Simon O Owino

RES AST PROF

Department: Department of Infectious Diseases & Immunology

Business Phone: (352) 294-4143

Business Email: sowino@ufl.edu

Research Profile

Dr. Simon Odera Owino is an experienced research professor with a demonstrated history of working in the higher education industry. Skilled in parasitology, research design, molecular biology, cell culture, and genetic engineering, Dr. Owino is a strong education professional with a Doctor of Philosophy (Ph.D.) focused in Infectious Diseases from the University of Georgia.

Dr. Owino’s current research mainly focuses on immunological crosstalk within the fetal-maternal interphase during malaria infection. To accomplish this goal, Dr. Owino harvests and cultures primary trophoblast cells, which are placental cells in contact with maternal blood, as well as maintains an immortalized cell line, BeWo, used as mimics for primary trophoblast. In addition to the work detailed above, Dr. Owino uses a mouse model designed to understand the course and impact of malaria infection during pregnancy. He is also interested in understanding intricate processes of hypoxia during malaria and how these processes influence pregnancy outcome.

Publications

2018

Evaluation of a temperature-restricted, mucosal tuberculosis vaccine in guinea pigs.

Tuberculosis (Edinburgh, Scotland). 113:179-188 [DOI] 10.1016/j.tube.2018.10.006. [PMID] 30514501.

View on: PubMed Publisher’s Site

2017

Broadened immunity and protective responses with emulsion-adjuvanted H5 COBRA-VLP vaccines.

Vaccine. 35(38):5209-5216 [DOI] 10.1016/j.vaccine.2017.07.107. [PMID] 28789850.

View on: PubMed Publisher’s Site

2017

Impact of age and pre-existing influenza immune responses in humans receiving split inactivated influenza vaccine on the induction of the breadth of antibodies to influenza A strains.

PloS one. 12(11) [DOI] 10.1371/journal.pone.0185666. [PMID] 29091724.

View on: PubMed Publisher’s Site

2015

Differential roles of inflammation and apoptosis in initiation of mid-gestational abortion in malaria-infected C57BL/6 and A/J mice.

Placenta. 36(7):738-49 [DOI] 10.1016/j.placenta.2015.04.007. [PMID] 25956987.

View on: PubMed Publisher’s Site

2012

Maternal malaria induces a procoagulant and antifibrinolytic state that is embryotoxic but responsive to anticoagulant therapy.

PloS one. 7(2) [DOI] 10.1371/journal.pone.0031090. [PMID] 22347435.

View on: PubMed Publisher’s Site

2012

Sequence polymorphism, segmental recombination and toggling amino acid residues within the DBL3X domain of the VAR2CSA placental malaria antigen.

PloS one. 7(2) [DOI] 10.1371/journal.pone.0031565. [PMID] 22347496.

View on: PubMed Publisher’s Site

2012

Temporal trends of sulphadoxine-pyrimethamine (SP) drug-resistance molecular markers in Plasmodium falciparum parasites from pregnant women in western Kenya.

Malaria journal. 11 [DOI] 10.1186/1475-2875-11-134. [PMID] 22540158.

View on: PubMed Publisher’s Site

2011

Natural hemozoin stimulates syncytiotrophoblast to secrete chemokines and recruit peripheral blood mononuclear cells.

Placenta. 32(8):579-85 [DOI] 10.1016/j.placenta.2011.05.003. [PMID] 21632106.

View on: PubMed Publisher’s Site

2009

C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria.

PloS one. 4(3) [DOI] 10.1371/journal.pone.0004953. [PMID] 19308263.

View on: PubMed Publisher’s Site

2009

Human immunodeficiency virus co-infection increases placental parasite density and transplacental malaria transmission in Western Kenya.