Jose I Aguirre

Jose I Aguirre,

Associate Professor

Department: Department of Physiological Sciences
Business Phone: (352) 294-4038
Business Email: aguirrej@ufl.edu

About Jose I Aguirre

I have been working in the field of bone biology, and in vivo animal models for more than 25 years. During my research career, I have acquired significant exceptional experiences at many distinguished international institutions. I learned and acquired expertise in veterinary gross and microscopic pathology, advanced cytological and histological techniques, immunocytochemistry, electron microscopy, bone histomorphometry, bone cell biology, basic bone biomechanics and in several molecular biology techniques including real time PCT-PCR, Southern, Northern, Western blotting, and microArray analyses. My veterinary degree in combination with my expertise in Laboratory Animal Medicine/Comparative medicine (DACLAM) and a veterinary pathology degree, make me well suited and competent to proper develop animal models, perform advanced techniques and interventions in laboratory animals, design experiments, conduct them and analyze the data. During these years, I have focused my research primarily on the study of conditions that induce bone loss (osteopenia) including osteoporosis, reduced mechanical loading, and spinal cord injury (SCI). In addition, my lab has been studying Osteonecrosis of the Jaw (ONJ), a potentially severe adverse event characterized by persistent exposure of necrotic bone in the jaw in patients treated with powerful anti-resorptives (pARs) and receptor activator of NFκb ligand (RANKL) antibodies. My studies involve the use of different rodent models to study different aspects of these conditions at both cellular and molecular levels and utilizing bone histomorphometry and many different histologic techniques.

Accomplishments

Distinguished Teacher of the Year
2018 · Zoetis
University of Florida
2018 · Cornelius Young Investigator
UF Excellence Award for Assistant Professors
2016 · University of Florida
Diplomate
2013 · American College of Laboratory Animal Medicine (DACLAM)
President’s Poster Competition Award
2012 · ASBMR, 34th annual meeting, Minneapolis, MN
Burroughs Wellcome Fund Postdoctoral Travel Award
2011 · National Veterinary Scholars Symposium, Orlando, FL
Young Investigator Travel Grant
2011 · ASBMR, 33th annual meeting. San Diego, CA
Young Investigator Award
2009 · The International Society of Bone Morphometry (ISBM), XIth Congress of the ISBM, Zell Am See, Austria
Young Investigator Travel Grant 2007
2007 · ASBMR, 29th annual meeting, Honolulu, HI
Juan de la Cierva Award
2005 · Spanish Ministry of Education and Science
Young Investigator Award
2005 · The American Society of Bone and Mineral Research (ASBMR)
Alice L. Jee Memorial Young Investigator Award
2004 · The 34th International Sun Valley Workshop on Skeletal Tissue Biology, Sun Valley, ID
Reentry Grant Award for Postgraduate Students
2000 · The Antorchas Foundation, Buenos Aires, Argentina
Biorad. Ltd. Co. Assistantship to support Diploma of The Imperial College in Pathology
1997 · Department of Histochemistry, Hammersmith Campus, Imperial College of Science, Technology and Medicine, London, United Kingdom
Award for Advanced Studies in the United Kingdom
1996 · The British Council and the British Embassy, London, United Kingdom
Graduate Scholarship Award
1996 · International Cooperation Agency, Argentinean Ministry of Education, Buenos Aires, Argentina
Laboratory Animals LTD grant
1996 · London, United Kingdom
Graduate Scholarship Award
1991 · Japanese International Cooperation Agency (JICA), Tokyo, Japan

Teaching Profile

Courses Taught
2013,2015-2023
VEM5101 Vet Gross Anatomy
2015-2022
VEM5111 Animal Systems 2
2015-2022
VEM5112 Animal Systems 3
2018
VME7979 Advanced Research
2015
VME6932 Seminar in Physiological Sciences

Research Profile

Skeletal effects of bisphosphonates and bone anabolic agents/drugs for the prevention and treatment of local osteopenias (e.g., jaw) and postmenopausal osteoporosis. Pathophysiology of osteonecrosis of the jaw (ARONJ), and other side effects of antiresorptive drugs. Small animal models of periodontitis. Extended half-life of RANK Ligand antagonists for preclinical testing of osteoporosis treatments in small animals. Comparative medicine.

Publications

2022
Bone structural, biomechanical, and histomorphometric characteristics of the hindlimb skeleton in the marsh rice rat (Oryzomys palustris).
Anatomical record (Hoboken, N.J. : 2007). 305(11):3133-3149 [DOI] 10.1002/ar.24876. [PMID] 35090092.
2021
Preventing or controlling periodontitis reduces the occurrence of osteonecrosis of the jaw (ONJ) in rice rats (Oryzomys palustris).
Bone. 145 [DOI] 10.1016/j.bone.2021.115866. [PMID] 33515777.
2020
Locomotor training with adjuvant testosterone preserves cancellous bone and promotes muscle plasticity in male rats after severe spinal cord injury.
Journal of neuroscience research. 98(5):843-868 [DOI] 10.1002/jnr.24564. [PMID] 31797423.
2019
Antibiotic Perturbation of Gut Microbiota Dysregulates Osteoimmune Cross Talk in Postpubertal Skeletal Development.
The American journal of pathology. 189(2):370-390 [DOI] 10.1016/j.ajpath.2018.10.017. [PMID] 30660331.
2019
Diet-induced Generalized Periodontitis in Lewis Rats.
Comparative medicine. 69(5):384-400 [DOI] 10.30802/AALAS-CM-18-000113. [PMID] 31575381.
2019
Potential therapeutic use of relaxin in accelerating closure of cranial bone defects in mice.
Physiological reports. 7(11) [DOI] 10.14814/phy2.14106. [PMID] 31155858.
2018
Impaired innate immune signaling due to combined Toll-like receptor 2 and 4 deficiency affects both periodontitis and atherosclerosis in response to polybacterial infection.
Pathogens and disease. 76(8) [DOI] 10.1093/femspd/fty076. [PMID] 30351354.
2018
Zoledronic acid increases the prevalence of medication-related osteonecrosis of the jaw in a dose dependent manner in rice rats (Oryzomys palustris) with localized periodontitis.
Bone. 108:79-88 [DOI] 10.1016/j.bone.2017.12.025. [PMID] 29289789.
2017
Age-related periodontitis and alveolar bone loss in rice rats.
Archives of oral biology. 73:193-205 [DOI] 10.1016/j.archoralbio.2016.10.018. [PMID] 27771588.
2017
Bone Mass Is Compromised by the Chemotherapeutic Trabectedin in Association With Effects on Osteoblasts and Macrophage Efferocytosis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 32(10):2116-2127 [DOI] 10.1002/jbmr.3196. [PMID] 28600866.
2017
Effects of Fructose-Induced Metabolic Syndrome on Rat Skeletal Cells and Tissue, and Their Responses to Metformin Treatment
Diabetes Research and Clinical Practice. 126:202-213 [DOI] 10.1016/j.diabres.2017.02.011.
2016
Fructose consumption does not worsen bone deficits resulting from high-fat feeding in young male rats.
Bone. 85:99-106 [DOI] 10.1016/j.bone.2016.02.004. [PMID] 26855373.
2016
Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats.
Bone. 84:148-159 [DOI] 10.1016/j.bone.2015.12.013. [PMID] 26721737.
2015
Differential temporal effects of sclerostin antibody and parathyroid hormone on cancellous and cortical bone and quantitative differences in effects on the osteoblast lineage in young intact rats.
Bone. 81:380-391 [DOI] 10.1016/j.bone.2015.08.007. [PMID] 26261096.
2015
Role of Polymer Architecture on the Activity of Polymer-Protein Conjugates for the Treatment of Accelerated Bone Loss Disorders.
Biomacromolecules. 16(8):2374-81 [DOI] 10.1021/acs.biomac.5b00623. [PMID] 26151628.
2014
Testosterone dose dependently prevents bone and muscle loss in rodents after spinal cord injury.
Journal of neurotrauma. 31(9):834-45 [DOI] 10.1089/neu.2013.3155. [PMID] 24378197.
2012
Enhanced alveolar bone loss in a model of non-invasive periodontitis in rice rats.
Oral diseases. 18(5):459-68 [DOI] 10.1111/j.1601-0825.2011.01893.x. [PMID] 22233442.
2012
Oncologic doses of zoledronic acid induce osteonecrosis of the jaw-like lesions in rice rats (Oryzomys palustris) with periodontitis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 27(10):2130-43 [DOI] 10.1002/jbmr.1669. [PMID] 22623376.
2011
Refinement of the Rice Rat (Oryzomys Palustris) Model of Periodontitis and Zoledronic Acid-Induced Osteonecrosis of the Jaw
Journal of the American Association for Laboratory Animal Science. 50:726-727
2011
Teriparatide [rhPTH (1-34)], but not strontium ranelate, demonstrated bone anabolic efficacy in mature, osteopenic, ovariectomized rats.
Endocrinology. 152(5):1767-78 [DOI] 10.1210/en.2010-1112. [PMID] 21343258.
2010
Effects of alendronate on bone healing after tooth extraction in rats.
Oral diseases. 16(7):674-85 [DOI] 10.1111/j.1601-0825.2010.01677.x. [PMID] 20846154.
2010
Establishing a Breeding Colony of Rice Rats (Oryzomys Palustris): An Animal Model for Periodontal Disease
Journal of the American Association for Laboratory Animal Science. 49
2010
The Rice Rat (Oryzomys Palustris) Model for Periodontal Disease: Characterization of the Lesions and Technical Features of the Model
Journal of the American Association for Laboratory Animal Science. 49
2009
In vitro and in vivo evidence for stimulation of bone resorption by an EP4 receptor agonist and basic fibroblast growth factor: Implications for their efficacy as bone anabolic agents.
Bone. 44(2):266-74 [DOI] 10.1016/j.bone.2008.10.041. [PMID] 19013265.
2009
Skeletal Effects of Fibroblast Growth Factor Mimetic (F2A) in Ovariectomized Rats
Journal of Musculoskeletal & Neuronal Interactions. 9:38-43
2009
Ultrasound-Guided Interscalene Block Should Be Compared With the Accepted Standard for the Neurostimulation Technique
Regional Anesthesia and Pain Medicine. 34
2008
Alendronate Transiently Impairs Removal of Alveolar Bone and Healing of the Root Socket After Tooth Extraction in Rats
Journal of Bone and Mineral Research. 23
2008
Role for beta1 integrins in cortical osteocytes during acute musculoskeletal disuse.
Matrix biology : journal of the International Society for Matrix Biology. 27(7):609-18 [DOI] 10.1016/j.matbio.2008.05.003. [PMID] 18619537.
2008
Skeletal Effects of a Fibroblast Growth Factor Agonist (F2A) in Ovariectomized Rats
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 23

Grants

Sep 2022 ACTIVE
Osteocyte Death in Osteonecrosis of the Jaw in Rice Rats: Role of Necroptosis and Temporal Relationship with Radiographic, Molecular and Histopathologic Findings
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Apr 2022 ACTIVE
Treatment of Knee Osteoarthritis via Intra-articular Delivery of an Immunosuppressive Enzyme
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Feb 2021 – Jun 2022
Intergovernmental Personnel Agreement (IPA) for Jose Ignacio Aguirre 2021-2022
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Dec 2018 – Nov 2020
IPA Agreement for Jose I. Aguirre
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Feb 2016 – Feb 2021
Miscellaneous Donors 209
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Feb 2016 – Jan 2021
MISCELLANEOUS DONORS
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Jul 2015 – Jan 2019
Potential Therapeutic Use of Relaxin in Healing Cranial Bone Defects
Role: Project Manager
Funding: US ARMY MED RES ACQUISITION via US DEPT OF DEFENSE
Aug 2014 – Jul 2021
Role of Periodontitis in Osteonecrosis of the Jaw Pathophysiology in Rice Rats
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Aug 2014 – Jul 2016
Exosomes in alveolar bone remodeling and root resorption
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Mar 2014 – Feb 2016
IPA for Jose Ignacio Aguirre
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR

Education

Resident in Laboratory Animal Medicine
2012 · University of Florida, Animal Care Services
Postdoctoral Research Fellow
2005 · University of Arkansas for Medical Sciences
PhD
2002 · Universidad Nacional de La Plata, Facultad de Ciencias Veterinarias
Diplomat in Pathology
1998 · Imperial College of Science, Technology and Medicine, Department of Histochemistry
Master in Vet. Pathology
1997 · University of London, Royal Veterinary College, UK
Diplomat
1992 · University of Tokyo, Department of Agriculture, Japan
DVM
1989 · Universidad Nacional de La Plata, Facultad de Ciencias Veterinarias, Argentina

Contact Details

Phones:
Business:
(352) 294-4038
Emails:
Business:
aguirrej@ufl.edu
Addresses:
Business Mailing:
PO Box 100144 RM
1600 SW ARCHER RD B2 003 BLDG 206
GAINESVILLE FL 32610