Donald C Bolser

Donald C Bolser,

Professor

Department: Department of Physiological Sciences
Business Phone: (352) 294-4026
Business Email: bolser@ufl.edu

Accomplishments

UF Research Foundation Professorship
2017-2020 · University of Florida
UF Term Professorship,
2017 · University of Florida
External referee
2016 · Research Foundation
Member
2016 · Animal Care and Experimentation Committee, American Physiological Society
UF Research Foundation Professorship
2016 · University of Florida
UF Termed Professor – Research Foundation Professor
2013-2017 · University of Florida
Member
2013 · NIH study section for P50 Clinical Research Center grant
Member, Panel on Evidence-based Clinical Practice Guidelines for Diagnosis and Management of Cough
2011 · American College of Chest Physicians
Co-Chair, organizer and invited speaker, Airway Protective Behaviors: Cough and Swallow
2010 · Experimental Biology Meeting Symposium
Animal Health Award for Research Excellence
2008 · Pfizer
Editorial Board
2005-2019 · Journal of Applied Physiology

Research Profile

Cough is the most common reason why sick patients visit physicians in the US. This defensive reflex is the most common manifestation of tobacco- and non-tobacco-related pulmonary diseases. Furthermore, cough suppressant (also called antitussive) drugs are among the most commonly prescribed in the world. Significant gaps exist in our understanding of how cough is produced and how this defensive reflex is inhibited by antitussive drugs. The long-range goal of research in our laboratory is to delineate the how the nervous system produces and regulates cough. We use antitussive drugs as tools to determine how the cough system is controlled. As such, our work also will expand our knowledge of the mechanisms by which these drugs inhibit cough. Our current approach incorporates the use of multiple extracellular electrode array technology to investigate the behavior of spontaneously active and recruited neurons in the brainstem during cough. Determination of the identity and functional relationships between these neurons will allow modeling of the configuration of the brainstem cough network. Perturbation of the behavior of these neurons with antitussive drugs will allow us to identify the mechanism by which cough suppressants act to inhibit this behavior.

Publications

2021
Acute morphine blocks spinal respiratory motor plasticity via long-latency mechanisms that require toll-like receptor 4 signalling.
The Journal of physiology. 599(15):3771-3797 [DOI] 10.1113/JP281362. [PMID] 34142718.
2021
Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.
PloS one. 16(6) [DOI] 10.1371/journal.pone.0253060. [PMID] 34153070.
2021
Global Physiology and Pathophysiology of Cough: Part 2. Demographic and Clinical Considerations: CHEST Expert Panel Report.
Chest. [DOI] 10.1016/j.chest.2021.04.039. [PMID] 33905678.
2021
Intra-Arterial, but Not Intrathecal, Baclofen and Codeine Attenuates Cough in the Cat.
Frontiers in physiology. 12 [DOI] 10.3389/fphys.2021.640682. [PMID] 33746778.
2021
Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding.
Journal of neurophysiology. 125(5):1899-1919 [DOI] 10.1152/jn.00017.2021. [PMID] 33826874.
2020
Good things come in small packages…except after spinal injury.
The Journal of physiology. 598(20):4427-4428 [DOI] 10.1113/JP280588. [PMID] 32833267.
2020
Impact of Tussigenic Stimuli on Perceived Upper Airway Sensation and Motor Cough Response Following Total Laryngectomy.
Frontiers in physiology. 11 [DOI] 10.3389/fphys.2020.00477. [PMID] 32547408.
2020
Respiratory-Swallow Pattern Following Total Laryngectomy.
Dysphagia. 35(2):321-327 [DOI] 10.1007/s00455-019-10031-y. [PMID] 31278485.
2020
Swallow Motor Pattern Is Modulated by Fixed or Stochastic Alterations in Afferent Feedback.
Frontiers in human neuroscience. 14 [DOI] 10.3389/fnhum.2020.00112. [PMID] 32327986.
2020
Transcutaneous Electrical Stimulation on the Submental Area: The Relations of Biopsychological Factors with Maximum Amplitude Tolerance and Perceived Discomfort Level.
Dysphagia. 35(2):301-307 [DOI] 10.1007/s00455-019-10029-6. [PMID] 31209638.
2019
Adult Outpatients With Acute Cough Due to Suspected Pneumonia or Influenza CHEST Guideline and Expert Panel Report
Chest. 155(1):155-167 [DOI] 10.1016/j.chest.2018.09.016. [PMID] 30296418.
2019
Clinically Diagnosing Pertussis-associated Cough in Adults and Children CHEST Guideline and Expert Panel Report
Chest. 155(1):147-154 [DOI] 10.1016/j.chest.2018.09.027. [PMID] 30321509.
2019
The Effects of Electrical Stimulation Pulse Duration on Lingual Palatal Pressure Measures During Swallowing in Healthy Older Adults.
Dysphagia. 34(4):529-539 [DOI] 10.1007/s00455-019-09991-y. [PMID] 30820657.
2019
The Role of the Cerebellum in Control of Swallow: Evidence of Inspiratory Activity During Swallow.
Lung. 197(2):235-240 [DOI] 10.1007/s00408-018-00192-2. [PMID] 30680516.
2019
Utilization of Near Infrared Fluorescence Imaging to Track and Quantify the Pulmonary Retention of Single-Walled Carbon Nanotubes in Mice.
NanoImpact. 14 [DOI] 10.1016/j.impact.2019.100167. [PMID] 32818159.
2018
Carotid chemoreceptors tune breathing via multipath routing: reticular chain and loop operations supported by parallel spike train correlations.
Journal of neurophysiology. 119(2):700-722 [DOI] 10.1152/jn.00630.2017. [PMID] 29046425.
2018
Central Respiration and Mechanical Ventilation in the Gating of Swallow With Breathing.
Frontiers in physiology. 9 [DOI] 10.3389/fphys.2018.00785. [PMID] 30013484.
2018
Correction: Suppression of Abdominal Motor Activity during Swallowing in Cats and Humans.
PloS one. 13(5) [DOI] 10.1371/journal.pone.0197525. [PMID] 29746585.
2018
GABA-ergic neurotransmission in the nucleus of the solitary tract modulates cough in the cat.
Respiratory physiology & neurobiology. 257:100-106 [DOI] 10.1016/j.resp.2018.02.009. [PMID] 29474953.
2018
Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow.
PloS one. 13(7) [DOI] 10.1371/journal.pone.0199903. [PMID] 30024913.
2018
Transcutaneous electrical stimulation on the anterior neck region: The impact of pulse duration and frequency on maximum amplitude tolerance and perceived discomfort.
Journal of oral rehabilitation. 45(6):436-441 [DOI] 10.1111/joor.12625. [PMID] 29574920.
2018
Treating Cough Due to Non-CF and CF Bronchiectasis With Nonpharmacological Airway Clearance: CHEST Expert Panel Report.
Chest. 153(4):986-993 [DOI] 10.1016/j.chest.2018.01.014. [PMID] 29355548.
2017
Anatomy and physiology of phrenic afferent neurons.
Journal of neurophysiology. 118(6):2975-2990 [DOI] 10.1152/jn.00484.2017. [PMID] 28835527.
2017
Microinjection of kynurenic acid in the rostral nucleus of the tractus solitarius disrupts spatiotemporal aspects of mechanically induced tracheobronchial cough.
Journal of neurophysiology. 117(6):2179-2187 [DOI] 10.1152/jn.00935.2016. [PMID] 28250153.
2017
Role of the dorsomedial medulla in suppression of cough by codeine in cats.
Respiratory physiology & neurobiology. 246:59-66 [DOI] 10.1016/j.resp.2017.07.011. [PMID] 28778649.
2016
Alterations in oropharyngeal sensory evoked potentials (PSEP) with Parkinson’s disease.
Respiratory physiology & neurobiology. 229:11-6 [DOI] 10.1016/j.resp.2016.04.004. [PMID] 27090350.
2016
Effect of laparotomy on respiratory muscle activation pattern.
Physiological reports. 4(1) [DOI] 10.14814/phy2.12668. [PMID] 26733250.
2016
Feed-forward and reciprocal inhibition for gain and phase timing control in a computational model of repetitive cough.
Journal of applied physiology (Bethesda, Md. : 1985). 121(1):268-78 [DOI] 10.1152/japplphysiol.00790.2015. [PMID] 27283917.
2015
Assessment of Intervention Fidelity and Recommendations for Researchers Conducting Studies on the Diagnosis and Treatment of Chronic Cough in the Adult: CHEST Guideline and Expert Panel Report.
Chest. 148(1):32-54 [DOI] 10.1378/chest.15-0164. [PMID] 25764280.
2015
Central administration of nicotine suppresses tracheobronchial cough in anesthetized cats.
Journal of applied physiology (Bethesda, Md. : 1985). 118(3):265-72 [DOI] 10.1152/japplphysiol.00075.2014. [PMID] 25477349.
2015
Effect of laparotomy on the swallow-breathing relationship in the cat.
Lung. 193(1):129-33 [DOI] 10.1007/s00408-014-9662-x. [PMID] 25331536.
2015
Functional connectivity in raphé-pontomedullary circuits supports active suppression of breathing during hypocapnic apnea.
Journal of neurophysiology. 114(4):2162-86 [DOI] 10.1152/jn.00608.2015. [PMID] 26203111.
2015
Peripheral chemoreceptors tune inspiratory drive via tonic expiratory neuron hubs in the medullary ventral respiratory column network.
Journal of neurophysiology. 113(1):352-68 [DOI] 10.1152/jn.00542.2014. [PMID] 25343784.
2015
Role of the dorsal medulla in the neurogenesis of airway protection.
Pulmonary pharmacology & therapeutics. 35:105-10 [DOI] 10.1016/j.pupt.2015.10.012. [PMID] 26549786.
2015
Somatic Cough Syndrome (Previously Referred to as Psychogenic Cough) and Tic Cough (Previously Referred to as Habit Cough) in Adults and Children: CHEST Guideline and Expert Panel Report.
Chest. 148(1):24-31 [DOI] 10.1378/chest.15-0423. [PMID] 25856777.
2015
Suppression of Abdominal Motor Activity during Swallowing in Cats and Humans.
PloS one. 10(5) [DOI] 10.1371/journal.pone.0128245. [PMID] 26020240.
2014
Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report.
Chest. 146(6):1633-1648 [DOI] 10.1378/chest.14-1481. [PMID] 25188530.
2014
Cats That Successfully Vent Gastric Acid-Derived Co2 Exhibit Different Muscle Activation Than Those That Do Not
The FASEB's Journal. 28(1, S)
2014
Coordination of Swallow and Breathing: in Vivo and Computational Model Simulations
The FASEB's Journal. 28(1, S)
2014
Functional neural-bone marrow pathways: implications in hypertension and cardiovascular disease.
Hypertension (Dallas, Tex. : 1979). 63(6):e129-39 [DOI] 10.1161/HYPERTENSIONAHA.114.02440. [PMID] 24688127.
2014
Variability of the pharyngeal phase of swallow in the cat.
PloS one. 9(8) [DOI] 10.1371/journal.pone.0106121. [PMID] 25171095.
2014
What is chronic cough in children?
Frontiers in physiology. 5 [DOI] 10.3389/fphys.2014.00322. [PMID] 25221517.
2013
Central neural circuits for coordination of swallowing, breathing, and coughing: predictions from computational modeling and simulation.
Otolaryngologic clinics of North America. 46(6):957-64 [DOI] 10.1016/j.otc.2013.09.013. [PMID] 24262953.
2013
Coordination of cough and swallow: a meta-behavioral response to aspiration.
Respiratory physiology & neurobiology. 189(3):543-51 [DOI] 10.1016/j.resp.2013.08.009. [PMID] 23998999.
2013
Effect of Repetitive Coughing On Swallowing in the Anesthetized Cat
The FASEB's Journal. 27
2013
Influence of Baclofen On Upper Airway and Spinal Motor Drive During Cough in the Anesthetized Cat
The FASEB's Journal. 27
2013
Laparotomy Disrupts Respiratory Phase Preference for Swallow
The FASEB's Journal. 27
2013
Persistent Activity and Interactions in the Brainstem Respiratory Network During Hyperventilatory Apnea
The FASEB's Journal. 27
2013
Prediction of Inverse Relationship Between Compression Phase Duration and Expulsive Airflow During Voluntary Cough in Humans By a Joint Neural Network Biomechanical Computational Model
The FASEB's Journal. 27
2013
Ventral Respiratory Column Tonic Expiratory Neurons: Nodes for Convergent Afferent Modulation of Inspiratory Drive
The FASEB's Journal. 27
2012
A joint computational respiratory neural network-biomechanical model for breathing and airway defensive behaviors.
Frontiers in physiology. 3 [DOI] 10.3389/fphys.2012.00264. [PMID] 22934020.
2012
Co-ordination of cough and swallow in vivo and in silico.
Experimental physiology. 97(4):469-73 [DOI] 10.1113/expphysiol.2011.063362. [PMID] 22198014.
2012
Discharge Identity of Medullary Inspiratory Neurons is Altered during Repetitive Fictive Cough.
Frontiers in physiology. 3 [DOI] 10.3389/fphys.2012.00223. [PMID] 22754536.
2012
Gastric Co2 Output Via the Esophagus Increases During Systemic Hypercapnia in Anesthetized Cat
The FASEB's Journal. 26
2012
Microinjection of Kynurenic Acid (Ka) Into the Medial Reticular Formation Elicits Behavior-Dependent Effects On Cough and Swallow Motor Patterns in the Anesthetized Cat
The FASEB's Journal. 26
2012
Modulation of Tracheobronchial Cough By Sensory Input: in Vivo Experiments and Model Simulations
The FASEB's Journal. 26
2012
Volitional control of reflex cough.
Journal of applied physiology (Bethesda, Md. : 1985). 113(1):39-46 [DOI] 10.1152/japplphysiol.01299.2011. [PMID] 22492938.
2012
Volitional Modification of Cough Induced By Supra-Threshold Concentrations of Capsaicin
Lung. 190
2011
Blood pressure changes alter tracheobronchial cough: computational model of the respiratory-cough network and in vivo experiments in anesthetized cats.
Journal of applied physiology (Bethesda, Md. : 1985). 111(3):861-73 [DOI] 10.1152/japplphysiol.00458.2011. [PMID] 21719729.
2011
Swallow remodeling of respiratory neural networks.
Head & neck. 33 Suppl 1:S8-13 [DOI] 10.1002/hed.21845. [PMID] 21901777.
2011
The use of multiscale systems biology approaches to facilitate understanding of complex control systems for airway protection.
Current opinion in pharmacology. 11(3):272-7 [DOI] 10.1016/j.coph.2011.06.002. [PMID] 21724463.
2011
Urge to cough with voluntary suppression following mechanical pharyngeal stimulation.
Bratislavske lekarske listy. 112(3):109-14 [PMID] 21452760.
View on: PubMed
2011
Workshop: tuning the ‘cough center’.
Pulmonary pharmacology & therapeutics. 24(3):344-52 [DOI] 10.1016/j.pupt.2010.12.010. [PMID] 21215322.
2010
A streetcar named urge-to-cough.
Journal of applied physiology (Bethesda, Md. : 1985). 108(5):1030-1 [DOI] 10.1152/japplphysiol.00177.2010. [PMID] 20185634.
2010
Cough following low thoracic hemisection in the cat.
Experimental neurology. 222(1):165-70 [DOI] 10.1016/j.expneurol.2009.12.015. [PMID] 20043908.
2010
Microinjection of codeine into the region of the caudal ventral respiratory column suppresses cough in anesthetized cats.
Journal of applied physiology (Bethesda, Md. : 1985). 108(4):858-65 [DOI] 10.1152/japplphysiol.00783.2009. [PMID] 20093669.
2010
Pharmacologic management of cough.
Otolaryngologic clinics of North America. 43(1):147-55, xi [DOI] 10.1016/j.otc.2009.11.008. [PMID] 20172264.
2010
Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.
European journal of pharmacology. 630(1-3):112-20 [DOI] 10.1016/j.ejphar.2009.12.003. [PMID] 20006596.
2009
Central mechanisms II: pharmacology of brainstem pathways.
Handbook of experimental pharmacology. (187):203-17 [DOI] 10.1007/978-3-540-79842-2_10. [PMID] 18825342.
2009
Cough and Aspiration Response
Chest. 136 [DOI] 10.1378/chest.09-0901. [PMID] 24305227.
2009
Effect of a novel NOP receptor agonist (SCH 225288) on guinea pig irritant-evoked, feline mechanically induced and canine infectious tracheobronchitis cough.
Pharmacology. 84(3):153-61 [DOI] 10.1159/000235601. [PMID] 19696521.
2009
Impact of expiratory muscle strength training on voluntary cough and swallow function in Parkinson disease.
Chest. 135(5):1301-1308 [DOI] 10.1378/chest.08-1389. [PMID] 19029430.
2009
Poster discussion: summary. Fifth International Cough Symposium.
Pulmonary pharmacology & therapeutics. 22(2):163-5 [DOI] 10.1016/j.pupt.2008.10.005. [PMID] 19026758.
2009
Predicting aspiration in patients with ischemic stroke: comparison of clinical signs and aerodynamic measures of voluntary cough.
Chest. 135(3):769-777 [DOI] 10.1378/chest.08-1122. [PMID] 19017886.
2009
Recovery of airway protective behaviors after spinal cord injury.
Respiratory physiology & neurobiology. 169(2):150-6 [DOI] 10.1016/j.resp.2009.07.018. [PMID] 19635591.
2009
Respiratory recovery following high cervical hemisection.
Respiratory physiology & neurobiology. 169(2):94-101 [DOI] 10.1016/j.resp.2009.06.014. [PMID] 19560562.
2009
Semantics and types of cough.
Pulmonary pharmacology & therapeutics. 22(2):139-42 [DOI] 10.1016/j.pupt.2008.12.008. [PMID] 19136069.
2009
Spatiotemporal regulation of the cough motor pattern.
Cough (London, England). 5 [DOI] 10.1186/1745-9974-5-12. [PMID] 20028523.
2009
The urge-to-cough and cough motor response modulation by the central effects of nicotine.
Pulmonary pharmacology & therapeutics. 22(2):82-9 [DOI] 10.1016/j.pupt.2008.11.013. [PMID] 19100331.
2009
Voluntary Cough and Swallow Function in Normal Control Middle Age and Older Subjects
Dysphagia. 24
2008
Brainstem circuitry of tracheal-bronchial cough: c-fos study in anesthetized cats.
Respiratory physiology & neurobiology. 160(3):289-300 [PMID] 18055277.
View on: PubMed
2008
Cervical prephrenic interneurons in the normal and lesioned spinal cord of the adult rat.
The Journal of comparative neurology. 511(5):692-709 [DOI] 10.1002/cne.21864. [PMID] 18924146.
2008
Influence of microinjections of D,L-homocysteic acid into the Botzinger complex area on the cough reflex in the cat.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 59 Suppl 6:585-96 [PMID] 19218685.
View on: PubMed
2008
Modest spontaneous recovery of ventilation following chronic high cervical hemisection in rats.
Experimental neurology. 211(1):97-106 [DOI] 10.1016/j.expneurol.2008.01.013. [PMID] 18308305.
2008
Older-generation antihistamines and cough due to upper airway cough syndrome (UACS): efficacy and mechanism.
Lung. 186 Suppl 1:S74-7 [PMID] 17909896.
View on: PubMed
2008
Short reflex expirations (expiration reflexes) induced by mechanical stimulation of the trachea in anesthetized cats.
Cough (London, England). 4 [DOI] 10.1186/1745-9974-4-1. [PMID] 18442388.
2008
Voluntary cough production and swallow dysfunction in Parkinson’s disease.
Dysphagia. 23(3):297-301 [DOI] 10.1007/s00455-007-9144-x. [PMID] 18483823.
2007
Brainstem regions involved in the expiration reflex. A c-fos study in anesthetized cats.
Brain research. 1184:168-77 [PMID] 17964550.
View on: PubMed
2007
Capsaicin exposure elicits complex airway defensive motor patterns in normal humans in a concentration-dependent manner.
Pulmonary pharmacology & therapeutics. 20(4):423-32 [PMID] 17236796.
View on: PubMed
2007
Codeine and cough: an ineffective gold standard.
Current opinion in allergy and clinical immunology. 7(1):32-6 [PMID] 17218808.
View on: PubMed
2007
Microinjection of DLH into the region of the caudal ventral respiratory column in the cat: evidence for an endogenous cough-suppressant mechanism.
Journal of applied physiology (Bethesda, Md. : 1985). 102(3):1014-21 [PMID] 17138836.
View on: PubMed
2007
Sulfur-dioxide exposure increases TRPV1-mediated responses in nodose ganglia cells and augments cough in guinea pigs.
Pulmonary pharmacology & therapeutics. 20(6):750-7 [PMID] 17126052.
View on: PubMed
2007
The effect of codeine on the Urge-to-Cough response to inhaled capsaicin.
Pulmonary pharmacology & therapeutics. 20(4):338-46 [PMID] 17292647.
View on: PubMed
2006
Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical practice guidelines.
Chest. 129(1 Suppl):238S-249S [DOI] 10.1378/chest.129.1_suppl.238S. [PMID] 16428717.
2006
Current and future centrally acting antitussives.
Respiratory physiology & neurobiology. 152(3):349-55 [PMID] 16517221.
View on: PubMed
2006
Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines.
Chest. 129(1 Suppl):1S-23S [DOI] 10.1378/chest.129.1_suppl.1S. [PMID] 16428686.
2006
Expiratory muscle strength training in persons with multiple sclerosis having mild to moderate disability: effect on maximal expiratory pressure, pulmonary function, and maximal voluntary cough.
Archives of physical medicine and rehabilitation. 87(4):468-73 [PMID] 16571384.
View on: PubMed
2006
Neurogenesis of cough, other airway defensive behaviors and breathing: A holarchical system?
Respiratory physiology & neurobiology. 152(3):255-65 [PMID] 16723284.
View on: PubMed
2005
Augmented breath phase volume and timing relationships in the anesthetized rat.
Neuroscience letters. 373(2):89-93 [PMID] 15567559.
View on: PubMed
2004
Experimental models and mechanisms of enhanced coughing.
Pulmonary pharmacology & therapeutics. 17(6):383-8 [PMID] 15564080.
View on: PubMed
2003
Respiratory motor recovery after unilateral spinal cord injury: eliminating crossed phrenic activity decreases tidal volume and increases contralateral respiratory motor output.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(6):2494-501 [PMID] 12657710.
View on: PubMed
2003
Urethane anesthesia in adult female rats: preliminary observations.
Veterinary anaesthesia and analgesia. 30(2) [DOI] 10.1046/j.1467-2995.2003.13335.x. [PMID] 28404410.
2002
Antitussive effect of nociceptin/orphanin FQ in experimental cough models.
Pulmonary pharmacology & therapeutics. 15(3):213-6 [PMID] 12099766.
View on: PubMed
2002
Functional organization of the central cough generation mechanism.
Pulmonary pharmacology & therapeutics. 15(3):221-5 [PMID] 12099768.
View on: PubMed
2002
Gray matter repair in the cervical spinal cord.
Progress in brain research. 137:49-70 [PMID] 12440359.
View on: PubMed
2002
Summary: animal models for cough.
Pulmonary pharmacology & therapeutics. 15(3):249-50 [PMID] 12099772.
View on: PubMed
2002
The effects of cervical spinal cord injury on the pattern of breathing in the rat.
Veterinary anaesthesia and analgesia. 29(2):111-112 [DOI] 10.1046/j.1467-2995.2002.00078_34.x. [PMID] 28404296.
2001
Altered respiratory motor drive after spinal cord injury: supraspinal and bilateral effects of a unilateral lesion.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 21(21):8680-9 [PMID] 11606656.
View on: PubMed
2001
Antitussive action of nociceptin in the cat.
European journal of pharmacology. 430(1):107-11 [PMID] 11698070.
View on: PubMed
2001
Assessment of aspiration risk in stroke patients with quantification of voluntary cough.
Neurology. 56(4):502-6 [PMID] 11222795.
View on: PubMed
2001
Cervical spinal cord injury alters the pattern of breathing in anesthetized rats.
Journal of applied physiology (Bethesda, Md. : 1985). 91(6):2451-8 [PMID] 11717204.
View on: PubMed
2000
Responses of the anterolateral abdominal muscles during cough and expiratory threshold loading in the cat.
Journal of applied physiology (Bethesda, Md. : 1985). 88(4):1207-14 [PMID] 10749809.
View on: PubMed
2000
Volume-timing relationships during cough and resistive loading in the cat.
Journal of applied physiology (Bethesda, Md. : 1985). 89(2):785-90 [PMID] 10926666.
View on: PubMed
1999
Influence of central antitussive drugs on the cough motor pattern.
Journal of applied physiology (Bethesda, Md. : 1985). 86(3):1017-24 [PMID] 10066718.
View on: PubMed
1998
Antitussive action of antihistamines is independent of sedative and ventilation activity in the guinea pig.
Pharmacology. 57(2):57-64 [PMID] 9691225.
View on: PubMed
1998
Inspiratory and expiratory patterns of the pectoralis major muscle during pulmonary defensive reflexes.
Journal of applied physiology (Bethesda, Md. : 1985). 85(5):1786-92 [PMID] 9804582.
View on: PubMed
1998
Studies on the pharmacology of the novel histamine H3 receptor agonist Sch 50971.
Arzneimittel-Forschung. 48(9):881-8 [PMID] 9793613.
View on: PubMed
1997
Central antitussive activity of the NK1 and NK2 tachykinin receptor antagonists, CP-99,994 and SR 48968, in the guinea-pig and cat.
British journal of pharmacology. 121(2):165-70 [PMID] 9154323.
View on: PubMed
1996
Mechanisms of action of central and peripheral antitussive drugs.
Pulmonary pharmacology. 9(5-6):357-64 [PMID] 9232675.
View on: PubMed
1995
Evan’s blue dye blocks capsaicin-induced cough and bronchospasm in the guinea pig.
European journal of pharmacology. 276(1-2):R1-3 [PMID] 7781678.
View on: PubMed
1995
Pharmacological studies of allergic cough in the guinea pig.
European journal of pharmacology. 277(2-3):159-64 [PMID] 7493604.
View on: PubMed
1995
Respiratory effects of baclofen and 3-aminopropylphosphinic acid in guinea-pigs.
British journal of pharmacology. 114(4):735-8 [PMID] 7773531.
View on: PubMed
1995
The pharmacology of SCH 50911: a novel, orally-active GABA-beta receptor antagonist.
The Journal of pharmacology and experimental therapeutics. 274(3):1393-8 [PMID] 7562513.
View on: PubMed
1994
Effect of codeine on the inspiratory and expiratory burst pattern during fictive cough in cats.
Brain research. 662(1-2):25-30 [PMID] 7859078.
View on: PubMed
1994
Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig.
British journal of pharmacology. 113(4):1344-8 [PMID] 7889290.
View on: PubMed
1993
Antitussive effects of GABAB agonists in the cat and guinea-pig.
British journal of pharmacology. 110(1):491-5 [PMID] 8220912.
View on: PubMed
1993
GABAB receptors in the lung.
Trends in pharmacological sciences. 14(1):26-9 [PMID] 8382886.
View on: PubMed
1992
Evidence that C1 and C2 propriospinal neurons mediate the inhibitory effects of viscerosomatic spinal afferent input on primate spinothalamic tract neurons.
Journal of neurophysiology. 67(4):852-60 [PMID] 1588386.
View on: PubMed
1992
Intracardiac phenylbiguanide causes excitation of spinal neurons by activation of cardiac sympathetic afferents.
European journal of pharmacology. 216(1):119-22 [PMID] 1526250.
View on: PubMed
1992
Segmental organization of visceral and somatic input onto C3-T6 spinothalamic tract cells of the monkey.
Journal of neurophysiology. 68(5):1575-88 [PMID] 1479431.
View on: PubMed
1991
Convergence of phrenic and cardiopulmonary spinal afferent information on cervical and thoracic spinothalamic tract neurons in the monkey: implications for referred pain from the diaphragm and heart.
Journal of neurophysiology. 65(5):1042-54 [PMID] 1869904.
View on: PubMed
1991
Effects of vagal afferent stimulation on cervical spinothalamic tract neurons in monkeys.
Pain. 44(1):81-87 [DOI] 10.1016/0304-3959(91)90152-N. [PMID] 2038494.
1991
Fictive cough in the cat.
Journal of applied physiology (Bethesda, Md. : 1985). 71(6):2325-31 [PMID] 1778930.
View on: PubMed
1991
Inhibitory effects of phrenic afferent fibers on primate lumbosacral spinothalamic tract neurons.
Brain research. 557(1-2):162-6 [PMID] 1747751.
View on: PubMed
1991
Ruthenium red decreases capsaicin and citric acid-induced cough in guinea pigs.
Neuroscience letters. 126(2):131-3 [PMID] 1717893.
View on: PubMed
1989
Effects of intracardiac bradykinin and capsaicin on spinal and spinoreticular neurons.
The American journal of physiology. 257(5 Pt 2):H1543-50 [PMID] 2589509.
View on: PubMed
1989
Synaptic effects of intercostal tendon organs on membrane potentials of medullary respiratory neurons.
Journal of neurophysiology. 61(5):918-26 [PMID] 2723734.
View on: PubMed
1988
Medullary neurons mediating the inhibition of inspiration by intercostal muscle tendon organs?
Journal of applied physiology (Bethesda, Md. : 1985). 65(6):2498-505 [PMID] 3215849.
View on: PubMed
1988
Respiratory pattern changes produced by intercostal muscle/rib vibration.
Journal of applied physiology (Bethesda, Md. : 1985). 64(6):2458-62 [PMID] 3403429.
View on: PubMed
1987
Medullary expiratory activity: influence of intercostal tendon organs and muscle spindle endings.
Journal of applied physiology (Bethesda, Md. : 1985). 62(3):1057-62 [PMID] 3571062.
View on: PubMed
1987
Medullary inspiratory activity: influence of intercostal tendon organs and muscle spindle endings.
Journal of applied physiology (Bethesda, Md. : 1985). 62(3):1046-56 [PMID] 3571061.
View on: PubMed
1985
Non-vagal reflex effects on medullary inspiratory neurons during inspiratory loading.
Respiration physiology. 60(2):193-204 [PMID] 4012092.
View on: PubMed

Grants

Jan 2021 ACTIVE
Influence of Opioids on the Brainstem Respiratory Network
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Dec 2016 ACTIVE
Modeling the role of the NTS in the neurogenesis of airway defensive behaviors
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Sep 2016 ACTIVE
Functional mapping of peripheral and central circuits for airway protection and breathing
Role: Principal Investigator
Funding: NATL INST OF HLTH OD
Dec 2015 – Dec 2016
Modeling the role of the NTS in the neurogenesis
Role: Principal Investigator
Funding: UF FOU
Jun 2012 – May 2016
Brainstem respiratory neuron interactions
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA TAMPA via NATL INST OF HLTH

Patents

Issued June 2016
Controlling Coughing and Swallowing (combined with 14242)
#9,375,568
Issued May 2015
Protecting Airways (combined with 14739)
#9,042,992

Education

PhD – Physiology
1985 · University of South Florida

Teaching Profile

Courses Taught
2009-2011,2015-2021
VEM5111 Animal Systems 2
2009-2012,2014-2021,2018-2021
VEM5112 Animal Systems 3
2017-2021
VEM5041 Animal Welfare/Ethics
2018
VME7980 Research for Doctoral Dissertation
2011,2013-2015,2015-2017,2017
VME5244 Physiology: Organ Systems
2010,2014-2016
VEM5110 Animal Systems 1
2015-2016
VME6905 Problems in Veterinary Medical Sciences
2010-2011,2021
VME6932 Seminar in Physiological Sciences

Contact Details

Phones:
Business:
(352) 294-4026
Emails:
Business:
bolser@ufl.edu