Sergei G Tevosian

Sergei G Tevosian,

Associate Professor

Department: Department of Physiological Sciences
Business Phone: (352) 294-4364
Business Email: stevosian@ufl.edu

Teaching Profile

Courses Taught
2011-2025
VEM5101 Vet Gross Anatomy
2016-2018,2020-2023
VEM5111 Animal Systems 2
2012-2013,2017-2023,2021-2025,2023-2025
VEM5902 Teaching Assistant Special Elective
2019
VEM5008 Personal/Prof Develop
2019
VME6932 Seminar in Physiological Sciences
2018
VEM5112 Animal Systems 3
2023-2024
VME6905 Problems in Veterinary Medical Sciences

Research Profile

Reproductive genetics, developmental genetics, cardiovascular development, developmental biology.

Publications

Academic Articles
2024
Metabolomics and proteomics in pheochromocytoma and paraganglioma: Translating biochemistry and biology to bedside.
Best practice & research. Clinical endocrinology & metabolism. 38(6) [DOI] 10.1016/j.beem.2024.101935. [PMID] 39299859.
2024
Niche for polyamine inhibition in treatment of metastatic pheochromocytoma and paraganglioma.
European journal of clinical investigation. 54(5) [DOI] 10.1111/eci.14162. [PMID] 38381501.
2024
Polyamine Pathway Inhibitor DENSPM Suppresses Lipid Metabolism in Pheochromocytoma Cell Line.
International journal of molecular sciences. 25(18) [DOI] 10.3390/ijms251810029. [PMID] 39337514.
2024
Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat.
Epigenetics & chromatin. 17(1) [DOI] 10.1186/s13072-024-00539-5. [PMID] 38715099.
2022
Case report: Two sisters with a germline CHEK2 variant and distinct endocrine neoplasias.
Frontiers in endocrinology. 13 [DOI] 10.3389/fendo.2022.1024108. [PMID] 36440216.
2022
Development of Human Adrenocortical Adenoma (HAA1) Cell Line from Zona Reticularis.
International journal of molecular sciences. 24(1) [DOI] 10.3390/ijms24010584. [PMID] 36614027.
2022
Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs.
Genes & development. 36(21-24):1129-1144 [DOI] 10.1101/gad.350145.122. [PMID] 36522129.
2022
Identification and characterization of novel abdominal and pelvic brown adipose depots in mice.
Adipocyte. 11(1):616-629 [DOI] 10.1080/21623945.2022.2133415. [PMID] 36260113.
2022
Nicotine Exposure during Rodent Pregnancy Alters the Composition of Maternal Gut Microbiota and Abundance of Maternal and Amniotic Short Chain Fatty Acids.
Metabolites. 12(8) [DOI] 10.3390/metabo12080735. [PMID] 36005607.
2021
Developmental exposure to chlordecone induces transgenerational effects in somatic prostate tissue which are associated with epigenetic histone trimethylation changes.
Environment international. 152 [DOI] 10.1016/j.envint.2021.106472. [PMID] 33711761.
2021
Epigenetic Effects Promoted by Neonicotinoid Thiacloprid Exposure.
Frontiers in cell and developmental biology. 9 [DOI] 10.3389/fcell.2021.691060. [PMID] 34295895.
2020
Expression of Key Androgen-Activating Enzymes in Ovarian Steroid Cell Tumor, Not Otherwise Specified.
Journal of investigative medicine high impact case reports. 8 [DOI] 10.1177/2324709620933416. [PMID] 32590918.
2020
Mice lacking uterine enhancer of zeste homolog 2 have transcriptomic changes associated with uterine epithelial proliferation.
Physiological genomics. 52(2):81-95 [DOI] 10.1152/physiolgenomics.00098.2019. [PMID] 31841397.
2020
Targeting pheochromocytoma/paraganglioma with polyamine inhibitors.
Metabolism: clinical and experimental. 110 [DOI] 10.1016/j.metabol.2020.154297. [PMID] 32562798.
2019
Molecular Mechanisms of Primary Aldosteronism.
Endocrinology and metabolism (Seoul, Korea). 34(4):355-366 [DOI] 10.3803/EnM.2019.34.4.355. [PMID] 31884735.
2019
Ovarian dysfunction following prenatal exposure to an insecticide, chlordecone, associates with altered epigenetic features.
Epigenetics & chromatin. 12(1) [DOI] 10.1186/s13072-019-0276-7. [PMID] 31084621.
2019
Pheochromocytomas and Paragangliomas.
Endocrinology and metabolism clinics of North America. 48(4):727-750 [DOI] 10.1016/j.ecl.2019.08.006. [PMID] 31655773.
2019
Transgenerational Inheritance of Environmentally Induced Epigenetic Alterations during Mammalian Development.
Cells. 8(12) [DOI] 10.3390/cells8121559. [PMID] 31816913.
2018
Gestational exposure to chlordecone promotes transgenerational changes in the murine reproductive system of males.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-28670-w. [PMID] 29980752.
2018
Pheochromocytoma/Paraganglioma: A Poster Child for Cancer Metabolism.
The Journal of clinical endocrinology and metabolism. 103(5):1779-1789 [DOI] 10.1210/jc.2017-01991. [PMID] 29409060.
2017
Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-03738-1. [PMID] 28615648.
2017
Membrane estrogen receptor 1 is required for normal reproduction in male and female mice.
Journal of endocrinology and reproduction : JER. 21(1):1-14 [PMID] 34321782.
2016
Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice.
Nucleic acids research. 44(20):9784-9802 [PMID] 27655631.
2015
Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors.
Endocrinology. 156(7):2503-17 [DOI] 10.1210/en.2014-1815. [PMID] 25933105.
2015
Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes.
Endocrinology. 156(5):1873-86 [DOI] 10.1210/en.2014-1907. [PMID] 25668066.
2014
GATA4 autoregulates its own expression in mouse gonadal cells via its distal 1b promoter.
Biology of reproduction. 90(2) [DOI] 10.1095/biolreprod.113.113290. [PMID] 24352556.
2014
Simultaneous gene deletion of gata4 and gata6 leads to early disruption of follicular development and germ cell loss in the murine ovary.
Biology of reproduction. 91(1) [DOI] 10.1095/biolreprod.113.117002. [PMID] 24899573.
2014
Transgenic mouse models in the study of reproduction: insights into GATA protein function.
Reproduction (Cambridge, England). 148(1):R1-R14 [DOI] 10.1530/REP-14-0086. [PMID] 24700325.
2013
DMRT1 owner’s manual: synchronized installation required to operate.
Biology of reproduction. 88(2) [DOI] 10.1095/biolreprod.113.107839. [PMID] 23349232.
2013
Genetic control of ovarian development.
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation. 7(1-3):33-45 [DOI] 10.1159/000339511. [PMID] 22846624.
2013
The transcription factor GATA4 is required for follicular development and normal ovarian function.
Developmental biology. 381(1):144-58 [DOI] 10.1016/j.ydbio.2013.06.004. [PMID] 23769843.
2012
Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.
PloS one. 7(12) [DOI] 10.1371/journal.pone.0051621. [PMID] 23236519.
2012
Gone without the WNT: a requirement for WNT5A in germ cell migration and testis development.
Biology of reproduction. 86(1):1-2 [DOI] 10.1095/biolreprod.111.096461. [PMID] 21957192.
2011
Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.
Developmental biology. 353(2):229-41 [DOI] 10.1016/j.ydbio.2011.02.032. [PMID] 21385577.
2011
GATA transcription factors in the developing reproductive system.
Advances in genetics. 76:93-134 [DOI] 10.1016/B978-0-12-386481-9.00004-3. [PMID] 22099693.
2011
The fellowship of the ring.
Cancer biology & therapy. 11(1):48-9 [PMID] 21079418.
2009
Cardiac expression of Tnnt1 requires the GATA4-FOG2 transcription complex.
TheScientificWorldJournal. 9:575-87 [DOI] 10.1100/tsw.2009.75. [PMID] 19578715.
2009
Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart.
The Journal of clinical investigation. 119(6):1462-76 [DOI] 10.1172/JCI38723. [PMID] 19411759.
2008
GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart development.
BMC developmental biology. 8 [DOI] 10.1186/1471-213X-8-67. [PMID] 18577233.
2008
Ovarian development in mice requires the GATA4-FOG2 transcription complex.
Development (Cambridge, England). 135(22):3731-43 [DOI] 10.1242/dev.024653. [PMID] 18927154.
2008
Serdin1/Lrrc10 is dispensable for mouse development.
Genesis (New York, N.Y. : 2000). 46(9):441-6 [DOI] 10.1002/dvg.20422. [PMID] 18781631.
2008
To beta or not to beta: canonical beta-catenin signaling pathway and ovarian development.
Developmental dynamics : an official publication of the American Association of Anatomists. 237(12):3672-80 [DOI] 10.1002/dvdy.21784. [PMID] 18985752.
2007
Fog2 excision in mice leads to premature mammary gland involution and reduced Esr1 gene expression.
Oncogene. 26(36):5204-13 [PMID] 17310981.
2007
The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models.
Developmental biology. 307(2):356-67 [PMID] 17540364.
2005
Expression and regulation of mouse SERDIN1, a highly conserved cardiac-specific leucine-rich repeat protein.
Developmental dynamics : an official publication of the American Association of Anatomists. 233(2):540-52 [PMID] 15830381.
2005
Fog2 is required for normal diaphragm and lung development in mice and humans.
PLoS genetics. 1(1):58-65 [PMID] 16103912.
2005
GATA-4:FOG interactions regulate gastric epithelial development in the mouse.
Developmental dynamics : an official publication of the American Association of Anatomists. 234(2):355-62 [PMID] 16127717.
2003
Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos.
Circulation research. 93(9):857-65 [PMID] 14551244.
2002
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2.
Development (Cambridge, England). 129(19):4627-34 [PMID] 12223418.
2001
Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1.
The EMBO journal. 20(16):4500-11 [PMID] 11500377.
2001
The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America. 98(13):7342-7 [PMID] 11404479.
2000
FOG acts as a repressor of red blood cell development in Xenopus.
Development (Cambridge, England). 127(10):2031-40 [PMID] 10769228.
2000
FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium.
Cell. 101(7):729-39 [PMID] 10892744.
1999
FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped.
Proceedings of the National Academy of Sciences of the United States of America. 96(3):950-5 [PMID] 9927674.
1998
Activation and repression of p21(WAF1/CIP1) transcription by RB binding proteins.
Oncogene. 17(26):3463-9 [PMID] 10030670.
1998
New perspectives on retinoblastoma family functions in differentiation.
Frontiers in bioscience : a journal and virtual library. 3:D532-47 [PMID] 9616132.
1998
Regulation of differentiation by HBP1, a target of the retinoblastoma protein.
Molecular and cellular biology. 18(8):4732-43 [PMID] 9671483.
1997
HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family.
Genes & development. 11(3):383-96 [PMID] 9030690.
1996
Expression of the E2F-1/DP-1 transcription factor in murine development.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 7(1):43-52 [PMID] 8788032.
1996
Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver.
Proceedings of the National Academy of Sciences of the United States of America. 93(23):12908-13 [PMID] 8917518.
1996
The N-terminal region of E2F-1 is required for transcriptional activation of a new class of target promoter.
The Journal of biological chemistry. 271(21):12261-8 [PMID] 8647824.
1994
Mapping initiation sites for simian virus 40 DNA synthesis events in vitro.
Molecular and cellular biology. 14(8):5043-55 [PMID] 8035788.
1994
Transcriptional activity of the homopurine-homopyrimidine repeat of the c-Ki-ras promoter is independent of its H-forming potential.
Nucleic acids research. 22(16):3271-9 [PMID] 8078760.
1991
[Differences in expression and functional organization of the rat tyrosine aminotransferase gene in two lines of Morris hepatoma, 8994 and 7777].
Molekuliarnaia biologiia. 25(2):431-41 [PMID] 1679193.
1991
[Regulatory protein factor CTCF interacts with a segment of the chicken c-myc oncogene promotor, capable of changing to a noncanonical conformation].
Molekuliarnaia biologiia. 25(4):1013-23 [PMID] 1795697.
1990
[Chemical reactions of double-helical nucleic acids. XI. Interaction between kinetic parameters of chemical ligation in modified DNA-duplexes and structure of the reaction site].
Bioorganicheskaia khimiia. 16(9):1195-209 [PMID] 2080927.

Grants

Jun 2020 – May 2023
Preclinical evaluation of the efficacy and mechanism of action for an alkylated polyamine analogue diethylnorspermine in treating pheochromocytoma/paraganglioma
Role: Co-Investigator
Funding: NATL INST OF HLTH NCATS
May 2018 – Sep 2021
The role of the gut-microbiome-brain axis in cardiovascular disease following prenatal exposure to nicotine
Role: Principal Investigator
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
Apr 2017 – Apr 2018
IPA Hatch 5.91FTE
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2006 – Dec 2020
21st Century Research & Economic Development Investment Program (REDIP)
Role: Project Manager
Funding: STATE UNIV SYS OF FL BOARD OF GOVERNORS

Education

PostDoc – Genetics
1997-2001 · Harvard Medical School, Department of Pediatrics and Howard Hughes Medical Institute
PhD – Biochemistry
1992-1997 · Tufts University, Sackler School of Graduate Biomedical Science
MS – Chemistry of Natural Compounds
1982-1987 · Moscow State University

Contact Details

Phones:
Business:
(352) 294-4364
Emails:
Business:
stevosian@ufl.edu
Addresses:
Business Mailing:
UNIVERSITY OF FLORIDA
PO BOX 100144
DEPARTMENT OF PHYSIOLOGICAL SCIENCES
GAINESVILLE FL 326100144
Business Street:
1333 CENTER DR
GAINESVILLE FL 32610