Jon Kim

Jon Kim,

Assistant Professor

Department: Small Animal Clinical Sciences
Business Phone: (352) 294-4412
Business Email: jkim19@ufl.edu

About Jon Kim

Dr. Jon Kim, DVM, PhD is an Assistant Professor in the Department of Small Animal Clinical Sciences, College of Veterinary Medicine at the University of Florida. He earned his DVM from Konkuk University in South Korea. He received his Ph.D in Veterinary Pathology from the same school, where he established veterinary and comparative oncology research. He completed a post-doctoral work at University of Minnesota and Masonic Cancer Center, and established independent comparative oncology research program. As a faculty of the UF AI Initiative, Dr. Kim is focusing on development of novel diagnostic and clinical applications in the field of comparative oncology and translational medicine by utilizing AI and machine learning. His primary research interest is to define fundamental mechanisms of cancers, particularly brain tumors, soft tissue sarcomas, and bone tumors such as osteosarcomas. These tumors occur naturally in companion dogs and children, and his team focuses on revolutionizing comparative oncology research to improve human and animal health. The efforts include integration of AI applications and cutting edge biotechniques such as iPSC modeling, bioprinting, and bioinformatics to create novel reliable models for cancers.

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-1645-0036

Publications

2022
Evaluation of coated platelets, a subset of highly procoagulant platelets, in healthy dogs and dogs with neoplasia.
American journal of veterinary research. 83(10) [DOI] 10.2460/ajvr.22.03.0042. [PMID] 35973003.
2022
Non-invasive cancer detection in canine urine through Caenorhabditis elegans chemotaxis
Frontiers in Veterinary Science. 9 [DOI] 10.3389/fvets.2022.932474.
2021
Efficacy and safety of a thermosensitive hydrogel for endoscopic submucosal dissection: An in vivo swine study
PLOS ONE. 16(12) [DOI] 10.1371/journal.pone.0260458. [PMID] 34882721.
2021
Feasibility and effectiveness of endoscopic irreversible electroporation for the upper gastrointestinal tract: an experimental animal study.
Scientific reports. 11(1) [DOI] 10.1038/s41598-021-94583-w. [PMID] 34321494.
2021
Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions
Molecular Cancer Research. 19(5):847-861 [DOI] 10.1158/1541-7786.mcr-20-0937.
2021
Machine learning application identifies novel gene signatures from transcriptomic data of spontaneous canine hemangiosarcoma
Briefings in Bioinformatics. 22(4) [DOI] 10.1093/bib/bbaa252.
2020
Interleukin-8 in the Tumor Immune Niche: Lessons from Comparative Oncology.
Advances in experimental medicine and biology. 1240:25-33 [DOI] 10.1007/978-3-030-38315-2_2. [PMID] 32060885.
2020
PIK3CA mutations matter for cancer in dogs.
Research in veterinary science. 133:39-41 [DOI] 10.1016/j.rvsc.2020.09.001. [PMID] 32932196.
2020
Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux.
Frontiers in oncology. 10 [DOI] 10.3389/fonc.2020.614288. [PMID] 33598432.
2019
Comparative Approach to the Temporo-Spatial Organization of the Tumor Microenvironment.
Frontiers in oncology. 9 [DOI] 10.3389/fonc.2019.01185. [PMID] 31788448.
2019
Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma
Molecular Cancer Research. 17(12):2410-2421 [DOI] 10.1158/1541-7786.mcr-19-0221.
2018
Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers
Veterinary and Comparative Oncology. 16(1):E176-E184 [DOI] 10.1111/vco.12368. [PMID] 29152836.
2017
Establishment of a Patient-Derived Xenograft of Canine Enteropathy-Associated T-Cell Lymphoma, Large Cell Type.
Journal of comparative pathology. 156(1):37-41 [DOI] 10.1016/j.jcpa.2016.11.271. [PMID] 28011041.
2017
Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma.
Veterinary and comparative oncology. 15(2):315-327 [DOI] 10.1111/vco.12165. [PMID] 26337509.
2017
Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR.
Molecular cancer therapeutics. 16(5):956-965 [DOI] 10.1158/1535-7163.MCT-16-0637. [PMID] 28193671.
2016
Anti-Insulin Immune Responses Are Detectable in Dogs with Spontaneous Diabetes.
PloS one. 11(3) [DOI] 10.1371/journal.pone.0152397. [PMID] 27031512.
2016
Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors.
Oncotarget. 7(36):57752-57769 [DOI] 10.18632/oncotarget.10759. [PMID] 27458163.
2015
Association of Sphingosine-1-phosphate (S1P)/S1P Receptor-1 Pathway with Cell Proliferation and Survival in Canine Hemangiosarcoma.
Journal of veterinary internal medicine. 29(4):1088-97 [DOI] 10.1111/jvim.13570. [PMID] 26118793.
2015
CD44+/CD24- Cancer Stem Cells Are Associated With Higher Grade of Canine Mammary Carcinomas.
Veterinary pathology. 52(6):1041-4 [DOI] 10.1177/0300985815593121. [PMID] 26173453.
2015
Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers.
PLoS genetics. 11(2) [DOI] 10.1371/journal.pgen.1004922. [PMID] 25642983.
2015
Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future Perspectives.
Veterinary sciences. 2(4):388-405 [DOI] 10.3390/vetsci2040388. [PMID] 29061949.
2014
Identification of three molecular and functional subtypes in canine hemangiosarcoma through gene expression profiling and progenitor cell characterization.
The American journal of pathology. 184(4):985-995 [DOI] 10.1016/j.ajpath.2013.12.025. [PMID] 24525151.
2014
Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment.
Experimental cell research. 323(1):155-164 [DOI] 10.1016/j.yexcr.2014.02.020. [PMID] 24582862.
2013
Breed-related differences in altered BRCA1 expression, phenotype and subtype in malignant canine mammary tumors.
Veterinary journal (London, England : 1997). 195(3):366-72 [DOI] 10.1016/j.tvjl.2012.07.014. [PMID] 22901454.
2013
Correlation of tumor-infiltrating lymphocytes to histopathological features and molecular phenotypes in canine mammary carcinoma: A morphologic and immunohistochemical morphometric study.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 77(2):142-9 [PMID] 24082407.
2013
Identification of triple-negative and basal-like canine mammary carcinomas using four basal markers.
Journal of comparative pathology. 148(4):298-306 [DOI] 10.1016/j.jcpa.2012.08.009. [PMID] 23079102.
2013
Infiltrating Foxp3+ regulatory T cells and histopathological features in canine classical and spermatocytic seminomas.
Reproduction in domestic animals = Zuchthygiene. 48(2):218-22 [DOI] 10.1111/j.1439-0531.2012.02135.x. [PMID] 22775571.
2012
Angiogenesis and expression of vascular endothelial growth factor, tumour necrosis factor-α and hypoxia inducible factor-1α in canine renal cell carcinoma.
Journal of comparative pathology. 147(2-3):129-38 [DOI] 10.1016/j.jcpa.2011.12.006. [PMID] 22300704.
2012
Correlation of Foxp3 positive regulatory T cells with prognostic factors in canine mammary carcinomas.
Veterinary journal (London, England : 1997). 193(1):222-7 [DOI] 10.1016/j.tvjl.2011.10.022. [PMID] 22130461.
2012
Increased expression of vascular endothelial growth factor in neo-vascularized canine brain tissue.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 76(1):62-8 [PMID] 22754097.
2012
P-glycoprotein expression in canine mammary gland tumours related with myoepithelial cells.
Research in veterinary science. 93(3):1346-52 [DOI] 10.1016/j.rvsc.2012.04.004. [PMID] 22554937.
2012
Possible role of Snail expression as a prognostic factor in canine mammary neoplasia.
Journal of comparative pathology. 147(2-3):121-8 [DOI] 10.1016/j.jcpa.2011.12.002. [PMID] 22297072.
2012
Primary central nervous system B-cell lymphoma in a young dog.
The Canadian veterinary journal = La revue veterinaire canadienne. 53(5):559-64 [PMID] 23115372.
2011
CDX-2 and HER-3 expression in canine gastric and colorectal adenocarcinomas.
Journal of comparative pathology. 145(1):12-9 [DOI] 10.1016/j.jcpa.2010.11.007. [PMID] 21238975.
2011
Expression of HER-2 and nuclear localization of HER-3 protein in canine mammary tumors: histopathological and immunohistochemical study.
Veterinary journal (London, England : 1997). 189(3):318-22 [DOI] 10.1016/j.tvjl.2010.08.012. [PMID] 20947393.
2011
Histopathological and immunohistochemical comparison of the brain of human patients with Alzheimer’s disease and the brain of aged dogs with cognitive dysfunction.
Journal of comparative pathology. 145(1):45-58 [DOI] 10.1016/j.jcpa.2010.11.004. [PMID] 21256508.
2011
Inflammatory mammary carcinoma with metastasis to the brain and distant organs in a spayed Shih Tzu dog.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 23(5):1079-82 [DOI] 10.1177/1040638711416622. [PMID] 21908380.
2011
Pro- and anti-inflammatory cytokine expression and histopathological characteristics in canine brain with traumatic brain injury.
Journal of veterinary science. 12(3):299-301 [PMID] 21897106.
2011
Tryptase-positive mast cells correlate with angiogenesis in canine mammary carcinoma.
Journal of comparative pathology. 144(2-3):157-63 [DOI] 10.1016/j.jcpa.2010.08.006. [PMID] 20934709.
2010
Canine classical seminoma: a specific malignant type with human classifications is highly correlated with tumor angiogenesis.
BMC cancer. 10 [DOI] 10.1186/1471-2407-10-243. [PMID] 20509912.
2010
Characterization of canine oral papillomavirus by histopathological and genetic analysis in Korea.
Journal of veterinary science. 11(1):21-5 [PMID] 20195061.
2010
Histopathological retrospective study of canine renal disease in Korea, 2003~2008.
Journal of veterinary science. 11(4):277-83 [PMID] 21113095.
2010
Lymphocyte infiltration, expression of interleukin (IL) -1, IL-6 and expression of mutated breast cancer susceptibility gene-1 correlate with malignancy of canine mammary tumours.
Journal of comparative pathology. 142(2-3):177-86 [DOI] 10.1016/j.jcpa.2009.10.023. [PMID] 19959182.
2009
Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors.
Journal of veterinary science. 10(1):1-7 [PMID] 19255517.
2009
Retrospective study of melamine/cyanuric acid-induced renal failure in dogs in Korea between 2003 and 2004.
Veterinary pathology. 46(2):348-54 [DOI] 10.1354/vp.46-2-348. [PMID] 19261650.
2008
Effects of T lymphocytes, interleukin-1, and interleukin-6 on renal fibrosis in canine end-stage renal disease.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 20(5):585-92 [PMID] 18776090.
Transcriptional and Functional Activity of Hemangiosarcoma Support Bone Marrow Nurse Cell Ontogeny
. [DOI] 10.1101/2021.05.21.445198.

Grants

Oct 2022 ACTIVE
Reprogramming the Tumor Immune Niche in Canine Hemangiosarcoma
Role: Principal Investigator
Funding: AMER KENNEL CLUB

Education

PhD
2011 · Konkuk University, Seoul, South Korea
DVM
2008 · Konkuk University, Seoul, South Korea

Contact Details

Phones:
Business:
(352) 294-4412
Emails:
Business:
jkim19@ufl.edu
Addresses:
Business Mailing:
PO Box 100116
2015 SW 16TH AVE
GAINESVILLE FL 32610
Business Street:
V2-147 VAB
2015 SW 16TH AVE
GAINESVILLE FL 32608