Christopher J. Martyniuk

Associate ProfessorMartyniukChris_200px

Center for Environmental and Human Toxicology &
Department of Physiological Sciences
2187 Mowry Road, Bldg 471
PO Box 110885
Gainesville, FL 32611
Office: 352-294-4636
Fax: 352-392-4707

Visit the Martyniuk Lab website


  • PhD Biology, University of Ottawa, Ottawa, ON, CAN
  • MSc Zoology, University of Guelph, Guelph, ON, CAN
  • BSc Biology, Simon Fraser University, Burnaby, BC, CAN

Courses Taught in College of Veterinary Medicine

  • VME 6603 Advanced Toxicology (Fall)
  • VEM 5176 Poisonous Plants (Spring)
  • VEM 5172 Veterinary Toxicology (Fall)

Honors and Awards

  • Zoetis Animal Health Award for Research Excellence, 2018

National and International Awards

  • 2013: The Gorbman – Bern New Independent Investigator Award. North American Society for Comparative Endocrinology
  • 2013: Canadian Society of Zoology, Bob Boutilier New Investigator Award

Research Interests

Toxicology, Neuroendocrinology, Neurogenic Hypertension, Transcriptomics, Proteomics, Endocrine Disruption

Current Projects

  • Pesticides and the dopamine system in larval zebrafish (F. Cao)
  • Adverse outcome pathways for mitochondrial dysfunction (D. Dreier)
  • Polycyclic aromatic hydrocarbons and the reproductive axis (J Loughery)
  • Effects of toxaphene on the mitochondrial bioenergetics of zebrafish (V. Perez)
  • Developmental effects of dipyridyl herbicides in zebrafish (H. Wang)
  • Phthalates as obesogens: Microbiome-host interactions (Dr. O. Adamovsky)
  • UV stabilizers and metabolic profiling in zebrafish (Dr. X. Liang)
  • Hybrid nanoparticles and behavior (Dr. L. Zhao)
  • Microbiome responses in the gut to legacy pesticides (Dr. H. Qing)

Recent Publications

Shontz EC, Souders CL 2nd, Schmidt JT, Martyniuk CJ. Domperidone upregulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio). Genes Brain Behav. 2018 Jan 27. doi: 10.1111/gbb.12460. [Epub ahead of print] PubMed PMID: 29377542.

Da Fonte DF, Martyniuk CJ, Xing L, Pelin A, Corradi N, Hu W, Trudeau VL. Secretoneurin A regulates neurogenic and inflammatory transcriptional networks in goldfish (Carassius auratus) radial glia. Sci Rep. 2017 Nov 2;7(1):14930. doi: 10.1038/s41598-017-14930-8. PubMed PMID: 29097753; PubMed Central PMCID: PMC5668316.

Olvera A, Martyniuk CJ, Buisine N, Jiménez-Jacinto V, Sanchez-Flores A, Sachs LM, Orozco A. Differential transcriptome regulation by 3,5-T2 and 3′,3,5-T3 in brain and liver uncovers novel roles for thyroid hormones in tilapia. Sci Rep. 2017 Nov 8;7(1):15043. doi: 10.1038/s41598-017-14913-9. PubMed PMID: 29118400; PubMed Central PMCID: PMC5678081.

Wang XH, Souders CL 2nd, Zhao YH, Martyniuk CJ. Mitochondrial bioenergetics and locomotor activity are altered in zebrafish (Danio rerio) after exposure to the bipyridylium herbicide diquat. Toxicol Lett. 2018 Feb;283:13-20. doi: 10.1016/j.toxlet.2017.10.022. Epub 2017 Nov 1. PubMed PMID: 29100808.

Liang X, Feswick A, Simmons D, Martyniuk CJ. Environmental toxicology and omics: A question of sex. J Proteomics. 2018 Feb 10;172:152-164. doi: 10.1016/j.jprot.2017.09.010. Epub 2017 Oct 14. PubMed PMID: 29037750.

Feswick A, Munkittrick KR, Martyniuk CJ. Estrogen-responsive gene networks in the teleost liver: What are the key molecular indicators? Environ Toxicol Pharmacol. 2017 Dec;56:366-374. doi: 10.1016/j.etap.2017.10.012. Epub 2017 Oct 31. PubMed PMID: 29126055.

Wang XH, Souders CL 2nd, Zhao YH, Martyniuk CJ. Paraquat affects mitochondrial bioenergetics, dopamine system expression, and locomotor activity in zebrafish (Danio rerio). Chemosphere. 2018 Jan;191:106-117. doi: 10.1016/j.chemosphere.2017.10.032. Epub 2017 Oct 6. PubMed PMID: 29031050.

Liang X, Souders CL 2nd, Zhang J, Martyniuk CJ. Tributyltin induces premature hatching and reduces locomotor activity in zebrafish (Danio rerio) embryos/larvae at environmentally relevant levels. Chemosphere. 2017 Dec;189:498-506. doi: 10.1016/j.chemosphere.2017.09.093. Epub 2017 Sep 20. PubMed PMID: 28961535.

Zhang J, Knight R, Wang Y, Sawyer TW, Martyniuk CJ, Langlois VS. Comprehensive assessment of shockwave intensity: Transcriptomic biomarker discovery for primary blast-induced mild traumatic brain injury using the mammalian hair follicle. Brain Inj. 2018;32(1):123-134. doi: 10.1080/02699052.2017.1342000. Epub 2017 Nov 20. PubMed PMID: 29157017.

Paré JF, Martyniuk CJ, Levin M. Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis. NPJ Regen Med. 2017 May 26;2:15. doi: 10.1038/s41536-017-0019-y. eCollection 2017. PubMed PMID: 29302351; PubMed Central PMCID: PMC5677984.

Huang T, Yan L, Zheng S, Wang Y, Wang X, Fan L, Li C, Zhao Y, Martyniuk CJ.  Discriminating modes of toxic action in mice using toxicity in BALB/c mouse fibroblast (3T3) cells. Chemosphere. 2017 Dec;188:73-80. doi: 10.1016/j.chemosphere.2017.08.135. Epub 2017 Aug 26. PubMed PMID: 28869848.

Levin M, Martyniuk CJ. The bioelectric code: An ancient computational medium for dynamic control of growth and form. Biosystems. 2018 Feb;164:76-93. doi: 10.1016/j.biosystems.2017.08.009. Epub 2017 Sep 2. Review. PubMed PMID: 28855098.

Schmidt JT, Rushin A, Boyda J, Souders CL 2nd, Martyniuk CJ. Dieldrin-induced neurotoxicity involves impaired mitochondrial bioenergetics and an endoplasmic reticulum stress response in rat dopaminergic cells. Neurotoxicology. 2017 Dec;63:1-12. doi: 10.1016/j.neuro.2017.08.007. Epub 2017 Aug 24. PubMed PMID: 28844784.

Paullin T, Powell C, Menzie C, Hill R, Cheng F, Martyniuk CJ, Westerheide SD. Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses. PLoS One. 2017 Aug 9;12(8):e0182930. doi: 10.1371/journal.pone.0182930. eCollection 2017. PubMed PMID: 28793334; PubMed Central PMCID: PMC5549971.

Dreier DA, Denslow ND, Martyniuk CJ. Computational analysis of the ToxCast estrogen receptor agonist assays to predict vitellogenin induction by chemicals in male fish. Environ Toxicol Pharmacol. 2017 Jul;53:177-183. doi: 10.1016/j.etap.2017.05.015. Epub 2017 Jun 13. PubMed PMID: 28645054.

Liang X, Zha J, Martyniuk CJ, Wang Z, Zhao J. Histopathological and proteomic responses in male Chinese rare minnow (Gobiocypris rarus) indicate hepatotoxicity following benzotriazole exposure. Environ Pollut. 2017 Oct;229:459-469. doi: 10.1016/j.envpol.2017.06.013. Epub 2017 Jun 30. PubMed PMID: 28624627.

Mudge JF, Martyniuk CJ, Houlahan JE. Optimal alpha reduces error rates in gene expression studies: a meta-analysis approach. BMC Bioinformatics. 2017 Jun 21;18(1):312. doi: 10.1186/s12859-017-1728-3. PubMed PMID: 28637422; PubMed Central PMCID: PMC5480162.

Wang XH, Fan LY, Wang S, Wang Y, Yan LC, Zheng SS, Martyniuk CJ, Zhao YH. Relationship between acute and chronic toxicity for prevalent organic pollutants in Vibrio fischeri based upon chemical mode of action. J Hazard Mater. 2017 Sep 15;338:458-465. doi: 10.1016/j.jhazmat.2017.05.058. Epub 2017 Jun 1. PubMed PMID: 28599262.

Jones ER, Martyniuk CJ, Morris JM, Krasnec MO, Griffitt RJ. Exposure to Deepwater Horizon oil and Corexit 9500 at low concentrations induces transcriptional changes and alters immune transcriptional pathways in sheepshead minnows. Comp Biochem Physiol Part D Genomics Proteomics. 2017 Sep;23:8-16. doi: 10.1016/j.cbd.2017.05.001. Epub 2017 May 26. PubMed PMID: 28578262.

Zubcevic J, Baker A, Martyniuk CJ. Transcriptional networks in rodent models support a role for gut-brain communication in neurogenic hypertension: a review of the evidence. Physiol Genomics. 2017 Jul 1;49(7):327-338. doi: 10.1152/physiolgenomics.00010.2017. Epub 2017 May 26. Review. PubMed PMID: 28550087.

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Last updated 21 Feb 2017

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