Leah D Stuchal

Leah D Stuchal, PhD

Research Assistant Professor

Department: Department of Physiological Sciences
Business Phone: (352) 294-4641
Business Email: lstuchal@ufl.edu

Research Profile

My interests and research include exposure modeling and refinement of exposure estimates for use in risk assessment. The University of Florida’s Center for Environmental and Human Toxicology holds the singular contract for the Florida Department of Environmental Protection (FDEP) to provide technical reviews of risk assessments for the State of Florida. Over past years we have produced hundreds of these technical reviews advising the FDEP on all aspects of risk assessment and have created exposure models for seafood consumption for high-end consumers on the Gulf of Mexico, irrigation of vegetable gardens and ornamental beds, and swimmers in creeks and the ocean. Our recent work includes an NIH grant to generate a threshold dose for memory impairment from long term exposure to domoic acid in clams. Additionally, we are currently working with the FDEP to develop screening criteria for perfluoroalkyl substances in surface water that are protective of human and ecological health.

Publications

2020
Dose-response assessment for impaired memory from chronic exposure to domoic acid among native American consumers of razor clams.
Regulatory toxicology and pharmacology : RTP. 117 [DOI] 10.1016/j.yrtph.2020.104759. [PMID] 32768666.
2020
Probabilistic risk assessment for high-end consumers of seafood on the northeastern Gulf coast.
Journal of exposure science & environmental epidemiology. 30(3):478-491 [DOI] 10.1038/s41370-019-0119-4. [PMID] 30728481.
2020
Test-Retest Reliability of a Food Frequency Questionnaire to Assess Seafood Intake Dynamics for High-End Consumers in Coastal Gulf of Mexico Communities.
Journal of environmental and public health. 2020 [DOI] 10.1155/2020/2704074. [PMID] 32322281.
2019
Bioaccessibility of polychlorinated dioxins and furans in soil from a Superfund site.
Chemosphere. 214:418-423 [DOI] 10.1016/j.chemosphere.2018.09.044. [PMID] 30268897.
2019
Derivation of a chronic reference dose for perfluorohexane sulfonate (PFHxS) for reproductive toxicity in mice.
Regulatory toxicology and pharmacology : RTP. 108 [DOI] 10.1016/j.yrtph.2019.104452. [PMID] 31487490.
2018
Incremental Sampling Methodology: Applications for Background Screening Assessments.
Risk analysis : an official publication of the Society for Risk Analysis. 38(1):194-209 [DOI] 10.1111/risa.12820. [PMID] 28556091.
2016
Potential arsenic exposures in 25 species of zoo animals living in CCA-wood enclosures.
The Science of the total environment. 551-552:614-21 [DOI] 10.1016/j.scitotenv.2016.02.065. [PMID] 26897404.
2015
Analysis of EPA’s endocrine screening battery and recommendations for further review.
Regulatory toxicology and pharmacology : RTP. 72(3):552-61 [DOI] 10.1016/j.yrtph.2015.05.028. [PMID] 26044367.
2014
Relevance weighting of tier 1 endocrine screening endpoints by rank order.
Birth defects research. Part B, Developmental and reproductive toxicology. 101(1):90-113 [DOI] 10.1002/bdrb.21096. [PMID] 24510745.
2013
Derivation of a chronic reference concentration for decalin.
Regulatory toxicology and pharmacology : RTP. 66(1):38-46 [DOI] 10.1016/j.yrtph.2013.02.011. [PMID] 23454102.
2008
Glucuronidation and sulfonation, in vitro, of the major endocrine-active metabolites of methoxychlor in the channel catfish, Ictalurus punctatus, and induction following treatment with 3-methylcholanthrene.
Aquatic toxicology (Amsterdam, Netherlands). 86(2):227-38 [PMID] 18078677.
View on: PubMed
2008
Stimulation of Transactivation of the Largemouth Bass Estrogen Receptors Alpha, Beta-A, and Beta-B By Methoxychlor and Its Mono- and Bis-Demethylated Metabolites in Hepg2 Cells
The Journal of steroid biochemistry and molecular biology. 108:55-63 [DOI] 10.1016/j.jsbmb.2007.06.004. [PMID] 17949972.
2008
Stimulation of transactivation of the largemouth bass estrogen receptors alpha, beta-a, and beta-b by methoxychlor and its mono- and bis-demethylated metabolites in HepG2 cells.
The Journal of steroid biochemistry and molecular biology. 108(1-2):55-63 [PMID] 17949972.
View on: PubMed
2008
Stimulation of transactivation of the largemouth bass estrogen receptors alpha, beta-α and beta-β by methoxychlor and its mono-and bis-demethylated metabolites in HepG2 cells
. (108):55-63
2006
Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus): evidence for roles of CYP1 and CYP3A family isozymes.
Drug metabolism and disposition: the biological fate of chemicals. 34(6):932-8 [PMID] 16510540.
View on: PubMed

Grants

Jul 2021 ACTIVE
Toxicological Support Services 2021-2022
Role: Principal Investigator
Funding: FL DEPT OF HLTH ENVIROMENTAL HEALTH
Jul 2020 ACTIVE
FL DEP HW677 Toxicological Support Services
Role: Principal Investigator
Funding: FL DEPT OF ENVIRONMENTAL PROTECT
Jul 2020 ACTIVE
FL DEP HW678 – Toxicological Support Services
Role: Principal Investigator
Funding: FL DEPT OF ENVIRONMENTAL PROTECT via US ENVIRONMENTAL PRO AGCY
Nov 2019 – Mar 2020
Toxicological support services
Role: Principal Investigator
Funding: FL DEPT OF HLTH ENVIROMENTAL HEALTH
Feb 2018 ACTIVE
Miami Dade Multi Sponsors
Role: Co-Investigator
Funding: MIAMI-DADE CNTY
Apr 2017 – Mar 2019
Rapid risk assessment of chronic domoic acid exposure in WA razor clam harvesters
Role: Co-Investigator
Funding: UNIV OF MARYLAND BALTIMORE via NATL INST OF HLTH NIEHS
Mar 2017 – Sep 2017
Dioxin Bioaccessibility Assessment for the American Creosote Works Site Center for Environmental & Human Toxicology
Role: Co-Investigator
Funding: GEOSYNTEC via FL DEPT OF ENVIRONMENTAL PROTECT
Jul 2015 – Mar 2017
Eagle and human health risk assessment
Role: Principal Investigator
Funding: US DEPT OF INTERIOR FISH AND WILDLIFE SE
Jun 2011 – Apr 2017
Health Impact of Deepwater Horizon Spill in Eastern Gulf Coast Communities
Role: Project Manager
Funding: NATL INST OF HLTH NIEHS
Aug 2010 – Jun 2020
Toxicological Support Services
Role: Co-Investigator
Funding: FL DEPT OF ENVIRONMENTAL PROTECT

Education

Ph.D., Medicinal Chemistry
2005 · University of Florida
B.S., Marine Science/Biology
1996 · University of Miami

Teaching Profile

Courses Taught
2013-2015,2017-2019
VME6607 Human Health Risk Assessment
2019
PHC6937 Special Topics in Public Health
2018
VME7980 Research for Doctoral Dissertation
2014,2021
PHC6722 Environmental and Global Health Research Methods Rotation
2011-2013
VEM5172 Veterinary Toxicology
2010
VEM5288 Sm An Clin Pharmacol

Contact Details

Phones:
Business:
(352) 294-4641
Emails:
Business:
lstuchal@ufl.edu