David E Freeman

David E Freeman,

Appleton Endowed Professor

Department: Large Animal Clinical Sciences
Business Phone: (352) 294-4362
Business Email: freemand@ufl.edu

Accomplishments

Award “in recognition of outstanding contributions to the development of equine surgery worldwide”
2011 · Federal University of Minas Gerais
Graduate Faculty
2007 · University of Florida, Research and Graduate Programs
Teacher of the Year Award
2007 · UF College of Veterinary Medicine
Phi Zeta Member
2006-2020 · University of Illinois, University of Florida
Sir Frederick Hobday Memorial Lecture: Advances in Diagnosis and Treatment of Colic
2004 · British Equine Veterinary Association, Royal College of Physicians

Research Profile

Pathophysiology and treatment of diseases that cause colic in horses, with special emphasis on ischemic diseases of the small and large intestines.

Publications

2021
Effect of feed deprivation on daily water consumption in healthy horses.
Equine veterinary journal. 53(1):117-124 [DOI] 10.1111/evj.13259. [PMID] 32150657.
2021
Effect of Feed Intake on Water Consumption in Horses: Relevance to Maintenance Fluid Therapy.
Frontiers in veterinary science. 8 [DOI] 10.3389/fvets.2021.626081. [PMID] 33732739.
2021
J-incision to approach the cranial abdomen in the adult horse.
Veterinary surgery : VS. 50(3):600-606 [DOI] 10.1111/vsu.13597. [PMID] 33624855.
2019
A standing pararectal approach to treat small colon obstruction by a pedunculated lipoma
Equine Veterinary Education. 31(11):594-598 [DOI] 10.1111/eve.12898.
2019
Is There Still a Place for Lidocaine in the (Postoperative) Management of Colics?
The Veterinary clinics of North America. Equine practice. 35(2):275-288 [DOI] 10.1016/j.cveq.2019.03.003. [PMID] 31076222.
2018
Post-operative reflux – a surgeon’s perspective
Equine Veterinary Education. 30(12):671-680 [DOI] 10.1111/eve.12735.
2017
Characterization of equine vitamin D-binding protein, development of an assay, and assessment of plasma concentrations of the protein in healthy horses and horses with gastrointestinal disease.
American journal of veterinary research. 78(6):718-728 [DOI] 10.2460/ajvr.78.6.718. [PMID] 28541149.
2017
Effect of lidocaine on inflammation in equine jejunum subjected to manipulation only and remote to intestinal segments subjected to ischemia.
American journal of veterinary research. 78(8):977-989 [DOI] 10.2460/ajvr.78.8.977. [PMID] 28738006.
2017
Response to early repeat celiotomy in horses after a surgical treatment of jejunal strangulation.
Veterinary surgery : VS. 46(6):843-850 [DOI] 10.1111/vsu.12670. [PMID] 28556997.
2016
Effects of ischemia and reperfusion on eosinophilic accumulation and distribution in mucosa of equine jejunum and colon.
American journal of veterinary research. 77(5):534-9 [DOI] 10.2460/ajvr.77.5.534. [PMID] 27111021.
2016
Surgical Repair of a Chronic, Oronasal Fistula in a Horse Using An Alveolar Bone Flap
Equine Veterinary Education. 28(10):550-555 [DOI] 10.1111/eve.12418.
2015
Anatomy of the vestibule of the omental bursa and epiploic foramen in the horse.
Equine veterinary journal. 47(1):83-90 [DOI] 10.1111/evj.12232. [PMID] 24467749.
2015
Letter to the editor.
Equine veterinary journal. 47(2) [DOI] 10.1111/evj.12389. [PMID] 25644769.
2015
Update on disorders and treatment of the guttural pouch.
The Veterinary clinics of North America. Equine practice. 31(1):63-89 [DOI] 10.1016/j.cveq.2014.11.010. [PMID] 25770066.
2014
Effects of experimental mechanical manipulations on local inflammation in the jejunum of horses.
American journal of veterinary research. 75(4):385-91 [DOI] 10.2460/ajvr.75.4.385. [PMID] 24669925.
2014
Standing diagnostic and therapeutic equine abdominal surgery.
The Veterinary clinics of North America. Equine practice. 30(1):143-68 [DOI] 10.1016/j.cveq.2013.11.010. [PMID] 24680210.
2014
Theriogenology question of the month. Peritonitis secondary to a vaginal laceration during natural breeding in a mare
Javma-Journal of the American Veterinary Medical Association. 1143-6 [DOI] 10.2460/javma.244.10.1143. [PMID] 24786159.
2014
Theriogenology question of the month. Peritonitis secondary to a vaginal laceration during natural breeding in a mare.
Journal of the American Veterinary Medical Association. 244(10):1143-6 [DOI] 10.2460/javma.244.10.1143. [PMID] 24786159.
2013
A single caudally based frontonasal bone flap for treatment of bilateral mucocele in the paranasal sinuses of an American miniature horse.
Veterinary surgery : VS. 42(4):427-32 [DOI] 10.1111/j.1532-950X.2013.01093.x. [PMID] 23373723.
2013
Antimicrobial use during colic surgery: finding the right strategy.
The Veterinary record. 172(11):285-6 [DOI] 10.1136/vr.f1549. [PMID] 23504168.
2013
Effect of large colon ischemia and reperfusion on concentrations of calprotectin and other clinicopathologic variables in jugular and colonic venous blood in horses.
American journal of veterinary research. 74(10):1281-90 [DOI] 10.2460/ajvr.74.10.1281. [PMID] 24066912.
2012
Effects of ischemia and reperfusion on production of nitrotyrosine, activation of eosinophils, and apoptosis in the large colonic mucosa of horses.
American journal of veterinary research. 73(1):53-61 [DOI] 10.2460/ajvr.73.1.53. [PMID] 22204288.
2012
Ischemia in Equine Intestine – Mechanisms of Injury and Methods of Treatment
Pferdeheilkunde. 28:366-387
2012
Liver lobe torsion in six horses.
Journal of the American Veterinary Medical Association. 241(5):615-20 [DOI] 10.2460/javma.241.5.615. [PMID] 22916859.
2012
Removal of ureteral calculi in two geldings via a standing flank approach.
Journal of the American Veterinary Medical Association. 241(9):1214-20 [DOI] 10.2460/javma.241.9.1214. [PMID] 23078570.
2012
The contribution of Barrie Edwards to the treatment of colic in the horse: an international perspective.
Equine veterinary journal. 44(2):127-9 [DOI] 10.1111/j.2042-3306.2012.00548.x. [PMID] 22309252.
2012
The effects of low-level laser therapy in a rat model of intestinal ischemia-reperfusion injury.
Lasers in surgery and medicine. 44(7):580-7 [DOI] 10.1002/lsm.22060. [PMID] 22886545.
2011
Clinical comparison between a continuous Lembert pattern wrapped in a carboxymethylcellulose and hyaluronate membrane with an interrupted Lembert pattern for one-layer jejunojejunostomy in horses.
Equine veterinary journal. 43(6):708-13 [DOI] 10.1111/j.2042-3306.2010.00340.x. [PMID] 21815916.
2011
In vitro and in vivo responses of mucosa from the large colon of horses to ischemia and reperfusion.
American journal of veterinary research. 72(7):982-9 [DOI] 10.2460/ajvr.72.7.982. [PMID] 21728860.
2010
Comparison of complications and long-term survival rates following hand-sewn versus stapled side-to-side jejunocecostomy in horses with colic.
Journal of the American Veterinary Medical Association. 237(9):1060-7 [DOI] 10.2460/javma.237.9.1060. [PMID] 21034346.
2010
Comparison of surgical and medical treatment of 49 postpartum mares with presumptive or confirmed uterine tears.
Veterinary surgery : VS. 39(2):254-60 [DOI] 10.1111/j.1532-950X.2010.00645.x. [PMID] 20210976.
2009
Carboxymethylcellulose and adhesion formation in horses.
Veterinary surgery : VS. 38(3) [DOI] 10.1111/j.1532-950X.2009.00497_2.x. [PMID] 19573112.
2009
Chemical Neuroanatomy of the Myenteric Plexus in the Equine Intestine
Journal of Neurochemistry. 110
2009
Effects of flunixin meglumine on recovery of colonic mucosa from ischemia in horses.
American journal of veterinary research. 70(2):236-46 [DOI] 10.2460/ajvr.70.2.236. [PMID] 19231957.
2009
Epidemiologic analysis of nosocomial Salmonella infections in hospitalized horses.
Journal of the American Veterinary Medical Association. 234(1):108-19 [DOI] 10.2460/javma.234.1.108. [PMID] 19119974.
2009
Expression of cyclooxygenase-1 and -2 in the left dorsal colon after different durations of ischemia and reperfusion in horses.
American journal of veterinary research. 70(12):1536-44 [DOI] 10.2460/ajvr.70.12.1536. [PMID] 19951126.
2009
Expression of cyclooxygenase-1 and -2 in the left dorsal colon after different durations of ischemia and reperfusion in horses.
American Journal of Veterinary Research. 70(12) [DOI] 10.2460/ajvr.70.12.1536. [PMID] 19951126.
2008
Complications of surgery for diseases of the guttural pouch.
The Veterinary clinics of North America. Equine practice. 24(3):485-97, vii [DOI] 10.1016/j.cveq.2008.10.003. [PMID] 19203697.
2008
Detection of calprotectin and its correlation to the accumulation of neutrophils within equine large colon during ischaemia and reperfusion.
Equine veterinary journal. 40(4):393-9 [DOI] 10.2746/042516408X302500. [PMID] 18487110.
2008
Effect of a novel solution for organ preservation on equine large colon in an isolated pulsatile perfusion system.
Equine veterinary journal. 40(4):306-12 [DOI] 10.2746/042516408X295455. [PMID] 18356130.
2008
Effect of suckling an isotonic solution of sodium acetate, sodium bicarbonate, or sodium chloride on abomasal emptying rate and luminal pH in calves.
American journal of veterinary research. 69(6):824-31 [DOI] 10.2460/ajvr.69.6.824. [PMID] 18518665.
2008
Immunohistochemical characterization and quantitative analysis of neurons in the myenteric plexus of the equine intestine.
Brain research. 1244:53-64 [DOI] 10.1016/j.brainres.2008.09.070. [PMID] 18930715.
2008
Mucosal distribution of eosinophilic granulocytes within the gastrointestinal tract of horses.
American journal of veterinary research. 69(7):874-9 [DOI] 10.2460/ajvr.69.7.874. [PMID] 18593236.
2008
Options for treatment of cecocolic intussusception in horses.
Journal of the American Veterinary Medical Association. 232(8) [PMID] 18441616.
View on: PubMed
2008
Peritonitis Secondary To Uterine Tears in Postpartum Mares: Retrospective Comparison of Surgical Versus Medical Treatment
Journal of Veterinary Internal Medicine. 22
2008
Post operative ileus (POI): another perspective.
Equine veterinary journal. 40(4):297-8 [DOI] 10.2746/042516408X302528. [PMID] 18672435.
2007
In vitro effects of reactive oxygen metabolites, with and without flunixin meglumine, on equine colonic mucosa.
American journal of veterinary research. 68(3):305-12 [PMID] 17331021.
View on: PubMed
2007
The clinical evidence article by Proudman et al. (2007).
Equine veterinary journal. 39(3) [PMID] 17520984.
View on: PubMed
2006
Evaluation of the rate of development of septic arthritis after elective arthroscopy in horses: 7 cases (1994-2003).
Journal of the American Veterinary Medical Association. 229(12):1949-54 [PMID] 17173536.
View on: PubMed
2006
Long-term follow-up on a large number of horses that underwent transarterial coil embolisation (TCE) for guttural pouch mycosis (GPM).
Equine veterinary journal. 38(3) [PMID] 16706285.
View on: PubMed
2006
Progression of mycosis of the auditory tube diverticulum (guttural pouch) after arterial occlusion in a horse with contralateral temporohyoid osteoarthropathy.
Journal of the American Veterinary Medical Association. 229(12):1945-8 [PMID] 17173535.
View on: PubMed
2005
Effects of sodium hyaluronate and methylprednisolone acetate on proteoglycan synthesis in equine articular cartilage explants.
American journal of veterinary research. 66(1):48-53 [PMID] 15691035.
View on: PubMed
2005
Extensive nasal septum resection in horses using a 3-wire method.
Veterinary surgery : VS. 34(2):167-73 [PMID] 15860109.
View on: PubMed
2004
Association between cribbing and entrapment of the small intestine in the epiploic foramen in horses: 68 cases (1991-2002).
Journal of the American Veterinary Medical Association. 224(4):562-4 [PMID] 14989551.
View on: PubMed
2004
Effects of phenylbutazone, indomethacin, prostaglandin E2, butyrate, and glutamine on restitution of oxidant-injured right dorsal colon of horses in vitro.
American journal of veterinary research. 65(11):1589-95 [PMID] 15566100.
View on: PubMed
2004
In vitro study of heat production during power reduction of equine mandibular teeth.
Journal of the American Veterinary Medical Association. 224(7):1128-32 [PMID] 15074859.
View on: PubMed
2004
Requests more information on intraluminal solution.
American journal of veterinary research. 65(7):889; author reply 889-90 [PMID] 15281645.
View on: PubMed
2003
Effects of acetylcysteine and migration of resident eosinophils in an in vitro model of mucosal injury and restitution in equine right dorsal colon.
American journal of veterinary research. 64(10):1205-12 [PMID] 14596455.
View on: PubMed
2003
Life-threatening hemorrhage from enterotomies and anastomoses in 7 horses.
Veterinary surgery : VS. 32(6):553-8 [PMID] 14648534.
View on: PubMed
2003
Sinus disease.
The Veterinary clinics of North America. Equine practice. 19(1):209-43, viii [PMID] 12747669.
View on: PubMed
2002
Clinical signs and treatment of chronic uterine torsion in two mares.
Journal of the American Veterinary Medical Association. 220(3):349-53, 323 [PMID] 11829267.
View on: PubMed
2002
In vitro anion transport alterations and apoptosis induced by phenylbutazone in the right dorsal colon of ponies.
American journal of veterinary research. 63(7):934-41 [PMID] 12118671.
View on: PubMed

Grants

Apr 2020 – Mar 2021
Effects of NSAIDs on anion transport in the equine colon
Role: Principal Investigator
Funding: GRAYSON JOCKEY CLUB RES FOU
May 2015 – Jun 2019
Mechanisms of HCO3- secretion in the equine right dorsal colon in vitro
Role: Principal Investigator
Funding: UF FOU
Jul 2012 – Jul 2018
Effects of a continuous rate infusion of lidocaine on ischemic injured equine large colon and jejunum
Role: Principal Investigator
Funding: UF FOU
Jul 2005 – Jun 2018
Equine Soundness Program – General
Role: Principal Investigator
Funding: UF FOU

Education

Diplomate
1989 · American College of Veterinary Surgeons
PhD – Comparative Medical Sciences
1985 · University of Pennsylvania
MVB, MRCVS
1972 · Veterinary College of Ireland, University College

Teaching Profile

Courses Taught
2010-2020
VEM5422 Equine Surgery and Lab
2006-2021
VEM5737 Core Clk Large An Sur
2007-2008,2010-2021
VEM5837 Senior Clk Lg An Surg
2017-2020
VEM5830 Equine Clerkship Elec
2011-2012,2015-2021
VEM5402 Introduction to Surgery
2017-2020
VEM5730 Equine Core Clerkship
2011-2021
VEM5112 Animal Systems 3
2008,2016-2020,2020
VME6905 Problems in Veterinary Medical Sciences
2018
VME7979 Advanced Research
2009
VME6940 Supervised Teaching
2021
VEM5402L Introduction to Surgery Lab

Contact Details

Phones:
Business:
(352) 294-4362
Emails:
Business:
freemand@ufl.edu

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