Nancy D. Denslow
College of Veterinary Medicine
Department of Physiological Sciences &
College of Medicine
Department of Biochemistry and Molecular Biology
PO Box 110885
2187 Mowry Rd, Bldg 471
Gainesville, FL 32611
- M.S., Biochemistry, Yale University
- Ph.D., Molecular Biology, University Of Florida
Honors and Awards
- 2007 Pfizer Award for Research Excellence, College of Veterinary Medicine, University of Florida
- 2009 University of Florida Research Professor
- 2009-2012 Blue Ribbon Scientific Advisory Panel for California State Water Resources Control Board
Dr. Denslow’s research involves developing and using molecular biomarkers to evaluate changes in gene expression depending on stress or exposure to contaminants. For environmental species, molecular approaches, including microarray analysis and proteomics, were developed for several non-model species, including fish, gastropods, and coral. Fish swim in waters that are contaminated by superfund chemicals and emerging contaminants of concern and, thus, provide a direct measure of effects of the contaminants in vertebrates. Many of the chemicals behave as endocrine disruptors and, in particular, as estrogen mimics. To better study the direct effects of these contaminants on reproduction, three largemouth bass estrogen receptors (alpha and two beta-like subtypes) were isolated, sequenced, and integrated into expression assays. The receptors appear to bind and are activated differentially by organochlorine pesticides. In addition, the tissue expression patterns are different for the three receptors.
In the human health arena, Dr. Denslow has recently served on a Blue Ribbon Panel to assess contaminants found in reused water in California. Southern California and other locations in the United States are suffering from shortages of fresh water and need to reclaim water for many different uses, including drinking water. It is important to assess the levels of contaminants in processed water and to determine whether or not they are causing a risk for human health directly or through epigenetic mechanisms.
- Hydrogen peroxide stimulates exosomal cathepsin B regulation of the receptor for advanced glycation end-products (RAGE).
Additional publications here