The human gastrointestinal (GI) tract harbors a complex consortium of trillions of microbes, thousands of bacterial phylotypes, methanogenic archaea, and fungi colonizing the entire length of the gut. Collectively this is termed microbiota, which contains at least 100 times as many gene products as the host genome. Although it is largely unexplored and underappreciated, the gut microbiota plays a critical role in states of both health and disease. Accumulating evidence indicates that the gut microbiota is essential in energy metabolism, host intestinal immune function and is also crucial in developing several diseases, including diabetes, non-alcoholic fatty liver disease, inflammatory bowel diseases, and even cancer. My research focuses on developing strategic alterations in microbiota, which will, in turn, treat human ailments, including those of infectious origin.
- Cancer Immunology and Immunotherapy
- Gastrointestinal physiology and immunology (necrotizing enterocolitis)
- Immune Tolerance
- Immune-Mediated Disease
- Mucosal immunology