Department of Physiological Sciences
1333 Center Drive
Gainesville, FL 32610-0144
Office: (352) 294-4048
Fax: (352) 392-5145
- B.A. , Psychobiology, University of California, Santa Cruz, 1980
- M.S., Kinesiology, University of Washington, Seattle, 1984
- Ph.D., Physiology, Northwestern University, Chicago, 1990
- Postdoctoral Training, Cardiovascular Research Center, University of Iowa, Iowa City, IA
Honors and Awards
The cardiovascular system is normally tightly regulated by various circulating hormones and sensory signals from the peripheral vasculature. These sensory and hormonal signals are integrated in sites in the brain which modify blood pressure and cardiac function. When sensory or hormonal feedback is altered due to genetic predispositions or peripheral damage, the central regulation of blood pressure and cardiac function becomes perturbed often leading to the development of hypertension. Hypertension remains one of the leading causes of death in the United States.
One main focus of my lab is to gain new knowledge on how the brain integrates sensory signals involved in regulation of blood pressure and compare how activation or inhibition of different regions of the brain produces changes in sympathetic and parasympathetic drive in both normotensive and hypertensive animals. Currently these studies are focusing on brain regions involved in mediating stress responses in the maintenance sympathoexcitation. A second focus of the lab is to utilize neuroanatomical tracers to characterize the interconnections between different brain regions relaying cardiovascular information and to identify the importance of these interconnections in mediating physiological responses to hemorrhage. All studies involve whole animal physiology as well as neuroanatomy and/or extracellular recording from single neurons in the brain.
- Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats.
Additional publications here