Department of Infectious Diseases & Immunology
The Center for Inflammation & Mucosal Immunology
College of Medicine, Department of Medicine, Division of Gastroenterology, Hepatology & Nutrition
College of Medicine, Department of Dermatology
Emerging Pathogens Institute
PO Box 110880
2015 SW 16th Ave
Gainesville, FL 32611-0882
- BS, Cellular & Molecular Biology, Johannes Gutenberg University/Germany, 1986
- MS, Cellular & Molecular Immunology, Johannes Gutenberg University, 1989
- PhD, Cellular & Molecular Immunology, Johannes Gutenberg University, 1991
Dr. Mohamadzadeh is an immunologist with over 25 years of expertise in the fields of inflammation, systemic/mucosal immunology, infection, and vaccine delivery. He is also experienced in working with various therapeutic approaches that focus on the role of innate immune cells, particularly dendritic cells, and how these cells determine the activation and differentiation of T lymphocytes—including T cells such as TH17 or extrathymic regulatory T cells (Tregs)—in steady state, during infection, and throughout autoinflammatory intestinal disorders such as inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC). In his opinion, understanding the molecular mechanisms underlying intestinal immune regulation is most effective when host interactions with intestinal bacterial species and their bacterial products are fully understood, and when the critical molecules that culminate in inflammation or anti-inflammatory responses are identified. Thus, his research is firmly centered on the specifics of beneficial gut microbes, their unique properties, and their role in the induction of stimulatory or regulatory signals in innate cells and T lymphocytes, contributing directly to further proinflammation or regulation of inflammatory diseases (IBD, NEC). Pragmatically, his research is tightly entwined with generating novel therapies for intestinal disorders (e.g. NEC) using beneficial bacteria such as P. UF1 to significantly regulate induced pathogenic inflammation in sufferers who urgently need it.
- The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue.
- Commensal Propionibacterium strain UF1 mitigates intestinal inflammation via Th17 cell regulation.
- Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis.
- Corrigendum: The Extracellular Calcium-Sensing Receptor in the Intestine: Evidence for Regulation of Colonic Absorption, Secretion, Motility, and Immunity.
Additional publications here