Mansour Mohamadzadeh

Mansour Mohamadzadeh, PhD

Director, Center For Inflammation & Mucosal Immunology; Professor

Department: MD-GASTROENTEROLOGY
Business Phone: (352) 294-4117
Business Email: m.zadeh@ufl.edu

About Mansour Mohamadzadeh

Dr. Mohamadzadeh is an immunologist with expertise in the fields of inflammation, systemic/mucosal immunology, infection, and vaccine delivery. He is also experienced in working with various therapeutic approaches that focus on the role of innate immune cells, particularly dendritic cells, and how these cells determine the fate of virgin T and B cells toward various T and B cell subset activation in steady state, infection, and auto inflammatory diseases, including IBD and colon cancer. Additionally, his focus is currently centered on an oral targeted vaccine that not only induces intestinal but also systemic immune responses against pathogen challenge.

Accomplishments

Honorary Member
2013-Current · Phi Zeta Society, Upsilon Chapter
Member
2012-Current · Society of Mucosal Immunology
Member
2012-Current · KL2 Multidisciplinary Advisory Committee, CTSI, University of Florida
Associate Editor
2011-Current · Frontiers in Immunology
Associate Editor
2011-Current · J. Immunotherapy
Member
2011-Current · Emerging Pathogens Institute (EPI), University of Florida
Member
2011-Current · Cancer Genetics Institute, UF
Member
2009-2012 · IACUC committee, NW University
Associate Editor
2007-2011 · Journal of Immunology
Member
2005-Current · American Society for Microbiology
Grants Merit Review
2003-Current · National Institute of Health (NIH)
Member
1998-2020 · American Association of Immunologists (AAI)
Member
1996-2020 · American Association for the Advancement of Science (AAAS)

Teaching Profile

Courses Taught
2012-2016,2018-2020
VME6934 Topics in Veterinary Medical Sciences
2018
VME7980 Research for Doctoral Dissertation
2017-2018,2021
VME4906 Problems in Veterinary Science
2013
VEM5110 Animal Systems 1
2021
VME6140 Mucosal Immunology

Research Profile

Dr. Mohamadzadeh is an immunologist with over 25 years of expertise in the fields of inflammation, systemic/mucosal immunology, infection, and vaccine delivery. He is also experienced in working with various therapeutic approaches that focus on the role of innate immune cells–particularly dendritic cells, and how these cells determine the activation and differentiation of T lymphocytes, including T cells, such as TH17 or extrathymic regulatory T cells (Tregs) in steady state, during infection, and throughout autoinflammatory intestinal disorders such as inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC). In his opinion, understanding the molecular mechanisms underlying intestinal immune regulation is most effective when host interactions with intestinal bacterial species and their bacterial products are fully understood, and when the critical molecules that culminate in inflammation or anti-inflammatory responses are identified. Thus, his research is firmly centered on the specifics of beneficial gut microbes, their unique properties, and their role in the induction of stimulatory or regulatory signals in innate cells and T lymphocytes, contributing directly to further proinflammation or regulation of inflammatory diseases (IBD, NEC). Pragmatically, his research is tightly entwined with generating novel therapies for intestinal disorders (e.g. NEC) using beneficial bacteria such as P. UF1 to significantly regulate induced pathogenic inflammation in sufferers who urgently need it. Furthermore, his team also established a novel targeted vaccine platform, dual route vaccine, to mobilize protective humoral immunity against infectious agents, including botulinum neurotoxin A complex (BoNT/A), in animals and man. The same dual route vaccine platform is currently optimized to elucidate the efficacy of probiotic bacterium, P. UF1, expressing PD-1 molecule to generate neutralizing antibody against PD-1 to inhibit T cell exhaustion and to protect against melanoma cancer. This elegant and less costly approach will be further developed and tested in higher animals, including dogs affected by melanoma and hopefully in phase 1 clinical trial in man in the near future.

Publications

2022
Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice.
iScience. 25(5) [DOI] 10.1016/j.isci.2022.104241. [PMID] 35494242.
2022
Vitamin B12 coordinates ileal epithelial cell and microbiota functions to resist Salmonella infection in mice.
The Journal of experimental medicine. 219(7) [DOI] 10.1084/jem.20220057. [PMID] 35674742.
2022
Vitamin B12 Regulates the Transcriptional, Metabolic, and Epigenetic Programing in Human Ileal Epithelial Cells.
Nutrients. 14(14) [DOI] 10.3390/nu14142825. [PMID] 35889782.
2021
A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity.
Gastroenterology. 160(4):1240-1255.e3 [DOI] 10.1053/j.gastro.2020.11.008. [PMID] 33189700.
2021
Neurovascular protection by adropin in experimental ischemic stroke through an endothelial nitric oxide synthase-dependent mechanism.
Redox biology. 48 [DOI] 10.1016/j.redox.2021.102197. [PMID] 34826783.
2021
Tryptophan Metabolism and Gut-Brain Homeostasis.
International journal of molecular sciences. 22(6) [DOI] 10.3390/ijms22062973. [PMID] 33804088.
2021
Vitamin B12 and gut-brain homeostasis in the pathophysiology of ischemic stroke.
EBioMedicine. 73 [DOI] 10.1016/j.ebiom.2021.103676. [PMID] 34749301.
2020
Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice.
Science translational medicine. 12(551) [DOI] 10.1126/scitranslmed.aax2220. [PMID] 32641487.
2020
Regulating colonic dendritic cells by commensal glycosylated large surface layer protein A to sustain gut homeostasis against pathogenic inflammation.
Mucosal immunology. 13(1):34-46 [DOI] 10.1038/s41385-019-0210-0. [PMID] 31619761.
2020
Regulating vitamin B12 biosynthesis via the cbiMCbl riboswitch in Propionibacterium strain UF1.
Proceedings of the National Academy of Sciences of the United States of America. 117(1):602-609 [DOI] 10.1073/pnas.1916576116. [PMID] 31836694.
2019
Composition of the gut microbiota transcends genetic determinants of malaria infection severity and influences pregnancy outcome.
EBioMedicine. 44:639-655 [DOI] 10.1016/j.ebiom.2019.05.052. [PMID] 31160271.
2019
Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species.
Proceedings of the National Academy of Sciences of the United States of America. 116(49):24760-24769 [DOI] 10.1073/pnas.1908128116. [PMID] 31740609.
2019
Neonatal intestinal immune regulation by the commensal bacterium, P. UF1.
Mucosal immunology. 12(2):434-444 [DOI] 10.1038/s41385-018-0125-1. [PMID] 30647410.
2018
Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease.
Gastroenterology. 154(8):2178-2193 [DOI] 10.1053/j.gastro.2018.02.019. [PMID] 29454797.
2018
Dual-route targeted vaccine protects efficiently against botulinum neurotoxin A complex.
Vaccine. 36(1):155-164 [DOI] 10.1016/j.vaccine.2017.11.008. [PMID] 29180028.
2018
Regulation of Th17 cells by P. UF1 against systemic Listeria monocytogenes infection.
Gut microbes. 9(3):279-287 [DOI] 10.1080/19490976.2017.1417731. [PMID] 29420115.
2017
Commensal Propionibacterium strain UF1 mitigates intestinal inflammation via Th17 cell regulation.
The Journal of clinical investigation. 127(11):3970-3986 [DOI] 10.1172/JCI95376. [PMID] 28945202.
2017
Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis.
Cancer research. 77(10):2620-2632 [DOI] 10.1158/0008-5472.CAN-16-3472. [PMID] 28416491.
2017
The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue.
Nature microbiology. 2(12):1586-1591 [DOI] 10.1038/s41564-017-0057-7. [PMID] 29109476.
2016
Corrigendum: The Extracellular Calcium-Sensing Receptor in the Intestine: Evidence for Regulation of Colonic Absorption, Secretion, Motility, and Immunity.
Frontiers in physiology. 7 [DOI] 10.3389/fphys.2016.00315. [PMID] 27461573.
2016
Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.
Proceedings of the National Academy of Sciences of the United States of America. 113(19):E2627-35 [DOI] 10.1073/pnas.1515793113. [PMID] 27114524.
2016
The Extracellular Calcium-Sensing Receptor in the Intestine: Evidence for Regulation of Colonic Absorption, Secretion, Motility, and Immunity.
Frontiers in physiology. 7 [DOI] 10.3389/fphys.2016.00245. [PMID] 27458380.
2016
The role of the calcium-sensing receptor in gastrointestinal inflammation.
Seminars in cell & developmental biology. 49:44-51 [DOI] 10.1016/j.semcdb.2015.10.040. [PMID] 26709005.
2015
Advancing the use of Lactobacillus acidophilus surface layer protein A for the treatment of intestinal disorders in humans.
Gut microbes. 6(6):392-7 [DOI] 10.1080/19490976.2015.1107697. [PMID] 26647142.
2015
Gut dysbiosis is linked to hypertension.
Hypertension (Dallas, Tex. : 1979). 65(6):1331-40 [DOI] 10.1161/HYPERTENSIONAHA.115.05315. [PMID] 25870193.
2015
Impact of Gastrointestinal Bacillus anthracis Infection on Hepatic B Cells.
Toxins. 7(9):3805-17 [DOI] 10.3390/toxins7093805. [PMID] 26402706.
2015
New insights into gastrointestinal anthrax infection.
Trends in molecular medicine. 21(3):154-63 [DOI] 10.1016/j.molmed.2014.12.003. [PMID] 25577136.
2015
SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis.
The EMBO journal. 34(7):881-95 [DOI] 10.15252/embj.201490296. [PMID] 25666591.
2014
Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis Infection.
PloS one. 9(6) [DOI] 10.1371/journal.pone.0100532. [PMID] 24945934.
2014
Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses.
FEBS letters. 588(22):4158-66 [DOI] 10.1016/j.febslet.2014.05.007. [PMID] 24842610.
2014
Impaired colonic B-cell responses by gastrointestinal Bacillus anthracis infection.
The Journal of infectious diseases. 210(9):1499-507 [DOI] 10.1093/infdis/jiu280. [PMID] 24829464.
2013
Activation of B cells by a dendritic cell-targeted oral vaccine.
Current pharmaceutical biotechnology. 14(10):867-77 [PMID] 24372255.
2013
Colonic immune stimulation by targeted oral vaccine.
PloS one. 8(1) [DOI] 10.1371/journal.pone.0055143. [PMID] 23383086.
2013
Macrophages and chemokines as mediators of angiogenesis.
Frontiers in physiology. 4 [DOI] 10.3389/fphys.2013.00159. [PMID] 23847541.
2013
Microbial activation of gut dendritic cells and the control of mucosal immunity.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 33(11):619-31 [DOI] 10.1089/jir.2013.0046. [PMID] 23962004.
2013
Microbiota impact on the epigenetic regulation of colorectal cancer.
Trends in molecular medicine. 19(12):714-25 [DOI] 10.1016/j.molmed.2013.08.005. [PMID] 24051204.
2013
New generation of oral mucosal vaccines targeting dendritic cells.
Current opinion in chemical biology. 17(6):918-24 [DOI] 10.1016/j.cbpa.2013.06.013. [PMID] 23835515.
2013
Tailoring gut immune responses with lipoteichoic acid-deficient Lactobacillus acidophilus.
Frontiers in immunology. 4 [DOI] 10.3389/fimmu.2013.00025. [PMID] 23390423.
2013
Targeting aberrant colon cancer-specific DNA methylation with lipoteichoic acid-deficient Lactobacillus acidophilus.
Gut microbes. 4(1):84-8 [DOI] 10.4161/gmic.22822. [PMID] 23137966.
2012
Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid.
Proceedings of the National Academy of Sciences of the United States of America. 109(26):10462-7 [DOI] 10.1073/pnas.1207230109. [PMID] 22689992.
2012
Induction of intestinal pro-inflammatory immune responses by lipoteichoic acid.
Journal of inflammation (London, England). 9 [DOI] 10.1186/1476-9255-9-7. [PMID] 22423982.
2012
Mitigating colon cancer with a novel strain of Lactobacillus acidophilus: a (re-)balancing act.
Immunotherapy. 4(11):1087-9 [DOI] 10.2217/imt.12.98. [PMID] 23194356.
2012
Modulating intestinal immune responses by lipoteichoic acid-deficient Lactobacillus acidophilus.
Immunotherapy. 4(2):151-61 [DOI] 10.2217/imt.11.163. [PMID] 22339459.
2011
Lipoteichoic acid-deficient Lactobacillus acidophilus regulates downstream signals.
Immunotherapy. 3(3):337-47 [DOI] 10.2217/imt.10.119. [PMID] 21395377.
2011
MHC class II epitope nesting modulates dendritic cell function and improves generation of antigen-specific CD4 helper T cells.
Journal of immunology (Baltimore, Md. : 1950). 187(1):316-24 [DOI] 10.4049/jimmunol.1100658. [PMID] 21613617.
2011
Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid.
Proceedings of the National Academy of Sciences of the United States of America. 108 Suppl 1:4623-30 [DOI] 10.1073/pnas.1005066107. [PMID] 21282652.
2011
Reprogramming intestinal immunity is the answer to induced pathogenic inflammation.
Immunotherapy. 3(12):1415-7 [DOI] 10.2217/imt.11.140. [PMID] 22091675.
2010
Induction of protective immunity against microbial challenge by targeting antigens expressed by probiotic bacteria to mucosal dendritic cells.
Current HIV research. 8(4):323-9 [PMID] 20353394.
2010
Key roles of dendritic cells in lung infection and improving anthrax vaccines.
Trends in molecular medicine. 16(7):303-12 [DOI] 10.1016/j.molmed.2010.04.006. [PMID] 20554248.
2010
Targeted expression of anthrax protective antigen by Lactobacillus gasseri as an anthrax vaccine.
Future microbiology. 5(8):1289-96 [DOI] 10.2217/fmb.10.78. [PMID] 20722604.
2009
Anthrax, toxins and vaccines: a 125-year journey targeting Bacillus anthracis.
Expert review of anti-infective therapy. 7(2):219-36 [DOI] 10.1586/14787210.7.2.219. [PMID] 19254170.
2009
Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge.
Proceedings of the National Academy of Sciences of the United States of America. 106(11):4331-6 [DOI] 10.1073/pnas.0900029106. [PMID] 19246373.
2009
Fibroblastic reticular cell infection by hemorrhagic fever viruses.
Immunotherapy. 1(2):187-97 [DOI] 10.2217/1750743X.1.2.187. [PMID] 20635940.
2009
Fibroblastic reticular cells and their role in viral hemorrhagic fevers.
Expert review of anti-infective therapy. 7(4):423-35 [DOI] 10.1586/eri.09.13. [PMID] 19400762.
2009
Potential factors induced by filoviruses that lead to immune supression.
Current molecular medicine. 9(2):174-85 [PMID] 19275625.
2008
Microenvironmental impact on lung cell homeostasis and immunity during infection.
Expert review of vaccines. 7(4):457-66 [DOI] 10.1586/14760584.7.4.457. [PMID] 18444892.
2008
Specific Lactobacillus species differentially activate Toll-like receptors and downstream signals in dendritic cells.
Expert review of vaccines. 7(8):1155-64 [DOI] 10.1586/14760584.7.8.1155. [PMID] 18844590.
2008
Targeting mucosal dendritic cells with microbial antigens from probiotic lactic acid bacteria.
Expert review of vaccines. 7(2):163-74 [DOI] 10.1586/14760584.7.2.163. [PMID] 18324887.
2007
How Ebola and Marburg viruses battle the immune system.
Nature reviews. Immunology. 7(7):556-67 [PMID] 17589545.
2007
Poly-gamma-glutamate capsule-degrading enzyme treatment enhances phagocytosis and killing of encapsulated Bacillus anthracis.
Antimicrobial agents and chemotherapy. 51(1):215-22 [PMID] 17074794.
2007
Status and challenges of filovirus vaccines.
Vaccine. 25(11):1923-34 [PMID] 17241710.
2006
Activation of triggering receptor expressed on myeloid cells-1 on human neutrophils by marburg and ebola viruses.
Journal of virology. 80(14):7235-44 [PMID] 16809329.
2006
Filoviruses and the balance of innate, adaptive, and inflammatory responses.
Viral immunology. 19(4):602-12 [PMID] 17201655.
2005
Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization.
Proceedings of the National Academy of Sciences of the United States of America. 102(8):2880-5 [PMID] 15710900.
2005
Lactobacilli as natural enhancer of cellular immune response.
Discovery medicine. 5(26):199-203 [PMID] 20704910.
2004
Defining T-cell-mediated immune responses in rotavirus-infected juvenile rhesus macaques.
Journal of virology. 78(19):10258-64 [PMID] 15367591.
2004
Dendritic cells generated in the presence of GM-CSF plus IL-15 prime potent CD8+ Tc1 responses in vivo.
European journal of immunology. 34(1):66-73 [PMID] 14971031.
2004
Dendritic cells: In the forefront of immunopathogenesis and vaccine development – A review.
Journal of immune based therapies and vaccines. 2(1) [PMID] 14720301.
2004
Ebola and Marburg virus-like particles activate human myeloid dendritic cells.
Virology. 326(2):280-7 [PMID] 15302213.
2004
Identification of proteases employed by dendritic cells in the processing of protein purified derivative (PPD).
Journal of immune based therapies and vaccines. 2(1) [PMID] 15287985.
2004
Peptides identified through phage display direct immunogenic antigen to dendritic cells.
Journal of immunology (Baltimore, Md. : 1950). 172(12):7425-31 [PMID] 15187120.
2003
Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation.
The Journal of infectious diseases. 188(11):1630-8 [PMID] 14639532.
2003
Ebola virus-like particles protect from lethal Ebola virus infection.
Proceedings of the National Academy of Sciences of the United States of America. 100(26):15889-94 [PMID] 14673108.
2001
Interleukin 15 skews monocyte differentiation into dendritic cells with features of Langerhans cells.
The Journal of experimental medicine. 194(7):1013-20 [PMID] 11581322.
2001
Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950). 167(9):5067-76 [PMID] 11673516.
2000
Development of a peptide inhibitor of hyaluronan-mediated leukocyte trafficking.
The Journal of experimental medicine. 192(6):769-79 [PMID] 10993908.
1999
Interleukin 15 induces endothelial hyaluronan expression in vitro and promotes activated T cell extravasation through a CD44-dependent pathway in vivo.
The Journal of experimental medicine. 190(1):9-19 [PMID] 10429666.
1998
Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivo.
The Journal of clinical investigation. 101(6):1261-72 [PMID] 9502767.
1998
Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion.
The Journal of clinical investigation. 101(1):97-108 [PMID] 9421471.
1997
Cytokine expression and antigen-presenting capacity of 4F7+ dendritic cells derived from dermis, spleen, and lymph nodes.
Archives of dermatological research. 289(8):435-9 [PMID] 9266019.
1996
Dendritic cells produce macrophage inflammatory protein-1 gamma, a new member of the CC chemokine family.
Journal of immunology (Baltimore, Md. : 1950). 156(9):3102-6 [PMID] 8617929.
1996
Epidermal cells enhance interleukin 4 and immunoglobulin E production after stimulation with protein allergen.
The Journal of investigative dermatology. 107(4):582-8 [PMID] 8823364.
1996
Expression of the common cytokine receptor gamma chain by murine dendritic cells including epidermal Langerhans cells.
European journal of immunology. 26(1):156-60 [PMID] 8566059.
1996
Functional roles for granzymes in murine epidermal gamma(delta) T-cell-mediated killing of tumor targets.
The Journal of investigative dermatology. 107(5):738-42 [PMID] 8875959.
1995
Heat-stable antigen is expressed by murine keratinocytes and delivers costimulatory signals in T-cell activation.
Experimental dermatology. 4(5):291-6 [PMID] 8589919.
1995
Human keratinocyte-derived IL-12 affects LC-induced allogeneic T-cell responses.
Advances in experimental medicine and biology. 378:519-21 [PMID] 8526131.
1995
In vitro analysis of the phenotypical and functional properties of the 4F7+ cutaneous accessory dendritic cell.
Archives of dermatological research. 287(3-4):273-8 [PMID] 7598532.
1995
Interleukin (IL)-15 promotes the growth of murine epidermal gamma delta T cells by a mechanism involving the beta- and gamma c-chains of the IL-2 receptor.
The Journal of investigative dermatology. 105(6):837-43 [PMID] 7490480.
1995
Modulation of contact sensitivity responses by bacterial superantigen.
The Journal of investigative dermatology. 105(2):220-4 [PMID] 7636304.
1995
Processing and presentation of protein and parasite-derived antigens by 4F7+ dendritic cells.
Advances in experimental medicine and biology. 378:233-5 [PMID] 8526063.
1995
Ultraviolet B radiation up-regulates the expression of IL-15 in human skin.
Journal of immunology (Baltimore, Md. : 1950). 155(9):4492-6 [PMID] 7594612.
1994
Freshly isolated mouse 4F7+ splenic dendritic cells process and present exogenous antigens to T cells.
European journal of immunology. 24(12):3170-4 [PMID] 7805745.
1994
Identification and induction of human keratinocyte-derived IL-12.
The Journal of clinical investigation. 94(5):1799-805 [PMID] 7962524.
1994
Induction of hapten-specific tolerance by interleukin 10 in vivo.
The Journal of experimental medicine. 179(4):1397-402 [PMID] 8145053.
1994
Regulation of cytokine expression by interferon-alpha in human bone marrow stromal cells: inhibition of hematopoietic growth factors and induction of interleukin-1 receptor antagonist.
Blood. 84(12):4142-50 [PMID] 7994029.
1993
Expression of an epitope as detected by the novel monoclonal antibody 4F7 on dermal and epidermal dendritic cells. I. Identification and characterization of the 4F7+ dendritic cell in situ.
The Journal of investigative dermatology. 101(6):832-8 [PMID] 7504027.
1993
Functional and morphological characterization of 4F7+ spleen accessory dendritic cells.
International immunology. 5(6):615-24 [PMID] 8347556.
1992
A novel monoclonal antibody to a distinct subset of cutaneous dendritic cells.
The Journal of investigative dermatology. 99(5):56S-58S [PMID] 1431217.
1992
Increased level of intracellular MHC class II molecules in murine Langerhans cells following in vivo and in vitro administration of contact allergens.
The Journal of investigative dermatology. 99(5):545-9 [PMID] 1331245.
1992
Induction of inflammatory cytokines in murine keratinocytes upon in vivo stimulation with contact sensitizers and tolerizing analogues.
Experimental dermatology. 1(2):76-83 [PMID] 1365308.

Grants

Sep 2020 – Sep 2021
Bacteria-associated VB12 regulates neonatal ileal epithelium homeostasis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2020 – Jun 2022
Determinants of follicular helper T cell expansion in lupus
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Jul 2019 – Jun 2021
Novel oral targeted breast carcinoma vaccine
Role: Principal Investigator
Funding: FL BREAST CANCER FOU
Jan 2019 – Jul 2022
Gut dysbiosis and tryptophan metabolism in lupus
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
May 2016 – Sep 2020
Bacterial surface layer specific immune protection gut microbial infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jan 2016 – Dec 2018
Gut dysbiosis induces iupus
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Feb 2015 ACTIVE
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jul 2014 – Dec 2018
The Role of the Intestinal Microbiota in the Development of Anxiety and Depression in Breast Cancer Patients Receiving Chemotherapy.
Role: Principal Investigator
Funding: FL BREAST CANCER FOU
Sep 2011 – Jul 2018
Novel multivalent vaccine for anthrax and botulinum
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2007 – Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU

Education

Doctor of Philosophy in Cellular & Molecular Immunology
1991 · Johannes Gutenberg University
Master of Science in Cellular & Molecular Immunology
1989 · Johannes Gutenberg University
Bachelor of Science in Cellular & Molecular Biology
1986 · Johannes Gutenberg University/Germany

Contact Details

Phones:
Business:
(352) 294-4117
Emails:
Business:
m.zadeh@ufl.edu
Addresses:
Business Mailing:
PO Box 110880
GAINESVILLE FL 32611
Business Street:
2015 SW 16TH AVE BLDG 1017
GAINESVILLE FL 32608