Shifeng Wang

Shifeng Wang,

Research Associate Professor

Department: Department of Infectious Diseases & Immunology
Business Phone: (352) 294-8185
Business Email: shifengwang@ufl.edu

Research Profile

My interests are in developing vaccines against infectious diseases in humans and animals (veterinary animal and poultry) using recombinant attenuated Salmonella vaccines (RASVs). Current work is focused on Salmonella, Streprococcus pneumonia, Mycobacterium tuberculosis and influenza.

Publications

2021
OmpC, a novel factor H-binding surface protein, is dispensable for the adherence and virulence of Salmonella enterica serovar Typhimurium
Veterinary Microbiology. [DOI] 10.1016/j.vetmic.2021.109157.
2021
Synthesis and delivery of Streptococcus pneumoniae capsular polysaccharides by recombinant attenuated Salmonella vaccines.
Proceedings of the National Academy of Sciences of the United States of America. 118(2) [DOI] 10.1073/pnas.2013350118. [PMID] 33380455.
2020
Effect of the selection pressure of vaccine antibodies on evolution of H9N2 avian influenza virus in chickens.
AMB Express. 10(1) [DOI] 10.1186/s13568-020-01036-0. [PMID] 32462233.
2020
Live attenuated Salmonella enterica serovar Choleraesuis vector delivering a conserved surface protein enolase induces high and broad protection against Streptococcus suis serotypes 2, 7, and 9 in mice.
Vaccine. 38(44):6904-6913 [DOI] 10.1016/j.vaccine.2020.08.062. [PMID] 32907758.
2020
Live attenuated Salmonella Typhimurium with monophosphoryl lipid A retains ability to induce T-cell and humoral immune responses against heterologous polysaccharide of Shigella flexneri 2a
International Journal of Medical Microbiology. 310(5) [DOI] 10.1016/j.ijmm.2020.151427.
2020
Live-attenuated Salmonella enterica serotype Choleraesuis vaccine with regulated delayed fur mutation confer protection against Streptococcus suis in mice.
BMC veterinary research. 16(1) [DOI] 10.1186/s12917-020-02340-4. [PMID] 32381017.
2019
Impact of the variations in potential glycosylation sites of the hemagglutinin of H9N2 influenza virus.
Virus genes. 55(2):182-190 [DOI] 10.1007/s11262-018-1623-7. [PMID] 30594968.
2019
Regulated Delayed Shigella flexneri 2a O-antigen Synthesis in Live Recombinant Salmonella enterica Serovar Typhimurium Induces Comparable Levels of Protective Immune Responses with Constitutive Antigen Synthesis System.
Theranostics. 9(12):3565-3579 [DOI] 10.7150/thno.33046. [PMID] 31281498.
2019
Serotype distribution, antimicrobial susceptibility, antimicrobial resistance genes and virulence genes of Salmonella isolated from a pig slaughterhouse in Yangzhou, China.
AMB Express. 9(1) [DOI] 10.1186/s13568-019-0936-9. [PMID] 31884559.
2018
Comparative evaluation of Salmonella Typhimurium vaccines derived from UK-1 and 14028S: Importance of inherent virulence.
PloS one. 13(9) [DOI] 10.1371/journal.pone.0203526. [PMID] 30192849.
2018
Effect of annexin II-mediated conversion of plasmin from plasminogen on airborne transmission of H9N2 avian influenza virus.
Veterinary microbiology. 223:100-106 [DOI] 10.1016/j.vetmic.2018.08.002. [PMID] 30173734.
2018
Evolution of H9N2 avian influenza virus in embryonated chicken eggs with or without homologous vaccine antibodies.
BMC veterinary research. 14(1) [DOI] 10.1186/s12917-018-1391-6. [PMID] 29510698.
2018
Genetic and biological characterization of H9N2 avian influenza viruses isolated in China from 2011 to 2014.
PloS one. 13(7) [DOI] 10.1371/journal.pone.0199260. [PMID] 29969454.
2018
Identification, sequence analysis, and infectivity of H9N2 avian influenza viruses isolated from geese.
Journal of veterinary science. 19(3):406-415 [DOI] 10.4142/jvs.2018.19.3.406. [PMID] 29366299.
2017
Salmonella enterica serovar Choleraesuis vector delivering SaoA antigen confers protection against Streptococcus suis serotypes 2 and 7 in mice and pigs.
Veterinary research. 48(1) [DOI] 10.1186/s13567-017-0494-6. [PMID] 29268787.
2015
Live attenuated Salmonella enterica serovar Choleraesuis vaccine vector displaying regulated delayed attenuation and regulated delayed antigen synthesis to confer protection against Streptococcus suis in mice.
Vaccine. 33(38):4858-67 [DOI] 10.1016/j.vaccine.2015.07.063. [PMID] 26238722.

Grants

Aug 2019 – Jul 2020
Design, construct and validate Salmonella Choleraesuis vaccine and vaccine vector strain with regulated delayed attenuation, regulated delayed synthesis of protective antigens, and regulated delayed lysis in vivo phenotypes
Role: Co-Investigator
Funding: CURTISS HEALTHCARE INC
Apr 2017 ACTIVE
A Food Safety Vaccine to Control Salmonella Enteritidis and Reduce Campylobacter in Poultry
Role: Co-Investigator
Funding: US DEPT OF AG NATL INST OF FOOD AND AG
Jan 2017 – Dec 2019
Manipulate cell surface by triple sugars for broad-spectrum Salmonella vaccine development
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID

Education

PhD
2002 · Chinese Academy of Preventative Medicine/Chinese CDC

Teaching Profile

Courses Taught
2021
BSC4910 Individual Mentored Research in Biology
2021
ZOO4911 Undergraduate Research in Zoology

Contact Details

Phones:
Business:
(352) 294-8185
Emails: