Seokyoung Kang

Seokyoung Kang,

Research Assistant Professor

Department: Department of Infectious Diseases & Immunology
Business Phone: (352) 294-8837
Business Email: skang1@ufl.edu

Research Profile

The long-term goal of Dr. Kang’s research is to reduce transmission of various arboviruses transmitted by Aedes mosquitoes, such as Ae. aegypti and Ae. albopictus. Aedes mosquitoes are the primary vectors responsible for transmitting many human-infecting viruses, such as Zika, dengue and chikungunya. Because of a lack of effective vaccines or therapeutic drugs, mosquito control strategies like bed-netting and insecticide-usage remain the primary approaches to reduce viral transmission worldwide. Some of the relatively newer strategies involve reducing viral transmission in mosquitoes using transmission-blocking vaccines or small molecules (low molecular-weight active and/or regulatory molecules)—the use and development of which should be preceded by elucidating how mosquitoes respond to the viral infection. Dr. Kang pursues research to understand the mosquito’s immune system and the basic biology of mosquitoes in the field against arboviruses. Currently, he is characterizing dengue virus restriction factors and Zika virus host/restriction factors in local Aedes mosquitoes.

Publications

2021
Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti.
Communications biology. 4(1) [DOI] 10.1038/s42003-020-01614-9. [PMID] 33452408.
2020
Profiling Transcripts of Vector Competence between Two Different Aedes aegypti Populations in Florida.
Viruses. 12(8) [DOI] 10.3390/v12080823. [PMID] 32751270.
2020
Under-the-Radar Dengue Virus Infections in Natural Populations of Aedes aegypti Mosquitoes.
mSphere. 5(2) [DOI] 10.1128/mSphere.00316-20. [PMID] 32350095.
2019
Homologs of Human Dengue-Resistance Genes, FKBP1B and ATCAY, Confer Antiviral Resistance in Aedes aegypti Mosquitoes.
Insects. 10(2) [DOI] 10.3390/insects10020046. [PMID] 30717390.
2019
Identification of anti-flaviviral drugs with mosquitocidal and anti-Zika virus activity in Aedes aegypti.
PLoS neglected tropical diseases. 13(8) [DOI] 10.1371/journal.pntd.0007681. [PMID] 31430351.
2018
Aminopeptidase secreted by Chromobacterium sp. Panama inhibits dengue virus infection by degrading the E protein.
PLoS neglected tropical diseases. 12(4) [DOI] 10.1371/journal.pntd.0006443. [PMID] 29694346.
2018
Culex quinquefasciatus (Diptera: Culicidae) From Florida Transmitted Zika Virus.
Frontiers in microbiology. 9 [DOI] 10.3389/fmicb.2018.00768. [PMID] 29755428.
2018
Optimization of double-stranded RNAi intrathoracic injection method in Aedes aegypti.
Entomological research. 48(4):269-278 [DOI] 10.1111/1748-5967.12300. [PMID] 30505333.
2017
Aedes aegypti Molecular Responses to Zika Virus: Modulation of Infection by the Toll and Jak/Stat Immune Pathways and Virus Host Factors.
Frontiers in microbiology. 8 [DOI] 10.3389/fmicb.2017.02050. [PMID] 29109710.
2017
An Aedes aegypti-associated fungus increases susceptibility to dengue virus by modulating gut trypsin activity.
eLife. 6 [DOI] 10.7554/eLife.28844. [PMID] 29205153.
2016
Comprehensive DNA methylation analysis of the Aedes aegypti genome.
Scientific reports. 6 [DOI] 10.1038/srep36444. [PMID] 27805064.
2016
Mosquito gut antiparasitic and antiviral immunity.
Developmental and comparative immunology. 64:53-64 [DOI] 10.1016/j.dci.2016.01.015. [PMID] 26827888.
2016
The Golgi associated ERI3 is a Flavivirus host factor.
Scientific reports. 6 [DOI] 10.1038/srep34379. [PMID] 27682269.
2014
Chromobacterium Csp_P reduces malaria and dengue infection in vector mosquitoes and has entomopathogenic and in vitro anti-pathogen activities.
PLoS pathogens. 10(10) [DOI] 10.1371/journal.ppat.1004398. [PMID] 25340821.
2014
Suppressing dengue-2 infection by chemical inhibition of Aedes aegypti host factors.
PLoS neglected tropical diseases. 8(8) [DOI] 10.1371/journal.pntd.0003084. [PMID] 25101828.
2013
Transcriptomic profiling of diverse Aedes aegypti strains reveals increased basal-level immune activation in dengue virus-refractory populations and identifies novel virus-vector molecular interactions.
PLoS neglected tropical diseases. 7(7) [DOI] 10.1371/journal.pntd.0002295. [PMID] 23861987.
2011
High quality RNA isolation from Aedes aegypti midguts using laser microdissection microscopy.
Parasites & vectors. 4 [DOI] 10.1186/1756-3305-4-83. [PMID] 21595925.
2008
Ex vivo promoter analysis of antiviral heat shock cognate 70B gene in Anopheles gambiae.
Virology journal. 5 [DOI] 10.1186/1743-422X-5-136. [PMID] 18986525.
2008
RNA interference in infectious tropical diseases.
The Korean journal of parasitology. 46(1):1-15 [DOI] 10.3347/kjp.2008.46.1.1. [PMID] 18344671.

Education

PhD – Parasitology
2011 · Tulane University
MS – Applied Entomology
2000 · Korea University

Contact Details

Phones:
Business:
(352) 294-8837
Emails:
Business:
skang1@ufl.edu

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