Autumn N Harris

Autumn N Harris, DVM

Assistant Professor

Department: Small Animal Clinical Sciences
Business Email: harrisa@ufl.edu

About Autumn N Harris

My name is Dr. Autumn Harris. I am a board-certified veterinary internist at the Small Animal Hospital at the University of Florida, College of Veterinary Medicine where I work as a clinician and researcher. I treat all animals with kidney and urinary tract diseases. I am especially passionate about improving the lives of dogs & cats with chronic kidney disease. My areas of interest for clinical research focus on improving our understanding of kidney failure with a particular focus on acid-base balance so we can optimize medical treatments for pets affected with this common disease.

Related Links:

Accomplishments

C.E. Cornelius Young Investigator Award
2020 · College of Veterinary Medicine, University of Florida
Postdoctoral Excellence in Renal Research Award
2019 · American Physiological Society
Resident Best Paper Award Author
2016 · Journal of Feline Medicine and Surgery
Phi Zeta Veterinary Honor Society
2012 · Mississippi State University
American Society of Animal Science Scholastic Achievement Award
2008 · Mississippi State University

Teaching Profile

Courses Taught
2020
VEM5200 Pnt Care Clin Skill 1
2019-2025
VEM5741 Small Animal Internal Medicine Clerkship
2019,2021-2025
VEM5841 Adv. Small Animal Medicine Clerkship
2021-2025
VEM5305 Veterinary Urology
2023
VEM5402L Introduction to Surgery Lab

Board Certifications

  • Diplomate, Small Animal Internal Medicine
    American College of Veterinary Internal Medicine

Clinical Profile

Areas of Interest
  • Chronic kidney disease
  • Distal renal tubular acidosis
  • Glomerulonephritis
  • Proximal renal tubular acidosis
  • Urinary incontinence

Research Profile

My research is both benchtop translational science as well as clinical discovery. My benchtop translational science is directed at understanding the mechanisms through which the kidneys maintain the correct acid-base balance in the body. My clinical research is focused on the goal of improving the lives of pets living with chronic kidney disease (CKD). I have reported on aspects such as novel biomarkers to aid in early diagnosis of common complications associated with worse outcomes in CKD, the use of novel therapies for CKD treatment, the renin-angiotensin-aldosterone system in CKD and high blood pressure, the role of the kidneys as it relates to heart disease. I am especially focused on the investigation of acid-base balance on CKD disease progression and determining if we can intervene medically to improve outcomes. Kidney disease is very common in cats and dogs, and while we have many medical options available for disease management, it is important that we continue clinical research efforts to better understand and treat pets with kidney disease.

Areas of Interest
  • Evaluation of the Renin-Angiotensin-Aldosterone system
  • Proteinuria
  • Renal Ammonia Metabolism
  • Renal Physiology
  • Sex Differences
  • chronic kidney disease
Open Researcher and Contributor ID (ORCID)

0000-0002-2329-3905

Publications

2024
Association of proteinuria at time of diagnosis with survival times in dogs with lymphoma.
Journal of veterinary internal medicine. [DOI] 10.1111/jvim.17144. [PMID] 39001675.
2024
Correlation between urine anion gap and urine ammonia-creatinine ratio in healthy cats and cats with kidney disease.
Journal of veterinary internal medicine. 38(2):1068-1073 [DOI] 10.1111/jvim.17002. [PMID] 38348890.
2024
Development of a reference interval for urinary ammonia‐to‐creatinine ratio in feline patients
Veterinary Clinical Pathology. 53(1):136-140 [DOI] 10.1111/vcp.13327.
2024
Sex differences in renal transporters: assessment and functional consequences.
Nature reviews. Nephrology. 20(1):21-36 [DOI] 10.1038/s41581-023-00757-2. [PMID] 37684523.
2023
An Update on Kidney Ammonium Transport Along the Nephron
Advances in Kidney Disease and Health. 30(2):189-196 [DOI] 10.1053/j.akdh.2022.12.005.
2023
Stump pyometra in a spayed female dog secondary to tamoxifen.
Veterinary medicine and science. 9(1):47-52 [DOI] 10.1002/vms3.1041. [PMID] 36571806.
2023
The proximal tubule through an NBCe1-dependent mechanism regulates collecting duct phenotypic and remodeling responses to acidosis
American Journal of Physiology-Renal Physiology. 324(1):F12-F29 [DOI] 10.1152/ajprenal.00175.2022. [PMID] 36264886.
2023
Use of serum osmolality to identify heart disease stage in dogs and relationship to mathematical chloride correction.
Journal of veterinary internal medicine. 37(6):2011-2020 [DOI] 10.1111/jvim.16863. [PMID] 37702389.
2022
Acid-base effects of combined renal deletion of NBCe1-A and NBCe1-B
American Journal of Physiology-Renal Physiology. 322(2):F208-F224 [DOI] 10.1152/ajprenal.00358.2021. [PMID] 35001662.
2022
Case Report: Septic Pericarditis With Achromobacter xyloxidans in an Immunosuppressed Dog.
Frontiers in veterinary science. 9 [DOI] 10.3389/fvets.2022.884654. [PMID] 35664856.
2021
Establishment of an RI for the urine ammonia‐to‐creatinine ratio in dogs
Veterinary Clinical Pathology. 50(4):597-602 [DOI] 10.1111/vcp.13032. [PMID] 34854107.
2021
Familial nephropathy in Bracchi Italiani: 8 cases (2012-2019).
Journal of the American Veterinary Medical Association. 259(12):1422-1427 [DOI] 10.2460/javma.20.07.0420. [PMID] 34757934.
2021
Role of the renal androgen receptor in sex differences in ammonia metabolism
American Journal of Physiology-Renal Physiology. 321(5):F629-F644 [DOI] 10.1152/ajprenal.00260.2021. [PMID] 34605272.
2021
Sex differences in renal ammonia metabolism
American Journal of Physiology-Renal Physiology. 320(1):F55-F60 [DOI] 10.1152/ajprenal.00531.2020. [PMID] 33308019.
2020
NBCe1-A is required for the renal ammonia and K+response to hypokalemia
American Journal of Physiology-Renal Physiology. 318(2):F402-F421 [DOI] 10.1152/ajprenal.00481.2019. [PMID] 31841393.
2020
Testosterone modulates renal ammonia metabolism
American Journal of Physiology-Renal Physiology. 318(4):F922-F935 [DOI] 10.1152/ajprenal.00560.2019. [PMID] 32116019.
2019
Differences in acidosis-stimulated renal ammonia metabolism in the male and female kidney
American Journal of Physiology-Renal Physiology. 317(4):F890-F905 [DOI] 10.1152/ajprenal.00244.2019. [PMID] 31390234.
2019
Regulation of renal NaDC1 expression and citrate excretion by NBCe1-A.
American journal of physiology. Renal physiology. 317(2):F489-F501 [DOI] 10.1152/ajprenal.00015.2019. [PMID] 31188034.
2018
Differences in renal ammonia metabolism in male and female kidney.
American journal of physiology. Renal physiology. 315(2):F211-F222 [DOI] 10.1152/ajprenal.00084.2018. [PMID] 29561185.
2018
Effects of Hyperkalemia on Renal Ammonia Metabolism
Journal of the American Society of Nephrology. 29(5):1411-1425
2018
Expression of the B splice variant of NBCe1 (SLC4A4) in the mouse kidney.
American journal of physiology. Renal physiology. 315(3):F417-F428 [DOI] 10.1152/ajprenal.00515.2017. [PMID] 29631353.
2018
Mechanism of Hyperkalemia-Induced Metabolic Acidosis
Journal of the American Society of Nephrology. 29(5):1411-1425 [DOI] 10.1681/asn.2017111163.
2018
Mechanism of Hyperkalemia-Induced Metabolic Acidosis
Journal of the American Society of Nephrology. 29(5):1411-1425 [DOI] 10.1681/asn.2017111163.
2018
NBCe1-A Regulates Proximal Tubule Ammonia Metabolism under Basal Conditions and in Response to Metabolic Acidosis
Journal of the American Society of Nephrology. 29(4):1182-1197 [DOI] 10.1681/asn.2017080935.
2018
NBCe1-A Regulates Proximal Tubule Ammonia Metabolism under Basal Conditions and in Response to Metabolic Acidosis
Journal of the American Society of Nephrology. 29(4):1182-1197 [DOI] 10.1681/asn.2017080935.
2017
Biologic variability of N-terminal pro-brain natriuretic peptide in adult healthy cats.
Journal of feline medicine and surgery. 19(2):216-223 [DOI] 10.1177/1098612X15623825. [PMID] 26767980.
2017
Investigation of an N‐Terminal Prohormone of Brain Natriuretic Peptide Point‐of‐Care ELISA in Clinically Normal Cats and Cats With Cardiac Disease
Journal of Veterinary Internal Medicine. 31(4):994-999 [DOI] 10.1111/jvim.14776. [PMID] 28617995.
2016
Use of endoscopic-assisted argon plasma coagulation for the treatment of colonic vascular ectasia (angiodysplasia) in an adult dog.
Journal of the American Veterinary Medical Association. 248(5):526-31 [DOI] 10.2460/javma.248.5.526. [PMID] 26885595.
2014
NEGATIVE REGULATORY EFFECTS OF PHOSPHATIDYLINOSITOL3-KINASE PATHWAY ON PHAGOCYTOSIS AND MACROPINOCYTOSIS IN BOVINE MONOCYTES.
Journal of veterinary medicine and research. 1(2) [PMID] 25893219.

Grants

Sep 2023 ACTIVE
Ammonia Excretion, A Novel Biomarker and Therapeutic Target for Feline CKD
Role: Principal Investigator
Funding: EVERYCAT HEALTH FOUNDATION
Mar 2023 ACTIVE
Kidney Disease in the Bracco Italiano
Role: Co-Project Director/Principal Investigator
Funding: BRACCO ITALIANO HEALTH FOUNDATION
Mar 2023 – Feb 2024
Rapamycin: Evaluation of Effectiveness in Renal Senescence The REVERSE Study
Role: Principal Investigator
Funding: OHIO STATE UNIV via TRIVIUMVET DESIGNATED ACTIVITY COMPANY
May 2022 ACTIVE
Novel Biomarker and Therapeutic Target for Chronic Kidney Disease in Dogs
Role: Principal Investigator
Funding: AMER KENNEL CLUB CANINE HLTH FOU
Apr 2022 ACTIVE
Tolerability and clinical efficacy of acetazolamide for treatment of hypochloremia in canine congestive heart failure
Role: Co-Investigator
Funding: AMER KENNEL CLUB CANINE HLTH FOU
Apr 2019 ACTIVE
Sex Differences in Renal Ammonia Metabolism
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK

Education

Post Doctoral Fellow
2016-2019 · Division of Nephrology, Hypertension, and Renal Transplantation; University of Florida
Resident, Small Animal Internal Medicine
2013-2016 · College of Veterinary Medicine; University of Florida
Intern, Small Animal Medicine and Surgery
2012-2013 · College of Veterinary Medicine, Kansas State University
Doctor of Veterinary Medicine
2008-2012 · College of Veterinary Medicine; Mississippi State University

Contact Details

Emails:
Business:
harrisa@ufl.edu
Addresses:
Business Mailing:
PO Box 100224
GAINESVILLE FL 32610