William L Castleman

William L Castleman

PROF

Department: VM-DEAN
Business Phone: (352) 283-0364
Business Email: castlemanw@ufl.edu

About William L Castleman

Teaching and Research Interests

— Broad interests in experimental and veterinary pathology

— Research interests in experimental pathology focus on pathogenesis of viral respiratory disease with recent emphasis on canine influenza virus infection

— Interests in veterinary pathology are diverse and stem from case-based studies in the UF Veterinary Hospitals and focus on diseases affecting horses, cattle, companion animals as well as laboratory animals used in research

— Coordination of the Laboratory of Comparative Pathology that provides veterinary pathology support to University of Florida research investigators in areas ranging from gene therapy, transgenic mouse models of human disease, and toxicologic pathology to evaluate safety in new drug development.

Accomplishments

Superior Accomplishment Award, Faculty
2004 · University of Florida

Publications

2021
Unaltered influenza disease outcomes in swine prophylactically treated with α-galactosylceramide.
Developmental and comparative immunology. 114 [DOI] 10.1016/j.dci.2020.103843. [PMID] 32871161.
2020
Hydroxyl functionalized multi-walled carbon nanotubes modulate immune responses without increasing 2009 pandemic influenza A/H1N1 virus titers in infected mice.
Toxicology and applied pharmacology. 404 [DOI] 10.1016/j.taap.2020.115167. [PMID] 32771490.
2019
Schwannosis in Three Foals and a Calf.
Veterinary pathology. 56(5):783-788 [DOI] 10.1177/0300985819846872. [PMID] 31109258.
2019
Utilization of Near Infrared Fluorescence Imaging to Track and Quantify the Pulmonary Retention of Single-Walled Carbon Nanotubes in Mice.
NanoImpact. 14 [DOI] 10.1016/j.impact.2019.100167. [PMID] 32818159.
2019
Mycotic Rhinitis and Sinusitis in Florida Horses.
Veterinary pathology. 56(4):586-598 [DOI] 10.1177/0300985818817046. [PMID] 30558508.
2017
Bovine Papillomavirus DNA and S100 Profiles in Sarcoids and Other Cutaneous Spindle Cell Tumors in Horses.
Veterinary pathology. 54(1):44-52 [DOI] 10.1177/0300985816653169. [PMID] 27312364.
2017
Gastric Intussusceptions in a Red Corn Snake (Pantherophis guttatus) Associated with Cryptosporidiosis.
Case reports in veterinary medicine. 2017 [DOI] 10.1155/2017/4270904. [PMID] 29955428.
2017
Single-walled carbon nanotubes modulate pulmonary immune responses and increase pandemic influenza a virus titers in mice.
Virology journal. 14(1) [DOI] 10.1186/s12985-017-0909-z. [PMID] 29273069.
2016
Spinal Cord Hamartomatous Myelodysplasia in 2 Horses With Clinical Neurologic Deficits.
Veterinary pathology. 53(4):844-6 [DOI] 10.1177/0300985815622971. [PMID] 26917551.
2016
α-Galactosylceramide protects swine against influenza infection when administered as a vaccine adjuvant.
Scientific reports. 6 [DOI] 10.1038/srep23593. [PMID] 27004737.
2015
Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry.
Journal of materials chemistry. B. 3(43):8492-8498 [DOI] 10.1039/c5tb00674k. [PMID] 32262689.
2015
Theriogenology Question of the Month. Vulvovaginitis or uterine, cervical, or vaginal neoplasia.
Journal of the American Veterinary Medical Association. 247(12):1369-71 [DOI] 10.2460/javma.247.12.1369. [PMID] 26642128.
2014
Hyperinsulinemic hypoglycemia syndrome in 2 dogs with bartonellosis.
Journal of veterinary internal medicine. 28(4):1331-5 [DOI] 10.1111/jvim.12381. [PMID] 24934703.
2014
Virus Replication and Cytokine Production in Primary Alveolar Macrophages and Airway Epithelial Cells Induced By Emerging Canine H3N8 Influenza Virus
The FASEB's Journal. 28(1, S)
2013
A comparison of two methods of endoscopic dilation of acute subglottic stenosis using a ferret model.
The Laryngoscope. 123(1):253-8 [DOI] 10.1002/lary.23508. [PMID] 22961260.
2012
Comparative evaluation of differential laser-induced perturbation spectroscopy as a technique to discriminate emerging skin pathology.
Journal of biomedical optics. 17(6) [DOI] 10.1117/1.JBO.17.6.067002. [PMID] 22734780.
2011
Rhabdomyosarcoma in 8 horses.
Veterinary pathology. 48(6):1144-50 [DOI] 10.1177/0300985810395785. [PMID] 21262788.
2010
Canine H3N8 influenza virus infection in dogs and mice.
Veterinary pathology. 47(3):507-17 [DOI] 10.1177/0300985810363718. [PMID] 20351357.
2009
Canine influenza virus replicates in alveolar macrophages and induces TNF-alpha.
Veterinary pathology. 46(6):1187-96 [DOI] 10.1354/vp.08-VP-0229-P-FL. [PMID] 19605916.
2009
Vertebral osteomyelitis with abscessation in a Holstein calf.
Veterinary Record. 164(23) [DOI] 10.1136/vr.164.23.723. [PMID] 19502630.
2009
Vertebral osteomyelitis with abscessation in a Holstein calf.
The Veterinary record. 164(23):723-4 [PMID] 19502630.
View on: PubMed
2008
Influenza A virus (H3N8) in dogs with respiratory disease, Florida.
Emerging infectious diseases. 14(6):902-8 [DOI] 10.3201/eid1406.071270. [PMID] 18507900.
2007
Experimental infection of neonatal foals with Rhodococcus equi triggers adult-like gamma interferon induction.
Clinical and vaccine immunology : CVI. 14(6):669-77 [PMID] 17409222.
View on: PubMed
2006
Imaging diagnosis: penile hemangiosarcoma.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 47(5):474-5 [PMID] 17009511.
View on: PubMed
2005
Mitral valve endocarditis after dental prophylaxis in a dog.
Journal of veterinary internal medicine. 19(2):268-70 [PMID] 15822575.
View on: PubMed
2005
Transmission of equine influenza virus to dogs.
Science (New York, N.Y.). 310(5747):482-5 [PMID] 16186182.
View on: PubMed
2005
A thymic carcinoid in a Bengal tiger (Panthera tigris).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 36(3):531-3 [PMID] 17312779.
View on: PubMed
2003
Simultaneous congenital and acquired extrahepatic portosystemic shunts in two dogs.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 44(1):38-42 [PMID] 12620048.
View on: PubMed
2003
Early high expression of IP-10 in F344 rats resistant to Sendai virus-induced airway injury.
American journal of physiology. Lung cellular and molecular physiology. 285(6):L1263-9 [PMID] 12909590.
View on: PubMed
2003
IL-12 reduces the severity of Sendai virus-induced bronchiolar inflammation and remodeling.
Cytokine. 24(3):103-13 [PMID] 14581004.
View on: PubMed
2002
Chronic postbronchiolitis airway instability induced with anti-IFN-gamma antibody in F344 rats.
Pediatric research. 52(3):382-6 [PMID] 12193672.
View on: PubMed
2002
Increased IFN-gamma protein in bronchoalveolar lavage fluid of anti-IP-10 antibody-treated F344 rats following Sendai viral infection.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 22(12):1175-9 [PMID] 12581489.
View on: PubMed
1999
Prevention of chronic postbronchiolitis airway sequelae with IFN-gamma treatment in rats.
American journal of respiratory and critical care medicine. 160(2):705-10 [PMID] 10430749.
View on: PubMed
1998
Attenuation of virus-induced airway dysfunction in rats treated with imiquimod.
The European respiratory journal. 11(2):324-9 [PMID] 9551732.
View on: PubMed
1998
Diagnosis of disseminated adenocarcinoma by bone marrow aspiration in a dog with leukoerythroblastosis and fever of unknown origin.
Veterinary clinical pathology. 27(3):80-84 [PMID] 12075543.
View on: PubMed
1998
Increased tumor necrosis factor-alpha (TNF-alpha) gene expression in parainfluenza type 1 (Sendai) virus-induced bronchiolar fibrosis.
The American journal of pathology. 152(2):513-22 [PMID] 9466578.
View on: PubMed
1997
Effects of 4-ipomeanol on bovine alveolar macrophage function.
Veterinary immunology and immunopathology. 58(2):133-45 [PMID] 9336881.
View on: PubMed
1997
Effects of dexamethasone on acute virus-induced airway dysfunction in adult rats.
Pediatric research. 41(6):872-7 [PMID] 9167201.
View on: PubMed
1996
Parainfluenza virus-induced persistence of airway inflammation, fibrosis, and dysfunction associated with TGF-beta 1 expression in brown Norway rats.
American journal of respiratory and critical care medicine. 154(6 Pt 1):1834-42 [PMID] 8970378.
View on: PubMed
1996
A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon.
The Journal of experimental medicine. 184(1):165-71 [PMID] 8691130.
View on: PubMed
1995
Virus-induced increases in bronchiolar mast cells in Brown Norway rats are associated with both local mast cell proliferation and increases in blood mast cell precursors.
Laboratory investigation; a journal of technical methods and pathology. 73(2):197-204 [PMID] 7543629.
View on: PubMed
1995
Virus-induced increases in airway mast cells in brown Norway rats are associated with enhanced pulmonary viral replication and persisting lymphocytic infiltration.
Experimental lung research. 21(2):197-213 [PMID] 7774525.
View on: PubMed
1994
Reversal of persistent postbronchiolitis airway abnormalities with dexamethasone in rats.
Journal of applied physiology (Bethesda, Md. : 1985). 76(1):333-8 [PMID] 8175526.
View on: PubMed
1994
Virus-induced airway obstruction and parasympathetic hyperresponsiveness in adult rats.
American journal of respiratory and critical care medicine. 150(1):28-34 [PMID] 8025764.
View on: PubMed
1993
Association of mononuclear cells and eosinophils with airway resistance and responsiveness in rat pulmonary inflammatory responses.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 4(3):144-51 [PMID] 7693231.
View on: PubMed
1993
Enhanced pulmonary pathology associated with the use of formalin-inactivated respiratory syncytial virus vaccine in cotton rats is not a unique viral phenomenon.
Vaccine. 11(14):1415-23 [PMID] 7508665.
View on: PubMed
1993
Immunogen-induced enhanced pulmonary histopathology in the RSV cotton rat model.
Vaccine. 11(6):689-90 [PMID] 8322496.
View on: PubMed
1993
Lack of detectable enhanced pulmonary histopathology in cotton rats immunized with purified F glycoprotein of respiratory syncytial virus (RSV) when challenged at 3-6 months after immunization.
Vaccine. 11(6):615-8 [PMID] 8322482.
View on: PubMed
1991
Brown Norway rats are high responders to bronchiolitis, pneumonia, and bronchiolar mastocytosis induced by parainfluenza virus.
Experimental lung research. 17(6):1025-45 [PMID] 1663031.
View on: PubMed
1991
Effects of 4-ipomeanol on bovine parainfluenza type 3 virus-induced pneumonia in calves.
Veterinary pathology. 28(5):428-37 [PMID] 1661042.
View on: PubMed
1991
Persistent airway hyperresponsiveness after neonatal viral bronchiolitis in rats.
Journal of applied physiology (Bethesda, Md. : 1985). 70(1):375-83 [PMID] 1849132.
View on: PubMed
1991
Replication of parainfluenza type-3 virus and bovine respiratory syncytial virus in isolated bovine type-II alveolar epithelial cells.
American journal of veterinary research. 52(6):880-5 [PMID] 1652906.
View on: PubMed
1990
Late pulmonary allergic responses in actively but not passively IgE-sensitized rats.
Journal of applied physiology (Bethesda, Md. : 1985). 69(3):1012-21 [PMID] 2246148.
View on: PubMed
1990
Morphometric and ultrastructural study of postnatal lung growth and development in calves.
American journal of veterinary research. 51(5):789-95 [PMID] 2337279.
View on: PubMed
1990
Pulmonary eosinophilia and granulomatous pulmonary arteritis induced in rats by intravenous Sephadex.
Veterinary pathology. 27(4):217-22 [PMID] 1698322.
View on: PubMed
1990
Pulmonary lesions induced by 3-methylindole and bovine respiratory syncytial virus in calves.
American journal of veterinary research. 51(11):1806-14 [PMID] 2173450.
View on: PubMed
1990
Ultrastructural morphogenesis of 4-ipomeanol-induced bronchiolitis and interstitial pneumonia in calves.
Veterinary pathology. 27(3):141-9 [PMID] 2353416.
View on: PubMed
1990
Viral bronchiolitis during early life induces increased numbers of bronchiolar mast cells and airway hyperresponsiveness.
The American journal of pathology. 137(4):821-31 [PMID] 1699421.
View on: PubMed
1990
Contribution of upper airways to antigen-induced late airway obstructive responses in guinea pigs.
The American review of respiratory disease. 142(1):138-42 [PMID] 2368959.
View on: PubMed
1989
Acute and persistent alterations in pulmonary inflammatory cells and airway mast cells induced by Sendai virus infection in neonatal rats.
Veterinary pathology. 26(1):18-25 [PMID] 2464229.
View on: PubMed
1989
Acute inflammatory lung injury retards pulmonary particle clearance.
Inflammation. 13(2):185-99 [PMID] 2547712.
View on: PubMed
1989
Effect of dietary fish oil on lung lipid profile and hypoxic pulmonary hypertension.
Journal of applied physiology (Bethesda, Md. : 1985). 66(4):1662-73 [PMID] 2732158.
View on: PubMed
1989
Influence of acute pulmonary interstitial inflammation on kinetics of phagocytosis by alveolar macrophages.
Inflammation. 13(4):429-41 [PMID] 2759685.
View on: PubMed
1989
Replication of parainfluenza (Sendai) virus in isolated rat pulmonary type II alveolar epithelial cells.
The American journal of pathology. 134(5):1135-42 [PMID] 2541612.
View on: PubMed
1988
The role of proteases in 4-ipomeanol-induced enhancement of Sendai viral pneumonia in mice.
Veterinary pathology. 25(3):199-204 [PMID] 2839923.
View on: PubMed
1988
Neonatal viral bronchiolitis and pneumonia induces bronchiolar hypoplasia and alveolar dysplasia in rats.
Laboratory investigation; a journal of technical methods and pathology. 59(3):387-96 [PMID] 3411939.
View on: PubMed
1988
In vitro Sendai viral replication in pulmonary macrophages from mice treated with 4-ipomeanol.
American journal of veterinary research. 49(10):1677-80 [PMID] 2847604.
View on: PubMed
1988
Analysis of leukotriene receptor antagonists on isolated human intralobar airways.
Annals of the New York Academy of Sciences. 524:181-6 [PMID] 2837953.
View on: PubMed
1987
4-Ipomeanol-induced effects on Sendai viral pneumonia in mice.
The American journal of pathology. 126(2):364-75 [PMID] 2435157.
View on: PubMed
1987
Alveolar macrophage phagocytic kinetics following pulmonary parainfluenza-3 virus infection.
Journal of leukocyte biology. 41(5):412-20 [PMID] 3033112.
View on: PubMed
1987
Laryngeal chondrosarcoma in a dog.
Journal of the American Veterinary Medical Association. 190(1):68-70 [PMID] 3818423.
View on: PubMed
1987
Pathogenesis of bronchiolitis and pneumonia induced in neonatal and weanling rats by parainfluenza (Sendai) virus.
The American journal of pathology. 129(2):277-86 [PMID] 2823613.
View on: PubMed
1987
Toxic hepatopathy and intrahepatic cholestasis associated with phenytoin administration in combination with other anticonvulsant drugs in three dogs.
Journal of the American Veterinary Medical Association. 190(2):194-8 [PMID] 3818433.
View on: PubMed
1986
Effect of pregnancy on the immune response of cattle to a Brucella vaccine.
Journal of reproductive immunology. 9(4):313-25 [PMID] 3820191.
View on: PubMed
1986
Light microscopic and electron microscopic changes in the livers of cats with extrahepatic bile duct obstruction.
American journal of veterinary research. 47(6):1278-82 [PMID] 3729128.
View on: PubMed
1986
Volume-controlled bronchopulmonary lavage of normal and pneumonic calves.
Veterinary pathology. 23(6):673-80 [PMID] 3811133.
View on: PubMed
1985
Severe respiratory disease in dairy cattle in New York State associated with bovine respiratory syncytial virus infection.
The Cornell veterinarian. 75(4):473-83 [PMID] 4053607.
View on: PubMed
1985
Pulmonary lesions induced by 3-methylindole in mice.
The American journal of pathology. 121(1):128-37 [PMID] 4050971.
View on: PubMed
1985
Pulmonary endothelial and bronchiolar epithelial lesions induced by 4-ipomeanol in mice.
The American journal of pathology. 118(1):66-75 [PMID] 3966538.
View on: PubMed
1985
Fibrillary deposits in glomerulonephritis in a horse.
Veterinary pathology. 22(6):647-9 [PMID] 4082394.
View on: PubMed
1985
Effects of long-term primidone and phenytoin administration on canine hepatic function and morphology.
American journal of veterinary research. 46(1):105-15 [PMID] 2857543.
View on: PubMed
1985
Experimental bovine respiratory syncytial virus infection in conventional calves: light microscopic lesions, microbiology, and studies on lavaged lung cells.
American journal of veterinary research. 46(3):547-53 [PMID] 3994121.
View on: PubMed
1985
Bronchiolitis obliterans and pneumonia induced in young dogs by experimental adenovirus infection.
The American journal of pathology. 119(3):495-504 [PMID] 2990219.
View on: PubMed
1985
Experimental bovine respiratory syncytial virus infection in conventional calves: ultrastructural respiratory lesions.
American journal of veterinary research. 46(3):554-60 [PMID] 3994122.
View on: PubMed
1984
Alterations in pulmonary ultrastructure and morphometric parameters induced by parainfluenza (Sendai) virus in rats during postnatal growth.
The American journal of pathology. 114(2):322-35 [PMID] 6320651.
View on: PubMed
1983
Immune response to porin in cattle immunized with whole cell, outer membrane, and outer membrane protein antigens of Brucella abortus combined with trehalose dimycolate and muramyl dipeptide adjuvants.
Infection and immunity. 42(3):1159-67 [PMID] 6315592.
View on: PubMed
1983
Leiomyosarcoma in the duodenum of a dog.
Journal of the American Veterinary Medical Association. 183(10):1096-7 [PMID] 6643219.
View on: PubMed
1983
Respiratory tract lesions in weanling outbred rats infected with Sendai virus.
American journal of veterinary research. 44(6):1024-31 [PMID] 6307091.
View on: PubMed
1983
Spontaneous pulmonary infections in animals affecting studies on comparative lung morphology and function.
The American review of respiratory disease. 128(2 Pt 2):S83-7 [PMID] 6881718.
View on: PubMed
1982
Hepatic cirrhosis associated with long-term anticonvulsant drug therapy in dogs.
Journal of the American Veterinary Medical Association. 181(4):357-62 [PMID] 7118708.
View on: PubMed
1982
Light and electron microscopic pulmonary lesions associated with retained microfilariae in canine occult dirofilariasis.
Veterinary pathology. 19(4):355-64 [PMID] 7090139.
View on: PubMed
1981
Assessment of hepatic function in rabbits with steroid-induced cholestatic liver injury.
Fundamental and applied toxicology : official journal of the Society of Toxicology. 1(4):329-33 [PMID] 6136444.
View on: PubMed
1980
Posterior paralysis and spinal osteomyelitis in a rhesus monkey with coccidioidomycosis.
Journal of the American Veterinary Medical Association. 177(9):933-4 [PMID] 7451346.
View on: PubMed
1980
Acute respiratory bronchiolitis: an ultrastructural and autoradiographic study of epithelial cell injury and renewal in rhesus monkeys exposed to ozone.
The American journal of pathology. 98(3):811-40 [PMID] 6767409.
View on: PubMed
1979
Ozone-induced alterations in collagen metabolism of rat lungs.
Toxicology and applied pharmacology. 51(2):247-58 [PMID] 531890.
View on: PubMed
1977
Adult heartworms in arteries and veins of a dog.
Journal of the American Veterinary Medical Association. 170(7):717-9 [PMID] 858687.
View on: PubMed
1977
Lesions in respiratory bronchioles and conducting airways of monkeys exposed to ambient levels of ozone.
Experimental and molecular pathology. 26(3):384-400 [PMID] 405246.
View on: PubMed
1976
[Hyperplastic and inflammatory lesions of the pulmonary airways in primates following subacute exposure to low doses of ozone (0.2 ppm)].
Bulletin of the International Union against Tuberculosis. 51(1 Pt 2):599-601 [PMID] 829971.
View on: PubMed
1975
Effect of ambient levels of ozone on monkeys.
Federation proceedings. 34(8):1670-4 [PMID] 1132526.
View on: PubMed
1975
Intrapulmonary airway morphology in three species of monkeys: a correlated scanning and transmission electron microscopic study.
The American journal of anatomy. 142(1):107-21 [PMID] 804810.
View on: PubMed
1973
Cytochemically detected alterations of lung acid phosphatase reactivity following ozone exposure.
Laboratory investigation; a journal of technical methods and pathology. 29(3):310-9 [PMID] 4126553.
View on: PubMed
1973
Histochemically detected enzymatic alterations in rat lung exposed to ozone.
Experimental and molecular pathology. 19(3):402-21 [PMID] 4128552.
View on: PubMed

Grants

Nov 2017 – Jun 2018
Hex-003-004
Role: Project Manager
Funding: UNIV OF MASSACHUSETTS MEDICAL SCHOOL
Aug 2017 ACTIVE
Harnessing Natural Killer T cells to counteract swine influenza
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
May 2017 – May 2020
Testing a role for NKT cells for swine influenza immunity
Role: Co-Investigator
Funding: US DEPT OF AG NATL INST OF FOOD AND AG
Sep 2013 – Aug 2016
Natural Killer T (NKT) Cell Control of Pandemic Swine Influenza Infection: A Novel Pig Model
Role: Project Manager
Funding: UF DSR OPPORTUNITY FUND

Patents

Issued June 2011
Canine Influenza Virus
#7,959,929
Issued May 2016
Materials and Methods for Respiratory Disease Control in Canines (DIV2)
#9,345,758
Issued March 2018
Materials and Methods for Respiratory Disease Control in Canines (DIV1)
#9,913,892

Education

PhD, Comparative Pathology (DVM-PhD program)
1979 · University of California, Davis
DVM, Veterinary Medicine
1977 · University of California, Davis
Masters of Science in Anatomy
1972 · University of California Davis

Teaching Profile

Courses Taught
2018
PHC7980 Research for Doctoral Dissertation
2007-2008,2011-2018
VEM5162 Vet Pathology 2
2010-2018
VEM5751 Core Clk Appl Pathol
2011-2012,2017-2018
VEM5851 Senior Clk App Pathol
2006-2007,2009-2017
VEM5161 Vet General Pathol
2009-2017
VEM5165 Large Anim Pathology
2006-2009
VME6934 Topics in Veterinary Medical Sciences

Contact Details

Phones:
Business:
(352) 283-0364
Emails:
Business:
castlemanw@ufl.edu

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