faculty – College of Veterinary Medicine http://www.vetmed.ufl.edu UNIVERSITY of FLORIDA Thu, 08 Dec 2016 00:17:30 +0000 en-US hourly 1 https://wordpress.org/?v=4.6.1 Leah R. Reznikov http://www.vetmed.ufl.edu/about-the-college/faculty-directory/leah-r-reznikov/ Wed, 22 Jun 2016 20:25:15 +0000 http://vetmed.sites.medinfo.ufl.edu/?page_id=9788 Assistant ProfessorDr. Leah Reznikov

Department of Physiological Sciences
Box 100144
Gainesville, FL 32610-0144
leahreznikov@ufl.edu
Office: 352-294-4059
Fax: 352-392-5145
Reznikov Lab website

 

 

Education

  • 08/2008 – 06/2016: Postdoctoral Scholar, Lung Biology and Cystic Fibrosis Center, University of Iowa, Iowa City, IA
  • 08/2004 – 08/2008: Ph.D, Biomedical Sciences; focus in Neuroscience. University of South Carolina School of Medicine, Columbia, SC
  • 02/2000 – 06/2000: Regents Semester Study Abroad Program. University of Newcastle, Newcastle, New South Wales, Australia
  • 08/1998 – 08/2002: B.S., Biology. Iowa State University, Ames, IA

Honors and Awards

  • 2014: K99/R00 Pathway to Independence Grant Recipient
  • 2014: University of Iowa 15th Annual Interdisciplinary Research Poster Session Best Poster Award
  • 2014: University of Iowa Carver College of Medicine Health Sciences Research Week Cover Art Winner
  • 2013: University of Iowa 14th Annual Interdisciplinary Research Poster Session Women in Science and Engineering Award
  • 2013: University of Iowa Carver College of Medicine Health Sciences Research Week Outstanding Poster Award in Postdoctoral Fellow and Staff Category
  • 2012: University of Iowa Carver College of Medicine Health Sciences Research Week Outstanding Poster Award in Postdoctoral Fellow and Staff Category
  • 2010: NIH T32 Institutional NRSA Postdoctoral Fellowship Recipient, Cardiovascular Center, Internal Medicine,  University of Iowa
  • 2007: International Society of Psychoneuroendocrinology Young Investigator Travel Award
  • 2007: Amygdala in Health & Disease Gordon Conference Chair’s Fund Recipient
  • 2006: Society for Neuroscience Graduate Student Travel Award
  • 2004: Research Assistantship from the Graduate School of University of South Carolina School of Medicine
  • 2002: Iowa State University Academic Recognition Scholarship

Research Interests

The research interests of my lab are centered on the interface of the nervous system and the airway. Using multidisciplinary approaches, we aim to answer three big picture questions:  1) Is dysfunction of the nervous system sufficient to induce airway disease? 2) What are the neural substrates that detect airway insults? 3) Can targeting the nervous system prevent airway disease?

To answer these questions, we use both porcine and rodent models of asthma and cystic fibrosis, with a special emphasis on early stage life.  We perform in vitro and in vivo studies in parallel, and utilize numerous techniques ranging from basic molecular biology to microscopy to ion transport studies to whole animal physiology.  We are keenly interested in the communication of the sensory nerves with the airway, and the processes governing transmission of that information to target tissues (i.e. epithelia, smooth muscle, submucosal glands, brainstem, etc).  The goal of all our efforts is to improve human health and discover new mechanisms of airway disease.

Recent Publications

  1. Reznikov LR.  Cystic Fibrosis and the Nervous System (2016).  Chest.
  2.  Reznikov LR, Meyerholz DK, Adam RJ, Abou Alaiwa M, Jaffer O, Michalski AS, Powers LS, Price MP, Stoltz DA, Welsh MJ. Acid -Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice (2016).
    PLoS One. 2016 Nov 7;11(11):e0166089.
  3. Shah VS, Meyerholz DK, Tang XX, Reznikov LR, Abou Alaiwa MH, Ernst SE, Karp PK, Wohlford-Lenane CL, Heilmann KP, Leidinger MR, Allen PD, Zabner J, McCray PB, Ostedgaard LS, Stoltz DA, Randak CO, Welsh MJ. Airway Acidification Initiates Host Defense Abnormalities in Cystic Fibrosis Mice. In press.  Science.
  4. Li K, Wohlford-Lenane C, Perlman S, Jewell AK, Gibson-Corley KN, Reznikov LR, Meyerholz DK, McCray PB. Middle east respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4. In press.  Journal of Infectious Diseases.
  5. Cook DP, Rector MV, Bouzek DC, Michalski AP, Gansemer ND, Reznikov LR, Stroik MR, Ostedgaard LS, Abou Alaiwa MH, Thompson MA, Prakash YS, Krishnan R, Meyerholz DK, Seow C, Stoltz DA. CFTR in sarcoplasmic reticulum of airway smooth muscle: implications for airway contractility.  In press. American Journal of Respiratory and Critical Care Medicine.
  6. Meyerholz DK, Lambertz A, Reznikov LR, Ofori-armanfo G, Karp PH, McCray PB, Welsh MJ, Stoltz DA, Immunohistochemical detection of porcine markers for translational studies of lung diseases in pigs and humans. In Press. Toxicologic Pathology.
  7. Du JY, Reznikov LR, Welsh MJ. (2014) Expression and Activity of Acid-Sensing Ion Channels in the Mouse Pituitary.   PLoS ONE.  9(12):e115310.
  8. Abou Alaiwa MH, Reznikov LR, Gansemer N, Sheets K, Horswill A, Stoltz DA, Zabner J, and Welsh MJ. (2014) pH modulates the activity and synergism of the airway antimicrobials B-defensin-3 and LL37.  Proceedings of the National Academy of Sciences.  30;111(52):18703-8.
  9. Du JY, Reznikov LR, Price MP, Zha XM, Yuan L, Moninger TO, Wemmie JA, Welsh MJ. (2014) Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala. Proceedings of the National Academy of Sciences. 11(24):8961-6.
  10. Reznikov LR, Abou Alaiwa MH, Dohrn CL, Gansemer N, Diekema DJ, Stoltz DA, Welsh MJ. (2014) Antibacterial properties of the CFTR potentiator ivacaftor. Journal of Cystic Fibrosis. pii: S1569-1993(14)00044-7.
  11. Price MP, Gong H, Parsons MG, Kundert JR, Reznikov LR, Bernardinelli L, Chaloner K, Buchanan GF, Wemmie JA, Richerson GB, Cassell MD, Welsh MJ (2013) Localization and Behaviors in Null Mice Suggest that ASIC1 and ASIC2 Modulate Responses to Aversive Stimuli.  Genes, Brain and Behavior. 13(2):179-94.
  12. Stoltz DA, Rokhlina T, Ernst SE, Pezzulo AA, Ostedgaard LS, Karp PH, Samuel MS, Reznikov LR, Rector MV, Gansemer ND, Bouzek DC, Abou Alaiwa MH, Hoegger MJ, Ludwig PS, Taft PJ, Wallen TJ Wohlford-Lenane C, McMenimen JD, Chen JH, Bogan KL, Adam RJ, Hornick EE, Nelson, IV GA, Hoffman EA, Chang EH, Zabner J, McCray, Jr. PB, Prather RS, Meyerholz DK, Welsh MJ. (2013) Intestinal CFTR Expression Alleviates Meconium Ileus in Cystic Fibrosis Pigs. J Clin Invest. Jun 3;123(6):2685-93. PMCID: PMC3668832
  13. Reznikov LR, Dong Q, Chen JH, Moninger TO, Park JM, Zhang Y, Du JY, Hildebrand MS, Smith RJ, Randak CO, Stoltz DA, Welsh MJ (2013) CFTR-Deficient pigs display peripheral nervous system defects at birth. Proceedings of the National Academy of Sciences. 110(8):3083-3088. PMCID: PMC3581923

Additional publications

Additional publications here

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Liang Zhou http://www.vetmed.ufl.edu/about-the-college/faculty-directory/liang-zhou/ Mon, 11 Jan 2016 19:40:01 +0000 http://vetmed.sites.medinfo.ufl.edu/?page_id=9317 Associate Professorphotograph of Dr. Liang Zhou

Department of Infectious Diseases and Pathology
liangzhou497@ufl.edu
PO Box 110880
2015 SW 16th Ave
Gainesville, FL  32611-0880
352-294-8293 (office)
352-294-8289, 294-8290 or 294-8291 (labs)
FAX 352-392-9704

Education

  • MD, Nanjing Medical University, China; Department of Clinical Medicine, 1996
  • PhD, University of California, Los Angeles; Department of Microbiology, Immunology, and Molecular Genetics, 2004

Honors and Awards

  • 2013: Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease Award
  • 2011: Pew Scholar in Biomedical Sciences
  • 2011:  Cancer Research Institute Investigator Award
  • 2010:  ICS Young Investigator Award – International Cytokine Society
  • 2005:  Ariad Research Fellow – Cancer Research Institute-Irvington Institute Fellowship

Research Interests

The goal of my laboratory is to determine the transcriptional regulation of intestinal immune responses. We have characterized the interactions between various transcription factors (e.g., RORγt and Foxp3) involved in specifying development of Th17 cells and the related iTreg lineage and how they eventually determine whether the T cell adopts the Th17 or Treg cell fate. Recently, we have been focusing on the molecular regulation of RORγt+ innate lymphoid cells by the aryl hydrocarbon receptor (Ahr), a ligand-dependent transcription factor under steady-state physiological conditions, during inflammation or autoimmunity. This work has implications for understanding how to modulate intestinal immune responses in different disease settings, may ultimately lead to identification of new therapeutic targets for human IBD or colon cancer.

Selected Publications

  • Li, S., Heller, J. J, Bostick, J. W., Lee, A., Schjerven, H., Kastner, P., Chan, S., Chen, Z. E., Zhou, L.  Ikaros inhibits Group 3 innate lymphoid cell development and function by suppressing the aryl hydrocarbon receptor pathway. Immunity, 45 (1) 185-197 (2016).
  • Zhou, L. Ahr function in lymphocytes: emerging concepts.  Trends Immunol. 37(1):17-31 (2016).
  • Bostick, J., Zhou, L. Innate lymphoid cells in intestinal immunity and inflammation. Cellular and Molecular Life Sciences. 73(2):237-52 (2016).
  • Heller, J. J., Schjerven, H., Li, S., Lee, A., Qiu, J., Chen Z. E., Smale, S. T., Zhou, L. Restriction of IL-22-producing T Cell Responses and Differential Regulation of Treg compartments by Zinc finger transcription factor Ikaros.  J. Immunol. 193(8): 3934-46 (2014).
  • Guo, X., Qiu, J., Tu, T., Deng, L., Anders, R. A., Zhou, L. *, Fu, Y-X *. Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection. Immunity. 40(1): 25-39 (2014). * Co-corresponding authors
  • Qiu, J., Zhou, L. Aryl Hydrocarbon Receptor Promotes RORγt+ ILCs and Controls Intestinal Immunity and Inflammation. SeminImmunopathology 35(6):657-70 (2013).
  • Qiu, J., Guo, X., Chen Z. E., He, L., Sonnenberg, G. F., Artis D., Fu, Y-X., Zhou, L. Group 3 innate lymphoid cells inhibit T cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity. 39(2): 386-99 (2013).
  • Qiu, J., Heller J. J., Guo, X, Chen Z. E., Fish, K., Fu Y-X, and Zhou, L. The Aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity 36, 92-104 (2012).
  • Zhou, L., Lopes, J., Chong, M. M. W., Ivanov, I. I., Min, R., Victora, G. D., Shen, Y., Du, J., Rubtsov, Y. P., Rudensky, A. Y., Ziegler, S. F., Littman, D. R. TGF-β-induced Foxp3 inhibits Th17 cell differentiation by antagonizing RORγt function. Nature  453 (7192), 236-40 (2008).
  • Zhou, L., Ivanov, I. I., Spolski, R., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., Littman, D. R. IL-6 programs Th17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nature  Immunol.  8 (9), 967-74 (2007).
  • Ivanov, I. I.*, McKenzie, B. S.*, Zhou, L *, Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., Littman, D. R. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells.  Cell.  126 (6) 1121-33 (2006). *equal contributions
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Christopher D. Vulpe http://www.vetmed.ufl.edu/about-the-college/faculty-directory/christopher-d-vulpe/ Wed, 06 Jan 2016 20:24:03 +0000 http://vetmed.sites.medinfo.ufl.edu/?page_id=9302 Chris_VulpeProfessor

Department of Physiological Sciences
Box 100144
Gainesville, FL 32610-0103
cvulpe@ufl.edu
Office: 352-294-4010
Fax: 352-392-2938
Vulpe Lab website

Education

  • M.D., Medicine, University of California, San Francisco, 1996
  • Ph.D., Biochemistry, Genetics, University of California, San Francisco, 1994
  • S.B., Biology, Massachusetts Institute of Technology, 1986

Research Interests

Copper and Iron Metabolism
Copper and iron are vital nutrients with a highly conserved and interwoven metabolism that is required for the growth and development of all organisms. An overall research goal of the laboratory is to further understand copper and iron metabolism in mammals with a focus on 1) characterizing the role of the multi-copper ferroxidases (Fe (II)-> Fe(III) in iron homeostasis and 2) identifying the genetic factors that influence iron status in mammals using “in silico” QTL analysis of inbred mouse strains and collaborations to study genetic determinants of iron deficiency in zebrafish and humans.

Toxicogenomics and Green Chemistry
We are utilizing systematic functional analysis through the use of “barcoding” analysis in the budding yeast Saccharomyces cerevisiae to identify conserved toxicity pathways that may provide insight on toxicant susceptibility in people. We are currently focused on breast cancer carcinogens, mitochondrial toxicants, pesticides and emerging contaminants. Most recently we have started using whole genome CRISPR approaches in a similar approach in mammalian cell lines.

Ecotoxicogenomics
We are developing a novel approach for identifying and understanding the toxicity of xenobiotics in aquatic ecosystems by monitoring changes in global gene expression patterns in aquatic indicator species representative of different trophic levels, including Daphnia magna (a crustacean), and Pimephales promelas (fathead minnow). We are assessing the sensitivity, specificity and utility of an ecotoxicogenomics approach for ecological toxicity assessment in real world environmental settings. Tools we are using include traditional microarray technologies as well as high-throughput sequencing methods.

Selected Publications

  • DE Vidal-Dorsch, SM Bay, S Moore, B Layton, AC Mehinto, CD Vulpe. M Brown-Augustine, A Loguinov, H Poynton, N Garcia-Reyero, EJ Perkins, L Escalon, ND Denslow, CR Cristina, T Doan, S Shukradas, J Bruno, L Brown, GV Agglen, P Jackman, M Bauer Ecotoxicogenomics: Microarray interlaboratory comparability. Chemosphere 2016 144, 193-200.
  • Pan S, Yuan C, Tagmount A, Rudel RA, Ackerman, JM, Yaswen, P, Vulpe CD, Leitman, DC. Parabens and Huan Epidermal Growth Factor Receptor Ligands Cross-Talk in Breast Cancer Cells. Environ Health Perspet. 2015 Oct 17.
  • Vidal-Dorsch DE, Bay SM, Moore S, Layton B, Mehinto AC, Vulpe CD, Brown-Augustine, M, Loguinov A, Poynton, H, Gracia-Reyero, N, Perkins, EJ, Escalon, L, Denslow, ND, Cristina CR, Doan, T, Shukradas, S, Bruno, J, Brown, L, Van Agglen, G, Jackman, P, Bauer, M. Ecotoxicogenomics: Microarray Interlaboratory Comparability. Chemosphere 2015 Sep 9;144:293-300. doi: 10.1016/j.chemosphere.2015.08.019.
  • Scanlan LD, Loguinov AV, Teng Q, Antczak P, Dailey KP, Nowinski DT, Kornbluh J, Lin XX, Lachenauer E, Arai A, Douglas NK, Falciani F, Stapleton HM, Vulpe CD. Gene Transcription, Metabolite and Lipid Profiling in Eco-Indicator Daphnia magna Indicate Diverse Mechanisms of Toxicity by Legacy and Emerging Flame-Retardants. Environ Sci Technol. 2015 Jun 16;49(12):7400-10. doi: 10.1021/acs.est.5b00977.
  • Lee SM, Lee SB, Prywes R, Vulpe CD. Iron Deficiency Upregulates Egr1 Expression. Genes Nutr. 2015 Jul; 10(4):468. doi: 10.1007/s.12263-015-0468-0.
  • Jiang R, Hua C, Wan Y, Jiang B, Hu H, Zheng J, Fuqua BK, Dunaief JL, Anderson GJ, David S, Vulpe CD, Chen H. Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain. J Nutr. 2015 May;145(5):1003-9. doi: 10.3945/jn.114.207316.
  • Gaytán BD, Vulpe CD. Functional toxicology: tools to advance the future of toxicity testing. Front Genet 2014 5:110; doi:10.3389/fgene.2014.00110.
  • Fuqua BK, Lu Y, Darshan D, Frazer DM, Wilkins SJ, Wolkow N, Bell AG, Hsu J, Yu CC, Chen H, Dunaief JL, Anderson GJ, Vulpe CD. The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice. PLoS One. 2014 Jun 4;9(6):e98792. doi: 10.1371/journal.pone.0098792.

Additional Publications here

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Mary Leissinger http://www.vetmed.ufl.edu/about-the-college/faculty-directory/mary-leissinger/ Wed, 17 Dec 2014 15:43:57 +0000 http://vetmed.sites.medinfo.ufl.edu/?page_id=8285 Clinical Assistant ProfessorLeissinger

Department of Physiological Sciences
Box 100144
Gainesville, FL 32610-0103
leissingerm@ufl.edu
Office: VS 114
Fax: 352-392-5145

Education

  • Clinical Pathology Residency and Master of Science, Louisiana State University School of Veterinary Medicine, 2011-2014
  • Small Animal Medicine and Surgery Rotating Internship, University of Tennessee College of Veterinary Medicine, 2010-2011
  • Doctor of Veterinary Medicine, Louisiana State University School of Veterinary Medicine, 2006-2010
  • Bachelor of Science, Biology, Louisiana State University, 2002-2006
  • Exchange Student, University of Nottingham, UK, 2005

Honors and Awards

  • CL Davis Award 2014
  • 3rd place oral presentation. The role of MCP-1 in Staphylococcus aureus infection in the murine lung. LSU Graduate Research Symposium, Baton Rouge LA, 2013
  • Outstanding Student Award Year IV 2010
  • Internal Medicine Certificate of Excellence 2010
  • Oncology Certificate of Excellence 2010
  • Clinical Pathology Award of Excellence 2010
  • Dean’s Honors List 2006-2010
  • Salsbury Scholarship 2008
  • Invisible Fence Scholarship 2007

Research Interests

  • Clinical chemistry
  • Coagulation

Selected Research Publications

  • Leissinger M, Brandao J, Wakamatsu N, Le Roux A, Rich G, Gaunt S. Pulmonary histiocytic sarcoma in a rabbit. Vet Clin Pathol. 2013; 42: 364-367.
  • Leissinger M, Pescosolido K, Royal A, What is your diagnosis? Equine transtracheal wash fluid. Vet Clin Pathol. 2013; 42: 529-530.
  • Brandão J, Woods S, Fowlkes N, Leissinger M et al. Disseminated histoplasmosis (Histoplasma capsulatum) in a pet rabbit: case report and review of the literature. J VET Diagn Invest. 2014; 26: 158-162.
  • Leissinger M, Kulkarni R, Zemans R, Downey G, Jeyaseelan S. Investigating the role of NOD-Like receptors in bacterial lung infection. AM J Respir Crit Care Med. 2014. 189:1461-8.
  • Leissinger MK, Garber JB, Fowlkes N, Grooters AM, Royal AB, Gaunt SD. Mycobacterium fortuitum lipoid pneumonia in a dog. Vet Pathol. Prepublished April 30, 2014 DOI:10.1177/0300985814531497.
  • Leissinger M, Walton S, Fletcher J, Gaunt S. What is your diagnosis? Blood smear from a cat. Vet Clin Pathol. 2014;46: 465-6.
  • Leissinger M, Del Piero F, Kawabata A, Dedeaux A, Gaunt S. Pathology in Practice. JAVMA. In Press.
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Sarah Beatty http://www.vetmed.ufl.edu/about-the-college/faculty-directory/sarah-beatty/ Mon, 24 Nov 2014 16:15:31 +0000 http://vetmed.sites.medinfo.ufl.edu/?page_id=8279 Clinical Assistant ProfessorBeattySarah

Department of Physiological Sciences
Box 100103
Gainesville, FL 32610-0103
skbeatty@ufl.edu
Office: 352-294-4031
Fax: 352-392-2938

Education

  • Diplomate, American College of Veterinary Pathologists, 2014
  • Residency, Veterinary Clinical Pathology, University of Florida, 2011-14
  • DVM, Salutatorian, Certificate: Food Animal Medicine, University of Florida, Gainesville, FL, 2011
  • BS, Cum Laude, Animal Biology Major, University of Florida, Gainesville, FL, 2007

Honors and Awards

  • 2016: Teacher of the Year, Class of 2017
  • 2013: CL Davis Foundation Student Scholarship Award, given to a veterinary pathology resident from a university who has demonstrated superior scholarship and diagnostic skills
  • 2013: Phi Zeta Research Emphasis Day: Best Resident Poster
  • 2011: Dr. Clyde and Lydia Spears Scholarship, awarded for performance in Food Animal Medicine
  • 2010-11: Elizabeth Fuschetto Memorial Scholarship, awarded to top 2 ranking individuals
  • 2010: Inducted into Phi Zeta Honor Society
  • 2010: American Association of Bovine Practitioners- Foundation – Pfizer Animal Health Scholarship
  • 2010: Joseph and Sophie Witten Scholarship
  • 2009-2010: Veterinary Medicine Board of Directors Scholarship
  • 2009: American Association of Bovine Practitioners- Amstutz Scholarship
  • 2009: American Association of Bovine Practitioners- Bovine Veterinary Student Recognition Award
  • 2008: Merck-Merial Veterinary Student Scholar

Clinical Research Interests

  • Large Animal Clinical Pathology
  • Oncology
  • Zoological and Wildlife Medicine
  • Infectious Disease
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Jasenka Zubcevic http://www.vetmed.ufl.edu/about-the-college/faculty-directory/jasenka-zubcevic/ Fri, 11 Jul 2014 13:32:37 +0000 http://vetmed.sites.medinfo.ufl.edu/?page_id=7757 Jasenka Zubcevic, photoAssistant Professor

Department of Physiological Sciences
Box 100144
1333 Center Drive
Gainesville, FL 32610-0144
jasenkaz@ufl.edu
Office:  352-294-4010
Fax: 352-392-5145

Education

  • BSc in Pharmacology, Bristol Heart Institute, University of Bristol, UK, 2003
  • PhD in Physiology, Bristol Heart Institute, University of Bristol, UK, 2008
  • Post-doctoral fellow, Department of Physiology and Functional Genomics, University of Florida, USA, 2010-2013
  • Research Assistant Professor, Department of Physiology and Functional Genomics, University of Florida, USA, 2013-2014

Honors and Awards

  • American Heart Association Best Presentation Award 2013
  • American Heart Association New Investigator Travel Award, 2011
  • American Heart Association Best Presentation Award, 2011
  • Donald J Reiss Memorial Trainee Award, 2006

Research Interests

Neural control of cardiovascular physiology, neurogenic hypertension, bone marrow immune responses in cardiovascular and metabolic diseases, the gut-brain axis in cardiovascular diseases.

Publications

PubMed listing

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José Ignacio Aguirre http://www.vetmed.ufl.edu/about-the-college/faculty-directory/jose-ignacio-aguirre/ Thu, 10 Jul 2014 21:02:05 +0000 http://vetmed.sites.medinfo.ufl.edu/?page_id=7729 Ignacio Aguirre Portrait

Assistant Professor

Department of Physiological Sciences
aguirrej@ufl.edu
PO Box 100144
1333 Center Drive
Gainesville, FL 32610-0144
352-294-4038
FAX: 352-392-5145

Education

  • Residency, University of Florida, Animal Care Services, College of Medicine, 2012
  • Postdoctoral Research Fellow, University of Arkansas for Medical Sciences, Division of Endocrinology and Metabolism, College of Medicine, 2005
  • PhD, Universidad Nacional de La Plata, Facultad de Ciencias Veterinarias, 2002
  • Diplomat, Imperial College of Science, Technology and Medicine, Department of Histochemistry, 1998
  • Master in Vet. Pathology, University of London, Royal Veterinary College, 1997
  • Diplomat, University of Tokyo, Department of Agriculture, 1992
  • DVM, Universidad Nacional de La Plata, Facultad de Ciencias Veterinarias, 1989

 Honors and Awards

  • UF Excellence Award for Assistant Professors, 2016
  • Diplomate of the American College of Laboratory Animal Medicine (DACLAM), 2013
  • President’s Poster Competition Award. ASBMR, 34th annual meeting, Minneapolis, MN, 2012
  • Young Investigator Travel Grant. ASBMR, 33th annual meeting. San Diego, CA, 2011
  • Burroughs Wellcome Fund Postdoctoral Travel Award. National Veterinary Scholars Symposium, Orlando, FL, 2011
  • Young Investigator Award. The International Society of Bone Morphometry (ISBM), XIth Congress of the ISBM, Zell Am See, Austria, 2009
  • Young Investigator Travel Grant 2007. ASBMR, 29th annual meeting, Honolulu, HI, 2007
  • Juan de la Cierva Award, Spanish Ministry of Education and Science. Barcelona, Spain, 2005
  • Young Investigator Award. The American Society of Bone and Mineral Research (ASBMR),2005
  • Alice L. Jee Memorial Young Investigator Award. The 34th International Sun Valley Workshop on Skeletal Tissue Biology, Sun Valley, ID, 2004
  • Reentry Grant Award for Postgraduate Students. The Antorchas Foundation, Buenos Aires, Argentina, 2000
  • Biorad. Ltd. Co. Assistantship to support Diploma of The Imperial College in Pathology, Department of Histochemistry, Hammersmith Campus, Imperial College of Science, Technology and Medicine, London, United Kingdom, 1997
  • Laboratory Animals LTD grant. London, United Kingdom, 1996
  • Graduate Scholarship Award. International Cooperation Agency, Argentinean Ministry of Education, Buenos Aires, Argentina, 1996
  • Award for Advanced Studies in the United Kingdom. The British Council and the British Embassy, London, United Kingdom, 1996
  • Graduate Scholarship Award. Japanese International Cooperation Agency (JICA), Tokyo, Japan, 1991

Research Interests

Skeletal effects of bisphosphonates and bone anabolic agents/drugs for the prevention and treatment of local osteopenias (e.g., jaw) and postmenopausal osteoporosis. Pathophysiology of osteonecrosis of the jaw (ARONJ), and other side effects of antiresorptive drugs. Small animal models of periodontitis. Extended half-life of RANK Ligand antagonists for preclinical testing of osteoporosis treatments in small animals. Comparative medicine.

Recent Publications

  1. Aguirre J.I.; Akhter M.; Kimmel D.; Pingel J.; Xia X.; Williams A.; Jorgensen M.; Edmonds K.; Lee J.; Reinhard M.; Battles A.; Kesavalu L.; Wronski T.J. Enhanced Alveolar Bone Loss in a Model of Non-Invasive Periodontitis in Rice Rats. Oral Dis. 18(5):459-468, 2012.
  2. Aguirre J.I.; Akhter M.; Kimmel D.; Pingel J.; Xia X.; Williams A.; Jorgensen M.; Kesavalu L.; Wronski T.J. Oncologic Doses of Zoledronic Acid Induce Osteonecrosis of the Jaw-Like Lesions in Rice Rats (Oryzomys palustris) with Periodontitis. J. Bone Mineral Res 27(10):2130-2143, 2012.
  3. Yarrow, J.F.; Conover, C.F.; Beggs, L.A.; Beck, D.T.; Otzel, D.; Baelez, A.; Combs, S.M.; Miller, J. R.; Ye, F.; Aguirre, J.I.; Neuville, K.G.; Williams, A.A.; Conrad, B.P.; Gregory, C.M.; Wronski, T.J.; Bose, P.K.; Borst, S.E. Testosterone Dose-Dependently Prevents Bone and Muscle Loss in Rodents Following Spinal Cord Injury. Journal of Neurotrauma 31(9):834-845, 2014.
  4. Aguirre, J.I.; Edmonds, K.; Zamora, B; Pingel, J.; Thomas, L.; Cancel, D.; Schneider, L.; Reinhard, M.K.; Battles, A.H.; Akhter, M.P.; Kimmel, D.B.; Wronski, T. J. Marsh rice rat (Oryzomys palustris) under laboratory conditions: breeding, rearing, veterinary care and hematologic findings in a small animal model for periodontitis. JAALAS. (Accepted; May, 2014).

Additional publications

  1. Aguirre, J.I.; Buttery, L.; O´shaughnessy, M.; Afzal, F.; Fernandez de Marticorena, I.; Hukkanen, M.; Huang, P.; MacIntyre, I.; Polak, J. Endothelial Nitric Oxide Synthase Gene-Deficient Mice Demonstrate Marked Retardation in Postnatal Bone Formation, Reduced Bone Volume, and Defects in Osteoblast Maturation and Activity. Am. J. Pathol. (USA) 158(1): 247-257, 2001.
  2. Chen, J.; Plotkin, L.; Aguirre, J.I.; Han L.; Peng H.; Kousteni S.; Bellido, T.; Manolagas, S. Transient Versus Sustained Activation and Nuclear Accumulation of ERKs Underlie the Anti-versus the Pro-apoptotic Effects of Estrogens on Osteoblasts/Osteocytes and Osteoclasts. J. Biol. Chem. (USA) 280(6):4632-4638, 2005.
  3. Plotkin, L.; Aguirre, J.I.; Kousteni, S.; Manolagas, S.C.; Bellido, T. Bisphosphonates and Estrogens Inhibit Osteocyte Apoptosis Via Distinct Molecular Mechanisms Downstream of ERK Activation. J. Biol. Chem. (USA) 280:7317-7325, 2005.
  4. Plotkin, L.; Mathov, I.; Aguirre, J.I.; Manolagas, S.C.; Bellido, T. Mechanical Stimulus Prevent Osteocytes Apoptosis Through an Integrin/SRC/ERK Signalsome Localized in Caveolae. Am. J. Physiol.- Cell Physiology (USA) 289: C633-C643, 2005.
  5. Aguirre, J.I.; Plotkin, L.I.; Stewart, S.A.; Weinstein, R.S.; Parfitt, A.M.; Manolagas, S.C.; Bellido.T. Osteocyte Apoptosis Precedes Osteoclastic Bone Resorption and The Loss of Bone Mineral and Strength Induced by Unloading in Mice. J. Bone Mineral Res (USA) 21 (4): 605-615, 2006.
  6. Aguirre, J.I.; Leal M.E., Rivera, M.F.; Vanegas, S.M.; Wronski, T.J. Effects of Basic Fibroblast Growth Factor and a Prostaglandin E2 Receptor Subtype 4 Agonist on Osteoblastogenesis and Adipogenesis in Aged Ovariectomized Rats. J. Bone Mineral Res (USA) 22 (6): 877-888, 2007.
  7. Aslanidi, G.; Kroutov, V.; Philipsberg, G.; Lamb, K.; Campbell-Thompson, M.; Walter, G.; Kurenov, S.; Aguirre, J.I.; Keller, P.; Hankenson, K.; MacDougald, O.; Zolotukhin, S. Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats. Am. J. Physiol.- Endocrinology and Metabolism (USA) 293 (3) E726-E736, 2007.
  8. Aguirre, J.I.; Plotkin, L.I.; Gortazar, A.R.; Martin Millan, M., O’brien C.A.; Manolagas, S.C.; Bellido.T. A Novel Ligand-independent Function of The Estrogen Receptor Is Essential for Osteocyte and Osteoblast Mechanotransduction. J. Biol. Chem. 282 (35) 25501-25508, 2007.
  9. Leal, M.E.; Holliday, S.; Aguirre, J.I.; Wronski, T.J. In Vitro and in Vivo Evidence for Stimulation of Bone Resorption by and EP4 Receptor Agonist and Basic Fibroblast Growth Factor: Implications for their Efficacy as Bone Anabolic Agents. Bone 44(2) 266-274, 2009.
  10. Aguirre, J.I.; Altman, M.K.; Vanegas, S.M.; Franz, S.E.; Bassit A.C.; Wronski, T.J. Effects of alendronate on bone healing after tooth extraction in rats. Oral Dis. 16(7):674-685, 2010.
  11. Ma Y.L.; Zeng, Q.Q.; Porras, L.L.; Harvey, A.; Moore, T.L.; Shelbourn, T.L.; Dalsky G.P.; Wronski, T.J.; Aguirre, J.I.; Bryant, H.U.; Sato, M. Teriparatide [rhPTH (1-34)], but not strontium ranelate, demonstrated bone anabolic efficacy in mature, osteopenic, ovariectomized rats. Endocrinology 152(5) 1767-78, 2011.
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Christopher J. Martyniuk http://www.vetmed.ufl.edu/about-the-college/faculty-directory/chris-martyniuk/ Fri, 24 Jan 2014 17:08:01 +0000 http://vetmed.sites.medinfo.ufl.edu/?page_id=7114 Associate ProfessorMartyniukChris_200px

Center for Environmental and Human Toxicology &
Department of Physiological Sciences
2187 Mowry Road, Bldg 471
PO Box 110885
Gainesville, FL 32611
Email: cmartyn@ufl.edu
Office: 352-294-4636
Fax: 352-392-4707

Education

  • PhD Biology, University of Ottawa, Ottawa, ON, CAN, 2006
  • MSc Zoology, University of Guelph, Guelph, ON, CAN, 2001
  • BSc Biology, Simon Fraser University, Burnaby, BC, CAN, 1996

Courses Taught in College of Veterinary Medicine

  • VME 6603 Advanced Toxicology (Fall)
  • VEM 5176 Poisonous Plants (Spring)
  • VEM 5172 Veterinary Toxicology (Fall)

Recent Honors and Awards

  • 2013: The Gorbman – Bern New Independent Investigator Award. North American Society for Comparative Endocrinology
  • 2013: Canadian Society of Zoology, Bob Boutilier New Investigator Award
  • 2010: UNB Harrison-McCain Young Researcher Award
  • 2008: ThermoElectron-ABRF 2008 Outstanding Scientist/Technologists Awardees
  • 2007: Finalist for top Ph.D. thesis in Canada (Canadian Society of Zoology)

Research Interests

aquatic toxicology, sex steroids, neuroendocrinology, gamma-aminobutyric acid, transcriptomics, proteomics, reproduction, fish biology

Current Projects

Ecotoxicology

  • Adverse outcome pathways for mitochondrial dysfunction in fish (D. Dreier, PhD candidate)
  • Mechanisms of intersex and sex differentiation in rainbow darter (P Bahamonde, PhD)
  • Impacts of polycyclic aromatic hydrocarbons on the reproductive axis (J Loughery, PhD candidate)
  • Molecular biomarkers for environmental assessments for selenium in trout (R. Kan, MSc candidate)

Human Health

  • Pesticide effects on GABAergic and dopaminergic signaling systems in zebrafish (A. Cowie, MSc candidate)
  • Natural product screening for angiogenesis in zebrafish (K. Sarty, MSc candidate)

Recent Research Articles

  • Mathieu-Denoncourt J, Martyniuk CJ, Loughery JR, Yargeau V, de Solla SR, Langlois VS. 2016. Lethal and sublethal effects of phthalate diesters in Silurana tropicalis larvae. Environ Toxicol Chem. In press
  • Marlatt VL, Sherrard R, Kennedy CJ, Elphick JR, Martyniuk CJ. 2016. Application of molecular endpoints in early life stage salmonid environmental biomonitoring. Aquat Toxicol. 173:178-91.
  • Collí-Dulá RC, Martyniuk CJ, Streets S, Denslow ND, Lehr R. 2016. Molecular impacts of perfluorinated chemicals (PFASs) in the liver and testis of male largemouth bass (Micropterus salmoides) in Minnesota Lakes. Comp Biochem Physiol Part D Genomics Proteomics. In press
  • Bahamonde PA, Feswick A, Isaacs MA, Munkittrick KR, Martyniuk CJ. 2016. Defining the role of omics in assessing ecosystem health: Perspectives from the Canadian environmental monitoring program. Environ Toxicol Chem. 35(1):20-35.
  • Ornostay A, Marr J, Loughery JR, Martyniuk CJ. 2016. Transcriptional networks associated with 5-alpha-dihydrotestosterone in the fathead minnow (Pimephales promelas) ovary. Gen Comp Endocrinol. 225:23-32.

  • Lobikin M, Lobo D, Blackiston DJ, Martyniuk CJ, Tkachenko E, Levin M. 2015. Serotonergic regulation of melanocyte conversion: A bioelectrically regulated network for stochastic all-or-none hyperpigmentation. Sci Signal. 8(397):ra99.
  • Zhang J, Koch I, Gibson LA, Loughery JR, Martyniuk CJ, Button M, Caumette G, Reimer KJ, Cullen WR, Langlois VS. 2015. Transcriptomic responses during early development following arsenic exposure in Western Clawed Frogs, Silurana tropicalis. Toxicol Sci. 148(2):603-17.
  • Wood RK, Crowley E, Martyniuk CJ. 2015. Developmental profiles and expression of the DNA methyltransferase genes in the fathead minnow (Pimephales promelas) following exposure to di-2-ethylhexyl phthalate. Fish Physiol Biochem. 42(1):7-18.
  • Miller LL, Isaacs MA, Martyniuk CJ, Munkittrick KR. 2015. Using molecular biomarkers and traditional morphometric measurements to assess the health of slimy sculpin (Cottus cognatus) from streams with elevated selenium in north-eastern British Columbia. Environ Toxicol Chem. 34:2335-46.
  • Cowie AM, Wood RK, Chishti Y, Feswick A, Loughery JR, Martyniuk CJ. 2015. Transcript variability and physiological correlates in the fathead minnow ovary: Implications for sample size, and experimental power. Comp Biochem Physiol B Biochem Mol Biol. 187:22-30.
  • Simmons DB, Benskin JP, Cosgrove JR, Duncker BP, Ekman DR, Martyniuk CJ, Sherry JP. 2015. Omics for aquatic ecotoxicology; Control of extraneous variability to enhance the analysis of environmental effects. Environ Toxicol Chem. 34(8):1693-704.
  • Wood RK, Seidel JS, Martyniuk CJ. 2015. Transcripts involved in steroid biosynthesis and steroid receptor signaling are expressed early in development in the fathead minnow (Pimephales promelas). Comp Biochem Physiol B Biochem Mol Biol. 182:64-72.
  • Bahamonde PA, Fuzzen ML, Bennett CJ, Tetreault GR, McMaster ME, Servos MR, Martyniuk CJ, Munkittrick KR. 2015. Whole organism responses and intersex severity in rainbow darter (Etheostoma caeruleum) following exposures to municipal wastewater in the Grand River basin, ON, Canada. Part A. Aquatic Toxicol. 159:290-301
  • Bahamonde PA, McMaster ME, Servos MR, Martyniuk CJ, Munkittrick KR. 2015. Molecular pathways associated with the intersex condition in rainbow darter (Etheostoma caeruleum) following exposures to municipal wastewater in the Grand River basin, ON, Canada. Part B. Aquatic Toxicol 159:302-16.
  • Tang F, Minch T, Dinning K, Martyniuk CJ, Kilada R, Rochette R. 2015. Size-at-age and body condition of juvenile American lobsters (Homarus americanus) living on cobble and mud in a mixed-bottom embayment in the Bay of Fundy. Mar Biol. 162: 69-79.α-dihydrotestosterone. Gen Comp Endocrinol. In press.

PubMed Search Results

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UF veterinarians develop technique to test for manatee heart problems http://www.vetmed.ufl.edu/2013/06/27/uf-veterinarians-develop-technique-to-test-for-manatee-heart-problems/ Thu, 27 Jun 2013 13:37:36 +0000 http://vetmed.sites.medinfo.ufl.edu/?p=6099  

An adult manatee receives an echocardiogram by Dr. Amara Estrada, a UF veterinary cardiologist, in the field at a Crystal River health assessment in the fall of 2011.

An adult manatee receives an echocardiogram by Dr. Amara Estrada, a UF veterinary cardiologist at Tampa’s Lowry Park Zoo. (Photo by Dave Parkinson, Lowry Park Zoo)

Leisurely swims in warm, tropical waters fueled by the gaze of admiring fans and a healthy vegetarian diet.

The life of a manatee hardly seems likely to prompt concerns about heart disease. But researchers at the University of Florida say the lumbering, loveable sea cow’s ticker deserves a closer look because of the animal’s endangered status.

That’s why they’ve developed a technique to test for cardiac problems in endangered manatees, both in the wild and in captivity. The new technique will enhance knowledge of how the manatee heart functions.

The UF researchers are using the technique to gather data they hope to share with wildlife and zoo veterinarians to ultimately save more manatee lives. Collaborating with scientists from Tampa’s Lowry Park Zoo and the Florida Fish and Wildlife Conservation Commission’s marine mammal pathology laboratory in St. Petersburg, they are using echocardiography on the large creatures, making use of a specially designed table built to hold animals weighing up to 2,000 pounds.

“There are a lot of gaps in our knowledge base on basic anatomy and physiology of manatees due to the obvious limitations of working with a 1,000- to 1,500-pound animal that spends its entire life in the water,” said Dr. Trevor Gerlach, an intern in UF’s aquatic animal health program and lead author on a paper that documents the first phase of the researchers’ study in the June issue of the Journal of Zoo and Wildlife Medicine. “Due to their current endangered status, it is important that we understand the animal in its entirety so that we can better tailor conservation efforts for the species.”

The researchers’ long-term goal is to provide practitioners at rehabilitation facilities and those working in the field with data from clinically healthy animals. Such animals could be compared to animals of concern to determine if cardiac disease is present.

To allow for effective testing, the researchers first developed a table built to hold the weight of 2,000-pound animals that were part of a large-scale manatee health assessment conducted by the U.S. Geological Survey in Crystal River. Fourteen healthy, wild and captive Florida manatees underwent echocardiography, administered using the table technique, between fall 2011 and winter 2012. The group included eight females and six males of various ages.

Manatee sonogram

A manatee receives an echocardiogram administered by Dr. Ivan Sosa, center, a UF veterinary cardiology resident. Also shown assisting are veterinary technician Melanie Powell, second from right, and Dr. Trevor Gerlach, an aquatic animal health intern, far right. (Photo courtesy of Lowry Park Zoo.)

“We were able to clearly visualize all valves and chambers,” Gerlach said, adding that other key indicators of heart function also were successfully obtained. Some abnormalities in the study animals also were documented.

“Our results indicate that echocardiography in the Florida manatee is possible, which has both clinical and research implications in larger epidemiologic studies evaluating diseases of the cardiopulmonary and cardiovascular systems,” Gerlach said.

Although extensive research has been conducted on comparative anatomy, physiology and ecology of sea cows, very few studies have evaluated the manatee heart. Basic cardiac morphology and a test called an electrocardiogram have been examined, but the diagnostic value is limited to electrical imbalances in the heart, the researchers said.

“Echocardiography is the gold standard for diagnosing valve diseases and structural abnormalities, and provides other information as well,” Gerlach said.

Researchers are finishing up the second phase of the study, which entails collecting more data from echocardiographs to establish normal testing parameters for manatees of various ages.

“Once we establish the parameters, we can begin larger epidemiological studies on the prevalence of heart disease in the wild population, which is one of our long-term goals,” Gerlach said.

Dr. Bob Bonde, a manatee researcher with the USGS, praised the new technique.

“Out-of-water, real-time assessment of these large aquatic mammals will benefit our evaluation of manatee health-related indices in the wild population,” “Knowledge of manatee reproductive fitness and nutritional condition is paramount to our fully understanding their recovery.”

Dr. Amara Estrada, a veterinary cardiology specialist who mentored Gerlach while he was a UF veterinary student and assisted with his research, said the collaborative aspects of the project were especially valuable to her both professionally and personally.

“The opportunity to work with such a diverse group of people toward a common goal is especially meaningful to me as a clinician/researcher and can only be accomplished by being a part of the University of Florida,” Estrada said.

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Thomas B. Waltzek http://www.vetmed.ufl.edu/about-the-college/faculty-directory/thomas-b-waltzek/ Mon, 24 Jun 2013 20:21:43 +0000 http://vetmed.sites.medinfo.ufl.edu/?page_id=6283 Waltzek2Assistant Professor
Research Coordinator, Aquatic Animal Health Program

Department of Infectious Diseases and Pathology
tbwaltzek@ufl.edu
PO Box 110880
Bldg. #1379, Mowry Road
Gainesville, FL 32611-0880
352-273-5202
FAX 352-392-9704

 Education

  • PhD, Comparative Pathology, University of California at Davis, 2010
  • DVM, University of California at Davis, 2009
  • MS, Ecology, University of California at Davis, 2002
  • BS, Biological Sciences, Florida State University, 1998

Honors and Awards

  • 2010 – John L. Pitts Veterinary Student/Recent Graduate Scholarship
  • 2009 – Merck Achievement Award, UC Davis
  • 2009 – Wilds Scholastic Award, UC Davis
  • 2009 – AVMA Achievement Award, UC Davis
  • 2007 – Best Student Presentation, 33rd Eastern Fish Health Workshop

Research Interests

  • Characterization of Emerging Aquatic Animal Viruses (EAAVs) using Metagenomics;
  • Phylogenomics to study the Biology, Epidemiology, and Evolution of EAAVs;
  • Development of Broadly Applicable Diagnostic Methodologies to Track EAAVs;
  • Determining the Role that International Commerce of Aquatic Animals Plays in the Emergence of AAVs as it Relates to Global Aquaculture and Ecosystem Health.
  • Aquatic Animal Zoonoses, Public Health, One Health

Recent Publications

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