Nancy D. Denslow

ProfessorDr. Nancy Denslow

Joint appointment
College of Veterinary Medicine
Department of Physiological Sciences &
College of Medicine
Department of Biochemistry and Molecular Biology
ndenslow@ufl.edu
PO Box 110885
2187 Mowry Rd, Bldg 471
Gainesville, FL 32611
Office: 352-294-4642
Fax: 352-392-4707

Education

  • M.S., Biochemistry, Yale University
  • Ph.D., Molecular Biology, University Of Florida

Honors and Awards

  • 2017 UF Research Professor
  • 2016 Founders Award Society of Environmental Toxicology and Chemistry
  • 2016 SETAC Fellow Society of Environmental Toxicology and Chemistry
  • 2007 Pfizer Award for Research Excellence, College of Veterinary Medicine, University of Florida
  • 2009 University of Florida Research Professor
  • 2009-2012 Blue Ribbon Scientific Advisory Panel for California State Water Resources Control Board

Research Interests

Dr. Denslow’s research involves developing and using molecular biomarkers to evaluate changes in gene expression depending on stress or exposure to contaminants. For environmental species, molecular approaches, including microarray analysis and proteomics, were developed for several non-model species, including fish, gastropods, and coral. Fish swim in waters that are contaminated by superfund chemicals and emerging contaminants of concern and, thus, provide a direct measure of effects of the contaminants in vertebrates. Many of the chemicals behave as endocrine disruptors and, in particular, as estrogen mimics. To better study the direct effects of these contaminants on reproduction, three largemouth bass estrogen receptors (alpha and two beta-like subtypes) were isolated, sequenced, and integrated into expression assays. The receptors appear to bind and are activated differentially by organochlorine pesticides. In addition, the tissue expression patterns are different for the three receptors.

In the human health arena, Dr. Denslow has recently served on a Blue Ribbon Panel to assess contaminants found in reused water in California. Southern California and other locations in the United States are suffering from shortages of fresh water and need to reclaim water for many different uses, including drinking water. It is important to assess the levels of contaminants in processed water and to determine whether or not they are causing a risk for human health directly or through epigenetic mechanisms.

Recent Publications

  1. Smith LC, Lavelle CM, Silva-Sanchez C, Denslow ND, Sabo-Attwood T. Early phosphoproteomic changes for adverse outcome pathway development in the fathead minnow (Pimephales promelas) brain. Sci Rep 2018 Jul 5; (1): 10212. doi:10.1038/s41598-018-28395-w.  PubMed PMID: 29977039; PubMed Central PMCID: PMC6033950
  2. Li E, Bolser DG, Kroll KJ, Brockmeier EK, Falciani F, Denslow ND. Comparative toxicity of three phenolic compounds in the embryo of fathead minnow, Pimephales promelas.  Aquat Toxicol. 2018 May 29; 201:66-72.  doi: 10.1016?j.aquatox.2018.05.024 [Epub ahead of print] PubMed PMID: 29879596
  3. Bolser DG, Dreier DA, Li E, Kroll KJ, Martyniuk CJ, Denslow ND. Toward an adverse outcome pathway for impaired growth: Mitochondrial dysfunction impairs growth in early life stages of the fathead minnow (Pimephales promelas). Comp Biochem Physiol C Toxicol Pharmacol. 2018 Jul; 209:46-53.  doi: 10.1016j?cbpc.2018.03.009. Epub 2018 Apr 3. Pub Med PMID: 2965345
  4. Dang VD, Kroll KJ, Supowit SD, Halden RU, Denslow ND. Activated carbon as a means of limiting bioaccumulations of organochlorine pesticides, triclosan, triclocarban, and fipronil from sediments rich in organic matter. Chemosphere. 2018 Apr; 197:627-633.  doi: 10.1016/j.chemosphere. 2018.01.062. Epub 2018 Jan 16.  PubMed PMID: 29407826; PubMed Central PMCID: PMC5811353
  5. Downs CA, Dang VD, Johnson NM, Denslow ND, Alli AA. Hydrogen peroxide stimulates exosomal cathepsin B regulation of the receptor for advanced glycation end-products (RAGE).  J Cell Biochem. 2018 119(1): 599-606.  doi: 10.1002/jcb.26219.  PubMed PMID: 28618037

All publications

Last updated 5 Dec 2018