College of Veterinary Medicine

Education:

B.A. , Psychobiology, University of California, Santa Cruz, 1980
M.S., Kinesiology, University of Washington, Seattle, 1984
Ph.D., Physiology, Northwestern University, Chicago, 1990
Postdoctoral Training, Cardiovascular Research Center, University of Iowa, Iowa City, IA

Honors and Awards:

 

Research Interests:

The cardiovascular system is normally tightly regulated by various circulating hormones and sensory signals from the peripheral vasculature. These sensory and hormonal signals are integrated in sites in the brain which modify blood pressure and cardiac function. When sensory or hormonal feedback is altered due to genetic predispositions or peripheral damage, the central regulation of blood pressure and cardiac function becomes perturbed often leading to the development of hypertension. Hypertension remains one of the leading causes of death in the United States.

One main focus of my lab is to gain new knowledge on how the brain integrates sensory signals involved in regulation of blood pressure and compare how activation or inhibition of different regions of the brain produces changes in sympathetic and parasympathetic drive in both normotensive and hypertensive animals. Currently these studies are focusing on brain regions involved in mediating stress responses in the maintenance sympathoexcitation. A second focus of the lab is to utilize neuroanatomical tracers to characterize the interconnections between different brain regions relaying cardiovascular information and to identify the importance of these interconnections in mediating physiological responses to hemorrhage. All studies involve whole animal physiology as well as neuroanatomy and/or extracellular recording from single neurons in the brain. Research in the lab is currently funded by NIH.

Selected Publications:

For Publications Extracted From Medline Click HERE

Berry, RB, Koch, G., and Hayward, LF. Low Dose Mirtazapine Increases Genioglossus Activity in the Anesthetized Rat. Sleep., 28: 78-84, 2005.

Hayward, LF, and Castellanos, M.Activation of the dorsal periaqueductal gray in the rat induces Fos-like immunoreactivity in select non-cholinergic mesopontine neurons. Neurosci Lett. 360(1-2):5-8, 2004.

Hayward, LF, Castellanos, M., and Davenport, PW.Activation of parabrachial neurons mediates the cardiorespiratory response to dorsal periaqueductal gray stimulation J. Appl. Physiol. J Appl Physiol. 96(3):1146-1154, 2004.

Hayward, LF., and Castellanos, M.Increased Fos expression in the lateral parabrachial nucleus following dorsal periaqueductal gray stimulation in rats.Brain Res.974, 153-166, 2003.

Berry,RB. and Hayward, LF.Selective augmentation of genioglossus EMG activity by L-5-Hydroxytryptophan (L-5HTP) in the rat.Pharm.. Biochem and Behav., 74:877-882, 2003.

Hayward, LF, Swartz, CL., and Davenport, PW.Respiratory response to activation or disinhibition of the dorsal periaqueductal gray in rats J. Appl. Physiol. 94:913-922, 2003.

Hayward, LF. and von Reiztenstein, M., Increased c-fos expression in central gray following both arterial chemoreceptor and baroreceptor stimulation in rats.Amer. J. Physiol., 283:H1975-H1984 2002.

Hayward, LF., Riley, A.P., and Felder, R.B., Alpha-2 adrenergic receceptors in the NTS facilitate baroreflex function in adult SH rats. Amer. J. Physiol. 282: H2336-H2345, 2002.

Hayward, LF., Evidence for alpha-2 adrenoreceptor modulation of the arterial chemoreflex in the caudal solitary nucleus of the rat. Amer. J. Physiol. , 281: R1464-1473, 2001.