Sandra M Bechtel

Sandra M Bechtel,

Associate Professor, Medical Oncology

Department: Small Animal Clinical Sciences
Business Phone: (352) 392-2235
Business Email: axiaks@ufl.edu

Teaching Profile

Courses Taught
2020,2023
VEM5200 Pnt Care Clin Skill 1
2020-2024
VEM5872C Veterinary Medical & Radiation Oncology Clerkship
2018-2023
VEM5308 Vet Med Oncology
2019-2021
VEM5008 Personal/Prof Develop
2018-2020
VEM5873 Oncology Clrkshp Elec
2019-2020
VME6905 Problems in Veterinary Medical Sciences
2021
VEM5874C Veterinary Surgical Oncology Clerkship
2021-2023
VEM5286 Vet Clin Pharmacology

Research Profile

Improving the lives of companion animals with naturally occurring cancer; providing translational models for research in cancer causation, progression, and treatment Investigating innate immune system function in dogs with cancer; and nanoparticle therapeutics in dogs with cancer

Open Researcher and Contributor ID (ORCID)

0000-0002-7773-5959

Publications

2023
Safety of TCMCB07, a melanocortin‐4 antagonist peptide, in dogs with naturally occurring cachexia
Journal of Veterinary Internal Medicine. 37(6):2344-2355 [DOI] 10.1111/jvim.16915. [PMID] 37897303.
2022
Paired 18F-Fluorodeoxyglucose (18F-FDG), and 64Cu-Copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone) (64Cu-ATSM) PET Scans in Dogs with Spontaneous Tumors and Evaluation for Hypoxia-Directed Therapy.
Radiation research. 197(3):253-260 [DOI] 10.1667/RADE-20-00186.1. [PMID] 34855934.
2021
Analysis of canine myeloid-derived suppressor cells (MDSCs) utilizing fluorescence-activated cell sorting, RNA protection mediums to yield quality RNA for single-cell RNA sequencing.
Veterinary immunology and immunopathology. 231 [DOI] 10.1016/j.vetimm.2020.110144. [PMID] 33278779.
2021
Novel application of single-cell next-generation sequencing for determination of intratumoral heterogeneity of canine osteosarcoma cell lines
Journal of Veterinary Diagnostic Investigation. 33(2):261-278 [DOI] 10.1177/1040638720985242. [PMID] 33446089.
2021
Pharmacokinetics and safety of TCMCB07, a melanocortin‐4 antagonist peptide in dogs
Pharmacology Research & Perspectives. 9(3) [DOI] 10.1002/prp2.777. [PMID] 34014033.
2020
Autologous cancer cell vaccination, adoptive T-cell transfer, and interleukin-2 administration results in long-term survival for companion dogs with osteosarcoma.
Journal of veterinary internal medicine. 34(5):2056-2067 [DOI] 10.1111/jvim.15852. [PMID] 32649801.
2020
Molecular diagnosis using RNAscope in-situ hybridization in canine malignancies.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 84(4):319-323 [PMID] 33012982.
2020
Transportation and Routine Veterinary Interventions Alter Immune Function in the Dog
Topics in Companion Animal Medicine. 39 [DOI] 10.1016/j.tcam.2020.100408.
2019
Dogs with osteosarcoma have altered pro‐ and anti‐inflammatory cytokine profiles
Veterinary Medicine and Science. 5(4):485-493 [DOI] 10.1002/vms3.191. [PMID] 31374161.
2018
Consecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors
Clinical Cancer Research. 24(24):6396-6407 [DOI] 10.1158/1078-0432.ccr-18-0703.
2018
Evaluation of intravenous and subcutaneous administration of a novel, excipient-free, nanoparticulate formulation of paclitaxel in dogs with spontaneously occurring neoplasia.
Veterinary and comparative oncology. 16(4):650-657 [DOI] 10.1111/vco.12435. [PMID] 30182530.
2015
Resveratrol decreases oxidative burst capacity and alters stimulated leukocyte cytokine production in vitro
Veterinary Immunology and Immunopathology. 163(3-4):164-173 [DOI] 10.1016/j.vetimm.2014.12.004.
2014
Chemotherapy and remission status do not alter pre-existing innate immune dysfunction in dogs with lymphoma
Research in Veterinary Science. 97(2):230-237 [DOI] 10.1016/j.rvsc.2014.07.009.

Grants

May 2022 – Apr 2023
Feasibility of radiotherapy combined with MT0321 intravenous administration for canine intranasal adenocarcinoma
Role: Principal Investigator
Funding: MALIGNANT TUMOR TREATMENT TECHNOLOGIES
Jul 2020 – Dec 2021
Characterization of Expression and Prognostic Implications of GD2S and GD3S in Canine Histiocytic Sarcoma
Role: Other
Funding: VETERINARY CANCER SOCIETY
Apr 2019 – Dec 2020
Development of RNA in-situ hybridization (RNAscope) to identify T regulatory cells and their function within the tumor microenvironment of canine oral malignant melanoma.
Role: Principal Investigator
Funding: AMER KENNEL CLUB CANINE HLTH FOU
Feb 2019 – Nov 2022
A pilot study to determine the safety and efficacy of CBD oil use during chemotherapy
Role: Principal Investigator
Funding: ELLEVET SCIENCES
Aug 2018 – Jan 2022
Melanocortin 4 receptor antagonist in the treatment of canine cachexia
Role: Principal Investigator
Funding: TENSIVE CONTROLS PEPTIDE THERAPEUTICS

Education

Diplomate – Internal Medicine (Oncology)
2008 · American College of Veterinary Medicine
Residency – Medical Oncology
2005-2008 · Gulf Coast Veterinary Specialists
Rotating Internship – Small Animal Medicine/Surgery
2004-2005 · Mississippi State University
DVM
2004 · Michigan State University

Contact Details

Phones:
Business:
(352) 392-2235
Emails:
Business:
axiaks@ufl.edu
Addresses:
Business Mailing:
PO Box 100116
GAINESVILLE FL 32610
Business Street:
2015 SW 16TH AVE
GAINESVILLE FL 32608