College of Veterinary Medicine

Education:

DVM, University of Montreal, Quebec, Canada, 1992
PhD, Microbiology and Immunology, University of Guelph, Ontario, Canada, 1999

Honors and Awards:

Large Animal Clinician of the year, College of Veterinary Medicine, 2002, 2004, 2006, 2007.
Carl Norden-Pfizer Distinguished Teacher Award, College of Veterinary Medicine, 2006.
Clinical Investigator Award, College of Veterinary Medicine, 2004.
C.E. Cornelius Young Investigator Award, College of Veterinary Medicine, 2002.

Research Interests:

My clinical interests include general equine internal medicine, with a particular emphasis in equine neonatology, cardiology, and respiratory disorders. My research interests include infections caused by Rhodococcus equi in foals, equine neonatal immunology, as well as the pharmacokinetics and pharmacodynamics of antimicrobial agents in horses.

Selected Publications:

For Publications Extracted From Medline Click HERE {coming soon}

Giguère S., Slade J.K., Sanchez L.C. 2008. Retrospective comparison of caffeine and doxapram for the treatment of hypercapnea in foals with hypoxic ischemic encephalopathy. J. Vet. Intern. Med. 22:401-405.

Sanchez L.C., Giguère S., Javsicas L.H., Bier J., Walrond C.J., Womble A.Y.2 2008. Gastric tonometry in normal neonatal foals: the Effect of age, feeding, and omeprazole administration. J. Vet. Intern. Med. 22:406-410.

Giguère S., Sanchez L.C., Shih A., Szabo N.J., Womble A.Y., Robertson S.A. 2007. Comparison of caffeine and doxapram on respiratory and cardiovascular function in foals with induced respiratory acidosis. Am. J. Vet. Res. 68: 1407-1416.

Fumuso E., Aguilar J., Giguère S., David O., Wade J., Rogan D. 2007. Immune parameters in mares resistant and susceptible to persistent post-breeding endometritis: effects of immunomodulation. J. Vet. Immunol. Immunopathol. 118:30-39.

Jacks S., Giguère S., Crawford P.C., Castelman W.L. 2007. Experimental infection of neonatal foals with Rhodococcus equi triggers adult-like IFN-ÿ induction. Clin. Vaccine Immunol. 14:669-677.

Womble A., Giguère S., Lee E.A. 2007. Pharmacokinetics of oral doxycycline and concentrations in body fluids and bronchoalveolar cells of foals. J. Vet. Pharmacol. Therap. 30:187-193.

Suarez-Mier G., Giguère S., Lee E.J.4 2007. Pulmonary disposition of erythromycin, azithromycin, and clarithromycin in foals. J. Vet. Pharmacol. Therap. 30:109-115.

Jacks S., Giguère S., Prescott J.F. 2007. In vivo expression of, and cell mediated immune responses to, the plasmid-encoded virulence associated proteins of Rhodococcus equi in foals. Clin. Vaccine Immunol. 14:369-374.

Valverde A., Giguère S., Morey T.E., Sanchez L.C., Shih A. 2007. Comparison of non-invasive cardiac output measured by use of partial carbon dioxide rebreathing or the lithium dilution method in anesthetized foals. Am. J. Vet. Res. 68:141-147.

Belknap J.K., Giguère S., Pettigrew A., Cochran A.M., Van Eps A.W., Pollitt C.C. 2007. Lamellar pro-inflammatory cytokine expression patterns at the developmental stage and at the onset of lameness: innate vs. adaptive immune response. Equine Vet. J. 39:42-47.

Womble A., Giguère S., Murthy Y.V.S.N., Cox C., Obare E. 2006. Pulmonary disposition of tilmicosin in foals and in vitro activity against Rhodococcus equi and other common equine bacterial pathogens. J. Vet. Pharmacol. Therap. 29:561-568.

Valverde A., Giguère S., Sanchez L.C., Shih A., Ryan C. 2006. Effects of dobutamine, norepinephrine and vasopressin on cardiovascular function in anesthetized neonatal foals with induced hypotension. Am. J. Vet. Res. 67:1730-1737.

Rohrbach R., Buchanan B., Drake J., Andrews F., Bain F., Byars D., Bernard B., Furr M., Paradis M., Lawler J., Giguère S., Dunkel B. 2006. Use of a multivariable model to estimate the probability of discharge in hospitalized foals that are 7 days of age or less. J. Am. Vet. Med. Assoc. 228:1748-1756.

Womble A., Giguère S., Lee E.A., Vickroy T. 2006. Pharmacokinetics of clarithromycin and concentrations in body fluids and bronchoalveolar cells of foals. Am. J. Vet. Res. 67:1681-1686.

Christensen B.W., Roberts J.F., Pozor M.A., Giguère S., Sells S.F., Donahue J.M. 2006. Nocardioform placentitis with isolation of Amycolatopsis spp in a Florida-bred mare. J. Am. Vet. Med. Assoc. 228:1234-1239.

Davis R., Giguère S. 2005. Evaluation of five commercially available assays and measurement of serum total protein concentration via refractometry for the diagnosis of failure of passive transfer of immunity in foals J. Am. Vet. Med. Assoc. 227:1640-1645.

Valverde A., Gunkel C., Doherty T.J., Giguère S., Pollak A.S. 2005. Effect of a constant rate infusion of lidocaine on the quality of recovery from sevoflurane or isoflurane general anesthesia. Equine Vet. J. 37:559-564.

Giguère S., Knowles H., Valverde A., Bucki E., Young L. 2005. Accuracy of indirect measurement of blood pressure in neonatal foals. J. Vet. Intern. Med. 19:571-576.

Giguère S., Bucki E., Adin D.B., Valverde A., Estrada A.H., Young L. 2005. Cardiac output measurement by partial carbon dioxide rebreathing, 2-dimensional echocardiography and lithium dilution method in anesthetized neonatal foals. J. Vet. Intern. Med. 19:737-743.

Ryan C.A., Sanchez L.C., Giguère S., Vickroy T. 2005. Pharmacokinetics and pharmacodynamics of pantoprazole in clinically normal neonatal foals. Equine Vet. J. 37:336-341s.

Sykes B.W., Furr M., Giguère S. 2005. In Vivo pretreatment with PGG-glucan fails to alter cytokine messenger RNA expression of equine peripheral blood mononuclear cells exposed to endotoxin ex vivo. Vet. Therap. 6:67-76.

Carrillo N., Giguère S., Gronwall R.R., Brown M.P., Merritt K.A., O'Kelly J. 2005. Disposition of oral cefpodoxime proxetil in foals and adult horses, and minimum inhibitory concentration of the drug against common equine bacterial pathogens. Am. J. Vet. Res. 66:30-35.

Cwikla S.J., Bélanger M., Giguère S., Progulske-Fox A., Vertucci FJ. 2005. Dentinal tubule disinfection using three calcium hydroxide formulations. J. Endod. 31:50-52.

Bucki E.P., Giguère S., Macpherson M., Davis R. 2004. Pharmacokinetics of once-daily amikacin in healthy foals and therapeutic drug monitoring in hospitalized equine neonates. J. Vet. Intern. Med. 18:728-733.

Tyson R., Graham J.P., Roberts G.D., Giguère S. 2004. What is your diagnosis? J. Am. Vet. Med. Assoc. 225:515-516.

Ernst N., Hernandez J., MacKay R., Brown M.P., Gaskin J.M., Nguyen A., Giguère S., Colahan P.T., Troedsson M.R., Haines G.R., Addison I.R., Miller B.J. 2004. Risk factors associated with fecal Salmonella shedding among hospitalized horses with signs of gastrointestinal tract disease. J. Am. Vet. Med. Assoc. 225:267-274.

Giguère S., Jacks S., Roberts G.D., Hernandez J., Long M.T., Ellis C. 2004. Retrospective comparison of azithromycin, clarithromycin and erythromycin for the treatment of foals with Rhodococcus equi pneumonia. J. Vet. Intern. Med. 18:568-573.

Taouji S., Nomura I., Giguère S., Tomomitsu S., Kakuda T., Ganne V., Takaï S. 2004. Immunogenecity of synthetic peptides representing linear B-cell epitopes of VapA of Rhodococcus equi in mice and horses. Vaccine. 22:1114-1123.

Stone A.E.S., Giguère S., Castleman W.L. 2003. IL-12 reduces the severity of Sendai virus-induced bronchiolar inflammation and remodeling. Cytokine. 24:103-113

Fumoso E., Giguère S., Wade J., Rogan D., Videla-Dorna I., Bowden R.A. 2003. Endometrial IL-1ÿ,IL-6 and TNF-ÿ, mRNA expression in mares resistant or susceptible to post-breeding endometritis. Effects of estrous cycle, artificial insemination and immunomodulation. Vet. Immunol. Immunopathol. 96:31-41.

MacNeill A.L., Alleman A.R., Franklin R.P., Long M., Giguère S., Uhl E., Lopez-Martinez A., Wilkerson M. 2003. What is your diagnosis? Pneumonia in a Paso-Fino mare.
Vet. Clin. Pathol. 32: 73-76.

Giguère S., Hernandez J., Gaskin J., Miller C., Bowman J.L. 2003. Evaluation of white blood cell counts, plasma fibrinogen concentrations and an agar gel immunodiffusion test for early identification of foals with Rhodococcus equi pneumonia. J. Am. Vet. Med. Assoc. 222: 775-781.

Jacks S.S., Giguère S., Nguyen A. 2003. In vitro susceptibility of Rhodococcus equi and other common equine pathogens to azithromycin, clarithromycin and 20 other antimicrobials. J. Antimicrob. Agent Chemotherap. 222: 1241-1247.

Porter M.B., Long M.T., Getman L.M., Giguère S., MacKay R.J., Lester G.D., Alleman A.R., Wamsley H.L., Franklin R.P., Jacks S., Buergelt C.D., Detrisac C. 2003. Retrospective study of 46 West Nile Virus encephalomyelitis suspect horses. J. Am. Vet. Med. Assoc. 222: 1241-1247.

Phillips W., Giguère S., Franklin R.P., Hernandez J, Adin D., Peloso J.G. 2003. Cardiac troponin I in pastured and race-training Thoroughbred horses. J. Vet. Intern. Med. 17: 597-599.

Giguère S., Hernandez J., Gaskin J., Prescott J.F., Takai S., Miller C. 2003. Performance of five serological assays for diagnosis of Rhodococcus equi pneumonia in foals. Clin. Diag. Lab. Immunol. 10: 241-245.

Ramaiah S.K., Harvey J.W., Giguère S., Franklin R.P., Crawford P.C. 2003. Intravascular hemolysis associated with liver disease in a horse with marked neutrophil hypersegmentation. J. Vet. Intern. Med. 17: 360-363.

LeBlanc M.M., Giguère S., Brauer K., Paccamonti D.L., Horohov D.W., Lester G.D., O’Donnell L.J., Sheerin B.R., Pablo L., Rodgerson D.H. 2002. Premature delivery in ascending placentitis is associated with increased expression of placental cytokines and allantoic fluid prostaglandins E2 and F2ÿ. Theriogenology 58: 841-844.

Cadario M.E., Losinno L., Giguère S., Aguilar J., Jack T.J., Macpherson M., Fitzpatrick C., Uhl E.W. 2002. Uterine expression of fibrogenic cytokines in the mare. Theriogenology 58:449-452.

Franklin R.P., Long M.T., MacNeill A., Alleman R., Giguère S., Uhl E., Lopez-Martinez A., Wilkerson M. 2002. Proliferative interstitial pneumonia, Pneumocystis carinii infection, and immunodeficiency in an adult Paso-Fino horse. J. Vet. Intern. Med. 16:607-611.

Garton N.J., Gilleron M., Brando T., Dan H.H., Giguère S., Puzo G., Prescott J.F., Sutcliffe I.C. 2002. A novel lipoarabinomannan from the equine pathogen Rhodococcus equi: structure and effect on macrophage cytokine production. J. Biol. Chem. 177: 31722-31733.

Jacks S., Giguère S., Gronwall R.R., Brown M.P., Merritt K.A. 2002. Disposition of oral chlarithromycin in foals. J. Vet. Pharmacol. Therap. 25:359-362.

Giguère S., Gaskin J., Miller C., Bowman J.M. 2002. Evaluation of a commercially available hyperimmune plasma product for the prevention of naturally acquired pneumonia caused by Rhodococcus equi in foals. J. Vet. Med. Assoc. 220: 59-63.

Giguère S., Viel L., Lee E., MacKay R.J., Hernandez H., Franchini M. 2002. Cytokine induction in pulmonary airways of horses with heaves and effect of therapy with inhaled fluticasone propionate. Vet. Immunol. Immunopathol. 85: 147-158.

Uhl E.W., Giguère S., Jack T.J., Hodge T. 2002. Increased pulmonary activation of nuclear factor-kB (NF-ÿB) in foals inoculated with Rhodococcus equi is associated with increased expression of inflammatory cytokines. Vet. Pathol. 39: 132-136.

Jacks S., Giguère S., Gronwall R.R., Brown M.P., Merritt K.A. 2001. Pharmacokinetics of azithromycin in foals and concentration of the drug in body fluids and bronchoalveolar cells. Am. J. Vet. Res. 62: 1870-1875.

Hooper-McGrevy K., Giguère S., Wilkie B.N., Prescott J.F. 2001. Antibody to virulence-associated proteins A and C in protection against Rhodococcus equi pneumonia in foals. Am. J. Vet. Res. 62:1307-1313.