Research Associate Professor
- Qingke Kong received his PhD from Nankai University, China in 2004.
- to develop attenuated live Salmonella vaccine and naturally generate nano-particle vaccines to prevent multiple enteric bacterial infections via remodeling Salmonella outer membrane to maximally expose the conserved outer membrane proteins to the host immune systems by genetic manipulation of Salmonella.
- to extend our technologies to construct live Salmonella to deliver polysaccharide from specific Gram-negative and Gram-positive pathogens, and to explore a cheap, easy way to deliver polysaccharide-based vaccines for children and elderly populations, while achieving strong induction of memory and protective immunity.
- to determine in situ structure of the intact injectisome by genetic manipulation combined with high-throughput cryo-electron tomography (cryo-ET). This work is done in collaboration with Dr. Jun Liu and Dr. Bo Hu at the University of Texas.
- Direct Structural and Chemical Characterization of the Photolytic Intermediates of Methylcobalamin Using Time-Resolved X-ray Absorption Spectroscopy.
- Bi-valent polysaccharides of Vi capsular and O9 O-antigen in attenuated Salmonella Typhimurium induce strong immune responses against these two antigens.
- O-Serotype Conversion in Salmonella Typhimurium Induces Protective Immune Responses against Invasive Non-Typhoidal Salmonella Infections.
- A biologically conjugated polysaccharide vaccine delivered by attenuated Salmonella Typhimurium provides protection against challenge of avian pathogenic Escherichia coli O1 infection.
Additional publications here