Janet K Yamamoto

Janet K Yamamoto

Professor, Immunology

Department: Department of Infectious Diseases & Immunology
Business Phone: (352) 294-4145
Business Email: yamamoto@ufl.edu

Accomplishments

Inductee
2015 · Florida Inventors Hall of Fame
Fellow
2014 · National Academy of Inventors (NIA)
Professorship Award
2011 · University of Florida Research Foundation
Faculty Achievement Recognition
2007 · University of Florida
Ad hoc grant reviewer
2006 · Medical Research Council, UK
Regular member, AIDS Immunology & Pathogenesis Study Section
2005-2008 · NIH, NIAID
Pfizer Animal Health Award for Research Excellence
2005 · University of Florida
Ad hoc member, AIDS ARR 2 Study Section
2004 · NIH
Ad hoc grant reviewer
2003-2004 · Medical Research Council, UK
Ad hoc member, Study Section on AIDS K08
2002 · NIH
Honorary member
2002 · Upsilon Chapter of the Society of Phi Zeta
Research Foundation Professorship Award
2002 · University of Florida
International Advisory Committee
2000-2014 · International Feline Retrovirus Research Symposium
Ad hoc member, AIDS ARR 2 Study Section
2000 · NIH
Ad hoc member, Vaccine Special Emphasis Panel (VACC 01, 02, 03, 010)
1998-2005 · NIH
Ad hoc member, Study Section on Small Business and STTR Grants
1998 · NIH, NIMH
Ad hoc team leader, Primate Research Center Site Visit
1998 · NIH, NCRR
Ad hoc member, Primate Research Center Site Visit
1996 · NIH, NCRR
Pfizer Animal Health Award for Research Excellence
1996 · University of Florida
Ad hoc member, Minority Enhancement Program Study Section
1995 · NIH, NIAID
Ad hoc member, Panel on RFA on Blood Brain Barrier in HIV
1995 · NIH, NIMH
Regular member, AIDS & Immunology Study Section (MHAI2)
1994-1998 · NIH, NIHM
Member, Immunology & Microbiology Study Section
1993-1995 · American Heart Association

Research Profile

Dr. Yamamoto has been working in the HIV-1 field since 1984 and is the co-discoverer of feline immunodeficiency virus (FIV, feline counterpart of HIV) and the inventor of the first commercial FIV vaccine (Fel-O-Vax® FIV, sold by Pfizer and Boehringer). Under the leadership of Dr. Murray Gardner (director of CFAR) in 1984, she set up the first HIV-1 laboratory at the University of California, Davis (UCD) which later became the main laboratory of the NIH-funded Center for AIDS Research (CFAR) at UCD. She is the first to publish together with Drs. Francois Barré-Sinousi (Nobelauriate) and Gardner that IFNα and IFNβ suppresses HIV-1 replication but IFNγ enhances HIV-1 replication. Based on her experience in large-scale production of HIV-1 viruses and HIV-1 immunoblots, she also served as the consultant on the second FDA-approved HIV-1 immunoblot by Bio-Rad Laboratories. She has extensive experience in adjuvants for protein vaccines including cytokine (IL12, IL15, IL18, IFNγ) supplement of adjuvants in cats. After the discovery of FIV, her laboratory has focused on the development of FIV vaccine for both prophylaxis and therapeutic uses and FIV infection of cats as the natural small animal model of HIV/AIDS. Her laboratory has been studying the immune mechanism(s) of the protection conferred by prototype and commercial dual-subtype FIV vaccines as an animal model for developing HIV-1 vaccine. Her laboratory has discovered that vaccine-induced T-cell immunity may be more important in prophylactic protection against both homologous-subtype and heterologous-subtype FIV than vaccine-induce antibody immunity. Based on this finding, her laboratory is developing a second-generation FIV vaccine which has no conflict with commercial FIV diagnostics. Her laboratory is also working on identifying T-cell epitopes on HIV for an effective HIV vaccine for prophylaxis and therapy. Yamamoto has had NIH grant for 30 years and the majority of 90 journal/book publications and 32 patent publications are on FIV or HIV-1.

Publications

2017 Journal of clinical & cellular immunology
2008 Veterinary Immunology and Immunopathology
1998 Veterinary Immunology and Immunopathology

Grants

Feb 2018 ACTIVE
MERCK/INTERVET ANIMAL CLINICAL VACCINE TRIAL
INTERVET · Principal Investigator
Mar 2017 – Mar 2020
Identification of potent neutralizing Zika virus antibodies using single-cell analysis technology
FL DEPT OF HLTH ·
Apr 2016 ACTIVE
Miscellaneous Donors Project 209
MISCELLANEOUS DONORS · Principal Investigator
Jul 2013 – Jun 2017
The Structural and Functional Basis of HLA-associated Dr
NATL INST OF HLTH NIAID · Project Manager

Patents

Issued May 1996
Retroviral Superantigens, Superantigen Peptides, and Methods of Use
#5,519,114
Issued December 1998
Feline-Derived T-Cell Lines for Producing FIV
#5,846,825
Issued October 1999
Retroviral Superantigens, Superantigen Peptides, and Methods of Use
#5,968,514
Issued July 2001
Multi-Subtype FIV Vaccines
#6,254,872
Published February 2002
MATERIALS AND METHODS FOR DETECTING, PREVENTING, AND TREATING OF RETROVIRAL INFECTIONS
#US-2003-0091987-A1
Issued September 2002
Multi-Subtype FIV Vaccines (CON of 1385 ORD/UTIL)
#6,447,993
Issued April 2003
MULTI-SUBTYPE FIV VACCINES
#6,544,528
Issued August 2003
Multi-Subtype FIV Vaccines
#6,605,282
Issued September 2007
Multi-Subtype FIV Vaccines
#7,267,824
Issued December 2007
Multi-Subtype FIV Vaccines
#7,311,921
Issued February 2010
HIV Vaccine Against FIV Infection (CIP of 11089)
#7,658,927
Published May 2012
Materials and Methods for Detecting, Preventing and Treating Retroviral Infection (CON)
#US-2012-0294891
Issued May 2012
Method For Inducing Cross-Reactive Immune Responses To The Human Immunodeficiency Virus (HIV) In A Host By Administering Feline Immunodeficiency Virus (FIV) Capsid (CA) Or Reverse Transcriptase (RT) Immunogens
#8,182,820
Issued April 2014
HIV Vaccine Against FIV Infection
#8,703,145
Published October 2014
Materials and Methods for Detecting, Preventing and Treating Retroviral Infection (CON)
#US-2015-0098965
Published January 2018
Cross-Reactive T Cell Epitopes of HIV, SIV, and FIV for Vaccines in Humans and Cats (CON of CIP 15559)
#US-2018-0228890
Issued March 2018
Cross-Reactive T Cell Epitopes of HIV, SIV and FIV for Vaccines in Humans and Cats (CIP)
#9,913,895

Education

PhD – Microbiology (Immunology)
1981 · The University of Texas Medical Branch, Galveston

Contact Details

Phones:
Business:
(352) 294-4145
Emails:
Business:
yamamoto@ufl.edu

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