Tom Wronski

Tom Wronski,

Professor Emeritus

Department: Department of Physiological Sciences
Business Phone: (352) 294-4044
Business Email: wronskit@ufl.edu

Accomplishments

College Council Teacher of the Year
2013 · UF College of Veterinary Medicine
SCAVMA Basic Sciences Teacher of the Year
2013 · UF College of Veterinary Medicine
President
2009-2012 · International Society of Bone Morphometry
Member
2006-2010 · Editorial Board for the Journal of Bone and Mineral Research
Teacher of Year Award, Class of 2007
2004 · UF College of Veterinary Medicine
Member, Board of Scientific Counselors
2003-2020 · National Space Biomedical Research Institute
Member, Board of Directors
1999-2020 · International Society of Bone Morphometry
Research Professorship Award
1999 · University of Florida
Member, External Advisory Council
1997-2003 · National Space Biomedical Research Institute
NIH MERIT Award for sustained contributions to aging research
1997 · National Institute on Aging
Graduate Student Service Award
1994 · UF College of Veterinary Medicine
SmithKline Beecham Award for Research Excellence
1994 · UF College of Veterinary Medicine
Member, Editorial Board
1989-2020 · Bone Journal
C.E. Cornelius Young Investigator Award
1988 · UF College of Veterinary Medicine
Cosmos Achievement Award, for participation in U.S. experiments on the Soviet Cosmos 1129 biological satellite
1981 · NASA

Research Profile

My research involves preclinical testing of new drugs and hormones for the prevention and treatment of postmenopausal osteoporosis, a bone disorder that afflicts millions of elderly women. These studies are performed in the ovariectomized rat, a widely accepted animal model for postmenopausal bone loss. Bone samples are subjected to histomorphometric analysis with a computer-assisted, image analysis system to determine the effects of the various treatments on bone mass and levels of bone resorption and formation. In addition, molecular biology techniques are used to determine the effects of novel osteoporosis therapies on gene expression for selected growth factors, cytokines, and bone matrix proteins. The same histomorphometric and molecular biology techniques are used to investigate the skeletal effects of actual and simulated space flight.

Publications

2021
The beta-glucuronidase intracisternal A particle insertion model results in similar overall MPSVII phenotype as the single base deletion model when on the same C57BL/6J mouse background.
Molecular genetics and metabolism reports. 27 [DOI] 10.1016/j.ymgmr.2021.100727. [PMID] 33604242.
2019
Longitudinal Examination of Bone Loss in Male Rats After Moderate-Severe Contusion Spinal Cord Injury.
Calcified tissue international. 104(1):79-91 [DOI] 10.1007/s00223-018-0471-8. [PMID] 30218117.
2018
Sclerostin Antibody Reverses Bone Loss By Increasing Bone Formation and Decreasing Bone Resorption in a Rat Model of Male Osteoporosis
Endocrinology. 159(1):260-271 [DOI] 10.1210/en.2017-00794.
2017
Treatment With a Soluble Bone Morphogenetic Protein Type 1A Receptor (BMPR1A) Fusion Protein Increases Bone Mass and Bone Formation in Mice Subjected to Hindlimb Unloading.
JBMR plus. 1(2):66-72 [DOI] 10.1002/jbm4.10012. [PMID] 30283882.
2016
Fructose consumption does not worsen bone deficits resulting from high-fat feeding in young male rats.
Bone. 85:99-106 [DOI] 10.1016/j.bone.2016.02.004. [PMID] 26855373.
2016
Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats.
Bone. 84:148-159 [DOI] 10.1016/j.bone.2015.12.013. [PMID] 26721737.
2015
Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss.
The Journal of endocrinology. 227(3):129-41 [DOI] 10.1530/JOE-15-0280. [PMID] 26487675.
2015
Sclerostin inhibition prevents spinal cord injury-induced cancellous bone loss.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 30(4):681-9 [DOI] 10.1002/jbmr.2396. [PMID] 25359699.
2014
Effects of Dried Plum Supplementation On Bone Metabolism in Adult C57Bl/6 Male Mice
Calcified Tissue International. 94(4):442-453 [DOI] 10.1007/s00223-013-9819-2. [PMID] 24357047.
2014
Testosterone dose dependently prevents bone and muscle loss in rodents after spinal cord injury.
Journal of neurotrauma. 31(9):834-45 [DOI] 10.1089/neu.2013.3155. [PMID] 24378197.
2013
Effect of Trenbolone Enanthate On Protein Degradation in Levator Ani/Bulbocavernosus (Labc) Muscle in Orchiectomized Rats
The FASEB's Journal. 27
2013
Testosterone Treatment Prevents Spinal Cord Injury-Induced Bone Loss in Male Rats
The FASEB's Journal. 27
2013
The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormone.
The Journal of biological chemistry. 288(10):6814-25 [DOI] 10.1074/jbc.M112.393363. [PMID] 23297399.
2012
17β-Hydroxyestra-4,9,11-trien-3-one (Trenbolone) preserves bone mineral density in skeletally mature orchiectomized rats without prostate enlargement.
Bone. 51(4):667-73 [DOI] 10.1016/j.bone.2012.07.008. [PMID] 22842328.
2012
A rehabilitation exercise program induces severe bone mineral deficits in estrogen-deficient rats after extended disuse.
Menopause (New York, N.Y.). 19(11):1267-76 [DOI] 10.1097/gme.0b013e318255657f. [PMID] 22713863.
2012
Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice.
Veterinary pathology. 49(6):998-1017 [DOI] 10.1177/0300985812453177. [PMID] 22732358.
2012
Cyclophosphamide creates a receptive microenvironment for prostate cancer skeletal metastasis.
Cancer research. 72(10):2522-32 [DOI] 10.1158/0008-5472.CAN-11-2928. [PMID] 22589273.
2012
Early Response of Bone Marrow Osteoprogenitors To Skeletal Unloading and Sclerostin Antibody
Calcified Tissue International. 91(1):50-58 [DOI] 10.1007/s00223-012-9610-9. [PMID] 22644321.
2012
Enhanced alveolar bone loss in a model of non-invasive periodontitis in rice rats.
Oral diseases. 18(5):459-68 [DOI] 10.1111/j.1601-0825.2011.01893.x. [PMID] 22233442.
2012
Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis.
The Journal of biological chemistry. 287(21):17894-17904 [DOI] 10.1074/jbc.M111.280511. [PMID] 22474295.
2012
Estrogen Is Required for Mechanical Loading Induced Restoration of Bone Following Disuse
Medicine and Science in Sports and Exercise. 44
2012
FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality.
The Journal of clinical investigation. 122(7):2543-53 [DOI] 10.1172/JCI61405. [PMID] 22728934.
2012
Oncologic doses of zoledronic acid induce osteonecrosis of the jaw-like lesions in rice rats (Oryzomys palustris) with periodontitis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 27(10):2130-43 [DOI] 10.1002/jbmr.1669. [PMID] 22623376.
2012
Proteoglycan 4: a Dynamic Regulator of Skeletogenesis and Parathyroid Hormone Skeletal Anabolism
Journal of Bone and Mineral Research. 27(1):11-25 [DOI] 10.1002/jbmr.508. [PMID] 21932346.
2012
Rational Identification of Enoxacin as a Novel V-Atpase-Directed Osteoclast Inhibitor
. 13:180-191
2011
17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate.
American journal of physiology. Endocrinology and metabolism. 300(4):E650-60 [DOI] 10.1152/ajpendo.00440.2010. [PMID] 21266670.
2011
Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 26(4):822-32 [DOI] 10.1002/jbmr.273. [PMID] 20939063.
2011
Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats.
Peptides. 32(8):1575-80 [DOI] 10.1016/j.peptides.2011.04.029. [PMID] 21640774.
2011
Effects of Pth(1-34) and Estrogen Status On Osteocyte Lacunar Properties in Rats
Bone. 48:S97-S98 [DOI] 10.1016/j.bone.2011.03.144.
2011
Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 26(7):1506-16 [DOI] 10.1002/jbmr.365. [PMID] 21328617.
2011
Issues in modern bone histomorphometry.
Bone. 49(5):955-64 [DOI] 10.1016/j.bone.2011.07.017. [PMID] 21810491.
2011
Refinement of the Rice Rat (Oryzomys Palustris) Model of Periodontitis and Zoledronic Acid-Induced Osteonecrosis of the Jaw
Journal of the American Association for Laboratory Animal Science. 50:726-727
2011
Teriparatide [rhPTH (1-34)], but not strontium ranelate, demonstrated bone anabolic efficacy in mature, osteopenic, ovariectomized rats.
Endocrinology. 152(5):1767-78 [DOI] 10.1210/en.2010-1112. [PMID] 21343258.
2010
Dietary dried plum increases bone mass in adult and aged male mice.
The Journal of nutrition. 140(10):1781-7 [DOI] 10.3945/jn.110.124198. [PMID] 20739449.
2010
Effects of alendronate on bone healing after tooth extraction in rats.
Oral diseases. 16(7):674-85 [DOI] 10.1111/j.1601-0825.2010.01677.x. [PMID] 20846154.
2010
Estrogen Status and Pth Effects On Osteocyte Lacunae in Rats
Bone. 47 [DOI] 10.1016/j.bone.2010.09.272.
2010
Methods to quantify sex steroid hormones in bone: applications to the study of androgen ablation and administration.
American journal of physiology. Endocrinology and metabolism. 299(5):E841-7 [DOI] 10.1152/ajpendo.00384.2010. [PMID] 20739509.
2010
The Rice Rat (Oryzomys Palustris) Model for Periodontal Disease: Characterization of the Lesions and Technical Features of the Model
Journal of the American Association for Laboratory Animal Science. 49
2009
Endogenous G(I) Signaling in Osteoblasts Participates in Sexually Dimorphic Regulation of Cancellous Bone Structure
Bone. 44 [DOI] 10.1016/j.bone.2009.01.337.
2009
Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screening.
Journal of medicinal chemistry. 52(16):5144-51 [DOI] 10.1021/jm900277z. [PMID] 19630402.
2009
In vitro and in vivo evidence for stimulation of bone resorption by an EP4 receptor agonist and basic fibroblast growth factor: Implications for their efficacy as bone anabolic agents.
Bone. 44(2):266-74 [DOI] 10.1016/j.bone.2008.10.041. [PMID] 19013265.
2009
Low Dose Teriparatide {[}Rhpth (1-34)] Is More Efficacious Than Strontium Ranelate in Osteopenic Ovariactomized Rats
Bone. 44 [DOI] 10.1016/j.bone.2009.03.425.
2009
Murine Model for Cystic Fibrosis Bone Disease Demonstrates Osteopenia and Sex-Related Differences in Bone Formation
Pediatric Research. 65:311-316
2009
Osteoclast polarization and orthodontic tooth movement.
Orthodontics & craniofacial research. 12(2):105-12 [DOI] 10.1111/j.1601-6343.2009.01443.x. [PMID] 19419453.
2009
Partial Osteopenic Phenotype Found in Cystic Fibrosis Heterozygote Mice
Pediatric Pulmonology.
2009
Skeletal Effects of Fibroblast Growth Factor Mimetic (F2A) in Ovariectomized Rats
Journal of Musculoskeletal & Neuronal Interactions. 9:38-43
2008
Alendronate Transiently Impairs Removal of Alveolar Bone and Healing of the Root Socket After Tooth Extraction in Rats
Journal of Bone and Mineral Research. 23
2008
Alterations in Bone Structure and Growth in Dwarf Rats With a Depressed Growth Hormone/Igf-I Axis
Journal of Bone and Mineral Research. 23
2008
Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia.
Endocrinology. 149(3):1329-37 [PMID] 18048501.
View on: PubMed
2008
Role for beta1 integrins in cortical osteocytes during acute musculoskeletal disuse.
Matrix biology : journal of the International Society for Matrix Biology. 27(7):609-18 [DOI] 10.1016/j.matbio.2008.05.003. [PMID] 18619537.
2008
Skeletal Effects of a Fibroblast Growth Factor Agonist (F2A) in Ovariectomized Rats
Journal of Bone and Mineral Research. 23
2008
Supraphysiological testosterone enanthate administration prevents bone loss and augments bone strength in gonadectomized male and female rats.
American journal of physiology. Endocrinology and metabolism. 295(5):E1213-22 [DOI] 10.1152/ajpendo.90640.2008. [PMID] 18780767.
2007
Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase.
American journal of physiology. Endocrinology and metabolism. 293(2):E507-14 [PMID] 17488806.
View on: PubMed
2007
Effects of basic fibroblast growth factor and a prostaglandin E2 receptor subtype 4 agonist on osteoblastogenesis and adipogenesis in aged ovariectomized rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 22(6):877-88 [PMID] 17352655.
View on: PubMed
2005
Effects of disrupted beta1-integrin function on the skeletal response to short-term hindlimb unloading in mice.
Journal of applied physiology (Bethesda, Md. : 1985). 98(2):690-6 [PMID] 15465888.
View on: PubMed
2005
Selected extraskeletal effects of systemic treatment with basic fibroblast growth factor in ovariectomized rats.
Toxicologic pathology. 33(5):577-83 [PMID] 16105801.
View on: PubMed
2003
Bone anabolic effects of subcutaneous treatment with basic fibroblast growth factor alone and in combination with estrogen in osteopenic ovariectomized rats.
Bone. 33(3):380-6 [PMID] 13678780.
View on: PubMed
2002
Sequential treatment with basic fibroblast growth factor and PTH is more efficacious than treatment with PTH alone for increasing vertebral bone mass and strength in osteopenic ovariectomized rats.
Endocrinology. 143(7):2515-26 [PMID] 12072383.
View on: PubMed
2001
Skeletal effects of systemic treatment with basic fibroblast growth factor.
Journal of musculoskeletal & neuronal interactions. 2(1):9-14 [PMID] 15758472.
View on: PubMed
1999
Bone and hormonal changes induced by skeletal unloading in the mature male rat.
American journal of physiology. Endocrinology and metabolism. 276(1):E62-E69 [DOI] 10.1152/ajpendo.1999.276.1.E62. [PMID] 29590881.
1999
Effects of age, estrogen depletion, and parathyroid hormone treatment on vertebral cancellous wall width in female rats.
Bone. 25(4):465-8 [PMID] 10511114.
View on: PubMed

Grants

Mar 2005 – Nov 2016
Bone Histomorphometry in Animal Models for Bone Disorders.
Role: Principal Investigator
Funding: MULTIPLE SPONSORS

Education

Ph.D. – Anatomy
1979 · University of Utah
B.S. – Biology
1972 · St. Joseph’s College

Teaching Profile

Courses Taught
2011-2014
VEM5112 Animal Systems 3
2011-2014
VEM5111 Animal Systems 2
2010-2013
VEM5101 Vet Gross Anatomy
2010-2011
VEM5902 Supervised Teach Dev
2009-2010
VME6932 Seminar in Physiological Sciences

Contact Details

Phones:
Business:
(352) 294-4044
Emails:
Business:
wronskit@ufl.edu

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