Reproductive genetics, developmental genetics, cardiovascular development, developmental biology.
Membrane estrogen receptor 1 is required for normal reproduction in male and female mice.
Journal of endocrinology and reproduction : JER. 21(1):1-14 [PMID] 34321782.
Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice.
Nucleic acids research. 44(20):9784-9802 [PMID] 27655631.
The fellowship of the ring.
Cancer biology & therapy. 11(1):48-9 [PMID] 21079418.
Fog2 excision in mice leads to premature mammary gland involution and reduced Esr1 gene expression.
Oncogene. 26(36):5204-13 [PMID] 17310981.
The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models.
Developmental biology. 307(2):356-67 [PMID] 17540364.
Expression and regulation of mouse SERDIN1, a highly conserved cardiac-specific leucine-rich repeat protein.
Developmental dynamics : an official publication of the American Association of Anatomists. 233(2):540-52 [PMID] 15830381.
Fog2 is required for normal diaphragm and lung development in mice and humans.
PLoS genetics. 1(1):58-65 [PMID] 16103912.
GATA-4:FOG interactions regulate gastric epithelial development in the mouse.
Developmental dynamics : an official publication of the American Association of Anatomists. 234(2):355-62 [PMID] 16127717.
Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos.
Circulation research. 93(9):857-65 [PMID] 14551244.
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2.
Development (Cambridge, England). 129(19):4627-34 [PMID] 12223418.
Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1.
The EMBO journal. 20(16):4500-11 [PMID] 11500377.
The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America. 98(13):7342-7 [PMID] 11404479.
FOG acts as a repressor of red blood cell development in Xenopus.
Development (Cambridge, England). 127(10):2031-40 [PMID] 10769228.
FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium.
Cell. 101(7):729-39 [PMID] 10892744.
FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped.
Proceedings of the National Academy of Sciences of the United States of America. 96(3):950-5 [PMID] 9927674.
Activation and repression of p21(WAF1/CIP1) transcription by RB binding proteins.
Oncogene. 17(26):3463-9 [PMID] 10030670.
New perspectives on retinoblastoma family functions in differentiation.
Frontiers in bioscience : a journal and virtual library. 3:D532-47 [PMID] 9616132.
Regulation of differentiation by HBP1, a target of the retinoblastoma protein.
Molecular and cellular biology. 18(8):4732-43 [PMID] 9671483.
HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family.
Genes & development. 11(3):383-96 [PMID] 9030690.
Expression of the E2F-1/DP-1 transcription factor in murine development.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 7(1):43-52 [PMID] 8788032.
Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver.
Proceedings of the National Academy of Sciences of the United States of America. 93(23):12908-13 [PMID] 8917518.
The N-terminal region of E2F-1 is required for transcriptional activation of a new class of target promoter.
The Journal of biological chemistry. 271(21):12261-8 [PMID] 8647824.
Mapping initiation sites for simian virus 40 DNA synthesis events in vitro.
Molecular and cellular biology. 14(8):5043-55 [PMID] 8035788.
Transcriptional activity of the homopurine-homopyrimidine repeat of the c-Ki-ras promoter is independent of its H-forming potential.
Nucleic acids research. 22(16):3271-9 [PMID] 8078760.
[Differences in expression and functional organization of the rat tyrosine aminotransferase gene in two lines of Morris hepatoma, 8994 and 7777].
Molekuliarnaia biologiia. 25(2):431-41 [PMID] 1679193.
[Regulatory protein factor CTCF interacts with a segment of the chicken c-myc oncogene promotor, capable of changing to a noncanonical conformation].
Molekuliarnaia biologiia. 25(4):1013-23 [PMID] 1795697.
[Chemical reactions of double-helical nucleic acids. XI. Interaction between kinetic parameters of chemical ligation in modified DNA-duplexes and structure of the reaction site].
Bioorganicheskaia khimiia. 16(9):1195-209 [PMID] 2080927.
Jun 2020 ACTIVE
Preclinical evaluation of the efficacy and mechanism of action for an alkylated polyamine analogue diethylnorspermine in treating pheochromocytoma/paraganglioma
Funding: NATL INST OF HLTH NCATS
May 2018 – Sep 2021
The role of the gut-microbiome-brain axis in cardiovascular disease following prenatal exposure to nicotine
Role: Principal Investigator
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
Apr 2017 – Apr 2018
IPA Hatch 5.91FTE
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2006 – Dec 2020
21st Century Research & Economic Development Investment Program (REDIP)
Role: Project Manager
Funding: STATE UNIV SYS OF FL BOARD OF GOVERNORS
PostDoc – Genetics1997-2001 · Harvard Medical School, Department of Pediatrics and Howard Hughes Medical Institute
PhD – Biochemistry1992-1997 · Tufts University, Sackler School of Graduate Biomedical Science
MS – Chemistry of Natural Compounds1982-1987 · Moscow State University
VEM5101 Vet Gross Anatomy
VEM5111 Animal Systems 2
VEM5902 Supervised Teach Dev
VEM5008 Personal/Prof Develop
VME6932 Seminar in Physiological Sciences
VEM5112 Animal Systems 3