Sergei G Tevosian

Sergei G Tevosian,

Associate Professor

Department: Department of Physiological Sciences
Business Phone: (352) 294-4364
Business Email: stevosian@ufl.edu

Research Profile

Reproductive genetics, developmental genetics, cardiovascular development, developmental biology.

Publications

2021
Developmental exposure to chlordecone induces transgenerational effects in somatic prostate tissue which are associated with epigenetic histone trimethylation changes.
Environment international. 152 [DOI] 10.1016/j.envint.2021.106472. [PMID] 33711761.
2020
Expression of Key Androgen-Activating Enzymes in Ovarian Steroid Cell Tumor, Not Otherwise Specified.
Journal of investigative medicine high impact case reports. 8 [DOI] 10.1177/2324709620933416. [PMID] 32590918.
2020
Mice lacking uterine enhancer of zeste homolog 2 have transcriptomic changes associated with uterine epithelial proliferation.
Physiological genomics. 52(2):81-95 [DOI] 10.1152/physiolgenomics.00098.2019. [PMID] 31841397.
2020
Targeting pheochromocytoma/paraganglioma with polyamine inhibitors.
Metabolism: clinical and experimental. 110 [DOI] 10.1016/j.metabol.2020.154297. [PMID] 32562798.
2019
Molecular Mechanisms of Primary Aldosteronism.
Endocrinology and metabolism (Seoul, Korea). 34(4):355-366 [DOI] 10.3803/EnM.2019.34.4.355. [PMID] 31884735.
2019
Ovarian dysfunction following prenatal exposure to an insecticide, chlordecone, associates with altered epigenetic features.
Epigenetics & chromatin. 12(1) [DOI] 10.1186/s13072-019-0276-7. [PMID] 31084621.
2019
Pheochromocytomas and Paragangliomas.
Endocrinology and metabolism clinics of North America. 48(4):727-750 [DOI] 10.1016/j.ecl.2019.08.006. [PMID] 31655773.
2019
Transgenerational Inheritance of Environmentally Induced Epigenetic Alterations during Mammalian Development.
Cells. 8(12) [DOI] 10.3390/cells8121559. [PMID] 31816913.
2018
Gestational exposure to chlordecone promotes transgenerational changes in the murine reproductive system of males.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-28670-w. [PMID] 29980752.
2018
Pheochromocytoma/Paraganglioma: A Poster Child for Cancer Metabolism.
The Journal of clinical endocrinology and metabolism. 103(5):1779-1789 [DOI] 10.1210/jc.2017-01991. [PMID] 29409060.
2017
Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-03738-1. [PMID] 28615648.
2016
Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice.
Nucleic acids research. 44(20):9784-9802 [PMID] 27655631.
View on: PubMed
2015
Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors.
Endocrinology. 156(7):2503-17 [DOI] 10.1210/en.2014-1815. [PMID] 25933105.
2015
Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes.
Endocrinology. 156(5):1873-86 [DOI] 10.1210/en.2014-1907. [PMID] 25668066.
2014
GATA4 autoregulates its own expression in mouse gonadal cells via its distal 1b promoter.
Biology of reproduction. 90(2) [DOI] 10.1095/biolreprod.113.113290. [PMID] 24352556.
2014
Simultaneous gene deletion of gata4 and gata6 leads to early disruption of follicular development and germ cell loss in the murine ovary.
Biology of reproduction. 91(1) [DOI] 10.1095/biolreprod.113.117002. [PMID] 24899573.
2014
Transgenic mouse models in the study of reproduction: insights into GATA protein function.
Reproduction (Cambridge, England). 148(1):R1-R14 [DOI] 10.1530/REP-14-0086. [PMID] 24700325.
2013
DMRT1 owner’s manual: synchronized installation required to operate.
Biology of reproduction. 88(2) [DOI] 10.1095/biolreprod.113.107839. [PMID] 23349232.
2013
Genetic control of ovarian development.
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation. 7(1-3):33-45 [DOI] 10.1159/000339511. [PMID] 22846624.
2013
The transcription factor GATA4 is required for follicular development and normal ovarian function.
Developmental biology. 381(1):144-58 [DOI] 10.1016/j.ydbio.2013.06.004. [PMID] 23769843.
2012
Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.
PloS one. 7(12) [DOI] 10.1371/journal.pone.0051621. [PMID] 23236519.
2012
Gone without the WNT: a requirement for WNT5A in germ cell migration and testis development.
Biology of reproduction. 86(1):1-2 [DOI] 10.1095/biolreprod.111.096461. [PMID] 21957192.
2011
Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.
Developmental biology. 353(2):229-41 [DOI] 10.1016/j.ydbio.2011.02.032. [PMID] 21385577.
2011
GATA transcription factors in the developing reproductive system.
Advances in genetics. 76:93-134 [DOI] 10.1016/B978-0-12-386481-9.00004-3. [PMID] 22099693.
2011
The fellowship of the ring.
Cancer biology & therapy. 11(1):48-9 [PMID] 21079418.
View on: PubMed
2009
Cardiac expression of Tnnt1 requires the GATA4-FOG2 transcription complex.
TheScientificWorldJournal. 9:575-87 [DOI] 10.1100/tsw.2009.75. [PMID] 19578715.
2009
Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart.
The Journal of clinical investigation. 119(6):1462-76 [DOI] 10.1172/JCI38723. [PMID] 19411759.
2008
GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart development.
BMC developmental biology. 8 [DOI] 10.1186/1471-213X-8-67. [PMID] 18577233.
2008
Ovarian development in mice requires the GATA4-FOG2 transcription complex.
Development (Cambridge, England). 135(22):3731-43 [DOI] 10.1242/dev.024653. [PMID] 18927154.
2008
Serdin1/Lrrc10 is dispensable for mouse development.
Genesis (New York, N.Y. : 2000). 46(9):441-6 [DOI] 10.1002/dvg.20422. [PMID] 18781631.
2008
To beta or not to beta: canonical beta-catenin signaling pathway and ovarian development.
Developmental dynamics : an official publication of the American Association of Anatomists. 237(12):3672-80 [DOI] 10.1002/dvdy.21784. [PMID] 18985752.
2007
Fog2 excision in mice leads to premature mammary gland involution and reduced Esr1 gene expression.
Oncogene. 26(36):5204-13 [PMID] 17310981.
View on: PubMed
2007
The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models.
Developmental biology. 307(2):356-67 [PMID] 17540364.
View on: PubMed
2005
Expression and regulation of mouse SERDIN1, a highly conserved cardiac-specific leucine-rich repeat protein.
Developmental dynamics : an official publication of the American Association of Anatomists. 233(2):540-52 [PMID] 15830381.
View on: PubMed
2005
Fog2 is required for normal diaphragm and lung development in mice and humans.
PLoS genetics. 1(1):58-65 [PMID] 16103912.
View on: PubMed
2005
GATA-4:FOG interactions regulate gastric epithelial development in the mouse.
Developmental dynamics : an official publication of the American Association of Anatomists. 234(2):355-62 [PMID] 16127717.
View on: PubMed
2003
Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos.
Circulation research. 93(9):857-65 [PMID] 14551244.
View on: PubMed
2002
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2.
Development (Cambridge, England). 129(19):4627-34 [PMID] 12223418.
View on: PubMed
2001
Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1.
The EMBO journal. 20(16):4500-11 [PMID] 11500377.
View on: PubMed
2001
The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America. 98(13):7342-7 [PMID] 11404479.
View on: PubMed
2000
FOG acts as a repressor of red blood cell development in Xenopus.
Development (Cambridge, England). 127(10):2031-40 [PMID] 10769228.
View on: PubMed
2000
FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium.
Cell. 101(7):729-39 [PMID] 10892744.
View on: PubMed
1999
FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped.
Proceedings of the National Academy of Sciences of the United States of America. 96(3):950-5 [PMID] 9927674.
View on: PubMed
1998
Activation and repression of p21(WAF1/CIP1) transcription by RB binding proteins.
Oncogene. 17(26):3463-9 [PMID] 10030670.
View on: PubMed
1998
New perspectives on retinoblastoma family functions in differentiation.
Frontiers in bioscience : a journal and virtual library. 3:D532-47 [PMID] 9616132.
View on: PubMed
1998
Regulation of differentiation by HBP1, a target of the retinoblastoma protein.
Molecular and cellular biology. 18(8):4732-43 [PMID] 9671483.
View on: PubMed
1997
HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family.
Genes & development. 11(3):383-96 [PMID] 9030690.
View on: PubMed
1996
Expression of the E2F-1/DP-1 transcription factor in murine development.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 7(1):43-52 [PMID] 8788032.
View on: PubMed
1996
Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver.
Proceedings of the National Academy of Sciences of the United States of America. 93(23):12908-13 [PMID] 8917518.
View on: PubMed
1996
The N-terminal region of E2F-1 is required for transcriptional activation of a new class of target promoter.
The Journal of biological chemistry. 271(21):12261-8 [PMID] 8647824.
View on: PubMed
1994
Mapping initiation sites for simian virus 40 DNA synthesis events in vitro.
Molecular and cellular biology. 14(8):5043-55 [PMID] 8035788.
View on: PubMed
1994
Transcriptional activity of the homopurine-homopyrimidine repeat of the c-Ki-ras promoter is independent of its H-forming potential.
Nucleic acids research. 22(16):3271-9 [PMID] 8078760.
View on: PubMed
1991
[Differences in expression and functional organization of the rat tyrosine aminotransferase gene in two lines of Morris hepatoma, 8994 and 7777].
Molekuliarnaia biologiia. 25(2):431-41 [PMID] 1679193.
View on: PubMed
1991
[Regulatory protein factor CTCF interacts with a segment of the chicken c-myc oncogene promotor, capable of changing to a noncanonical conformation].
Molekuliarnaia biologiia. 25(4):1013-23 [PMID] 1795697.
View on: PubMed
1990
[Chemical reactions of double-helical nucleic acids. XI. Interaction between kinetic parameters of chemical ligation in modified DNA-duplexes and structure of the reaction site].
Bioorganicheskaia khimiia. 16(9):1195-209 [PMID] 2080927.
View on: PubMed

Grants

Jun 2020 ACTIVE
Preclinical evaluation of the efficacy and mechanism of action for an alkylated polyamine analogue diethylnorspermine in treating pheochromocytoma/paraganglioma
Role: Co-Investigator
Funding: NATL INST OF HLTH NCATS
May 2018 ACTIVE
The role of the gut-microbiome-brain axis in cardiovascular disease following prenatal exposure to nicotine
Role: Principal Investigator
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
Apr 2017 – Apr 2018
IPA Hatch 5.91FTE
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2006 – Dec 2020
21st Century Research & Economic Development Investment Program (REDIP)
Role: Project Manager
Funding: STATE UNIV SYS OF FL BOARD OF GOVERNORS

Education

PostDoc – Genetics
1997-2001 · Harvard Medical School, Department of Pediatrics and Howard Hughes Medical Institute
PhD – Biochemistry
1992-1997 · Tufts University, Sackler School of Graduate Biomedical Science
MS – Chemistry of Natural Compounds
1982-1987 · Moscow State University

Teaching Profile

Courses Taught
2011-2020
VEM5101 Vet Gross Anatomy
2016-2018,2020-2021
VEM5111 Animal Systems 2
2012-2013,2017-2019
VEM5902 Supervised Teach Dev
2019
VEM5008 Personal/Prof Develop
2019
VME6932 Seminar in Physiological Sciences
2018
VEM5112 Animal Systems 3

Contact Details

Phones:
Business:
(352) 294-4364
Emails:
Business:
stevosian@ufl.edu

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