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Anthony F. Barbet

photograph of Dr. Tony BarbetProfessor
Department of Infectious Diseases and Pathology
barbet@ufl.edu
PO Box 110880
2015 SW 16th AV
Gainesville, FL 32611-0880
352-294-4119
FAX 352-392-9704

Education

  • PhD, Biochemical Parasitology, University of Cambridge, England, 1977

Honors and Awards

  • SmithKline-Beecham award for research excellence, 1993
  • Pfizer Award for research excellence, 2000
  • University of Florida Research Professor, 2007

Research Interests

Defining molecular mechanisms of pathogenesis in emerging infectious diseases, development of recombinant vaccines and improved molecular diagnostics. A long-term research focus has been to understand the molecular basis for persistent infections, beginning with investigations of antigenic variation in African trypanosomes and now including persistent infections caused by rickettsias of veterinary and human importance. An important finding has been the discovery of gene sequence mosaics in trypanosomes and Anaplasma. These mosaics are formed by contribution of sequence to genomic expression sites by different functional pseudogenes. This allows extensive surface diversity to be created from the small Anaplasma genomes because of the large number of different combinatorial possibilities. With the completion of genome sequence for these organisms, this research is now extending in two main directions: 1) analysis of gene expression and variation at the whole genome level. 2) development of transformation systems to knock-out virulence genes to develop new vaccines.

Recent Publications

Additional publications here

 

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