Bikash Sahay

Bikash Sahay

CLIN AST PROF

Department: Department of Infectious Diseases & Immunology
Business Phone: (352) 294-4155
Business Email: sahayb@ufl.edu

Research Profile

Borrelia burgdorferi is the causative agent of Lyme disease in humans, and susceptibility to it varies widely within a population, a phenomenon also observed in mice. Different mouse strains were used to understand the differences and similarities between disease susceptibility and resistance in human populations. The C3H/HeN mouse strain is the most susceptible, whereas the C57BL/6 strain is most resistant to Lyme Borreliosis. There are several factors associated with the differential disease phenotype, and one of the major determining factors is the IL-10 production between the mice strains. C3H/HeN mice and macrophages (MΦ) isolated from them do not produce adequate IL-10 in response to B. burgdorferi; instead they produce genes belonging to interferon response factors. We found that C3H/HeN MΦ harbored less cAMP in their cytoplasm, and the addition of exogenous cAMP converts their phenotype closer to resistant MΦs isolated from C57/BL6 mice. Currently, my research focuses on the evaluation of the role of cAMP in modulating epigenetic landscape of disease susceptibility and resistance genes, including IL-10.

Publications

2017 Journal of clinical & cellular immunology
2013 Current Pharmaceutical Biotechnology

Grants

Sep 2020 ACTIVE
SBIR – A Novel Immunological Probiotic for Treating Inflammatory Bowel Disease.
RISE THERAPEUTICS · Principal Investigator
Apr 2019 ACTIVE
A Novel Probiotic Engineered for Enhanced Immunological Function for Treating Inflammatory Bowel Disease
RISE THERAPEUTICS · Principal Investigator
Nov 2018 – Mar 2019
DNA vaccine against Lyme disease
INOVIO PHARMACEUTICALS INC · Principal Investigator
Jul 2018 – Jun 2020
A Novel Immunological Probiotic for Treating Inflammatory Bowel Disease
RISE THERAPEUTICS · Principal Investigator
Feb 2018 – Dec 2019
MERCK/INTERVET ANIMAL CLINICAL VACCINE TRIAL
INTERVET ·
Jun 2017 – Apr 2019
CART Cells for Sarcoma
Sarcoma Foundation of America ·

Patents

Published October 2016
Lipoteichoic Acid From Lactobacilli as a Potent Immune Stimulatory Adjuvant for Vaccine Development
#US-2017-0035880-A1
Published November 2017
Propionibacterium Freudenreichii as a Probiotic for Infants
#US-2018-0199611-A1

Education

Doctor of Philosophy
2005 · Indian Veterinary Research Institute
Master of Veterinary Science
2001 · Indian Veterinary Research Institute
Bachelor of Veterinary Science
1999 · Bihar Veterinary College, Rajendra Agricultural University

Contact Details

Phones:
Business:
(352) 294-4155
Emails:
Business:
sahayb@ufl.edu

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