Meg Sleeper,
Clinical Professor; Cardiology Service Chief
Department:
Small Animal Clinical Sciences
Business Phone:
(352) 392-2235
Business Email:
margaretmsleeper@ufl.edu
Teaching Profile
Courses Taught
2017-2021
VEM5301 Cardiopul Disorders
2015-2023
VEM5862 Vet Cardio Clerkship
2017-2023
VEM5289 Lg An Clin Pharmacol
2018-2023
VEM5355 Ruminant Medicine
2019-2020
VEM5111 Animal Systems 2
2017-2019
VEM5335 Equine Medicine
2017
VEM5991 Clkship Indiv Invest
2017
VEM5262 Adv Sm Anin Diag Imag
Research Profile
Areas of Interest
- Gene therapy for cardiovascular disease
- inherited heart disease
Publications
2022
A review of the underlying genetics and emerging therapies for canine cardiomyopathies.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology.
40:2-14
[DOI] 10.1016/j.jvc.2021.05.003.
[PMID] 34147413.
2020
GREAT APE HEART PROJECT GUIDELINES FOR THE ECHOCARDIOGRAPHIC ASSESSMENT OF GREAT APES.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
50(4):822-836
[DOI] 10.1638/2018-0164.
[PMID] 31926512.
2020
Monitoring great ape heart health through innovative electrocardiogram technology: Training methodologies and welfare implications.
Zoo biology.
39(6):443-447
[DOI] 10.1002/zoo.21567.
[PMID] 32909258.
2019
Pharmacokinetics of furosemide after intravenous, oral and transdermal administration to cats
Journal of Feline Medicine and Surgery.
21(10):882-886
2018
Acupuncture and Traditional Chinese Veterinary Medicine for Treatment of a Mare With Rectal Paralysis
Equine Veterinary Education.
30(9):460-463
[DOI] 10.1111/eve.12692.
2018
Sample Size Determination for Evaluation of Time Domain Heart Rate Variability Indices in Canine Lameness
Journal of the American Animal Hospital Association.
54(5):235-238
[DOI] 10.5326/JAAHA-MS-6533.
2017
Equine Cardiovascular Therapeutics.
The Veterinary clinics of North America. Equine practice.
33(1):163-179
[DOI] 10.1016/j.cveq.2016.11.005.
[PMID] 28325177.
2017
Status of Therapeutic Gene Transfer to Treat Cardiovascular Disease in Dogs and Cats.
The Veterinary clinics of North America. Small animal practice.
47(5):1113-1121
[DOI] 10.1016/j.cvsm.2017.04.005.
[PMID] 28647114.
2016
Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle.
JCI insight.
1(21)
[DOI] 10.1172/jci.insight.90341.
[PMID] 28018975.
2016
Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts.
Journal of the American Heart Association.
5(8)
[DOI] 10.1161/JAHA.116.003911.
[PMID] 27506543.
2015
Myocardial infarct associated with a partial thickness left atrial tear in a dog with mitral insufficiency.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology.
17(3):229-36
[DOI] 10.1016/j.jvc.2015.04.003.
[PMID] 26263842.
2015
The Evolving Mcart Multimodal Imaging Core: Establishing a Protocol for Computed Tomography and Echocardiography in the Rhesus Macaque to Perform Longitudinal Analysis of Radiation-Induced Organ Injury.
Health physics.
109(5):479-92
[DOI] 10.1097/HP.0000000000000344.
[PMID] 26425907.
2014
Comparison of echocardiographic measurements in elite and nonelite Arabian endurance horses.
American journal of veterinary research.
75(10):893-8
[DOI] 10.2460/ajvr.75.10.893.
[PMID] 25255178.
2014
Echocardiography parameters of clinically normal adult captive chimpanzees (Pan troglodytes).
Journal of the American Veterinary Medical Association.
244(8):956-60
[DOI] 10.2460/javma.244.8.956.
[PMID] 24697773.
2014
Effects of acepromazine or methadone on midazolam-induced behavioral reactions in dogs.
The Canadian veterinary journal = La revue veterinaire canadienne.
55(9):875-85
[PMID] 25183896.
2014
Evaluation of blood cardiac troponin I concentrations obtained with a cage-side analyzer to differentiate cats with cardiac and noncardiac causes of dyspnea.
Journal of the American Veterinary Medical Association.
244(4):425-30
[DOI] 10.2460/javma.244.4.425.
[PMID] 24479456.
2013
Long-term wheel running compromises diaphragm function but improves cardiac and plantarflexor function in the mdx mouse.
Journal of applied physiology (Bethesda, Md. : 1985).
115(5):660-6
[DOI] 10.1152/japplphysiol.00252.2013.
[PMID] 23823150.
2013
The effect of neonatal gene therapy with a gamma retroviral vector on cardiac valve disease in mucopolysaccharidosis VII dogs after a decade.
Molecular genetics and metabolism.
110(3):311-8
[DOI] 10.1016/j.ymgme.2013.06.015.
[PMID] 23860311.
2013
Use of the vertebral heart scale for differentiation of cardiac and noncardiac causes of respiratory distress in cats: 67 cases (2002-2003).
Journal of the American Veterinary Medical Association.
242(3):366-71
[DOI] 10.2460/javma.242.3.366.
[PMID] 23327180.
2012
Cardiotoxicity, inflammation, and immune response after rattlesnake envenomation in the horse.
Journal of veterinary internal medicine.
26(6):1457-63
[DOI] 10.1111/j.1939-1676.2012.01022.x.
[PMID] 23113840.
2012
Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping.
Molecular therapy : the journal of the American Society of Gene Therapy.
20(3):580-9
[DOI] 10.1038/mt.2011.264.
[PMID] 22146342.
2012
Mitochondrial dysfunction in myocardium obtained from clinically normal dogs, clinically normal anesthetized dogs, and dogs with dilated cardiomyopathy.
American journal of veterinary research.
73(11):1759-64
[DOI] 10.2460/ajvr.73.11.1759.
[PMID] 23106461.
2012
Neonatal gene therapy with a gamma retroviral vector in mucopolysaccharidosis VI cats.
Molecular therapy : the journal of the American Society of Gene Therapy.
20(5):898-907
[DOI] 10.1038/mt.2012.9.
[PMID] 22395531.
2012
Primary infundibular stenosis and pedigree analysis in three Golden Retriever littermates.
Journal of the American Animal Hospital Association.
48(1):50-3
[DOI] 10.5326/JAAHA-MS-5654.
[PMID] 22186718.
2011
Association of brain-type natriuretic protein and cardiac troponin I with incipient cardiovascular disease in chimpanzees (Pan troglodytes).
Comparative medicine.
61(2):163-9
[PMID] 21535928.
2011
Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines.
Human gene therapy.
22(8):969-77
[DOI] 10.1089/hum.2011.035.
[PMID] 21542669.
2011
Cardiac magnetic resonance in the differentiation of neoplastic and nonneoplastic pericardial effusion.
Journal of veterinary internal medicine.
25(5):1003-9
[DOI] 10.1111/j.1939-1676.2011.0762.x.
[PMID] 21781165.
2011
Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice.
PloS one.
6(6)
[DOI] 10.1371/journal.pone.0020856.
[PMID] 21731628.
2011
Effects of aging and blood contamination on the urinary protein-creatinine ratio in captive chimpanzees (Pan troglodytes).
Journal of the American Association for Laboratory Animal Science : JAALAS.
50(3):374-7
[PMID] 21640034.
2011
Evaluation of adeno-associated viral vectors for liver-directed gene transfer in dogs.
Human gene therapy.
22(8):985-97
[DOI] 10.1089/hum.2010.194.
[PMID] 21204705.
2011
Long-term amelioration of feline Mucopolysaccharidosis VI after AAV-mediated liver gene transfer.
Molecular therapy : the journal of the American Society of Gene Therapy.
19(3):461-9
[DOI] 10.1038/mt.2010.257.
[PMID] 21119624.
2011
Long-term systemic myostatin inhibition via liver-targeted gene transfer in golden retriever muscular dystrophy.
Human gene therapy.
22(12):1499-509
[DOI] 10.1089/hum.2011.102.
[PMID] 21787232.
2011
Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 in the canine.
Methods in molecular biology (Clifton, N.J.).
709:369-78
[DOI] 10.1007/978-1-61737-982-6_24.
[PMID] 21194041.
2011
Status of therapeutic gene transfer to treat cardiovascular disease in dogs and cats.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology.
13(2):131-40
[DOI] 10.1016/j.jvc.2011.04.001.
[PMID] 21640678.
2011
Transendocardial delivery of AAV6 results in highly efficient and global cardiac gene transfer in rhesus macaques.
Human gene therapy.
22(8):979-84
[DOI] 10.1089/hum.2011.042.
[PMID] 21563985.
2011
Use of an implantable loop recorder in the investigation of arrhythmias in adult captive chimpanzees (Pan troglodytes).
Comparative medicine.
61(1):71-5
[PMID] 21819684.
2010
Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of Duchenne muscular dystrophy.
Muscle & nerve.
42(5):722-30
[DOI] 10.1002/mus.21743.
[PMID] 20730876.
2010
Cardiac magnetic resonance imaging in normal dogs and two dogs with heart base tumor.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association.
51(4):428-35
[PMID] 20806875.
2010
Clinical efficacy of sildenafil in treatment of pulmonary arterial hypertension in dogs.
Journal of veterinary internal medicine.
24(4):850-4
[DOI] 10.1111/j.1939-1676.2010.0517.x.
[PMID] 20412435.
2010
Computed tomographic changes associated with the prepatent and early patent phase of dirofilariasis in an experimentally infected dog.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association.
51(2):136-40
[PMID] 20402396.
2010
Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse model.
PloS one.
5(4)
[DOI] 10.1371/journal.pone.0010230.
[PMID] 20419100.
2010
Overexpression of SERCA1a in the mdx diaphragm reduces susceptibility to contraction-induced damage.
Human gene therapy.
21(12):1735-9
[DOI] 10.1089/hum.2010.077.
[PMID] 20540606.
2010
Perceptions of quality of life and priorities of owners of cats with heart disease.
Journal of veterinary internal medicine.
24(6):1421-6
[DOI] 10.1111/j.1939-1676.2010.0583.x.
[PMID] 20738770.
2010
Status of therapeutic gene transfer to treat canine dilated cardiomyopathy in dogs.
The Veterinary clinics of North America. Small animal practice.
40(4):717-24
[DOI] 10.1016/j.cvsm.2010.03.005.
[PMID] 20610021.
2010
Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice.
PloS one.
5(2)
[DOI] 10.1371/journal.pone.0009176.
[PMID] 20161803.
2010
Use of biomarkers of collagen types I and III fibrosis metabolism to detect cardiovascular and renal disease in chimpanzees (Pan troglodytes).
Comparative medicine.
60(2):154-8
[PMID] 20412692.
2009
Association of periodontal disease, oral procedures, and other clinical findings with bacterial endocarditis in dogs.
Journal of the American Veterinary Medical Association.
234(1):100-7
[DOI] 10.2460/javma.234.1.100.
[PMID] 19119972.
2009
Effect of azotemia on serum N-terminal proBNP concentration in dogs with normal cardiac function: a pilot study.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology.
11 Suppl 1:S81-6
[DOI] 10.1016/j.jvc.2009.02.001.
[PMID] 19394913.
2009
Gene therapy in large animal models of human cardiovascular genetic disease.
ILAR journal.
50(2):199-205
[PMID] 19293462.
2009
Is it acute heart failure or sudden cardiac death in the chimpanzee?
Journal of medical primatology.
38(2)
[DOI] 10.1111/j.1600-0684.2009.00351.x.
[PMID] 19335474.
2009
Questions validity of study on periodontal disease and cardiovascular events in dogs.
Journal of the American Veterinary Medical Association.
234(12):1525-8; author reply 1526
[DOI] 10.2460/javma.234.12.1525.
[PMID] 19527122.
2008
A novel locus for dilated cardiomyopathy maps to canine chromosome 8.
Genomics.
91(6):517-21
[DOI] 10.1016/j.ygeno.2008.03.007.
[PMID] 18442891.
2008
Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat.
Human gene therapy.
19(12):1359-68
[DOI] 10.1089/hum.2008.123.
[PMID] 18795839.
2008
Assessment of plasma cardiac troponin I concentration as a means to differentiate cardiac and noncardiac causes of dyspnea in cats.
Journal of the American Veterinary Medical Association.
233(8):1261-4
[DOI] 10.2460/javma.233.8.1261.
[PMID] 18922052.
2008
Chronic oral therapy with enalapril in normal ponies.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology.
10(2):111-5
[DOI] 10.1016/j.jvc.2008.08.002.
[PMID] 19019755.
2008
Clinical characterization of cardiovascular abnormalities associated with feline mucopolysaccharidosis I and VI.
Journal of inherited metabolic disease.
31(3):424-31
[DOI] 10.1007/s10545-008-0821-1.
[PMID] 18509743.
2008
ECG of the month. Arrythmia.
Journal of the American Veterinary Medical Association.
233(10):1548-50
[DOI] 10.2460/javma.233.10.1548.
[PMID] 19014285.
2008
Echocardiographic reference ranges for sedated healthy cynomolgus monkeys (Macaca fascicularis).
Journal of the American Association for Laboratory Animal Science : JAALAS.
47(1):22-5
[PMID] 18210994.
2008
Exploring human/animal intersections: converging lines of evidence in comparative models of aging.
Alzheimer's & dementia : the journal of the Alzheimer's Association.
4(1):1-5
[DOI] 10.1016/j.jalz.2007.09.007.
[PMID] 18631944.
2008
Gene therapy for cardiovascular manifestations of lysosomal storage diseases.
Heart and metabolism : management of the coronary patient.
41:21-24
[PMID] 26937225.
2008
Perceptions and priorities of owners of dogs with heart disease regarding quality versus quantity of life for their pets.
Journal of the American Veterinary Medical Association.
233(1):104-8
[DOI] 10.2460/javma.233.1.104.
[PMID] 18593317.
2008
Percutaneous Transendocardial Delivery of Self-complementary Adeno-associated Virus 6 Achieves Global Cardiac Gene Transfer in Canines.
Molecular therapy : the journal of the American Society of Gene Therapy.
16(12):1953-1959
[DOI] 10.1038/mt.2008.202.
[PMID] 28189009.
2007
Canine bacterial endocarditis: a review.
Journal of the American Animal Hospital Association.
43(5):258-63
[PMID] 17823474.
2007
Correction of clinical manifestations of canine mucopolysaccharidosis I with neonatal retroviral vector gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy.
15(8):1423-31
[PMID] 17519893.
2007
ECG of the month. Sinus arrhythmia with first-degree atrioventricular block.
Journal of the American Veterinary Medical Association.
230(7):1002-4
[PMID] 17397337.
2007
Pericardial effusion in cats: a retrospective study of clinical findings and outcome in 146 cats.
Journal of veterinary internal medicine.
21(5):1002-7
[PMID] 17939556.
2006
Canine trichinosis presenting with syncope and AV conduction disturbance.
Journal of veterinary internal medicine.
20(5):1228-31
[PMID] 17063722.
2006
Electrocardiogram abnormalities in captive chimpanzees (Pan troglodytes).
Comparative medicine.
56(6):512-8
[PMID] 17219782.
2005
Echocardiographic diagnosis of transposition of the great arteries in a neonatal foal.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association.
46(3):259-62
[PMID] 16050286.
2005
Successful treatment of idiopathic dilated cardiomyopathy in an adult chimpanzee (Pan troglodytes).
Comparative medicine.
55(1):80-4
[PMID] 15766214.
2004
Gene therapy ameliorates cardiovascular disease in dogs with mucopolysaccharidosis VII.
Circulation.
110(7):815-20
[PMID] 15289379.
2003
Inheritance, biochemical abnormalities, and clinical features of feline mucolipidosis II: the first animal model of human I-cell disease.
The Journal of heredity.
94(5):363-73
[PMID] 14557388.
2002
Cardiac troponin I in feline hypertrophic cardiomyopathy.
Journal of veterinary internal medicine.
16(5):558-64
[PMID] 12322706.
2002
Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs.
Proceedings of the National Academy of Sciences of the United States of America.
99(20):13102-7
[PMID] 12232044.
2001
Aortic root disease in four horses.
Journal of the American Veterinary Medical Association.
219(4):491-6, 459
[PMID] 11518177.
2001
Cardiac troponin I in the normal dog and cat.
Journal of veterinary internal medicine.
15(5):501-3
[PMID] 11596740.
2001
Differing opinion regarding the etiology of juvenile cardiomyopathy in Portuguese water dogs.
American journal of medical genetics.
104(3):262-4
[PMID] 11754056.
2001
Vertebral scale system to measure heart size in growing puppies.
Journal of the American Veterinary Medical Association.
219(1):57-9
[PMID] 11439770.
2000
Aortitis in a Paint gelding.
Equine veterinary journal.
32(4):354-7
[PMID] 10952387.
1999
Familial dilated cardiomyopathy of young Portuguese water dogs.
Journal of veterinary internal medicine.
13(1):65-71
[PMID] 10052066.
Grants
Sep 2016
ACTIVE
Therapeutic gene transfer abrogates canine dilated cardiomyopathy
Role: Principal Investigator
Funding: AMER KENNEL CLUB
Education
Diplomate, American College of Veterinary Internal Medicine (cardiology)
1997
·
University of Pennsylvania
Residency
1997
·
University of Pennsylvania
Internship
1994
·
Midatlantic Equine Medical Center
Veterinary Medicine Degree
1993
·
University of Pennsylvania
Contact Details
Phones:
- Business:
- (352) 392-2235
Emails:
- Business:
- margaretmsleeper@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100126
GAINESVILLE FL 32610 - Business Street:
-
VC-67, BLDG. 215
GAINESVILLE FL 32610