College of Veterinary Medicine

Education:

DVM, University of Saskatchewan, College of Veterinary Medicine, 1972
MSc, University of Saskatchewan, Comparative Pathology, 1975
Diploma, University of California, Large Animal Surgery Resident, 1975

Honors and Awards:

Large Animal Clinician of the Year - U of F - 1984, 1993, 1999, 2001
SCAVMA Teacher of the Year - 1993, 1998
Teacher of the Year, Class of 1999 – 1999

Research Interests:

For approximately the last 10 years, my research has focused on osteoarthritis. Although my interest is primarily osteoarthritis in horses, it has become apparent that the horse is also a good translational model for osteoarthritis in other species, particularly humans. In collaboration with Dr. Troy Trumble, I have concentrated on developing, validating, and using biomarkers (biochemical markers) of joint metabolism to help diagnose, monitor progression, and treatment effects related to joint disease and injury. I also have an interest in identifying new targets for the development of osteoarthritic drugs. I have focused on the inter-relationships of articular metabolic by-products of synthesis and degradation of bone and cartilage in the synovial fluid, serum, and urine. By using biomarker concentrations and ratios in these fluids to predict the presence or absence of joint injury, we have found that some of these tests have an accuracy greater than 90%. Although many of the biomarkers that we use are commercially available enzyme-linked immunoassays, I have also developed a number of original assays in my laboratory that may be useful in the diagnosis of osteoarthritis and the monitoring of treatment effects.

Selected Publications:

For Publications Extracted From Medline Click HERE {coming soon}

Errico JA, Trumble TN, Bueno ACD, Davis JL, Brown MP. Comparison of two indirect techniques for local delivery of a high dose of an antimicrobial in the distal portion of the forelimbs of horses. Am J Vet Res 2008; (In press).

Preston S, Trumble TN, Zimmel DN, Chmielewski TL, Brown MP, Hernandez J. Lameness, athletic performance and financial returns in Thoroughbred pinhooked horses. J Amer Vet Med Assoc 2008; 232:85-90.

Trumble TN, Brown MP, Merritt KA, Billinghurst RC. Joint dependent concentrations of bone alkaline phosphatase in serum and synovial fluids of horses with osteochondral injury: An analytical and clinical validation. Osteoarthritis and Cartilage; 2007; doi:10.1016/j.joca.2007.11.008.

Brown MP, Trumble TN, Sandy JD, Merritt KA. A simplified method of determining synovial fluid chondroitin sulfate chain length. Osteoarthritis Cartilage; 2007; 15:1443-1445.

Brown MP, Trumble TN, Plaas AHK, Sandy JD, Romano M, Hernandez J, Merritt KA. Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid. Osteoarthritis Cartilage; 2007; 15:1315-1325.

Canapp SO, Cross AR, Brown MP, Lewis DD, Tran-Son-Tay R, Hernandez J, Merritt KA. Examination of synovial fluid and serum following intravenous injections of hyaluronan for the treatment of osteoarthritis in dogs. Vet Comp Orthop Traumatol 2005;18:169-174.

Adams AR, Haines GR, Brown MP, Gronwall RR, Merritt KA. Pharmacokinetics of difloxacin and its concentration in body fluids and endometrial tissues of mares after repeated intragastric administration. Can J Vet Res 2005;69:229-235.

Ott EA, Brown MP, Roberts GD, Kivipelto J. Influence of starch intake on growth and skeletal development of weanling horses. J Anim Sci 2005;83:1033-1043.

Carrillo N, Giguère S, Gronwall RR, Brown MP, Merritt KA, O'Kelly J. Disposition of oral cefpodoxime proxetil in foals and adult horses, and minimum inhibitory concentration of the drug against common equine bacterial pathogens. Am J Vet Res 2005;66:30-35.

Wellehan JFX, Farina LL, Keoughan CG, Lafortune M, Grooters AM, Mendoza L, Brown MP, Terrell SP, Jacobson ER, Heard DJ. Pythiosis in a dromedary camel (Camelus dromedarius). Journal of Zoo and Wildlife Medicine 2004;35:564–568.

Ernst NS, Hernandez JA, MacKay RJ, Brown MP, Gaskin JM, Nguyen AD, Giguere S, Colahan PT, Troedsson MR, Haines GR, Addison IR, Miller BJ. Risk factors associated with fecal Salmonella shedding among hospitalized horses with signs of gastrointestinal tract disease. J Am Vet Med Assoc. 2004;225:275-81.

Broome TA, Brown MP, Gronwall RR, Casey MF, Merritt KA.Pharmacokinetics and plasma concentrations of acetylsalicylic acid after intravenous, rectal, and intragastric administration to horses. Can J Vet Res. 2003 Oct;67(4):297-302.