Roy Curtiss, III

Roy Curtiss, III

PROF

Department: Department of Infectious Diseases & Immunology
Business Email: rcurtiss@ufl.edu

About Roy Curtiss, III

Expertise: Biotechnology, genetics, microbiology, immunology, vaccinology

Dr. Curtiss is a member of the National Academy of Sciences and Fellow of the American Academy of Microbiology, the American Association for the Advancement of Science, the St. Louis Academy of Sciences and the Arizona Arts, Science and Technology Academy. He has conducted research at Cornell University, Brookhaven National Laboratory, University of Chicago, Oak Ridge National Laboratory, University of Tennessee, University of Alabama at Birmingham, Washington University in St. Louis and Arizona State University.

Research Profile

Expertise: Biotechnology, genetics, microbiology, immunology, vaccinology

Dr. Curtiss is a member of the National Academy of Sciences and Fellow of the American Academy of Microbiology, the American Association for the Advancement of Science, the St. Louis Academy of Sciences and the Arizona Arts, Science and Technology Academy. He has conducted research at Cornell University, Brookhaven National Laboratory, University of Chicago, Oak Ridge National Laboratory, University of Tennessee, University of Alabama at Birmingham, Washington University in St. Louis and Arizona State University.

Dr. Curtiss’ early work was in avian genetics on cross breeding of White Plymouth Rock and White Cornish as a better broiler, genetics of bacteriophage P22 of Salmonella, mechanisms of bacterial conjugation in E. coli and use of bacterial minicells for studies of plasmids and cloned genes. Later work focused on establishing the molecular genetic bases for pathogenicity of Streptococcus mutans, Shigella flexneri, Mycobacterium leprae, Salmonella enterica, Escherichia coli pathovars and Bordatella avium. The Curtiss group developed biological containment first for cloned genes and then for recombinant attenuated Salmonella vaccines (RASVs) and most recently for cyanobacteria. The Curtiss lab developed the use of attenuated derivatives of pathogenic bacteria as vectors to deliver protective antigens encoded by genes from other pathogens. Dr. Curtiss also introduced use of transgenic plants as vaccine components and vectors.

Most recently members of the Curtiss lab group have contributed major technical innovations to more effectively deliver protective antigens and DNA vaccines by RASVs to stimulate all three branches of the immune system. This includes development of multiple methods for regulated delayed attenuation and regulated delayed synthesis of protective antigens to better enable vaccine strains to retain wild-type attributes at time of oral needle-free immunization. This will allow the vaccine to persist and to withstand host defenses, and efficiently evade effector lymphocytes before displaying complete attenuation to preclude induction of disease symptoms. The net result will be the synthesis and delivery of protective antigens to maximize induction of protective immunity. Safety of such vaccines and improvement of immunogenicity was achieved by developing the regulated delayed lysis in vivo attribute to confer complete biological containment and delivery of either protective antigens or DNA vaccines encoding them. These technologies are being used to address problems of global concern to design, construct and evaluate live RASVs to reduce morbidity and mortality caused by infectious disease agents of fish, poultry, swine, cattle and humans. Other efforts are directed at dealing with zoonotic threats and in developing preventative and therapeutic vaccines against cancer.

Publications

Grants

Feb 2020 ACTIVE
Edwardsiella piscicida DNA vaccine vector to prevent Tilapia Lake Virus (TiLV) infection and develop generalized vaccine vectors to protect commercial fish from multiple infectious diseases to improve aquaculture productivity
FOUNDATION FOR FOOD AND AGRICULTURE RES · Principal Investigator
Aug 2019 – Jul 2020
Design, construct and validate Salmonella Choleraesuis vaccine and vaccine vector strain with regulated delayed attenuation, regulated delayed synthesis of protective antigens, and regulated delayed lysis in vivo phenotypes
CURTISS HEALTHCARE INC · Principal Investigator
Jul 2018 ACTIVE
Edwardsiella piscicida: A vaccine delivery platform for multiple fish pathogens.
US DEPT OF AG NATL INST OF FOOD AND AG · Principal Investigator
Jan 2018 – Mar 2019
Brucellosis Vaccine Prize: Phase 1
GALVMED · Principal Investigator
Nov 2017 – Nov 2018
Recombinant immunocontraceptive vaccines for management of cat and dog populations
UF FOU · Principal Investigator
Sep 2017 – Aug 2019
Recombinant immunocontraceptive vaccines to control rodent and ultimately other wildlife species.
DIETRICH W BOTSTIBER FOU · Principal Investigator
Apr 2017 ACTIVE
A Food Safety Vaccine to Control Salmonella Enteritidis and Reduce Campylobacter in Poultry
US DEPT OF AG NATL INST OF FOOD AND AG · Principal Investigator
Jan 2017 – Dec 2019
Manipulate cell surface by triple sugars for broad-spectrum Salmonella vaccine development
NATL INST OF HLTH NIAID ·
Feb 2016 – Jul 2017
Disease prevention in Gallus domesticus, Sus scrofa and Bos taurus
CURTISS HEALTHCARE INC · Principal Investigator
Oct 2015 ACTIVE
Heterologous polysaccharide synthesis in attenuated Salmonella
NATL INST OF HLTH NIAID · Principal Investigator
Aug 2015 – Apr 2017
Recombinant Attenuated bacterial vaccines against
NATL INST OF HLTH NIAID · Principal Investigator
Aug 2015 – May 2020
Recombinant Attenuated Salmonella Vaccines for Humans
NATL INST OF HLTH NIAID · Principal Investigator

Education

PhD
1962 · University of Chicago

Contact Details

Emails:
Business:
rcurtiss@ufl.edu

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