Sergei G Tevosian,
Associate Professor
Department:
Department of Physiological Sciences
Business Phone:
(352) 294-4364
Business Email:
stevosian@ufl.edu
Teaching Profile
Courses Taught
2011-2022
VEM5101 Vet Gross Anatomy
2016-2018,2020-2023
VEM5111 Animal Systems 2
2012-2013,2017-2021,2021
VEM5902 Supervised Teach Dev
2019
VEM5008 Personal/Prof Develop
2019
VME6932 Seminar in Physiological Sciences
2018
VEM5112 Animal Systems 3
Research Profile
Reproductive genetics, developmental genetics, cardiovascular development, developmental biology.
Publications
2022
Case report: Two sisters with a germline CHEK2 variant and distinct endocrine neoplasias.
Frontiers in endocrinology.
13
[DOI] 10.3389/fendo.2022.1024108.
[PMID] 36440216.
2022
Development of Human Adrenocortical Adenoma (HAA1) Cell Line from Zona Reticularis.
International journal of molecular sciences.
24(1)
[DOI] 10.3390/ijms24010584.
[PMID] 36614027.
2022
Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs.
Genes & development.
36(21-24):1129-1144
[DOI] 10.1101/gad.350145.122.
[PMID] 36522129.
2022
Identification and characterization of novel abdominal and pelvic brown adipose depots in mice.
Adipocyte.
11(1):616-629
[DOI] 10.1080/21623945.2022.2133415.
[PMID] 36260113.
2022
Nicotine Exposure during Rodent Pregnancy Alters the Composition of Maternal Gut Microbiota and Abundance of Maternal and Amniotic Short Chain Fatty Acids.
Metabolites.
12(8)
[DOI] 10.3390/metabo12080735.
[PMID] 36005607.
2021
Developmental exposure to chlordecone induces transgenerational effects in somatic prostate tissue which are associated with epigenetic histone trimethylation changes.
Environment international.
152
[DOI] 10.1016/j.envint.2021.106472.
[PMID] 33711761.
2021
Epigenetic Effects Promoted by Neonicotinoid Thiacloprid Exposure.
Frontiers in cell and developmental biology.
9
[DOI] 10.3389/fcell.2021.691060.
[PMID] 34295895.
2020
Expression of Key Androgen-Activating Enzymes in Ovarian Steroid Cell Tumor, Not Otherwise Specified.
Journal of investigative medicine high impact case reports.
8
[DOI] 10.1177/2324709620933416.
[PMID] 32590918.
2020
Mice lacking uterine enhancer of zeste homolog 2 have transcriptomic changes associated with uterine epithelial proliferation.
Physiological genomics.
52(2):81-95
[DOI] 10.1152/physiolgenomics.00098.2019.
[PMID] 31841397.
2020
Targeting pheochromocytoma/paraganglioma with polyamine inhibitors.
Metabolism: clinical and experimental.
110
[DOI] 10.1016/j.metabol.2020.154297.
[PMID] 32562798.
2019
Molecular Mechanisms of Primary Aldosteronism.
Endocrinology and metabolism (Seoul, Korea).
34(4):355-366
[DOI] 10.3803/EnM.2019.34.4.355.
[PMID] 31884735.
2019
Ovarian dysfunction following prenatal exposure to an insecticide, chlordecone, associates with altered epigenetic features.
Epigenetics & chromatin.
12(1)
[DOI] 10.1186/s13072-019-0276-7.
[PMID] 31084621.
2019
Pheochromocytomas and Paragangliomas.
Endocrinology and metabolism clinics of North America.
48(4):727-750
[DOI] 10.1016/j.ecl.2019.08.006.
[PMID] 31655773.
2019
Transgenerational Inheritance of Environmentally Induced Epigenetic Alterations during Mammalian Development.
Cells.
8(12)
[DOI] 10.3390/cells8121559.
[PMID] 31816913.
2018
Gestational exposure to chlordecone promotes transgenerational changes in the murine reproductive system of males.
Scientific reports.
8(1)
[DOI] 10.1038/s41598-018-28670-w.
[PMID] 29980752.
2018
Pheochromocytoma/Paraganglioma: A Poster Child for Cancer Metabolism.
The Journal of clinical endocrinology and metabolism.
103(5):1779-1789
[DOI] 10.1210/jc.2017-01991.
[PMID] 29409060.
2017
Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice.
Scientific reports.
7(1)
[DOI] 10.1038/s41598-017-03738-1.
[PMID] 28615648.
2017
Membrane estrogen receptor 1 is required for normal reproduction in male and female mice.
Journal of endocrinology and reproduction : JER.
21(1):1-14
[PMID] 34321782.
2016
Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice.
Nucleic acids research.
44(20):9784-9802
[PMID] 27655631.
2015
Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors.
Endocrinology.
156(7):2503-17
[DOI] 10.1210/en.2014-1815.
[PMID] 25933105.
2015
Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes.
Endocrinology.
156(5):1873-86
[DOI] 10.1210/en.2014-1907.
[PMID] 25668066.
2014
GATA4 autoregulates its own expression in mouse gonadal cells via its distal 1b promoter.
Biology of reproduction.
90(2)
[DOI] 10.1095/biolreprod.113.113290.
[PMID] 24352556.
2014
Simultaneous gene deletion of gata4 and gata6 leads to early disruption of follicular development and germ cell loss in the murine ovary.
Biology of reproduction.
91(1)
[DOI] 10.1095/biolreprod.113.117002.
[PMID] 24899573.
2014
Transgenic mouse models in the study of reproduction: insights into GATA protein function.
Reproduction (Cambridge, England).
148(1):R1-R14
[DOI] 10.1530/REP-14-0086.
[PMID] 24700325.
2013
DMRT1 owner’s manual: synchronized installation required to operate.
Biology of reproduction.
88(2)
[DOI] 10.1095/biolreprod.113.107839.
[PMID] 23349232.
2013
Genetic control of ovarian development.
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation.
7(1-3):33-45
[DOI] 10.1159/000339511.
[PMID] 22846624.
2013
The transcription factor GATA4 is required for follicular development and normal ovarian function.
Developmental biology.
381(1):144-58
[DOI] 10.1016/j.ydbio.2013.06.004.
[PMID] 23769843.
2012
Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.
PloS one.
7(12)
[DOI] 10.1371/journal.pone.0051621.
[PMID] 23236519.
2012
Gone without the WNT: a requirement for WNT5A in germ cell migration and testis development.
Biology of reproduction.
86(1):1-2
[DOI] 10.1095/biolreprod.111.096461.
[PMID] 21957192.
2011
Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.
Developmental biology.
353(2):229-41
[DOI] 10.1016/j.ydbio.2011.02.032.
[PMID] 21385577.
2011
GATA transcription factors in the developing reproductive system.
Advances in genetics.
76:93-134
[DOI] 10.1016/B978-0-12-386481-9.00004-3.
[PMID] 22099693.
2009
Cardiac expression of Tnnt1 requires the GATA4-FOG2 transcription complex.
TheScientificWorldJournal.
9:575-87
[DOI] 10.1100/tsw.2009.75.
[PMID] 19578715.
2009
Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart.
The Journal of clinical investigation.
119(6):1462-76
[DOI] 10.1172/JCI38723.
[PMID] 19411759.
2008
GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart development.
BMC developmental biology.
8
[DOI] 10.1186/1471-213X-8-67.
[PMID] 18577233.
2008
Ovarian development in mice requires the GATA4-FOG2 transcription complex.
Development (Cambridge, England).
135(22):3731-43
[DOI] 10.1242/dev.024653.
[PMID] 18927154.
2008
Serdin1/Lrrc10 is dispensable for mouse development.
Genesis (New York, N.Y. : 2000).
46(9):441-6
[DOI] 10.1002/dvg.20422.
[PMID] 18781631.
2008
To beta or not to beta: canonical beta-catenin signaling pathway and ovarian development.
Developmental dynamics : an official publication of the American Association of Anatomists.
237(12):3672-80
[DOI] 10.1002/dvdy.21784.
[PMID] 18985752.
2007
Fog2 excision in mice leads to premature mammary gland involution and reduced Esr1 gene expression.
Oncogene.
26(36):5204-13
[PMID] 17310981.
2007
The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models.
Developmental biology.
307(2):356-67
[PMID] 17540364.
2005
Expression and regulation of mouse SERDIN1, a highly conserved cardiac-specific leucine-rich repeat protein.
Developmental dynamics : an official publication of the American Association of Anatomists.
233(2):540-52
[PMID] 15830381.
2005
Fog2 is required for normal diaphragm and lung development in mice and humans.
PLoS genetics.
1(1):58-65
[PMID] 16103912.
2005
GATA-4:FOG interactions regulate gastric epithelial development in the mouse.
Developmental dynamics : an official publication of the American Association of Anatomists.
234(2):355-62
[PMID] 16127717.
2003
Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos.
Circulation research.
93(9):857-65
[PMID] 14551244.
2002
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2.
Development (Cambridge, England).
129(19):4627-34
[PMID] 12223418.
2000
FOG acts as a repressor of red blood cell development in Xenopus.
Development (Cambridge, England).
127(10):2031-40
[PMID] 10769228.
2000
FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium.
Cell.
101(7):729-39
[PMID] 10892744.
1999
FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped.
Proceedings of the National Academy of Sciences of the United States of America.
96(3):950-5
[PMID] 9927674.
1998
Activation and repression of p21(WAF1/CIP1) transcription by RB binding proteins.
Oncogene.
17(26):3463-9
[PMID] 10030670.
1998
New perspectives on retinoblastoma family functions in differentiation.
Frontiers in bioscience : a journal and virtual library.
3:D532-47
[PMID] 9616132.
1998
Regulation of differentiation by HBP1, a target of the retinoblastoma protein.
Molecular and cellular biology.
18(8):4732-43
[PMID] 9671483.
1997
HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family.
Genes & development.
11(3):383-96
[PMID] 9030690.
1996
Expression of the E2F-1/DP-1 transcription factor in murine development.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
7(1):43-52
[PMID] 8788032.
1996
Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver.
Proceedings of the National Academy of Sciences of the United States of America.
93(23):12908-13
[PMID] 8917518.
1996
The N-terminal region of E2F-1 is required for transcriptional activation of a new class of target promoter.
The Journal of biological chemistry.
271(21):12261-8
[PMID] 8647824.
1994
Mapping initiation sites for simian virus 40 DNA synthesis events in vitro.
Molecular and cellular biology.
14(8):5043-55
[PMID] 8035788.
1994
Transcriptional activity of the homopurine-homopyrimidine repeat of the c-Ki-ras promoter is independent of its H-forming potential.
Nucleic acids research.
22(16):3271-9
[PMID] 8078760.
1991
[Differences in expression and functional organization of the rat tyrosine aminotransferase gene in two lines of Morris hepatoma, 8994 and 7777].
Molekuliarnaia biologiia.
25(2):431-41
[PMID] 1679193.
1991
[Regulatory protein factor CTCF interacts with a segment of the chicken c-myc oncogene promotor, capable of changing to a noncanonical conformation].
Molekuliarnaia biologiia.
25(4):1013-23
[PMID] 1795697.
1990
[Chemical reactions of double-helical nucleic acids. XI. Interaction between kinetic parameters of chemical ligation in modified DNA-duplexes and structure of the reaction site].
Bioorganicheskaia khimiia.
16(9):1195-209
[PMID] 2080927.
Grants
Jun 2020
ACTIVE
Preclinical evaluation of the efficacy and mechanism of action for an alkylated polyamine analogue diethylnorspermine in treating pheochromocytoma/paraganglioma
Role: Co-Investigator
Funding: NATL INST OF HLTH NCATS
May 2018
– Sep 2021
The role of the gut-microbiome-brain axis in cardiovascular disease following prenatal exposure to nicotine
Role: Principal Investigator
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
Apr 2017
– Apr 2018
IPA Hatch 5.91FTE
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2006
– Dec 2020
21st Century Research & Economic Development Investment Program (REDIP)
Role: Project Manager
Funding: STATE UNIV SYS OF FL BOARD OF GOVERNORS
Education
PostDoc – Genetics
1997-2001
·
Harvard Medical School, Department of Pediatrics and Howard Hughes Medical Institute
PhD – Biochemistry
1992-1997
·
Tufts University, Sackler School of Graduate Biomedical Science
MS – Chemistry of Natural Compounds
1982-1987
·
Moscow State University
Contact Details
Phones:
- Business:
- (352) 294-4364
Emails:
- Business:
- stevosian@ufl.edu
Addresses:
- Business Mailing:
-
UNIVERSITY OF FLORIDA
PO BOX 100144
DEPARTMENT OF PHYSIOLOGICAL SCIENCES
GAINESVILLE FL 326100144 - Business Street:
-
1333 CENTER DR
GAINESVILLE FL 32610