About Jose I Aguirre
I have been working in the field of bone biology, and in vivo animal models for more than 25 years. During my research career, I have acquired significant exceptional experiences at many distinguished international institutions. I learned and acquired expertise in veterinary gross and microscopic pathology, advanced cytological and histological techniques, immunocytochemistry, electron microscopy, bone histomorphometry, bone cell biology, basic bone biomechanics and in several molecular biology techniques including real time PCT-PCR, Southern, Northern, Western blotting, and microArray analyses. My veterinary degree in combination with my expertise in Laboratory Animal Medicine/Comparative medicine (DACLAM) and a veterinary pathology degree, make me well suited and competent to proper develop animal models, perform advanced techniques and interventions in laboratory animals, design experiments, conduct them and analyze the data. During these years, I have focused my research primarily on the study of conditions that induce bone loss (osteopenia) including osteoporosis, reduced mechanical loading, and spinal cord injury (SCI). In addition, my lab has been studying Osteonecrosis of the Jaw (ONJ), a potentially severe adverse event characterized by persistent exposure of necrotic bone in the jaw in patients treated with powerful anti-resorptives (pARs) and receptor activator of NFκb ligand (RANKL) antibodies. My studies involve the use of different rodent models to study different aspects of these conditions at both cellular and molecular levels and utilizing bone histomorphometry and many different histologic techniques.
Skeletal effects of bisphosphonates and bone anabolic agents/drugs for the prevention and treatment of local osteopenias (e.g., jaw) and postmenopausal osteoporosis. Pathophysiology of osteonecrosis of the jaw (ARONJ), and other side effects of antiresorptive drugs. Small animal models of periodontitis. Extended half-life of RANK Ligand antagonists for preclinical testing of osteoporosis treatments in small animals. Comparative medicine.