Rhoel Dinglasan

Rhoel Dinglasan

Professor

Department: Department of Infectious Diseases & Immunology
Business Phone: (352) 294-8448
Business Email: rdinglasan@epi.ufl.edu

Accomplishments

Host-Pathogen Working Group
current · NIH-funded MaHPIC program of Emory University
Editorial Board
current · PLoS Neglected Tropical Diseases
Advisory Board
current · United States Military Malaria Vaccine Program
Director
2016-current · CDC Southeastern Regional Center of Excellence in Vector Borne Diseases: Gateway Program, The University of Florida
Faculty
2015-current · Developing Excellence in Leadership and Genetic Training for Malaria Elimination in Sub-Saharan Africa (DELTAS) Training Program, Wellcome Trust, UK
Young Investigators Award
2012 · Human Frontiers Science Program (Strasbourg, France)

Research Profile

Much of Dr. Dinglasan’s research has focused on finding a vaccine that will prevent malaria transmission. As part of this effort, Dinglasan has focused specifically on ways in which interactions between the human malaria parasites Plasmodium falciparum and P. vivax and the Anopheles mosquito midgut can be better understood to disrupt the transmission of these pathogens to humans. To better study these interactions, he is interested in the application of mass spectrometry toward the molecular and cellular analysis of critical transition steps during malaria parasite transmission. He has also studied how nanoparticle technology can contribute to the development of vaccine and drug delivery systems.

His interest in preventing the spread of malaria has led him to study the developmental biology of the malaria parasite – concentrating on the parasite’s sexual stage. This stage of the parasite’s life cycle does not actually cause disease in humans, so it has not been studied as thoroughly as the erythrocytic stages, where the parasite infects red blood cells and causes disease.

Dinglasan’s lab also has an interest in both supplementing and innovating the current arsenal of anti-malarial treatments. By investigating pathways of infection and disease development, his team hopes to find natural product compounds with potential as drug scaffolds for new anti-malaria drugs. Dinglasan’s lab hopes to preempt eventual drug resistance by focusing on novel biochemical pathways in the parasite that can be targeted by natural product compounds. Combining these approaches allows the lab to target multiple aspects of the pathway from transmission to disease.

Grants

Oct 2019 ACTIVE
Commercial development of a Saliva-based Malaria Asymptomatic and Asexual Rapid Test (SMAART-1)
GLOBAL HEALTH INNOVATIVE TECHNOLOGY FUND · Principal Investigator
Aug 2019 – Jul 2020
Tranexamic acid project
TRANEXAMIC TECHNOLOGIES · Principal Investigator
Mar 2019 – Jun 2019
Prevent & Protect: Mosquito Messages for Your Community
FL DEPT OF HLTH · Project Manager
Aug 2018 – Jul 2019
Saliva-based Electrochemical Paper Microfluidic Malaria Rapid Test for Early Detection and Exclusion in Point-of-Need (PON) and Clinical Settings
CROSSLIFE TECHNOLOGIES · Principal Investigator
Jun 2018 ACTIVE
Determinants of malaria transmission by submicroscopic gametocytemia
UNIV OF NORTH CAROLINA · Principal Investigator
Mar 2018 – Mar 2020
Process Development and Clinical Manufacturing of an Immuno-focused, Mosquito-based Pan-malaria transmission-blocking vaccine: AnAPN1 v. 2.0.
GLOBAL HEALTH INNOVATIVE TECHNOLOGY FUND · Principal Investigator
Mar 2018 – Jul 2018
Communicating with Local Officials and the Public about Mosquito Control
FL DEPT OF HLTH · Project Manager
Feb 2018 ACTIVE
RDT-undetectable Malaria in the DR Congo
UNIV OF NORTH CAROLINA · Principal Investigator
Dec 2016 ACTIVE
Southeastern Regional CoE in Vector-Borne Diseases: The Gateway Program
CTRS FOR DISEASE CONTROL AND PREVENTION · Principal Investigator
Oct 2016 – Nov 2017
Function and Mechanism of O-Fucosylation of Malaria Parasite TSR Domain Proteins
NATL INST OF HLTH NIAID · Principal Investigator
Sep 2016 ACTIVE
A biodegradable nano-microparticle prime-boost vaccine strategy
NATL INST OF HLTH NIAID · Principal Investigator
Mar 2016 – Jun 2017
Lead optimization of an evolution-proof malaria
GLOBAL HEALTH INNOVATIVE TECHNOLOGY FUND · Principal Investigator

Education

Doctor of Philosophy in Microbiology & Immunology
2004 · University of Maryland School of Medicine
Master of Philosophy in Vector Biology
2002 · Yale University
Master of Public Health in Infectious Disease Epidemiology/Global Health
1998 · Yale University

Contact Details

Phones:
Business:
(352) 294-8448
Emails:

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