Nancy D Denslow

Nancy D Denslow

Professor And Director Of Aquatic Toxicology

Department: Department of Physiological Sciences
Business Phone: (352) 294-4642
Business Email: ndenslow@ufl.edu

Accomplishments

Research Professor
2017 · University of Florida
SETAC Fellow
2016 · Society of Environmental Toxicology and Chemistry
Founders Award
2016 · Society of Environmental Toxicology and Chemistry
Blue Ribbon Scientific Advisory Panel
2009-2012 · California State Water Resources Control Board
Research Professor
2009 · University of Florida
Pfizer Award for Research Excellence
2007 · College of Veterinary Medicine, University of Florida

Research Profile

Dr. Denslow’s research involves developing and using molecular biomarkers to evaluate changes in gene expression depending on stress or exposure to contaminants. For environmental species, molecular approaches, including microarray analysis and proteomics, were developed for several non-model species, including fish, gastropods, and coral. Fish swim in waters that are contaminated by superfund chemicals and emerging contaminants of concern and, thus, provide a direct measure of effects of the contaminants in vertebrates. Many of the chemicals behave as endocrine disruptors and, in particular, as estrogen mimics. To better study the direct effects of these contaminants on reproduction, three largemouth bass estrogen receptors (alpha and two beta-like subtypes) were isolated, sequenced, and integrated into expression assays. The receptors appear to bind and are activated differentially by organochlorine pesticides. In addition, the tissue expression patterns are different for the three receptors.

Publications

2020 Proceedings of the National Academy of Sciences of the United States of America
2020 Comparative biochemistry and physiology. Part D, Genomics & proteomics
2017 Journal of toxicology and environmental health. Part B, Critical reviews
2017 FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2017 Reviews of environmental contamination and toxicology
2016 Comparative biochemistry and physiology. Part D, Genomics & proteomics
2016 Archives of environmental contamination and toxicology
2013 Toxicological sciences : an official journal of the Society of Toxicology
2013 Water science and technology : a journal of the International Association on Water Pollution Research
2012 Integrative and Comparative Biology
2012 Ecotoxicology and environmental safety
2012 Toxicological sciences : an official journal of the Society of Toxicology
2011 Environmental toxicology and chemistry
2011 Environmental toxicology and chemistry
2010 Toxicological sciences : an official journal of the Society of Toxicology
2009 Toxicological sciences : an official journal of the Society of Toxicology
2009 General and Comparative Endocrinology
2009 General and comparative endocrinology
2008 The American Journal of Tropical Medicine and Hygiene
2008 International Journal of Nanotechnology
2008 International Journal of Nanotechnology
2007 Comparative biochemistry and physiology. Part D, Genomics & proteomics
2007 Comparative Biochemistry and Physiology D-Genomics & Proteomics
2007 The Journal of Biomolecular Techniques
2006 Mass spectrometry reviews
2006 Environmental science & technology
2006 Environmental Science & Technology
2006 Journal of experimental zoology. Part A, Comparative experimental biology
2006 The Journal of Biomolecular Techniques
2005 Current protocols in protein science
2004 International review of neurobiology
2003 Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
2003 Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
2003 EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences
2002 Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
2001 Current protocols in protein science
2001 Current protocols in protein science
2001 Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
2001 Current protocols in protein science
2000 Journal of biomolecular techniques : JBT
1998 Journal of neurology, neurosurgery, and psychiatry
1996 Methods in enzymology
1994 Biochemical and biophysical research communications
1990 Biochimica et biophysica acta
1989 The Journal of biological chemistry
1982 The Journal of biological chemistry

Grants

Sep 2020 ACTIVE
Early-Career Gulf Research Institution Fellowship Grant Agreement
NATL ACADEMIES OF SCIENCE ENG AND MED · Mentor
Oct 2019 ACTIVE
Unraveling the biological impacts of complex chemical mixtures and chemicals of emerging concern
US ARMY ENG RES AND DEVELOPMENT CENTER · Principal Investigator
Dec 2018 – Mar 2020
Persistent occurrence of glyphosate in the Lake Okechobee area and effects on the immune system of manatees
EVERGLADES FOUNDATION · Project Manager
Aug 2018 ACTIVE
Drinking Water Treatment Residuals as Material for in situ Capping of Metal-Contaminated Sediments
SERDP-STRATEGIC ENV R AND D PROG ·
Jan 2018 – Jun 2020
Designing Nanoparticle-based Dispersants with Improved Efficiency and Biocompatibility
GULF OF MEXICO RESEARCH INITIATIVE ·
Aug 2017 – Jan 2019
Ex Vivo Verification of Hard and Soft Acid-Base (HSAB) Rank Predictions for Protein Adducts & Histopathology
US ENVIRONMENTAL PRO AGCY ·
Apr 2017 – Feb 2018
Early Life Effects of Produced Water on Menidia Beryllina
ENVIRONMENTAL DEFENSE · Principal Investigator
Sep 2016 – Sep 2018
Toxicity Screen for Eastern Mosquitofish Exposed to the Ultraviolet Screen Chemical Benzophenone-3
US DEPT OF INTERIOR US GEOLOGICAL SURVEY · Principal Investigator
Jan 2016 – Jun 2016
ENZYMATIC TESTING OF RESTORSEA CReMES — PROJECT 10
BIOREGENCY · Principal Investigator
Oct 2015 – Feb 2018
DEVELOPMENT OF A HTS ASSAY FOR A NEUROLOGICAL LYSOSOMAL
NATL INST OF HLTH NINDS · Project Manager
Oct 2015 – Dec 2015
ENZYMATIC TEST OF RESTORSEA DAY CREAM SAMPLES
BIOREGENCY · Principal Investigator
Jul 2015 – Aug 2015
Enzymatic testing of egg-hatching fluid-part 6
BIOREGENCY · Principal Investigator
May 2015 – May 2018
Evaluating Emerging Contaminants of Concern
FL DEPT OF ENVIRONMENTAL PROTECT · Principal Investigator
Mar 2015 – Feb 2016
Applied Biosystems SCIEX Q-TRAP 6500 LC/MS/MS Mass Spect
NATL INST OF HLTH OD · Principal Investigator
Mar 2015 – Feb 2016
DRS MATCH: APPLIED BIOSYSTEMS SCIEX Q-TRAP 6500 LC/MS/MS
UF DIV OF SPONSORED RES MATCHING FUNDS · Principal Investigator
Jul 2014 – Jun 2016
DISSERTATION RESEARCH: Behavioral and Reproductive Impli
NATL SCIENCE FOU · Principal Investigator
Jul 2014 – Jul 2015
Protein Profiling of Aquabeautine XL (fish hatching flui
BIOREGENCY · Principal Investigator
Jul 2014 – Jun 2018
Linkage of In Vitro Assay Results With In Vivo End Point
San Francisco Estuary Institute · Principal Investigator
Sep 2012 – Aug 2016
Impact of Single-Walled Carbon Nanotubes on Growth and
NATL SCIENCE FOU · Project Manager
Sep 2011 – Jun 2016
In Situ sampling tool and approach for assessing bioav
ARIZONA STATE UNIVERSITY · Principal Investigator
Sep 2004 – Jun 2017
Environmental Estrogens
UF RESEARCH FOU SALARY EXPENSE TRANSFERS · Principal Investigator

Patents

Issued July 1997
Cells Producing Stem Cell Proliferation Factor Autocrine Growth Factor
#5,650,299
Issued November 1999
Stem Cell Proliferation Factor
#5,981,708
Published September 2003
Detecting Hormonally Active Compounds
#US2004-0166509-A1

Contact Details

Phones:
Business:
(352) 294-4642
Emails:
Business:
ndenslow@ufl.edu

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