Anthony F Barbet

Anthony F Barbet

Professor Emeritus

Department: VM-DEAN
Business Phone: (352) 294-4115
Business Email: barbet@ufl.edu

Accomplishments

Research Professor Award
2007 · University of Florida
Research Excellence Award
2000 · Pfizer
Research Excellence Award
1993 · SmithKline-Beecham

Research Profile

Defining molecular mechanisms of pathogenesis in emerging infectious diseases, development of recombinant vaccines and improved molecular diagnostics. A long-term research focus has been to understand the molecular basis for persistent infections, beginning with investigations of antigenic variation in African trypanosomes and now including persistent infections caused by rickettsias of veterinary and human importance. An important finding has been the discovery of gene sequence mosaics in trypanosomes and Anaplasma. These mosaics are formed by contribution of sequence to genomic expression sites by different functional pseudogenes. This allows extensive surface diversity to be created from the small Anaplasma genomes because of the large number of different combinatorial possibilities. With the completion of genome sequence for these organisms, this research is now extending in two main directions: 1) analysis of gene expression and variation at the whole genome level. 2) development of transformation systems to knock-out virulence genes to develop new vaccines.

Publications

2009 Onderstepoort Journal of Veterinary Research
2009 Emerging Infectious Diseases

Grants

Jul 2014 – Jun 2016
Structure and function of VirB6 in the Rickettsiales
NATL INST OF HLTH NIAID · Principal Investigator

Patents

Issued February 2000
Nucleic Acid Vaccines Against Rickettsial Diseases of Animals and Humans
#6,025,338
Issued June 2001
Nucleic Acid Vaccines Against Rickettsial Diseases and Methods of Use
#6,251,872
Issued January 2002
MATERIALS AND METHODS FOR PREVENTION OR REDUCTION OF THE SEVERITY OF HEARTWATER
#6,342,230
Published February 2002
Ehrlichia Ruminantium Polypeptides, Antigens, Polynucleotides and Methods of Use
#US-2003-0044422-A1
Issued July 2003
Nucleic Acid Vaccines Against Rickettsial Diseases And Methods Of Use
#6,593,147
Published November 2003
Nucleic Acid Vaccines Against Rickettsial Diseases and Methods of Use
#US-2004-0126871-A1
Issued November 2003
Nucleic Acid Vaccines Against Rickettsial Diseases And Methods Of Use
#6,653,128
Issued December 2007
Polynucleotides and Polypeptides of Anaplasma Phagocytophilum and Methods of Using the Same
#7,304,139

Education

PhD – Biochemical Parasitology
1977 · University of Cambridge

Contact Details

Phones:
Business:
(352) 294-4115
Emails:
Business:
barbet@ufl.edu

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