Marília Takada,
Assistant Professor, Radiation Oncology Service Chief
Department:
Small Animal Clinical Sciences
Business Phone:
(352) 392-2235
Business Email:
mtakada@ufl.edu
Accomplishments
E. Gregory MacEwen Memorial Award
2022
·
Veterinary Cancer Society
Young Investigator Award – National Veterinary Scholar's Symposium
2018
·
AVMA/AVMF
International Training Scholarship at University of Tokyo
2009
·
Japan International Cooperation Agency
Teaching Profile
Courses Taught
2021-2024
VEM5872C Veterinary Medical & Radiation Oncology Clerkship
2022-2024
VEM5181 Radiol Tech W/Lab
2022-2024
VEM5308 Vet Med Oncology
Board Certifications
-
Diplomate in Radiation OncologyAmerican College of Veterinary Radiology
Research Profile
Research interests include the investigation of: – Hypofractionated radiation protocols, and the combination of radiation with targeted therapeutic agents. – Trametinib as a novel targeted drug for canine histiocytic sarcoma. – Oncogenic drivers of canine histiocytic sarcoma, and development of biomarkers for early detection/treatment response.
Open Researcher and Contributor ID (ORCID)
0000-0001-9509-0528
Publications
2024
Population Pharmacokinetics, Pharmacodynamics and Safety Properties of Trametinib in Dogs With Cancer: A Phase I Dose Escalating Clinical Trial
Veterinary and Comparative Oncology.
22(3):410-421
[DOI] 10.1111/vco.12989.
2024
Successful definitive radiation treatment of refractory canine oral papillomatosis
Veterinary Radiology & Ultrasound.
[DOI] 10.1111/vru.13383.
2022
Identification of a Hypomorphic FANCG Variant in Bernese Mountain Dogs
Genes.
13(10)
[DOI] 10.3390/genes13101693.
[PMID] 36292578.
2020
Definitive-intent radiotherapy for sinonasal carcinoma in cats: A multicenter retrospective assessment.
Veterinary and comparative oncology.
18(4):626-633
[DOI] 10.1111/vco.12583.
2019
Activating Mutations in PTPN11 and KRAS in Canine Histiocytic Sarcomas.
Genes.
10(7)
[DOI] 10.3390/genes10070505.
[PMID] 31277422.
2019
Development of an Orthotopic Intrasplenic Xenograft Mouse Model of Canine Histiocytic Sarcoma and Its Use in Evaluating the Efficacy of Treatment with Dasatinib.
Comparative medicine.
69(1):22-28
[DOI] 10.30802/AALAS-CM-18-000065.
[PMID] 30717820.
2019
Dynamic Contrast-Enhanced MRI of OATP Dysfunction in Diabetes.
Diabetes.
68(2):271-280
[DOI] 10.2337/db18-0525.
[PMID] 30487262.
2018
A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies.
BMC cancer.
18(1)
[DOI] 10.1186/s12885-018-4132-0.
[PMID] 29490634.
2018
Gain-of-function mutation in PTPN11 in histiocytic sarcomas of Bernese Mountain Dogs.
Veterinary and comparative oncology.
16(2):220-228
[DOI] 10.1111/vco.12357.
[PMID] 28929581.
2018
Investigation of novel chemotherapeutics for feline oral squamous cell carcinoma.
Oncotarget.
9(69):33098-33109
[DOI] 10.18632/oncotarget.26006.
[PMID] 30237854.
2018
Targeting MEK in a Translational Model of Histiocytic Sarcoma.
Molecular cancer therapeutics.
17(11):2439-2450
[DOI] 10.1158/1535-7163.MCT-17-1273.
[PMID] 30135215.
2016
Prostate cancer characterization by optical contrast enhanced photoacoustics.
Proceedings of SPIE–the International Society for Optical Engineering.
9708
[DOI] 10.1117/12.2213064.
[PMID] 28529403.
Grants
May 2024
ACTIVE
Percutaneous cementoplasty in dogs with appendicular osteosarcoma treated with stereotactic body radiation therapy: A pilot study
Role: Other
Funding: AMERICAN COLLEGE OF VETERINARY RADIOLOGY
Sep 2023
ACTIVE
Phase II open-label non-randomized multicenter clinical trial of trametinib for dogs with histiocytic sarcoma
Role: Principal Investigator
Funding: MICHIGAN STATE UNIV
via MORRIS ANIMAL FOU
Jun 2022
– Feb 2024
A multicenter, randomized, double-blind, placebo-controlled, pilot clinical study comparing primary radiotherapy with radiotherapy combined with MT0321 intravenous administration for canine intranasal adenocarcinoma
Role: Principal Investigator
Funding: MALIGNANT TUMOR TREATMENT TECHNOLOGIES
May 2022
– Apr 2023
Feasibility of radiotherapy combined with MT0321 intravenous administration for canine intranasal adenocarcinoma
Role: Co-Investigator
Funding: MALIGNANT TUMOR TREATMENT TECHNOLOGIES
Mar 2022
ACTIVE
Mechanism of LSD1 Function and Its Therapeutic Application for Progressive Oral Malignancy
Role: Co-Project Director/Principal Investigator
Funding: BOSTON UNIV
via NATL INST OF HLTH NIDCR
Education
Residency in Radiation Oncology
2021
·
University of Wisconsin – Madison
PhD in Comparative Medicine and Integrative Biology
2018
·
Michigan State University
MSc in Comparative Medicine and Integrative Biology
2013
·
Michigan State University
Residency in Small Animal Surgery
2008
·
Anhembi Morumbi University (Brazil)
Doctor of Veterinary Medicine
2005
·
University of Sao Paulo (Brazil)
Contact Details
Phones:
- Business:
- (352) 392-2235
Emails:
- Business:
- mtakada@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100116
GAINESVILLE FL 32610