College of Veterinary Medicine

Education:

DVM, Veterinary Medicine, University of California, Davis, 1977
PhD, Comparative Pathology (DVM-PhD program), Univ. of California, Davis, 1979
Diplomate, American College of Veterinary Pathologists, 1982

Honors and Awards:

University of Florida Superior Accomplishment Award, Faculty, 2004

Research Interests:

I have broad interests in experimental and veterinary pathology.  Research interests in experimental pathology focus on pathogenesis of viral respiratory disease with recent emphasis on canine influenza virus infection.  Interests in veterinary pathology are diverse and stem from case-based studies in the UF Veterinary Medical Center on diseases affecting horses, cattle, companion animals as well as laboratory animals used in research.  I coordinate the Laboratory of Comparative Pathology that provides veterinary pathology support to University of Florida research investigators in areas ranging from gene therapy and stem cell therapy to transgenic mouse models of human disease.

Selected Publications:

For Publications Extracted From Medline Click HERE

Stone ES, Castleman WL: IL-12 reduces the severity of Sendai-virus induced bronchiolar inflammation and remodeling. Cytokine, 24:103-113, 2003.

Cai X, Castleman WL: Early high expression of IP-10 in F344 rats resistant to Sendai virus-induced airway injury. Am. J. Physiol. Lung Cell. Mol. Physiol, 285:L1263-L1269, 2003.

Crawford PC, Dubovi EJ, Castleman WL , Stephenson I, Gibbs EP, Chen L, Smith C, Hill RC, Ferro P, Pompey J, Bright RA, Medina MJ, Johnson CM, Olsen CW, Cox NJ, Klimov AI, Katz JM, Donis RO: Transmission of equine influenza virus to dogs. Science 310(5747):482-485, 2005.

Powe J, Castleman W, Fiorello C: A thymic carcinoid in a Bengal tiger (Panthera tigris). J Zoo Wildlife Med 36:531-533, 2005.

Jacks S, Giguère S, Crawford PC, Castleman WL: Experimental infection of neonatal foals with Rhodococcus equi triggers adult-like gamma interferon induction. Clin Vaccine Immunol, 14:669-677,2007.

Payungporn S, Crawford PC, Kouo TS, Chen LM, Pompey J, Castleman WL, Dubovi EJ, Katz JM, Donis RO:  Influenza A (H3N8) in dogs with respiratory disease, Florida.  Emerg Inf Dis, 14: 902-908, 2008.

Frederick JD, Mackay RJ, Winter MD, Castleman WL: Vertebral osteomyelitis with abscessation in a Holstein calf.    Vet Record 164: 723-724, 2009.

Powe JR, Castleman WL:  Canine influenza virus replicates in alveolar macrophages and induces TNF-α.  Vet Pathol, In press

Castleman WL, Powe JR, Crawford PC, Gibbs EPJ, Dubovi EJ, Donis RO, Hanshaw D:  Canine H3N8 influenza virus infection in dogs and mice.  Vet Pathol, Accepted for publication