Jose Aguirre, I

Jose Aguirre, I

Assistant Professor

Department: Department of Physiological Sciences
Business Phone: (352) 294-4038
Business Email: aguirrej@ufl.edu

About Jose Aguirre, I

I have been working in the field of bone biology, and in vivo animal models for more than 25 years. During my research career, I have acquired significant exceptional experiences at many distinguished international institutions. I learned and acquired expertise in veterinary gross and microscopic pathology, advanced cytological and histological techniques, immunocytochemistry, electron microscopy, bone histomorphometry, bone cell biology, basic bone biomechanics and in several molecular biology techniques including real time PCT-PCR, Southern, Northern, Western blotting, and microArray analyses. My veterinary degree in combination with my expertise in Laboratory Animal Medicine/Comparative medicine (DACLAM) and a veterinary pathology degree, make me well suited and competent to proper develop animal models, perform advanced techniques and interventions in laboratory animals, design experiments, conduct them and analyze the data. During these years, I have focused my research primarily on the study of conditions that induce bone loss (osteopenia) including osteoporosis, reduced mechanical loading, and spinal cord injury (SCI). In addition, my lab has been studying Osteonecrosis of the Jaw (ONJ), a potentially severe adverse event characterized by persistent exposure of necrotic bone in the jaw in patients treated with powerful anti-resorptives (pARs) and receptor activator of NFκb ligand (RANKL) antibodies. My studies involve the use of different rodent models to study different aspects of these conditions at both cellular and molecular levels and utilizing bone histomorphometry and many different histologic techniques.

Accomplishments

Distinguished Teacher of the Year
2018 · Zoetis
University of Florida
2018 · Cornelius Young Investigator
UF Excellence Award for Assistant Professors
2016 · University of Florida
Diplomate
2013 · American College of Laboratory Animal Medicine (DACLAM)
President’s Poster Competition Award
2012 · ASBMR, 34th annual meeting, Minneapolis, MN
Burroughs Wellcome Fund Postdoctoral Travel Award
2011 · National Veterinary Scholars Symposium, Orlando, FL
Young Investigator Travel Grant
2011 · ASBMR, 33th annual meeting. San Diego, CA
Young Investigator Award
2009 · The International Society of Bone Morphometry (ISBM), XIth Congress of the ISBM, Zell Am See, Austria
Young Investigator Travel Grant 2007
2007 · ASBMR, 29th annual meeting, Honolulu, HI
Juan de la Cierva Award
2005 · Spanish Ministry of Education and Science
Young Investigator Award
2005 · The American Society of Bone and Mineral Research (ASBMR)
Alice L. Jee Memorial Young Investigator Award
2004 · The 34th International Sun Valley Workshop on Skeletal Tissue Biology, Sun Valley, ID
Reentry Grant Award for Postgraduate Students
2000 · The Antorchas Foundation, Buenos Aires, Argentina
Biorad. Ltd. Co. Assistantship to support Diploma of The Imperial College in Pathology
1997 · Department of Histochemistry, Hammersmith Campus, Imperial College of Science, Technology and Medicine, London, United Kingdom
Award for Advanced Studies in the United Kingdom
1996 · The British Council and the British Embassy, London, United Kingdom
Graduate Scholarship Award
1996 · International Cooperation Agency, Argentinean Ministry of Education, Buenos Aires, Argentina
Laboratory Animals LTD grant
1996 · London, United Kingdom
Graduate Scholarship Award
1991 · Japanese International Cooperation Agency (JICA), Tokyo, Japan

Research Profile

Skeletal effects of bisphosphonates and bone anabolic agents/drugs for the prevention and treatment of local osteopenias (e.g., jaw) and postmenopausal osteoporosis. Pathophysiology of osteonecrosis of the jaw (ARONJ), and other side effects of antiresorptive drugs. Small animal models of periodontitis. Extended half-life of RANK Ligand antagonists for preclinical testing of osteoporosis treatments in small animals. Comparative medicine.

Publications

2010 Journal of the American Association for Laboratory Animal Science
2009 Journal of Musculoskeletal & Neuronal Interactions

Grants

Dec 2018 ACTIVE
IPA Agreement for Jose I. Aguirre
US DEPT OF VET AFF GAINESVILLE MED CTR · Principal Investigator
Feb 2016 ACTIVE
MISCELLANEOUS DONORS
MISCELLANEOUS DONORS · Principal Investigator
Feb 2016 ACTIVE
Miscellaneous Donors 209
MISCELLANEOUS DONORS · Principal Investigator
Jul 2015 – Jan 2019
Potential Therapeutic Use of Relaxin in Healing Cranial Bone Defects
US ARMY MED RES ACQUISITION · Project Manager
Aug 2014 – Jul 2016
Exosomes in alveolar bone remodeling and root resorption
NATL INST OF HLTH NIDCR · Project Manager
Aug 2014 ACTIVE
Role of Periodontitis in Osteonecrosis of the Jaw Pathophysiology in Rice Rats
NATL INST OF HLTH NIDCR · Principal Investigator
Mar 2014 – Feb 2016
IPA for Jose Ignacio Aguirre
US DEPT OF VET AFF GAINESVILLE MED CTR · Principal Investigator

Education

Resident in Laboratory Animal Medicine
2012 · University of Florida, Animal Care Services
Postdoctoral Research Fellow
2005 · University of Arkansas for Medical Sciences
PhD
2002 · Universidad Nacional de La Plata, Facultad de Ciencias Veterinarias
Diplomat in Pathology
1998 · Imperial College of Science, Technology and Medicine, Department of Histochemistry
Master in Vet. Pathology
1997 · University of London, Royal Veterinary College, UK
Diplomat
1992 · University of Tokyo, Department of Agriculture, Japan
DVM
1989 · Universidad Nacional de La Plata, Facultad de Ciencias Veterinarias, Argentina

Contact Details

Phones:
Business:
(352) 294-4038
Emails:
Business:
aguirrej@ufl.edu

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