Department of Infectious Diseases & Immunology
The Center for Inflammation & Mucosal Immunology
College of Medicine, Department of Medicine, Division of Gastroenterology, Hepatology & Nutrition
College of Medicine, Department of Dermatology
Emerging Pathogens Institute
PO Box 110880
2015 SW 16th Ave
Gainesville, FL 32611-0882
- BS, Cellular & Molecular Biology, Johannes Gutenberg University/Germany, 1986
- MS, Cellular & Molecular Immunology, Johannes Gutenberg University, 1989
- PhD, Cellular & Molecular Immunology, Johannes Gutenberg University, 1991
Dr. Mohamadzadeh is an immunologist with over 25 years of expertise in the fields of inflammation, systemic/mucosal immunology, infection, and vaccine delivery. He is also experienced in working with various therapeutic approaches that focus on the role of innate immune cells–particularly dendritic cells, and how these cells determine the activation and differentiation of T lymphocytes, including T cells, such as TH17 or extrathymic regulatory T cells (Tregs) in steady state, during infection, and throughout autoinflammatory intestinal disorders such as inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC). In his opinion, understanding the molecular mechanisms underlying intestinal immune regulation is most effective when host interactions with intestinal bacterial species and their bacterial products are fully understood, and when the critical molecules that culminate in inflammation or anti-inflammatory responses are identified. Thus, his research is firmly centered on the specifics of beneficial gut microbes, their unique properties, and their role in the induction of stimulatory or regulatory signals in innate cells and T lymphocytes, contributing directly to further proinflammation or regulation of inflammatory diseases (IBD, NEC). Pragmatically, his research is tightly entwined with generating novel therapies for intestinal disorders (e.g. NEC) using beneficial bacteria such as P. UF1 to significantly regulate induced pathogenic inflammation in sufferers who urgently need it. Furthermore, his team also established a novel targeted vaccine platform, dual route vaccine, to mobilize protective humoral immunity against infectious agents, including botulinum neurotoxin A complex (BoNT/A), in animals and man. The same dual route vaccine platform is currently optimized to elucidate the efficacy of probiotic bacterium, P. UF1, expressing PD-1 molecule to generate neutralizing antibody against PD-1 to inhibit T cell exhaustion and to protect against melanoma cancer. This elegant and less costly approach will be further developed and tested in higher animals, including dogs affected by melanoma and hopefully in phase 1 clinical trial in man in the near future.
- Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-cell Receptor-positive Cells and Pathogenesis of Cholestatic Liver Disease.
- Regulation of Th17 cells by P. UF1 against systemic Listeria monocytogenes infection.
- Dual-route targeted vaccine protects efficiently against botulinum neurotoxin A complex.
- The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue.
Additional publications here