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Murray P. Brown

Appleton Endowed Professor

Large Animal Clinical Sciences
Large Animal Surgery
brownmu@ufl.edu
PO Box 100136
2015 SW 16th Ave
Gainesville, FL 32608-0136
352-392-2229
FAX: 352-392-8289

Education

  • Diplomate, American College of Veterinary Surgeons, 1980
  • Resident, Large Animal Surgery, University of California, Davis, Davis, Calif., 1975
  • MSc, Comparative Pathology, University of Saskatchewan, Saskatchewan, Canada, 1975
  • DVM, University of Saskatchewan College of Veterinary Medicine, Saskatchewan, Canada, 1972

Honors and Awards

  • Large Animal Clinician of the Year, University of Florida, Gainesville, Fla. 1984, 1993, 1999, 2001
  • SCAVMA Teacher of the Year, University of Florida, Gainesville, Fla. 1993, 1998
  • Teacher of the Year, University of Florida, Gainesville, Fla. Class of 1999

Research Interests

For approximately the last 10 years, Dr. Brown’s research has focused on osteoarthritis, primarily osteoarthritis in horses. However, it has become apparent that the horse is also a good translational model for osteoarthritis in other species, particularly humans. In collaboration with Dr. Troy Trumble, Dr. Brown has concentrated on developing, validating, and using biomarkers (biochemical markers) of joint metabolism to help diagnose, monitor progression, and treatment effects related to joint disease and injury. Dr. Brown also has an interest in identifying new targets for the development of osteoarthritic drugs. He has focused on the inter-relationships of articular metabolic by-products of synthesis and degradation of bone and cartilage in the synovial fluid, serum, and urine. By using biomarker concentrations and ratios in these fluids to predict the presence or absence of joint injury, we have found that some of these tests have an accuracy greater than 90%. Although many of the biomarkers used are commercially available enzyme-linked immunoassays, Dr. Brown has also developed a number of original assays in his laboratory that may be useful in the diagnosis of osteoarthritis and the monitoring of treatment effects. His research is currently funded by the National Institutes of Health.

Recent Publications

Publications listed here.