Christopher Vulpe, MD, PhD

Dr. Vulpe is a Professor at the University of Florida, Gainesville, in the Center for Environmental and Human Toxicology. Dr. Vulpe received his MD and Ph.D. from the University of California, San Francisco and completed his postdoctoral fellowship there as well. He was a faculty member at the University of California, Berkeley from 1998-2015 in the Nutritional Sciences and Toxicology Department before moving to the University of Florida. His group uses functional, genomic, and genetic approaches to provide insight into the mechanisms of toxicity of diverse environmental chemicals. Dr. Vulpe is an author of more than 140 papers in peer-reviewed journals and books. He recently served on the National Academy of Sciences and Engineering (NASEM) special committee on new approach methods (NAMs) in toxicology, which recently published its consensus report “Building Confidence in New Evidence Streams for Human Health Risk Assessment,” as well as the EPA Transcriptomic Assessment Products (ETAP) Panel.

Dr. Vulpe’s group uses systems level approaches in eukaryotes from yeast to people to identify the functional components that respond to and modulate the consequences of environmental stressors. Most recently, his laboratory is utilizing genome wide and targeted CRISPR screens to understand the mechanisms of toxicity of environmental chemicals, chemotherapeutics, and other exogenous stressors. His group uses functional, genomic, and genetic approaches to provide insight into mechanisms of toxicity in diverse model systems including human models such as human cell culture, organoids, and rodents, as well as ecologically relevant organisms such as Daphnia magna.