Paul S Cooke

Paul S Cooke,

PROF

Department: Department of Physiological Sciences
Business Phone: (352) 294-4008
Business Email: paulscooke@ufl.edu

Teaching Profile

Courses Taught
2011-2024
VEM5110 Animal Systems 1
2011-2016,2018-2022
VEM5271 Sm An Reproduct Med
2018
VME7980 Research for Doctoral Dissertation
2014,2018
VME3001 The Dog
2018
ZOO7980 Research for Doctoral Dissertation
2011,2013-2015,2015-2017,2017
VME5244 Physiology: Organ Systems

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9370-4896

Publications

2024
Role for Nongenomic Estrogen Signaling in Male Fertility
Endocrinology. 165(3) [DOI] 10.1210/endocr/bqad180. [PMID] 38066676.
2023
Functions of Steroid Hormones in the Male Reproductive Tract as Revealed by Mouse Models.
International journal of molecular sciences. 24(3) [DOI] 10.3390/ijms24032748. [PMID] 36769069.
2023
Targeting estrogen signaling and biosynthesis for aged skin repair.
Frontiers in physiology. 14 [DOI] 10.3389/fphys.2023.1281071. [PMID] 38028803.
2023
Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss.
iScience. 26(7) [DOI] 10.1016/j.isci.2023.107028. [PMID] 37360688.
2022
Identification and characterization of novel abdominal and pelvic brown adipose depots in mice.
Adipocyte. 11(1):616-629 [DOI] 10.1080/21623945.2022.2133415. [PMID] 36260113.
2022
Nonclassical androgen and estrogen signaling is essential for normal spermatogenesis.
Seminars in cell & developmental biology. 121:71-81 [DOI] 10.1016/j.semcdb.2021.05.032. [PMID] 34119408.
2022
Pharmacological Inhibition of Inositol Hexakisphosphate Kinase 1 Protects Mice against Obesity-Induced Bone Loss.
Biology. 11(9) [DOI] 10.3390/biology11091257. [PMID] 36138736.
2022
Regulation of AKT Signaling in Mouse Uterus
Endocrinology. 163(1) [DOI] 10.1210/endocr/bqab233. [PMID] 34791100.
2021
Cornification and classical versus nonclassical androgen receptor signaling in mouse penile/preputial development.
Differentiation; research in biological diversity. 121:1-12 [DOI] 10.1016/j.diff.2021.08.002. [PMID] 34416482.
2021
Male fertility in mice requires classical and nonclassical androgen signaling.
Cell reports. 36(7) [DOI] 10.1016/j.celrep.2021.109557. [PMID] 34407397.
2021
Multiple Lesions Contribute to Infertility in Males Lacking Autoimmune Regulator.
The American journal of pathology. 191(9):1592-1609 [DOI] 10.1016/j.ajpath.2021.05.021. [PMID] 34126085.
2021
Role of nuclear and membrane estrogen signaling pathways in the male and female reproductive tract.
Differentiation; research in biological diversity. 118:24-33 [DOI] 10.1016/j.diff.2020.11.002. [PMID] 33339644.
2021
Spatial transcriptomics analysis of uterine gene expression in enhancer of zeste homolog 2 conditional knockout mice†.
Biology of reproduction. 105(5):1126-1139 [DOI] 10.1093/biolre/ioab147. [PMID] 34344022.
2020
Androgen-independent events in penile development in humans and animals.
Differentiation; research in biological diversity. 111:98-114 [DOI] 10.1016/j.diff.2019.07.005. [PMID] 31783219.
2020
Mice lacking uterine enhancer of zeste homolog 2 have transcriptomic changes associated with uterine epithelial proliferation.
Physiological genomics. 52(2):81-95 [DOI] 10.1152/physiolgenomics.00098.2019. [PMID] 31841397.
2020
The Roles of the Histone Protein Modifier EZH2 in the Uterus and Placenta.
Epigenomes. 4(3) [DOI] 10.3390/epigenomes4030020. [PMID] 33732505.
2019
Endocrine disruption through membrane estrogen receptors and novel pathways leading to rapid toxicological and epigenetic effects.
The Journal of steroid biochemistry and molecular biology. 187:106-117 [DOI] 10.1016/j.jsbmb.2018.11.007. [PMID] 30465854.
2019
Mice lacking membrane estrogen receptor 1 are protected from reproductive pathologies resulting from developmental estrogen exposure†
Biology of Reproduction. 101(2):392-404 [DOI] 10.1093/biolre/ioz090. [PMID] 31141131.
2019
The histone methyltransferase EZH2 is required for normal uterine development and function in mice†
Biology of Reproduction. 101(2):306-317 [DOI] 10.1093/biolre/ioz097. [PMID] 31201420.
2018
Estrogen in the male: a historical perspective.
Biology of reproduction. 99(1):27-44 [DOI] 10.1093/biolre/ioy043. [PMID] 29438493.
2018
Tissue interactions and estrogenic response during human female fetal reproductive tract development.
Differentiation; research in biological diversity. 101:39-45 [DOI] 10.1016/j.diff.2018.04.002. [PMID] 29684808.
2017
Another piece of the meiosis puzzle.
Asian journal of andrology. 19(1):3-4 [DOI] 10.4103/1008-682X.189210. [PMID] 27633909.
2017
Estrogens in Male Physiology.
Physiological reviews. 97(3):995-1043 [DOI] 10.1152/physrev.00018.2016. [PMID] 28539434.
2017
Membrane estrogen receptor 1 is required for normal reproduction in male and female mice.
Journal of endocrinology and reproduction : JER. 21(1):1-14 [PMID] 34321782.
2017
Transdifferentiation of adult rat stem Leydig cells into prostatic and uterine epithelium, but not epidermis.
Andrology. 5(6):1165-1173 [DOI] 10.1111/andr.12415. [PMID] 29073338.
2016
Membrane-Localized Estrogen Receptor 1 Is Required for Normal Male Reproductive Development and Function in Mice.
Endocrinology. 157(7):2909-19 [DOI] 10.1210/en.2016-1085. [PMID] 27145009.
2016
Mouse hypospadias: A critical examination and definition.
Differentiation; research in biological diversity. 92(5):306-317 [DOI] 10.1016/j.diff.2016.03.004. [PMID] 27068029.
2015
Deficiency of CDKN1A or both CDKN1A and CDKN1B affects the pubertal development of mouse Leydig cells.
Biology of reproduction. 92(3) [DOI] 10.1095/biolreprod.114.118463. [PMID] 25609837.
2015
How to make a human germ cell.
Asian journal of andrology. 17(3):441-2 [DOI] 10.4103/1008-682X.151401. [PMID] 25791734.
2015
Maximal Dexamethasone Inhibition of Luminal Epithelial Proliferation Involves Progesterone Receptor (PR)- and Non-PR-Mediated Mechanisms in Neonatal Mouse Uterus.
Biology of reproduction. 92(5) [DOI] 10.1095/biolreprod.114.123463. [PMID] 25882702.
2015
Neonatal uterine and vaginal cell proliferation and adenogenesis are independent of estrogen receptor 1 (ESR1) in the mouse.
Biology of reproduction. 92(3) [DOI] 10.1095/biolreprod.114.125724. [PMID] 25653281.
2015
Plasticity of spermatogonial stem cells.
Asian journal of andrology. 17(3):355-9 [DOI] 10.4103/1008-682X.148072. [PMID] 25677134.
2014
Testicular development in male rats is sensitive to a soy-based diet in the neonatal period.
Biology of reproduction. 90(2) [DOI] 10.1095/biolreprod.113.113787. [PMID] 24451983.
2013
Aorta-derived mesoangioblasts can be differentiated into functional uterine epithelium, but not prostatic epithelium or epidermis, by instructive mesenchymes.
Cells, tissues, organs. 198(3):169-78 [DOI] 10.1159/000354900. [PMID] 24192012.
2013
Dynamic changes in fetal Leydig cell populations influence adult Leydig cell populations in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(7):2657-66 [DOI] 10.1096/fj.12-225060. [PMID] 23568777.
2013
Expression of the rhesus glycoproteins, ammonia transporter family members, RHCG and RHBG in male reproductive organs.
Reproduction (Cambridge, England). 146(3):283-96 [DOI] 10.1530/REP-13-0154. [PMID] 23904565.
2013
Therapeutic effects of progesterone and its metabolites in traumatic brain injury may involve non-classical signaling mechanisms.
Frontiers in neuroscience. 7 [DOI] 10.3389/fnins.2013.00108. [PMID] 23781171.
2013
Uterine glands: development, function and experimental model systems.
Molecular human reproduction. 19(9):547-58 [DOI] 10.1093/molehr/gat031. [PMID] 23619340.
2012
Brief exposure to progesterone during a critical neonatal window prevents uterine gland formation in mice.
Biology of reproduction. 86(3) [DOI] 10.1095/biolreprod.111.097188. [PMID] 22133692.
2012
Low-dose dietary genistein negates the therapeutic effect of tamoxifen in athymic nude mice.
Carcinogenesis. 33(4):895-901 [DOI] 10.1093/carcin/bgs017. [PMID] 22266527.
2012
Uterine gland development begins postnatally and is accompanied by estrogen and progesterone receptor expression in the dog.
Theriogenology. 78(8):1787-95 [DOI] 10.1016/j.theriogenology.2012.05.028. [PMID] 22959316.
2011
The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2.
Science (New York, N.Y.). 331(6019):912-6 [DOI] 10.1126/science.1197454. [PMID] 21330545.
2011
The fused toes locus is essential for somatic-germ cell interactions that foster germ cell maturation in developing gonads in mice.
Biology of reproduction. 84(5):1024-32 [DOI] 10.1095/biolreprod.110.088559. [PMID] 21293032.
2010
Acute and chronic effects of oral genistein administration in neonatal mice.
Biology of reproduction. 83(1):114-21 [DOI] 10.1095/biolreprod.109.080549. [PMID] 20357267.
2010
ETV5 regulates sertoli cell chemokines involved in mouse stem/progenitor spermatogonia maintenance.
Stem cells (Dayton, Ohio). 28(10):1882-92 [DOI] 10.1002/stem.508. [PMID] 20799334.
2010
Spermatogonial stem cells, in vivo transdifferentiation and human regenerative medicine.
Expert opinion on biological therapy. 10(4):519-30 [DOI] 10.1517/14712591003614731. [PMID] 20146635.
2010
The effect of relaxin on cell proliferation in mouse cervix requires estrogen receptor {alpha} binding to estrogen response elements in stromal cells.
Endocrinology. 151(6):2811-8 [DOI] 10.1210/en.2009-1327. [PMID] 20308531.
2009
Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function.
Biology of reproduction. 81(5):871-9 [DOI] 10.1095/biolreprod.109.077040. [PMID] 19571261.
2009
Direct transdifferentiation of stem/progenitor spermatogonia into reproductive and nonreproductive tissues of all germ layers.
Stem cells (Dayton, Ohio). 27(7):1666-75 [DOI] 10.1002/stem.93. [PMID] 19544441.
2009
Estrogen signaling is not required for prostatic bud patterning or for its disruption by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicology and applied pharmacology. 239(1):80-6 [DOI] 10.1016/j.taap.2009.06.001. [PMID] 19523480.
2009
Increased proliferation but decreased steroidogenic capacity in Leydig cells from mice lacking cyclin-dependent kinase inhibitor 1B.
Biology of reproduction. 80(6):1232-8 [DOI] 10.1095/biolreprod.108.074229. [PMID] 19211806.
2009
Loss of Etv5 decreases proliferation and RET levels in neonatal mouse testicular germ cells and causes an abnormal first wave of spermatogenesis.
Biology of reproduction. 81(2):258-66 [DOI] 10.1095/biolreprod.108.075200. [PMID] 19369650.
2009
Relative roles of the epithelial and stromal tissue compartment(s) in mediating the actions of relaxin and estrogen on cell proliferation and apoptosis in the mouse lower reproductive tract.
Annals of the New York Academy of Sciences. 1160:121-9 [DOI] 10.1111/j.1749-6632.2008.03799.x. [PMID] 19416172.
2009
Stromal progesterone receptors mediate induction of Indian Hedgehog (IHH) in uterine epithelium and its downstream targets in uterine stroma.
Endocrinology. 150(8):3871-6 [DOI] 10.1210/en.2008-1691. [PMID] 19372202.
2008
Behavioral rhythmicity of mice lacking AhR and attenuation of light-induced phase shift by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Journal of biological rhythms. 23(3):200-10 [DOI] 10.1177/0748730408316022. [PMID] 18487412.
2008
Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial stem cell loss, and fertility in mice.
Biology of reproduction. 78(3):483-9 [PMID] 18032421.
2008
Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina.
Endocrinology. 149(5):2072-9 [DOI] 10.1210/en.2007-1176. [PMID] 18218691.
2007
Common and distinct factors regulate expression of mRNA for ETV5 and GDNF, Sertoli cell proteins essential for spermatogonial stem cell maintenance.
Experimental cell research. 313(14):3090-9 [PMID] 17574550.
2007
Estrogen receptor alpha mediates estrogen-inducible abnormalities in the developing penis.
Reproduction (Cambridge, England). 133(5):1057-67 [PMID] 17616734.
2007
ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood testes barrier function and testicular immune privilege.
Annals of the New York Academy of Sciences. 1120:144-51 [PMID] 17911411.
2007
Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus.
Physiology & behavior. 90(5):771-81 [PMID] 17291550.
2007
Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice.
Biology of reproduction. 76(5):804-12 [PMID] 17229929.
2007
Role of connexin 43 in Sertoli cells of testis.
Annals of the New York Academy of Sciences. 1120:131-43 [PMID] 17905936.
2007
The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo.
Obesity (Silver Spring, Md.). 15(6):1400-8 [PMID] 17557977.
2006
Genistein, estrogen receptors, and the acquired immune response.
The Journal of nutrition. 136(3):704-8 [PMID] 16484547.
2006
Mechanistic insights into the regulation of the spermatogonial stem cell niche.
Cell cycle (Georgetown, Tex.). 5(11):1164-70 [PMID] 16721062.
2005
Altered prostatic epithelial proliferation and apoptosis, prostatic development, and serum testosterone in mice lacking cyclin-dependent kinase inhibitors.
Biology of reproduction. 73(5):951-8 [PMID] 16014817.
2005
Cell-cycle inhibitors p27Kip1 and p21Cip1 regulate murine Sertoli cell proliferation.
Biology of reproduction. 72(6):1429-36 [PMID] 15728790.
2005
Effects of estrogens and the phytoestrogen genistein on adipogenesis and lipogenesis in males and females.
Birth defects research. Part A, Clinical and molecular teratology. 73(7):472-3 [PMID] 15959885.
2005
Gene expression profiling of 17beta-estradiol and genistein effects on mouse thymus.
Toxicological sciences : an official journal of the Society of Toxicology. 87(1):97-112 [PMID] 15947025.
2005
In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on the prostate and its response to castration in senescent C57BL/6J mice.
Toxicological sciences : an official journal of the Society of Toxicology. 86(2):387-95 [PMID] 15888670.
2005
Regulation of neonatal Sertoli cell development by thyroid hormone receptor alpha1.
Biology of reproduction. 73(3):396-403 [PMID] 15858214.
2005
Understanding the role of thyroid hormone in Sertoli cell development: a mechanistic hypothesis.
Cell and tissue research. 322(1):133-40 [PMID] 15856309.
2004
Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice.
Biology of reproduction. 71(3):966-72 [PMID] 15151933.
2004
Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18(15):1925-7 [PMID] 15469964.
2004
Role of estrogens in adipocyte development and function.
Experimental biology and medicine (Maywood, N.J.). 229(11):1127-35 [PMID] 15564439.
2004
Role of stromal-epithelial interactions in hormonal responses.
Archives of histology and cytology. 67(5):417-34 [PMID] 15781983.
2004
Thyroid hormone, glucocorticoids, and prolactin at the nexus of physiology, reproduction, and toxicology.
Toxicology and applied pharmacology. 194(3):309-35 [PMID] 14761686.
2003
The phytoestrogen genistein suppresses cell-mediated immunity in mice.
The Journal of endocrinology. 176(2):267-74 [PMID] 12553875.
2003
The soy isoflavone genistein decreases adipose deposition in mice.
Endocrinology. 144(8):3315-20 [PMID] 12865308.
2003
Thyroid hormone regulates the cell cycle inhibitor p27Kip1 in postnatal murine Sertoli cells.
Endocrinology. 144(9):3732-8 [PMID] 12933641.
2002
Dioxin inhibition of estrogen-induced mouse uterine epithelial mitogenesis involves changes in cyclin and transforming growth factor-beta expression.
Toxicological sciences : an official journal of the Society of Toxicology. 66(1):62-8 [PMID] 11861973.
2002
Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor alpha (ERalpha): a potential role for estrogen receptor beta (ERbeta).
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 34(11-12):758-63 [PMID] 12660895.
2002
The phytoestrogen genistein induces thymic and immune changes: a human health concern?
Proceedings of the National Academy of Sciences of the United States of America. 99(11):7616-21 [PMID] 12032332.
2001
Altered prostate growth and daily sperm production in male mice exposed prenatally to subclinical doses of 17alpha-ethinyl oestradiol.
Human reproduction (Oxford, England). 16(5):988-96 [PMID] 11331650.
2001
Epithelial-stromal tissue interaction in paramesonephric (Müllerian) epithelial differentiation.
Developmental biology. 240(1):194-211 [PMID] 11784056.
2001
Regulation of progesterone receptors and decidualization in uterine stroma of the estrogen receptor-alpha knockout mouse.
Biology of reproduction. 64(1):272-83 [PMID] 11133684.
2000
Antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse uterus: critical role of the aryl hydrocarbon receptor in stromal tissue.
Toxicological sciences : an official journal of the Society of Toxicology. 57(2):302-11 [PMID] 11006360.
2000
Increased adipose tissue in male and female estrogen receptor-alpha knockout mice.
Proceedings of the National Academy of Sciences of the United States of America. 97(23):12729-34 [PMID] 11070086.
2000
Myocardial ischemia-reperfusion injury in estrogen receptor-alpha knockout and wild-type mice.
American journal of physiology. Heart and circulatory physiology. 278(5):H1640-7 [PMID] 10775144.
2000
Normal development of thymus in male and female mice requires estrogen/estrogen receptor-alpha signaling pathway.
Endocrine. 12(3):207-13 [PMID] 10963039.
2000
Paracrine mechanisms of mouse mammary ductal growth.
Advances in experimental medicine and biology. 480:93-7 [PMID] 10959414.
2000
Paracrine regulation of epithelial progesterone receptor and lactoferrin by progesterone in the mouse uterus.
Biology of reproduction. 62(4):831-8 [PMID] 10727250.
2000
Paracrine regulation of epithelial progesterone receptor by estradiol in the mouse female reproductive tract.
Biology of reproduction. 62(4):821-30 [PMID] 10727249.
2000
Postulated human sperm count decline may involve historic elimination of juvenile iodine deficiency: a new hypothesis with experimental evidence in the rat.
Toxicological sciences : an official journal of the Society of Toxicology. 53(2):400-10 [PMID] 10696788.
2000
The differential fate of mesonephric tubular-derived efferent ductules in estrogen receptor-alpha knockout versus wild-type female mice.
Endocrinology. 141(10):3792-8 [PMID] 11014235.
1999
Ah receptor and ARNT protein and mRNA concentrations in rat prostate: effects of stage of development and 2,3,7, 8-tetrachlorodibenzo-p-dioxin treatment.
Toxicology and applied pharmacology. 155(2):177-89 [PMID] 10053172.
1999
Tissue compartment-specific estrogen receptor-alpha participation in the mouse uterine epithelial secretory response.
Endocrinology. 140(1):484-91 [PMID] 9886861.
1998
A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior.
Toxicology and industrial health. 14(1-2):239-60 [PMID] 9460178.
1998
Mechanism of estrogen action: lessons from the estrogen receptor-alpha knockout mouse.
Biology of reproduction. 59(3):470-5 [PMID] 9716542.
1998
Role of stromal and epithelial estrogen receptors in vaginal epithelial proliferation, stratification, and cornification.
Endocrinology. 139(10):4345-52 [PMID] 9751518.
1998
Thyroid hormone and follicle-stimulating hormone regulate Müllerian-inhibiting substance messenger ribonucleic acid expression in cultured neonatal rat Sertoli cells.
Endocrinology. 139(11):4489-95 [PMID] 9794457.
1998
Thyroid hormone effects on androgen receptor messenger RNA expression in rat Sertoli and peritubular cells.
The Journal of endocrinology. 156(1):43-50 [PMID] 9496232.
1997
Elucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombinants.
Journal of mammary gland biology and neoplasia. 2(4):393-402 [PMID] 10935027.
1997
Estrogen receptor (alpha and beta) expression in the excurrent ducts of the adult male rat reproductive tract.
Journal of andrology. 18(6):602-11 [PMID] 9432133.
1997
Neonatal hypothyroidism alters the pattern of prostatic growth and differentiation, as well as plasminogen activator and metalloprotease expression, in the rat.
Biology of reproduction. 56(2):475-82 [PMID] 9116149.
1997
Neonatal hypothyroidism permanently alters follicle-stimulating hormone and luteinizing hormone production in the male rat.
Endocrinology. 138(7):2713-21 [PMID] 9202208.
1997
Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium.
Proceedings of the National Academy of Sciences of the United States of America. 94(12):6535-40 [PMID] 9177253.
1996
Increased proliferation of Leydig cells induced by neonatal hypothyroidism in the rat.
Journal of andrology. 17(3):231-8 [PMID] 8792213.
1996
Neonatal polychlorinated biphenyl treatment increases adult testis size and sperm production in the rat.
Toxicology and applied pharmacology. 136(1):112-7 [PMID] 8560463.
1995
Neonatal hypothyroidism causes delayed Sertoli cell maturation in rats treated with propylthiouracil: evidence that the Sertoli cell controls testis growth.
The Anatomical record. 242(1):57-69 [PMID] 7604982.
1994
Developmental expression of testis messenger ribonucleic acids in the rat following propylthiouracil-induced neonatal hypothyroidism.
Biology of reproduction. 51(4):706-13 [PMID] 7819453.
1994
Triiodothyronine inhibits proliferation and stimulates differentiation of cultured neonatal Sertoli cells: possible mechanism for increased adult testis weight and sperm production induced by neonatal goitrogen treatment.
Biology of reproduction. 51(5):1000-5 [PMID] 7531505.
1993
Adult testicular enlargement induced by neonatal hypothyroidism is accompanied by increased Sertoli and germ cell numbers.
Endocrinology. 132(6):2607-13 [PMID] 8504761.
1993
Estrogenic and antiestrogenic actions of PCBs in the female rat: in vitro and in vivo studies.
Reproductive toxicology (Elmsford, N.Y.). 7(3):237-48 [PMID] 8318755.
1993
Increased testis growth and sperm production in adult rats following transient neonatal goitrogen treatment: optimization of the propylthiouracil dose and effects of methimazole.
Journal of reproduction and fertility. 97(2):493-9 [PMID] 8501721.
1993
Leydig cells increase their numbers but decline in steroidogenic function in the adult rat after neonatal hypothyroidism.
Endocrinology. 132(6):2417-20 [PMID] 8504746.
1993
Neonatal goitrogen treatment increases adult testis size and sperm production in the mouse.
Journal of andrology. 14(6):448-55 [PMID] 8294229.
1992
Androgen receptor expression and 5 alpha-reductase activity along the proximal-distal axis of the rat prostatic duct.
Endocrinology. 130(5):3066-73 [PMID] 1572313.
1992
Blind-ending tubules and branching patterns of the rat ductuli efferentes.
The Anatomical record. 232(3):423-31 [PMID] 1543266.
1992
Developmental hormonal profiles accompanying the neonatal hypothyroidism-induced increase in adult testicular size and sperm production in the rat.
Endocrinology. 131(2):559-65 [PMID] 1639007.
1992
Induction of increased testis growth and sperm production in adult rats by neonatal administration of the goitrogen propylthiouracil (PTU): the critical period.
Biology of reproduction. 46(1):146-54 [PMID] 1547312.
1991
Androgen receptor expression in developing male reproductive organs.
Endocrinology. 128(6):2867-73 [PMID] 2036966.
1991
Early hypothyroidism in rats causes increased adult testis and reproductive organ size but does not change testosterone levels.
Endocrinology. 129(1):237-43 [PMID] 2055186.
1991
Estrogen receptor expression in developing epididymis, efferent ductules, and other male reproductive organs.
Endocrinology. 128(6):2874-9 [PMID] 2036967.
1991
Increased sperm production in adult rats after transient neonatal hypothyroidism.
Endocrinology. 129(1):244-8 [PMID] 2055187.
1991
Neonatal seminal vesicle mesenchyme induces a new morphological and functional phenotype in the epithelia of adult ureter and ductus deferens.
Development (Cambridge, England). 111(1):145-58 [PMID] 2015790.
1991
Thyroid hormones and testis development: a model system for increasing testis growth and sperm production.
Annals of the New York Academy of Sciences. 637:122-32 [PMID] 1785766.
1990
Anti-androgenic effects of Win 49,596 on development of the neonatal mouse bulbourethral gland in culture.
The Prostate. 17(2):145-54 [PMID] 2399190.
1990
Inhibitory effects of technical grade methoxychlor on development of neonatal male mouse reproductive organs.
Biology of reproduction. 42(3):585-96 [PMID] 2340338.
1990
Morphological and biochemical alterations in reproductive tracts of neonatal female mice treated with the pesticide methoxychlor.
Biology of reproduction. 42(3):573-83 [PMID] 2340337.
1988
Cellular heterogeneity and insulin-like growth factor I immunoreactivity among epiphysial growth plate chondrocytes in the pig.
Acta anatomica. 133(1):66-9 [PMID] 3213408.
1987
A new model system for studying androgen-induced growth and morphogenesis in vitro: the bulbourethral gland.
Endocrinology. 121(6):2161-70 [PMID] 2960517.
1987
Androgen dependence of growth and epithelial morphogenesis in neonatal mouse bulbourethral glands.
Endocrinology. 121(6):2153-60 [PMID] 3678144.
1987
The endocrinology and developmental biology of the prostate.
Endocrine reviews. 8(3):338-62 [PMID] 3308446.
1987
Vaginal and uterine stroma maintain their inductive properties following primary culture.
In vitro cellular & developmental biology : journal of the Tissue Culture Association. 23(3):159-66 [PMID] 3558251.
1986
A simple efficient method for separating murine uterine epithelial and mesenchymal cells.
The American journal of physiology. 251(5 Pt 1):E630-6 [PMID] 3777165.
1986
Restoration of normal morphology and estrogen responsiveness in cultured vaginal and uterine epithelia transplanted with stroma.
Proceedings of the National Academy of Sciences of the United States of America. 83(7):2109-13 [PMID] 3457377.
1985
Stromal-epithelial interactions in adult organs.
Cell differentiation. 17(3):137-48 [PMID] 3902250.
1985
The internal milieu of the pregnant rat is not growth promoting for maternal tissues and it reduces growth of fetal paw transplants.
Endocrinology. 116(5):1899-904 [PMID] 3987623.
1984
Development of thyroid hormone dependence for growth in the rat: a study involving transplanted fetal, neonatal, and juvenile tissues.
Endocrinology. 115(6):2059-64 [PMID] 6499761.
1984
Role of insulin in the growth of fetal rat tissues.
Endocrinology. 114(2):638-43 [PMID] 6360671.
1983
A transplant system for studying hormonal control of growth of fetal rat tissues: effects of hypophysectomy growth hormone, prolactin, and thyroxine.
Endocrinology. 112(3):806-12 [PMID] 6822211.

Grants

Sep 2023 ACTIVE
Steroid Hormone Pathways Regulating BPH and LUTS
Role: Principal Investigator
Funding: MAGEE-WOMENS RESEARCH INSTITUTE & FDN via NATL INST OF HLTH NIA
Jan 2022 – Dec 2023
GnRH Expression in Adult Male Mice following Intramuscular, Intravenous or Subcutaneous Injection of an Adeno-associated virus type 9 (AAV9) and Assessment of Impact on Fertility
Role: Principal Investigator
Funding: MICHELSON FOUND ANIMALS FOUNDATION
Aug 2021 – Aug 2023
Effects on Fertility in Adult Mice following Intramuscular Injection of an Adeno-associated virus type 9 (AAV9) expressing anti-GnRH VHH Antibodies
Role: Principal Investigator
Funding: MICHELSON FOUND ANIMALS FOUNDATION
Sep 2018 – Jan 2024
Estrogen receptor mediated reprogramming of prostate in BPH
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jun 2018 – May 2021
OR-DRPD-ROF2018: A commonly used human anesthetic may act as an endocrine disruptor, contributing to sex-dependent developmental effects of neonatal anesthesia
Role: Principal Investigator
Funding: UF RESEARCH
Apr 2017 – Mar 2020
Role of Membrane Estrogen Receptor 1 in Uterine Epithelial Response to Estrogen
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Mar 2017 – Sep 2018
IPA Aguirre .116FTE
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Sep 2016 – Aug 2019
Membrane estrogen receptor 1 mediation of epigenetic effects of estrogen
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Sep 2014 – Sep 2016
Development and Testing of a White Matter Stoke Model in the Rat
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2014 – Jul 2017
IPA for Jiamei Hou at the Malcom Randall VA Medical Center
Role: Other
Funding: US DEPT OF VETERANS AFFAIRS
Sep 2011 – Jul 2016
Hypospadias, Differentiation and Endocrine Disruptors
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via NATL INST OF HLTH NIDDK
Jul 2006 – Dec 2020
21st Century Research & Economic Development Investment Program (REDIP)
Role: Project Manager
Funding: STATE UNIV SYS OF FL BOARD OF GOVERNORS

Contact Details

Phones:
Business:
(352) 294-4008
Emails:
Business:
paulscooke@ufl.edu
Addresses:
Business Mailing:
PO Box 100144
GAINESVILLE FL 32610
Business Street:
1600 SW ARCHER RD RM B3 6
BASIC SCIENCE BLDG
GAINESVILLE FL 32610