelial cells after oxalate exposure.
The Journal of urology. 162(4):1480-6 [PMID] 10492241.
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1998
Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjögren’s syndrome.
Proceedings of the National Academy of Sciences of the United States of America. 95(13):7538-43 [PMID] 9636185.
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1998
Salivary gland changes in the NOD mouse model for Sjögren’s syndrome: is there a non-immune genetic trigger?
European journal of morphology. 36 Suppl:247-51 [PMID] 9825931.
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1998
Infiltrating lymphocyte populations and cytokine production in the salivary and lacrimal glands of autoimmune NOD mice.
Advances in experimental medicine and biology. 438:493-7 [PMID] 9634926.
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1998
Excessive synthesis of matrix metalloproteinases in exocrine tissues of NOD mouse models for Sjögren’s syndrome.
The Journal of rheumatology. 25(12):2371-80 [PMID] 9858432.
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1998
Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid mice.
Clinical and experimental rheumatology. 16(6):675-81 [PMID] 9844759.
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1998
Absence of Oxalobacter formigenes in cystic fibrosis patients: a risk factor for hyperoxaluria.
Lancet (London, England). 352(9133):1026-9 [PMID] 9759746.
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1998
Aberrant expression and potential function for parotid secretory protein (PSP) in the NOD (non-obese diabetic) mouse.
Advances in experimental medicine and biology. 438:925-30 [PMID] 9634989.
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1998
A novel NOD-derived murine model of primary Sjögren’s syndrome.
Arthritis and rheumatism. 41(1):150-6 [PMID] 9433880.
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1998
Characterization of the changing lymphocyte populations and cytokine expression in the exocrine tissues of autoimmune NOD mice.
Autoimmunity. 27(1):29-44 [PMID] 9482205.
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1997
DNA sequencing and expression of the formyl coenzyme A transferase gene, frc, from Oxalobacter formigenes.
Journal of bacteriology. 179(10):3378-81 [PMID] 9150242.
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1997
Elevated levels of cysteine protease activity in saliva and salivary glands of the nonobese diabetic (NOD) mouse model for Sjögren syndrome.
Proceedings of the National Academy of Sciences of the United States of America. 94(11):5767-71 [PMID] 9159148.
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1997
Identification and classification of Oxalobacter formigenes strains by using oligonucleotide probes and primers.
Journal of clinical microbiology. 35(2):350-3 [PMID] 9003594.
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1997
In vitro-generation of islets in long-term cultures of pluripotent stem cells from adult mouse pancreas.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 29(6):271-7 [PMID] 9230348.
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1997
PSP expression in murine lacrimal glands and function as a bacteria binding protein in exocrine secretions.
The American journal of physiology. 272(4 Pt 1):G863-71 [PMID] 9142919.
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1996
Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice.
The Journal of pharmacology and experimental therapeutics. 279(2):790-4 [PMID] 8930185.
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1996
Genetically programmed development of salivary gland abnormalities in the NOD (nonobese diabetic)-scid mouse in the absence of detectable lymphocytic infiltration: a potential trigger for sialoadenitis of NOD mice.
Clinical immunology and immunopathology. 79(1):50-9 [PMID] 8612351.
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1996
Experimental and clinical allogeneic heart transplant rejection: correlations between histology and immune reactivity detected by cytokine messenger RNA.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 15(8):778-89 [PMID] 8878760.
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1996
A gene map of the human genome.
Science (New York, N.Y.). 274(5287):540-6 [PMID] 8849440.
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1996
Autoimmune diabetes-prone NOD mice express the Lyt2 alpha (Lyt2.1) and Lyt3 alpha (Lyt3.1) alleles of CD8.
Immunogenetics. 43(1-2):6-12 [PMID] 8537123.
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1996
Competitive RNA templates for detection and quantitation of growth factors, cytokines, extracellular matrix components and matrix metalloproteinases by RT-PCR.
BioTechniques. 20(4):670-4 [PMID] 8800688.
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1995
Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.
The Journal of clinical investigation. 95(2):628-34 [PMID] 7860747.
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1994
Molecular cloning, DNA sequence, and gene expression of the oxalyl-coenzyme A decarboxylase gene, oxc, from the bacterium Oxalobacter formigenes.
Journal of bacteriology. 176(8):2468-72 [PMID] 8157618.
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1993
Insulin-dependent diabetes in the NOD mouse model. II. Beta cell destruction in autoimmune diabetes is a TH2 and not a TH1 mediated event.
Autoimmunity. 15(2):113-22 [PMID] 8105989.
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1993
Antioxidant enzyme activities in IDD-prone and IDD-resistant mice: a comparative study.
Free radical biology & medicine. 14(4):409-20 [PMID] 8468025.
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1993
Insulin-dependent diabetes in the NOD mouse model. I. Detection and characterization of autoantibody bound to the surface of pancreatic beta cells prior to development of the insulitis lesion in prediabetic NOD mice.
Autoimmunity. 15(2):123-35 [PMID] 8218837.
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1991
Cloning and expression of the oxalyl-CoA decarboxylase gene from the bacterium, Oxalobacter formigenes: prospects for gene therapy to control Ca-oxalate kidney stone formation.
American journal of kidney diseases : the official journal of the National Kidney Foundation. 17(4):381-5 [PMID] 2008903.
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1991
Pertussigen treatment retards, but fails to prevent, the development of type I, insulin-dependent diabetes mellitus (IDDM) in NOD mice.
Autoimmunity. 9(4):311-7 [PMID] 1954311.
View on: PubMed
1990
Flow cytometric enumeration of mononuclear cell populations infiltrating the islets of Langerhans in prediabetic NOD mice: development of a model of autoimmune insulitis for type I diabetes.
Regional immunology. 3(6):305-17 [PMID] 2132756.
View on: PubMed
1989
Reciprocal allogeneic bone marrow transplantation between NOD mice and diabetes-nonsusceptible mice associated with transfer and prevention of autoimmune diabetes.
Diabetes. 38(7):894-901 [PMID] 2661286.
View on: PubMed
1988
A comment on H-2-restricted T cell recognition of Mls determinants: a question of perspective.
Journal of immunogenetics. 15(1-3):77-85 [PMID] 2466908.
View on: PubMed
1988
Gene transfer into hematopoietic progenitor cells mediated by an adeno-associated virus vector.
Virology. 162(2):483-6 [PMID] 2829430.
View on: PubMed
1987
Nonresponsiveness to Mlsd in F1 hybrid mice carrying Mlsa and Mlsc genes.
Journal of immunology (Baltimore, Md. : 1950). 139(2):321-5 [PMID] 2955035.
View on: PubMed
1987
Production of 35 H-2 homozygous strains from wild mice.
Immunogenetics. 26(1-2):115-9 [PMID] 2956187.
View on: PubMed
1987
Successful semiallogeneic and allogeneic bone marrow reconstitution of lethally irradiated adult mice mediated by neonatal spleen cells.
Transplantation. 44(5):614-20 [PMID] 2961109.
View on: PubMed
1986
Naturally occurring, spleen-associated suppressor activity of the newborn mouse. Biochemical and functional identification of three monokines secreted by newborn suppressor-inducer monocytes.
Scandinavian journal of immunology. 23(1):35-44 [PMID] 2939550.
View on: PubMed
1984
A novel anti-Ia monoclonal antibody which specifically enhances the corresponding T cell alloreactivity.
Journal of immunology (Baltimore, Md. : 1950). 133(5):2360-4 [PMID] 6332845.
View on: PubMed
1984
Changes in the Ir gene controlled response phenotypes in mice of the Ap and Ak family of alleles expressing naturally occurring variant molecules.
Journal of immunology (Baltimore, Md. : 1950). 133(3):1410-6 [PMID] 6205082.
View on: PubMed
1984
Naturally occurring spleen-associated suppressor activity of the newborn mouse. Requirement for two genetic restrictions in suppression of lethal graft-versus-host disease by newborn spleen cells.
Scandinavian journal of immunology. 20(1):81-91 [PMID] 6463591.
View on: PubMed
1983
Variant class II molecules from H-2 haplotypes in wild mouse populations: functional characteristics of closely related class II gene products.
Journal of immunology (Baltimore, Md. : 1950). 131(5):2432-9 [PMID] 6415169.
View on: PubMed
1983
Lethal murine graft-versus-host disease in the absence of detectable cytotoxic T lymphocytes.
Transplantation. 36(3):281-9 [PMID] 6604351.
View on: PubMed
1983
Lack of shared lymphocyte-stimulating determinants between H-2I and HLA-D/DR using mouse primed lymphocyte typing cells.
Human immunology. 7(2):105-15 [PMID] 6190790.
View on: PubMed
1983
Heterogeneity of an anti-H-2 I-A response as determined by cloned T cell reactivity.
Journal of immunology (Baltimore, Md. : 1950). 130(5):2067-70 [PMID] 6220077.
View on: PubMed
1983
Functional reactivities of lymphocytes primed in murine graft-versus-host reactions.
Transplantation. 35(1):84-90 [PMID] 6218667.
View on: PubMed
1983
Isolation and identification of the naturally occurring, newborn spleen-associated suppressor cells. A mixed monocyte/mast cell population with separable suppressor activities.
Scandinavian journal of immunology. 17(5):443-53 [PMID] 6222470.
View on: PubMed
1982
Cellular and genetic restrictions in the immunoregulatory activity of alpha-fetoprotein. III. Role of the MLC-stimulating cell population in alpha-fetoprotein-induced suppression of T cell-mediated cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950). 128(3):1134-40 [PMID] 6173421.
View on: PubMed
1981
Receptor specificity, functional characteristics, and cell-surface phenotype of a highly selected anti-I-Ab-specific, long-term T-cell line.
Immunogenetics. 12(5-6):525-40 [PMID] 6971252.
View on: PubMed
1981
The mouse primed lymphocyte typing (mPLT)test. II. Detection of variant H-2 K and D molecules in the typing analysis of the class I-associated lymphocyte-stimulating (LS) determinants, using the B10.W lines.
Scandinavian journal of immunology. 13(5):453-60 [PMID] 6171866.
View on: PubMed
1980
T-lymphocyte recognition of the I-EC gene products (Ia) requires concomitant recognition of I-AB gene products.
Scandinavian journal of immunology. 11(2):235-9 [PMID] 9537050.
View on: PubMed
1980
The mouse-primed lymphocyte typing test. III. Dissociation of T lymphocyte-stimulating determinants and antibody-defined specificities of the I region-associated Ia antigens.
Journal of immunology (Baltimore, Md. : 1950). 125(3):1978-86 [PMID] 6157729.
View on: PubMed
1979
Non-T cell nature of the naturally occurring, spleen-associated suppressor cells present in the newborn mouse.
European journal of immunology. 9(9):737-46 [PMID] 159828.
View on: PubMed
1976
Specificity in T cell mediated lympholysis: identical genetic control of the proliferative and effector phases of allogeneic and xenogeneic reactions.
Transplantation reviews. 29:189-221 [PMID] 58457.
View on: PubMed
1975
Mouse cell-mediated lympholysis assay in serum-free and mouse serum-supplemented media: culture conditions and genetic factors.
Scandinavian journal of immunology. 4(1):53-62 [PMID] 49078.
View on: PubMed
1975
Specificity of cell-mediated lympholysis for public and private H-2 determinants.
Scandinavian journal of immunology. 4(5-6):541-53 [PMID] 52182.
View on: PubMed
1974
Differential recognition by thymocytes of H-2 and non H-2 alloantigens.
Nature. 252(5483):507-8 [PMID] 4279342.
View on: PubMed
1973
Cellular reactivities associated with theta-antigen disparity.
Transplantation proceedings. 5(4):1611-3 [PMID] 4272820.
View on: PubMed
1973
Immune responses in vitro. 3. Enhancement of the mouse mixed lymphocyte interaction by isologous and homologous sera.
European journal of immunology. 3(7):385-92 [PMID] 4271347.
View on: PubMed
1973
Immune responses in vitro. II. Mixed leukocyte interaction in a protein-free medium.
European journal of immunology. 3(7):379-85 [PMID] 4271346.
View on: PubMed

Patents

Issued February 1997
Method and Kit for Detection of Oxalate Conversion of Oxalate to Formate and Carbon Dioxide in Presence of Formyl-coA Transferase Together with Oxalyl-coA Decarboxylase
#5,604,111
Issued November 1998
In Vitro-Grown Islets of Langerhan for Curing Diabetes
#5,834,308
Issued November 1998
Materials and Methods for Detection of Oxalobacter Formigenes (CIP)
#5,837,833
Issued June 1999
Materials and Methods for Dectection of Oxalobacter (CIP)
#5,912,125
Issued December 1999
In Vitro Growth Of Functional Islets Of Langerhans And In Vivo Uses Thereof (CIP)
#6,001,647
Issued July 2000
Materials and Methods for Detection of Oxalobactor Formigenes (CIP)
#6,090,628
Issued April 2001
Materials and Methods for Detection of Oxalobactor (CIP)
#6,214,980
Published September 2003
Materials and Methods for Detection of Oxalobacter Formigenes
#US-2004-0038286-A1
Issued March 2004
Reversal of Insulin-Dependent Diabetes by Islet-Producing Stem Cells, Islet Progenitor Cells and Islet-Like Structures (CIP)
#6,703,017
Issued March 2004
Materials and Methods for Detection of Oxalobacter Formigenes (CON)
#6,709,820
Issued August 2005
Polynucleotides Encoding Oxalate Decarboxylase From Aspergillus Niger and Mehtods of Use
#6,929,940
Published January 2008
Reversal of Insulin-Dependent Diabetes by Islet-Producing Stem Cells, Islet Progenitor Cells and Islet-Like Structures (CON)
#US-2008-0274090-A1
Published July 2009
Materials and Methods For The Detection, Prevention and Treatment of Autoimmune Disease
#US-2010-0178652-A1
Published May 2013
Differential Detection and Quantification of Oxalobacter
#2014-0113284 A1
Published May 2015
Compositions and Methods for Monitoring Oxalate (DIV of 13413)
#US-2016-0041151-A1
Issued June 2015
Compositions and Methods for Monitoring Oxalate
#9,045,794

Education

Doctor of Philosophy in Medical Microbiology
1972 · University of Wisconsin
Bachelor of Science in Bacteriology
1968 · Syracuse University

Teaching Profile

Courses Taught
2018
GMS7980 Research for Doctoral Dissertation
2013,2015-2017,2017
VME6505 Autoimmunity
2011-2017
DEN5120C Physiology
2015-2016
GMS6140 Principles of Immunology
2016
GMS7003 Respon Conduct Biomed
2011-2014
DEN6128 Host Defense
2010-2012
GMS6030 Autoimmunity
2010
IDH4905 Individual Work

Contact Details

Phones:
Business:
(352) 294-4211
Emails:
Business:
peck@ufl.edu

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