Jose I Aguirre

Jose I Aguirre,

Associate Professor

Department: Department of Physiological Sciences
Business Phone: (352) 294-4038
Business Email: aguirrej@ufl.edu

About Jose I Aguirre

I have worked in bone biology and comparative medicine for ~30 years. My DVM degree and Laboratory Animal Medicine and Veterinary Pathology training have allowed me to acquire the expertise, skills and experience to design and conduct comprehensive in vivo studies, direct the execution of advanced procedures, and analyze complex data.

My research has focused on bone biology & skeletal disorders, including osteoporosis and osteonecrosis of the jaw (ONJ). I have participated in novel preclinical studies investigating antiresorptives, particularly N-containing bisphosphonates, as well as different bone anabolic agents, including nitric oxide, prostaglandins, parathyroid hormone, sex steroids, basic fibroblast growth factors, mechanical forces, small molecules, and biologic drugs targeting the Wnt signaling pathway. In almost all of my research studies, I have used bone histomorphometry techniques as a fundamental approach. I was introduced to this sophisticated technique more than 25 years ago when I performed my Diploma in Pathology at the Imperial College London under the direction of Dr. Julia M. Polak and Prof. Iain MacIntyre. I further enhanced my experience in bone histomorphometry during my Ph.D. program. Later, as a Postdoc under the direction of Dr. Michael Parfitt and Robert Weinstein I continued to strengthen my experience and knowledge in this discipline, working for more than ten years under the mentorship of Dr. Thomas Wronski, a world-renowned expert in bone histomorphometry who set many field standards. Since 2014, I have continued the legacy by continuing the bone histomorphometry service in our lab, which Dr. Wronski established at the University of Florida in 1983.

In the last 15 years, my research has also focused on pathologic conditions that affect oral bone, including periodontitis, oral bone healing, and ONJ. Our current study has contributed to recognizing periodontitis and oral infections as oral risk factors for ONJ.

During the most recent time, I have been exploring new areas of research within the bone biology arena, including investigation of the effects of herbicides and chemical substances or factors that negatively affect the environment on the skeleton. Specifically, I have been captivated by the hypothesis that bone could represent a critical reservoir and sustained-released system for certain toxic compounds into circulation and, by this mechanism, induce long-term side effects to different organs and systems.

Accomplishments

Teacher of the Year
2023 · College of Veterinary Medicine, University of Florida
Postgraduate Certificate in Veterinary Education with Merits
2022 · Royal Veterinary College, University of London, United Kingdom
Honorable Mention for the Class of 2024 Teacher of the Year Award
2021 · College of Veterinary Medicine, University of Florida
Zoetis Award for Research Excellence
2019 · Zoetis
Distinguished Teacher of the Year
2018 · Zoetis
University of Florida
2018 · Cornelius Young Investigator
UF Excellence Award for Assistant Professors
2016 · University of Florida
Diplomate
2013 · American College of Laboratory Animal Medicine (DACLAM)
President’s Poster Competition Award
2012 · ASBMR, 34th annual meeting, Minneapolis, MN
Burroughs Wellcome Fund Postdoctoral Travel Award
2011 · National Veterinary Scholars Symposium, Orlando, FL
Young Investigator Travel Grant
2011 · ASBMR, 33th annual meeting. San Diego, CA
Young Investigator Award
2009 · The International Society of Bone Morphometry (ISBM), XIth Congress of the ISBM, Zell Am See, Austria
Young Investigator Travel Grant 2007
2007 · ASBMR, 29th annual meeting, Honolulu, HI
Juan de la Cierva Award
2005 · Spanish Ministry of Education and Science
Young Investigator Award
2005 · The American Society of Bone and Mineral Research (ASBMR)
Alice L. Jee Memorial Young Investigator Award
2004 · The 34th International Sun Valley Workshop on Skeletal Tissue Biology, Sun Valley, ID
Reentry Grant Award for Postgraduate Students
2000 · The Antorchas Foundation, Buenos Aires, Argentina
Biorad. Ltd. Co. Assistantship to support Diploma of The Imperial College in Pathology
1997 · Department of Histochemistry, Hammersmith Campus, Imperial College of Science, Technology and Medicine, London, United Kingdom
Award for Advanced Studies in the United Kingdom
1996 · The British Council and the British Embassy, London, United Kingdom
Graduate Scholarship Award
1996 · International Cooperation Agency, Argentinean Ministry of Education, Buenos Aires, Argentina
Laboratory Animals LTD grant
1996 · London, United Kingdom
Graduate Scholarship Award
1991 · Japanese International Cooperation Agency (JICA), Tokyo, Japan

Teaching Profile

Courses Taught
2013,2015-2022
VEM5101 Vet Gross Anatomy
2015-2022,2024
VEM5111 Animal Systems 2
2015-2024
VEM5112 Animal Systems 3
2018
VME7979 Advanced Research
2015
VME6932 Seminar in Physiological Sciences
2024
VME6905 Problems in Veterinary Medical Sciences
2024
VEM5334L Equine Lameness and Imaging

Research Profile

Skeletal effects of bisphosphonates and bone anabolic agents/drugs for the prevention and treatment of local osteopenias (e.g., jaw) and postmenopausal osteoporosis. Pathophysiology of osteonecrosis of the jaw (ARONJ), and other side effects of antiresorptive drugs. Small animal models of periodontitis. Extended half-life of RANK Ligand antagonists for preclinical testing of osteoporosis treatments in small animals. Comparative medicine.

Open Researcher and Contributor ID (ORCID)

0000-0001-8100-5839

Publications

2023
Bone pathology within Sanfilippo syndrome type B mice as a novel biometric for peripheral disease correction
Molecular Genetics and Metabolism. 138(2) [DOI] 10.1016/j.ymgme.2022.107009.
2023
Femoral Structure and Biomechanical Characteristics in Sanfilippo Syndrome Type-B Mice.
International journal of molecular sciences. 24(18) [DOI] 10.3390/ijms241813988. [PMID] 37762291.
2023
Intermittent parathyroid hormone enhances the healing of medication-related osteonecrosis of the jaw lesions in rice rats
Frontiers in Medicine. 10 [DOI] 10.3389/fmed.2023.1179350. [PMID] 37404809.
2023
Minocycline-induced disruption of the intestinal FXR/FGF15 axis impairs osteogenesis in mice
JCI Insight. 8(1) [DOI] 10.1172/jci.insight.160578. [PMID] 36413391.
2023
Passive Cycle Training Promotes Bone Recovery after Spinal Cord Injury without Altering Resting-State Bone Perfusion
Medicine & Science in Sports & Exercise. 55(5):813-823 [DOI] 10.1249/mss.0000000000003101.
2022
Bone structural, biomechanical, and histomorphometric characteristics of the hindlimb skeleton in the marsh rice rat (Oryzomys palustris)
The Anatomical Record. 305(11):3133-3149 [DOI] 10.1002/ar.24876. [PMID] 35090092.
2021
Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity
Science Advances. 7(40) [DOI] 10.1126/sciadv.abj3658. [PMID] 34586848.
2021
Preventing or controlling periodontitis reduces the occurrence of osteonecrosis of the jaw (ONJ) in rice rats (Oryzomys palustris).
Bone. 145 [DOI] 10.1016/j.bone.2021.115866. [PMID] 33515777.
2020
Anti-vascular endothelial growth factor antibody monotherapy causes destructive advanced periodontitis in rice rats (Oryzomys palustris)
Bone. 130 [DOI] 10.1016/j.bone.2019.115141. [PMID] 31707108.
2020
Locomotor training with adjuvant testosterone preserves cancellous bone and promotes muscle plasticity in male rats after severe spinal cord injury.
Journal of neuroscience research. 98(5):843-868 [DOI] 10.1002/jnr.24564. [PMID] 31797423.
2019
Antibiotic Perturbation of Gut Microbiota Dysregulates Osteoimmune Cross Talk in Postpubertal Skeletal Development
The American Journal of Pathology. 189(2):370-390 [DOI] 10.1016/j.ajpath.2018.10.017. [PMID] 30660331.
2019
Diet-induced Generalized Periodontitis in Lewis Rats.
Comparative medicine. 69(5):384-400 [DOI] 10.30802/AALAS-CM-18-000113. [PMID] 31575381.
2019
Potential therapeutic use of relaxin in accelerating closure of cranial bone defects in mice.
Physiological reports. 7(11) [DOI] 10.14814/phy2.14106. [PMID] 31155858.
2018
Impaired innate immune signaling due to combined Toll-like receptor 2 and 4 deficiency affects both periodontitis and atherosclerosis in response to polybacterial infection.
Pathogens and disease. 76(8) [DOI] 10.1093/femspd/fty076. [PMID] 30351354.
2018
Zoledronic acid increases the prevalence of medication-related osteonecrosis of the jaw in a dose dependent manner in rice rats (Oryzomys palustris) with localized periodontitis
Bone. 108:79-88 [DOI] 10.1016/j.bone.2017.12.025. [PMID] 29289789.
2017
Age-related periodontitis and alveolar bone loss in rice rats.
Archives of oral biology. 73:193-205 [DOI] 10.1016/j.archoralbio.2016.10.018. [PMID] 27771588.
2017
Bone Mass Is Compromised by the Chemotherapeutic Trabectedin in Association With Effects on Osteoblasts and Macrophage Efferocytosis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 32(10):2116-2127 [DOI] 10.1002/jbmr.3196. [PMID] 28600866.
2017
Effects of Fructose-Induced Metabolic Syndrome on Rat Skeletal Cells and Tissue, and Their Responses to Metformin Treatment
Diabetes Research and Clinical Practice. 126:202-213 [DOI] 10.1016/j.diabres.2017.02.011.
2016
Fructose consumption does not worsen bone deficits resulting from high-fat feeding in young male rats.
Bone. 85:99-106 [DOI] 10.1016/j.bone.2016.02.004. [PMID] 26855373.
2016
Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats.
Bone. 84:148-159 [DOI] 10.1016/j.bone.2015.12.013. [PMID] 26721737.
2015
Differential temporal effects of sclerostin antibody and parathyroid hormone on cancellous and cortical bone and quantitative differences in effects on the osteoblast lineage in young intact rats.
Bone. 81:380-391 [DOI] 10.1016/j.bone.2015.08.007. [PMID] 26261096.
2015
Role of Polymer Architecture on the Activity of Polymer-Protein Conjugates for the Treatment of Accelerated Bone Loss Disorders.
Biomacromolecules. 16(8):2374-81 [DOI] 10.1021/acs.biomac.5b00623. [PMID] 26151628.
2014
Testosterone dose dependently prevents bone and muscle loss in rodents after spinal cord injury.
Journal of neurotrauma. 31(9):834-45 [DOI] 10.1089/neu.2013.3155. [PMID] 24378197.
2012
Enhanced alveolar bone loss in a model of non-invasive periodontitis in rice rats.
Oral diseases. 18(5):459-68 [DOI] 10.1111/j.1601-0825.2011.01893.x. [PMID] 22233442.
2012
Oncologic doses of zoledronic acid induce osteonecrosis of the jaw-like lesions in rice rats (Oryzomys palustris) with periodontitis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 27(10):2130-43 [DOI] 10.1002/jbmr.1669. [PMID] 22623376.
2011
Refinement of the Rice Rat (Oryzomys Palustris) Model of Periodontitis and Zoledronic Acid-Induced Osteonecrosis of the Jaw
Journal of the American Association for Laboratory Animal Science. 50:726-727
2011
Teriparatide [rhPTH (1-34)], but not strontium ranelate, demonstrated bone anabolic efficacy in mature, osteopenic, ovariectomized rats.
Endocrinology. 152(5):1767-78 [DOI] 10.1210/en.2010-1112. [PMID] 21343258.
2010
Effects of alendronate on bone healing after tooth extraction in rats.
Oral diseases. 16(7):674-85 [DOI] 10.1111/j.1601-0825.2010.01677.x. [PMID] 20846154.
2010
Establishing a Breeding Colony of Rice Rats (Oryzomys Palustris): An Animal Model for Periodontal Disease
Journal of the American Association for Laboratory Animal Science. 49
2010
The Rice Rat (Oryzomys Palustris) Model for Periodontal Disease: Characterization of the Lesions and Technical Features of the Model
Journal of the American Association for Laboratory Animal Science. 49
2009
In vitro and in vivo evidence for stimulation of bone resorption by an EP4 receptor agonist and basic fibroblast growth factor: Implications for their efficacy as bone anabolic agents.
Bone. 44(2):266-74 [DOI] 10.1016/j.bone.2008.10.041. [PMID] 19013265.
2009
Skeletal Effects of Fibroblast Growth Factor Mimetic (F2A) in Ovariectomized Rats
Journal of Musculoskeletal & Neuronal Interactions. 9:38-43
2009
Ultrasound-Guided Interscalene Block Should Be Compared With the Accepted Standard for the Neurostimulation Technique
Regional Anesthesia and Pain Medicine. 34
2008
Alendronate Transiently Impairs Removal of Alveolar Bone and Healing of the Root Socket After Tooth Extraction in Rats
Journal of Bone and Mineral Research. 23
2008
Role for beta1 integrins in cortical osteocytes during acute musculoskeletal disuse.
Matrix biology : journal of the International Society for Matrix Biology. 27(7):609-18 [DOI] 10.1016/j.matbio.2008.05.003. [PMID] 18619537.
2008
Skeletal Effects of a Fibroblast Growth Factor Agonist (F2A) in Ovariectomized Rats
Journal of Bone and Mineral Research. 23
2007
Effects of basic fibroblast growth factor and a prostaglandin E2 receptor subtype 4 agonist on osteoblastogenesis and adipogenesis in aged ovariectomized rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 22(6):877-88 [PMID] 17352655.

Grants

Dec 2023 ACTIVE
Effects of TLR4 antagonism on brain and bone function in MPS IIIB
Role: Faculty
Funding: CURE SANFILIPPO FOU
Apr 2023 ACTIVE
Impact of Tetracycline Antibiotics on Skeletal Maturation
Role: Principal Investigator
Funding: MEDICAL UNIV OF SOUTH CAROLINA via NATL INST OF HLTH NIAMS
Sep 2022 ACTIVE
Osteocyte Death in Osteonecrosis of the Jaw in Rice Rats: Role of Necroptosis and Temporal Relationship with Radiographic, Molecular and Histopathologic Findings
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Apr 2022 ACTIVE
Treatment of Knee Osteoarthritis via Intra-articular Delivery of an Immunosuppressive Enzyme
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Feb 2021 – Jun 2022
Intergovernmental Personnel Agreement (IPA) for Jose Ignacio Aguirre 2021-2022
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Dec 2018 – Nov 2020
IPA Agreement for Jose I. Aguirre
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Feb 2016 – Feb 2021
Miscellaneous Donors 209
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Feb 2016 – Jan 2021
MISCELLANEOUS DONORS
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Jul 2015 – Jan 2019
Potential Therapeutic Use of Relaxin in Healing Cranial Bone Defects
Role: Project Manager
Funding: US ARMY MED RES ACQUISITION via US DEPT OF DEFENSE
Aug 2014 – Jul 2021
Role of Periodontitis in Osteonecrosis of the Jaw Pathophysiology in Rice Rats
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Aug 2014 – Jul 2016
Exosomes in alveolar bone remodeling and root resorption
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Mar 2014 – Feb 2016
IPA for Jose Ignacio Aguirre
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR

Education

Resident in Laboratory Animal Medicine
2012 · University of Florida, Animal Care Services
Postdoctoral Research Fellow
2005 · University of Arkansas for Medical Sciences
PhD
2002 · Universidad Nacional de La Plata, Facultad de Ciencias Veterinarias
Diplomat in Pathology
1998 · Imperial College of Science, Technology and Medicine, Department of Histochemistry
Master in Vet. Pathology
1997 · University of London, Royal Veterinary College, UK
Diplomat
1992 · University of Tokyo, Department of Agriculture, Japan
DVM
1989 · Universidad Nacional de La Plata, Facultad de Ciencias Veterinarias, Argentina

Contact Details

Phones:
Business:
(352) 294-4038
Emails:
Business:
aguirrej@ufl.edu
Addresses:
Business Mailing:
PO Box 100144 RM
1600 SW ARCHER RD B2 003 BLDG 206
GAINESVILLE FL 32610