Rhoel Dinglasan,
Professor
Department:
Department of Infectious Diseases & Immunology
Business Phone:
(352) 294-8448
Business Email:
rdinglasan@epi.ufl.edu
About Rhoel Dinglasan
Accomplishments
Advisory Board/Steering Committee – Emerging Infectious Diseases
current
·
United States Military Infectious Diseases Research Program
Editorial Board
current
·
PLoS Neglected Tropical Diseases
Director
2016-current
·
CDC Southeastern Regional Center of Excellence in Vector Borne Diseases: Gateway Program, The University of Florida
Faculty
2015-current
·
Developing Excellence in Leadership and Genetic Training for Malaria Elimination in Sub-Saharan Africa (DELTAS) Training Program, Wellcome Trust, UK
Young Investigators Award
2012
·
Human Frontiers Science Program (Strasbourg, France)
Teaching Profile
Courses Taught
2019-2021,2024
VME6934 Topics in Veterinary Medical Sciences
2020,2023-2024
VME4906 Problems in Veterinary Science
2020-2023
VME6937L VMS Graduate Seminar Series
2019,2023-2024
VME6905 Problems in Veterinary Medical Sciences
2019
PHC7979 Advanced Research
2018
GMS7979 Advanced Research
2017
HSC4913 Supervised Research Experience
2017
GMS6691 Special Topics in Cell Biology and Anatomy
2021
VME6933 Seminar in Infectious Diseases and Experimental Pathology
Research Profile
Much of Dr. Dinglasan’s research has focused on finding a vaccine that will prevent malaria transmission. As part of this effort, Dinglasan has focused specifically on ways in which interactions between the human malaria parasites Plasmodium falciparum and P. vivax and the Anopheles mosquito midgut can be better understood to disrupt the transmission of these pathogens to humans. To better study these interactions, he is interested in the application of mass spectrometry toward the molecular and cellular analysis of critical transition steps during malaria parasite transmission. He has also studied how nanoparticle technology can contribute to the development of vaccine and drug delivery systems.
His interest in preventing the spread of malaria has led him to study the developmental biology of the malaria parasite – concentrating on the parasite’s sexual stage. This stage of the parasite’s life cycle does not actually cause disease in humans, so it has not been studied as thoroughly as the erythrocytic stages, where the parasite infects red blood cells and causes disease.
Dinglasan’s lab also has an interest in both supplementing and innovating the current arsenal of anti-malarial treatments. By investigating pathways of infection and disease development, his team hopes to find natural product compounds with potential as drug scaffolds for new anti-malaria drugs. Dinglasan’s lab hopes to preempt eventual drug resistance by focusing on novel biochemical pathways in the parasite that can be targeted by natural product compounds. Combining these approaches allows the lab to target multiple aspects of the pathway from transmission to disease.
Open Researcher and Contributor ID (ORCID)
0000-0001-5433-8179
Publications
2024
CK1 and PP1 regulate Rift Valley fever virus genome replication through L protein phosphorylation
Antiviral Research.
226
[DOI] 10.1016/j.antiviral.2024.105895.
2024
Evaluating vector competence for Yellow fever in the Caribbean
Nature Communications.
15(1)
[DOI] 10.1038/s41467-024-45116-2.
[PMID] 38336944.
2024
Indole-3-pyruvate: Analysis and Control of Tautomerism and Reactivity.
Analytical chemistry.
96(25):10399-10407
[DOI] 10.1021/acs.analchem.4c01584.
[PMID] 38858849.
2024
RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins.
The Journal of infectious diseases.
229(3):795-799
[DOI] 10.1093/infdis/jiad471.
[PMID] 37889513.
2024
Syndromic surveillance of population-level COVID-19 burden with cough monitoring in a hospital emergency waiting room.
Frontiers in public health.
12
[DOI] 10.3389/fpubh.2024.1279392.
[PMID] 38605877.
2023
A mixed methods study assessing the adoption potential of a saliva-based malaria rapid test in the Democratic Republic of Congo.
Malaria journal.
22(1)
[DOI] 10.1186/s12936-023-04599-y.
[PMID] 37291561.
2023
Adipokinetic hormone signaling in the malaria vector Anopheles gambiae facilitates Plasmodium falciparum sporogony
Communications Biology.
6(1)
[DOI] 10.1038/s42003-023-04518-6.
[PMID] 36782045.
2023
Impact of malaria diagnostic choice on monitoring of Plasmodium falciparum prevalence estimates in the Democratic Republic of the Congo and relevance to control programs in high-burden countries
PLOS Global Public Health.
3(7)
[DOI] 10.1371/journal.pgph.0001375.
[PMID] 37494361.
2023
Niclosamide as a chemical probe for analyzing SARS-CoV-2 modulation of host cell lipid metabolism.
Frontiers in microbiology.
14
[DOI] 10.3389/fmicb.2023.1251065.
[PMID] 37901834.
2023
Passive Monitoring of Crowd-Level Cough Counts in Waiting Areas produces Reliable Syndromic Indicator for Total COVID-19 Burden in a Hospital Emergency Clinic.
Research square.
[DOI] 10.21203/rs.3.rs-3084318/v1.
[PMID] 37461489.
2023
Plasmodium falciparum with pfhrp2/3 Deletion Not Detected in a 2018-2021 Malaria Longitudinal Cohort Study in Kinshasa Province, Democratic Republic of the Congo.
The American journal of tropical medicine and hygiene.
109(2):273-276
[DOI] 10.4269/ajtmh.22-0715.
[PMID] 37339759.
2023
Virology under the Microscope-a Call for Rational Discourse.
mSphere.
8(2)
[DOI] 10.1128/msphere.00034-23.
[PMID] 36700653.
2023
Whole genome sequencing of outbreak strains from 2017 to 2018 reveals an endemic clade of dengue 1 virus in Cameroon.
Emerging microbes & infections.
12(2)
[DOI] 10.1080/22221751.2023.2281352.
[PMID] 37933502.
2022
A molecular surveillance-guided vector control response to concurrent dengue and West Nile virus outbreaks in a COVID-19 hotspot of Florida
The Lancet Regional Health – Americas.
11
[DOI] 10.1016/j.lana.2022.100231.
[PMID] 36778921.
2022
A thermostable Cas12b from Brevibacillus leverages one-pot discrimination of SARS-CoV-2 variants of concern
eBioMedicine.
77
[DOI] 10.1016/j.ebiom.2022.103926.
[PMID] 35290826.
2022
Imported Dengue Case Numbers and Local Climatic Patterns Are Associated with Dengue Virus Transmission in Florida, USA
Insects.
13(2)
[DOI] 10.3390/insects13020163.
[PMID] 35206736.
2022
Intrinsic variation in the vertically transmitted core virome of the mosquito Aedes aegypti.
Molecular ecology.
31(9):2545-2561
[DOI] 10.1111/mec.16412.
[PMID] 35229389.
2022
Needs Assessment of Southeastern United States Vector Control Agencies: Capacity Improvement Is Greatly Needed to Prevent the Next Vector-Borne Disease Outbreak
Tropical Medicine and Infectious Disease.
7(5)
[DOI] 10.3390/tropicalmed7050073.
[PMID] 35622700.
2022
Riding the Wave: Reactive Vector-Borne Disease Policy Renders the United States Vulnerable to Outbreaks and Insecticide Resistance.
Journal of medical entomology.
59(2):401-411
[DOI] 10.1093/jme/tjab219.
[PMID] 35064260.
2022
Seasonality and transmissibility of Plasmodium ovale in Bagamoyo District, Tanzania.
Parasites & vectors.
15(1)
[DOI] 10.1186/s13071-022-05181-2.
[PMID] 35164867.
2021
A Thermostable Cas12b from Brevibacillus Leverages One-pot Detection of SARS-CoV-2 Variants of Concern.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2021.10.15.21265066.
[PMID] 34704101.
2021
Are malaria transmission-blocking vaccines acceptable to high burden communities? Results from a mixed methods study in Bo, Sierra Leone
Malaria Journal.
20(1)
[DOI] 10.1186/s12936-021-03723-0.
[PMID] 33849572.
2021
Chikungunya viruses containing the A226V mutation detected retrospectively in Cameroon form a new geographical subclade.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
113:65-73
[DOI] 10.1016/j.ijid.2021.09.058.
[PMID] 34592442.
2021
Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti
Communications Biology.
4(1)
[DOI] 10.1038/s42003-020-01614-9.
[PMID] 33452408.
2021
Derivatization increases mosquito larvicidal activity of the sesquiterpene lactone parthenin isolated from the invasive weed Parthenium hysterophorus.
Pest management science.
77(2):659-665
[DOI] 10.1002/ps.6131.
[PMID] 33034953.
2021
Geographic Partitioning of Dengue Virus Transmission Risk in Florida
Viruses.
13(11)
[DOI] 10.3390/v13112232.
[PMID] 34835038.
2021
Immunofocusing humoral immunity potentiates the functional efficacy of the AnAPN1 malaria transmission-blocking vaccine antigen
npj Vaccines.
6(1)
[DOI] 10.1038/s41541-021-00309-4.
[PMID] 33824336.
2021
Immunopotentiation by Lymph-Node Targeting of a Malaria Transmission-Blocking Nanovaccine.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.729086.
[PMID] 34512663.
2021
Infection Kinetics and Transmissibility of a Reanimated Dengue Virus Serotype 4 Identified Originally in Wild Aedes aegypti From Florida.
Frontiers in microbiology.
12
[DOI] 10.3389/fmicb.2021.734903.
[PMID] 34630357.
2021
Modelling distributions of Aedes aegypti and Aedes albopictus using climate, host density and interspecies competition.
PLoS neglected tropical diseases.
15(3)
[DOI] 10.1371/journal.pntd.0009063.
[PMID] 33764975.
2021
Root exudate chemical cues of an invasive plant modulate oviposition behavior and survivorship of a malaria mosquito vector.
Scientific reports.
11(1)
[DOI] 10.1038/s41598-021-94043-5.
[PMID] 34285252.
2021
Transmission Potential of Floridian Aedes aegypti Mosquitoes for Dengue Virus Serotype 4: Implications for Estimating Local Dengue Risk.
mSphere.
6(4)
[DOI] 10.1128/mSphere.00271-21.
[PMID] 34232077.
2020
Leishmania-infected macrophages release extracellular vesicles that can promote lesion development
Life Science Alliance.
3(12)
[DOI] 10.26508/lsa.202000742.
[PMID] 33122174.
2020
Biodegradable PLGA-b-PEG Nanoparticles Induce T Helper 2 (Th2) Immune Responses and Sustained Antibody Titers via TLR9 Stimulation
Vaccines.
8(2)
[DOI] 10.3390/vaccines8020261.
[PMID] 32485944.
2020
Under-the-Radar Dengue Virus Infections in Natural Populations of Aedes aegypti Mosquitoes.
mSphere.
5(2)
[DOI] 10.1128/mSphere.00316-20.
[PMID] 32350095.
2019
A saliva-based rapid test to quantify the infectious subclinical malaria parasite reservoir
Science Translational Medicine.
11(473)
[DOI] 10.1126/scitranslmed.aan4479.
[PMID] 30602535.
2019
Critical Size Limit of Biodegradable Nanoparticles for Enhanced Lymph Node Trafficking and Paracortex Penetration.
Nano research.
12(4):837-844
[DOI] 10.1007/s12274-019-2301-3.
[PMID] 33343832.
2019
Homologs of Human Dengue-Resistance Genes, FKBP1B and ATCAY, Confer Antiviral Resistance in Aedes aegypti Mosquitoes.
Insects.
10(2)
[DOI] 10.3390/insects10020046.
[PMID] 30717390.
2019
Naturally acquired immunity against immaturePlasmodium falciparumgametocytes
Science Translational Medicine.
11(495)
[DOI] 10.1126/scitranslmed.aav3963.
[PMID] 31167926.
2019
NPC1161B, an 8-Aminoquinoline Analog, Is Metabolized in the Mosquito and Inhibits Plasmodium falciparum Oocyst Maturation.
Frontiers in pharmacology.
10
[DOI] 10.3389/fphar.2019.01265.
[PMID] 31708786.
2019
Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross.
Nature communications.
10(1)
[DOI] 10.1038/s41467-019-12256-9.
[PMID] 31541097.
2019
Protein O-Fucosyltransferase 2 Is Not Essential for Plasmodium berghei Development.
Frontiers in cellular and infection microbiology.
9
[DOI] 10.3389/fcimb.2019.00238.
[PMID] 31334132.
2019
Ribosomal/nucleolar stress induction regulates tert-Butyl hydroperoxide (tBHP) mediated oxidative stress in Anopheles gambiae midguts
BMC Research Notes.
12(1)
[DOI] 10.1186/s13104-019-4196-1.
[PMID] 30922378.
2019
The Selection of a Hepatocyte Cell Line Susceptible to Plasmodium falciparum Sporozoite Invasion That Is Associated With Expression of Glypican-3.
Frontiers in microbiology.
10
[DOI] 10.3389/fmicb.2019.00127.
[PMID] 30891005.
2018
Kupffer Cells Survive Plasmodium berghei Sporozoite Exposure and Respond with a Rapid Cytokine Release.
Pathogens (Basel, Switzerland).
7(4)
[DOI] 10.3390/pathogens7040091.
[PMID] 30477234.
2018
Paraquat-Mediated Oxidative Stress in Anopheles gambiae Mosquitoes Is Regulated by An Endoplasmic Reticulum (ER) Stress Response.
Proteomes.
6(4)
[DOI] 10.3390/proteomes6040047.
[PMID] 30424486.
2017
Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony.
Nature microbiology.
2
[DOI] 10.1038/nmicrobiol.2017.38.
[PMID] 28263306.
2017
Sugar nucleotide quantification by liquid chromatography tandem mass spectrometry reveals a distinct profile in Plasmodium falciparum sexual stage parasites.
The Biochemical journal.
474(6):897-905
[DOI] 10.1042/BCJ20161030.
[PMID] 28104756.
2016
A Malaria Transmission-Blocking (+)-Usnic Acid Derivative Prevents Plasmodium Zygote-to-Ookinete Maturation in the Mosquito Midgut
ACS Chemical Biology.
11(12):3461-3472
[DOI] 10.1021/acschembio.6b00902.
[PMID] 27978709.
2016
An antibody against an Anopheles albimanus midgut myosin reduces Plasmodium berghei oocyst development.
Parasites & vectors.
9(1)
[DOI] 10.1186/s13071-016-1548-8.
[PMID] 27165123.
2016
Impact of exposure to mosquito transmission-blocking antibodies on Plasmodium falciparum population genetic structure.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.
45:138-144
[DOI] 10.1016/j.meegid.2016.08.025.
[PMID] 27566334.
2016
Molecular Profiling of Phagocytic Immune Cells in Anopheles gambiae Reveals Integral Roles for Hemocytes in Mosquito Innate Immunity.
Molecular & cellular proteomics : MCP.
15(11):3373-3387
[PMID] 27624304.
2016
The disruption of GDP-fucose de novo biosynthesis suggests the presence of a novel fucose-containing glycoconjugate in Plasmodium asexual blood stages.
Scientific reports.
6
[DOI] 10.1038/srep37230.
[PMID] 27849032.
2016
The fucomic potential of mosquitoes: Fucosylated N-glycan epitopes and their cognate fucosyltransferases.
Insect biochemistry and molecular biology.
68:52-63
[DOI] 10.1016/j.ibmb.2015.11.001.
[PMID] 26617287.
2016
The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission.
Antimicrobial agents and chemotherapy.
60(4):2108-17
[DOI] 10.1128/AAC.02002-15.
[PMID] 26787692.
2015
Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.
Proteomics.
15(12):2066-77
[DOI] 10.1002/pmic.201500063.
[PMID] 25914232.
2015
Integrated microfluidic chip and online SCX separation allows untargeted nanoscale metabolomic and peptidomic profiling.
Journal of proteome research.
14(3):1621-6
[DOI] 10.1021/pr5011422.
[PMID] 25574574.
2015
The Anopheles-midgut APN1 structure reveals a new malaria transmission-blocking vaccine epitope.
Nature structural & molecular biology.
22(7):532-9
[DOI] 10.1038/nsmb.3048.
[PMID] 26075520.
2015
The cellular and proteomic response of primary and immortalized murine Kupffer cells following immune stimulation diverges from that of monocyte-derived macrophages.
Proteomics.
15(2-3):545-53
[DOI] 10.1002/pmic.201400216.
[PMID] 25266554.
2014
A male and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs.
Antimicrobial agents and chemotherapy.
58(12):7292-302
[DOI] 10.1128/AAC.03666-14.
[PMID] 25267664.
2014
Antibodies to a single, conserved epitope in Anopheles APN1 inhibit universal transmission of Plasmodium falciparum and Plasmodium vivax malaria.
Infection and immunity.
82(2):818-29
[DOI] 10.1128/IAI.01222-13.
[PMID] 24478095.
2014
Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment.
The Journal of biological chemistry.
289(47):32526-37
[DOI] 10.1074/jbc.M114.606269.
[PMID] 25261472.
2014
Differential roles of an Anopheline midgut GPI-anchored protein in mediating Plasmodium falciparum and Plasmodium vivax ookinete invasion.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.
28:635-47
[DOI] 10.1016/j.meegid.2014.05.025.
[PMID] 24929123.
2014
Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut.
Proceedings of the National Academy of Sciences of the United States of America.
111(4):E492-500
[DOI] 10.1073/pnas.1315517111.
[PMID] 24474798.
2014
Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility.
Malaria journal.
13
[DOI] 10.1186/1475-2875-13-315.
[PMID] 25124718.
2014
Sex-partitioning of the Plasmodium falciparum stage V gametocyte proteome provides insight into falciparum-specific cell biology.
Molecular & cellular proteomics : MCP.
13(10):2705-24
[DOI] 10.1074/mcp.M114.040956.
[PMID] 25056935.
2014
The acute transcriptomic and proteomic response of HC-04 hepatoma cells to hepatocyte growth factor and its implications for Plasmodium falciparum sporozoite invasion.
Molecular & cellular proteomics : MCP.
13(5):1153-64
[DOI] 10.1074/mcp.M113.035584.
[PMID] 24532842.
2013
A bioinformatics approach for integrated transcriptomic and proteomic comparative analyses of model and non-sequenced anopheline vectors of human malaria parasites.
Molecular & cellular proteomics : MCP.
12(1):120-31
[DOI] 10.1074/mcp.M112.019596.
[PMID] 23082028.
2013
A protocol for membrane feeding assays to determine the infectiousness of P. falciparum naturally infected individuals to Anopheles gambiae.
MalariaWorld journal.
4
[DOI] 10.5281/zenodo.10926272.
[PMID] 38828116.
2013
A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut.
PLoS pathogens.
9(11)
[DOI] 10.1371/journal.ppat.1003757.
[PMID] 24278017.
2013
Can field-based mosquito feeding assays be used for evaluating transmission-blocking interventions?
Trends in parasitology.
29(2):53-9
[DOI] 10.1016/j.pt.2012.11.004.
[PMID] 23273727.
2013
Liver-targeting of primaquine-(poly-γ-glutamic acid) and its degradation in rat hepatocytes.
Bioorganic & medicinal chemistry.
21(17):5275-81
[DOI] 10.1016/j.bmc.2013.06.028.
[PMID] 23859775.
2013
Single-dose microparticle delivery of a malaria transmission-blocking vaccine elicits a long-lasting functional antibody response.
Current molecular medicine.
13(4):479-87
[PMID] 23331003.
2012
Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine.
Infection and immunity.
80(4):1606-14
[DOI] 10.1128/IAI.06212-11.
[PMID] 22311924.
2012
Mosquito feeding assays to determine the infectiousness of naturally infected Plasmodium falciparum gametocyte carriers.
PloS one.
7(8)
[DOI] 10.1371/journal.pone.0042821.
[PMID] 22936993.
2012
Structural characterization and inhibition of the Plasmodium Atg8-Atg3 interaction.
Journal of structural biology.
180(3):551-62
[DOI] 10.1016/j.jsb.2012.09.001.
[PMID] 22982544.
2012
Transcriptome of the adult female malaria mosquito vector Anopheles albimanus.
BMC genomics.
13
[DOI] 10.1186/1471-2164-13-207.
[PMID] 22646700.
2011
A role for heparan sulfate proteoglycans in Plasmodium falciparum sporozoite invasion of anopheline mosquito salivary glands.
The Biochemical journal.
438(3):475-83
[DOI] 10.1042/BJ20110694.
[PMID] 21663594.
2011
Ookinete-interacting proteins on the microvillar surface are partitioned into detergent resistant membranes of Anopheles gambiae midguts.
Journal of proteome research.
10(11):5150-62
[DOI] 10.1021/pr2006268.
[PMID] 21905706.
2010
An improved method for the in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes.
Malaria journal.
9
[DOI] 10.1186/1475-2875-9-194.
[PMID] 20615232.
2010
Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito.
The Journal of biological chemistry.
285(35):27045-27056
[DOI] 10.1074/jbc.M110.122275.
[PMID] 20573956.
2009
Anopheles gambiae Croquemort SCRBQ2, expression profile in the mosquito and its potential interaction with the malaria parasite Plasmodium berghei.
Insect biochemistry and molecular biology.
39(5-6):395-402
[DOI] 10.1016/j.ibmb.2009.03.008.
[PMID] 19366631.
2009
The Anopheles gambiae adult midgut peritrophic matrix proteome.
Insect biochemistry and molecular biology.
39(2):125-34
[DOI] 10.1016/j.ibmb.2008.10.010.
[PMID] 19038338.
2009
The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission.
PLoS pathogens.
5(2)
[DOI] 10.1371/journal.ppat.1000302.
[PMID] 19229315.
2008
Flipping the paradigm on malaria transmission-blocking vaccines.
Trends in parasitology.
24(8):364-70
[DOI] 10.1016/j.pt.2008.05.002.
[PMID] 18599352.
2007
Disruption of Plasmodium falciparum development by antibodies against a conserved mosquito midgut antigen.
Proceedings of the National Academy of Sciences of the United States of America.
104(33):13461-6
[PMID] 17673553.
2007
Plasmodium falciparum ookinetes require mosquito midgut chondroitin sulfate proteoglycans for cell invasion.
Proceedings of the National Academy of Sciences of the United States of America.
104(40):15882-7
[PMID] 17873063.
2006
Plasmodium yoelii: axenic development of the parasite mosquito stages.
Experimental parasitology.
112(2):99-108
[PMID] 16289466.
2005
Insight into a conserved lifestyle: protein-carbohydrate adhesion strategies of vector-borne pathogens.
Infection and immunity.
73(12):7797-807
[PMID] 16299269.
2005
Peptide mimics as surrogate immunogens of mosquito midgut carbohydrate malaria transmission blocking targets.
Vaccine.
23(21):2717-24
[PMID] 15780718.
2005
Sugar epitopes as potential universal disease transmission blocking targets.
Insect biochemistry and molecular biology.
35(1):1-10
[PMID] 15607650.
2003
Monoclonal antibody MG96 completely blocks Plasmodium yoelii development in Anopheles stephensi.
Infection and immunity.
71(12):6995-7001
[PMID] 14638789.
Grants
Apr 2024
ACTIVE
West-Central Africa EMERGENTS International Center of Excellence in Malaria Research (ICEMR)
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Sep 2022
ACTIVE
Xenosurveillance of Flies in Wet Markets to Monitor for the Emergence and Spillover Potential of Viral, Bacterial, and Parasitic Pathogens
Role: Principal Investigator
Funding: US DEPT OF AG AG RES SVC
Jul 2022
ACTIVE
Relapsing malaria in Africa: mechanisms for persistence amid falciparum decline
Role: Principal Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via NATL INST OF HLTH NIAID
Jul 2022
– Jul 2022
Relapsing malaria in Africa: mechanisms for persistence amid falciparum decline
Role: Principal Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via NATL INST OF HLTH NIAID
Jul 2022
ACTIVE
CDC Southeastern Center of Excellence in Vector-Borne Diseases: Gateway Program
Role: Principal Investigator
Funding: CTRS FOR DISEASE CONTROL AND PREVENTION
Sep 2021
– Jan 2024
RDT-undetectable Malaria in the DR Congo: Epidemiology and Development of Alternatives: DRC Diversity Supplement
Role: Principal Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via NATL INST OF HLTH NIAID
Aug 2021
– Aug 2024
COVID-19: SICA Study: Seroepidemiological Insight into COVID-19 transmission in Africa
Role: Principal Investigator
Funding: CTRS FOR DISEASE CONTROL AND PREVENTION
Mar 2021
ACTIVE
First-In-Human Trial of the Pan-Malaria Transmission-Blocking Vaccine AnAPN1
Role: Principal Investigator
Funding: GLOBAL HEALTH INNOVATIVE TECHNOLOGY FUND
Dec 2020
– Feb 2023
Accelerating discovery of an efficacious Plasmodium vivax multivalent multi-stage vaccine
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA
via NATL INST OF HLTH NIAID
Oct 2019
– Jun 2022
Commercial development of a Saliva-based Malaria Asymptomatic and Asexual Rapid Test (SMAART-1)
Role: Principal Investigator
Funding: GLOBAL HEALTH INNOVATIVE TECHNOLOGY FUND
Aug 2019
– Jul 2020
Tranexamic acid project
Role: Principal Investigator
Funding: TRANEXAMIC TECHNOLOGIES
Mar 2019
– Jun 2019
Prevent & Protect: Mosquito Messages for Your Community
Role: Project Manager
Funding: FL DEPT OF HLTH
via CTRS FOR DISEASE CONTROL AND PREVENTION
Aug 2018
– Jul 2019
Saliva-based Electrochemical Paper Microfluidic Malaria Rapid Test for Early Detection and Exclusion in Point-of-Need (PON) and Clinical Settings
Role: Principal Investigator
Funding: CROSSLIFE TECHNOLOGIES
via NATL INST OF HLTH NIAID
Jun 2018
– May 2023
Determinants of malaria transmission by submicroscopic gametocytemia
Role: Principal Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via NATL INST OF HLTH NIAID
Mar 2018
– Mar 2020
Process Development and Clinical Manufacturing of an Immuno-focused, Mosquito-based Pan-malaria transmission-blocking vaccine: AnAPN1 v. 2.0.
Role: Principal Investigator
Funding: GLOBAL HEALTH INNOVATIVE TECHNOLOGY FUND
Mar 2018
– Jul 2018
Communicating with Local Officials and the Public about Mosquito Control
Role: Co-Investigator
Funding: FL DEPT OF HLTH
via CTRS FOR DISEASE CONTROL AND PREVENTION
Feb 2018
– Jan 2024
RDT-undetectable Malaria in the DR Congo
Role: Principal Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via NATL INST OF HLTH NIAID
Dec 2016
– Jun 2022
Southeastern Regional CoE in Vector-Borne Diseases: The Gateway Program
Role: Principal Investigator
Funding: CTRS FOR DISEASE CONTROL AND PREVENTION
Oct 2016
– Nov 2017
Function and Mechanism of O-Fucosylation of Malaria Parasite TSR Domain Proteins
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Sep 2016
– Mar 2021
A biodegradable nano-microparticle prime-boost vaccine strategy
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Mar 2016
– Jun 2017
Lead optimization of an evolution-proof malaria transmission -blocking vaccine immunogen that is based on a mosquito protein target and effective against both P. falciparurm and P. vivax
Role: Principal Investigator
Funding: GLOBAL HEALTH INNOVATIVE TECHNOLOGY FUND
Education
Doctor of Philosophy in Microbiology & Immunology
2004
·
University of Maryland School of Medicine
Master of Philosophy in Vector Biology
2002
·
Yale University
Master of Public Health in Infectious Disease Epidemiology/Global Health
1998
·
Yale University
Contact Details
Phones:
- Business:
- (352) 294-8448
Emails:
- Business:
- rdinglasan@epi.ufl.edu
Addresses:
- Business Mailing:
-
2055 MOWRY RD RM 375
EMERGING PATHOGENS INSTITUTE
GAINESVILLE FL 32611-2079 - Business Street:
-
2055 MOWRY RD RM 375
GAINESVILLE MD 32611