Leah R. Reznikov
- 08/2008 – 06/2016: Postdoctoral Scholar, Lung Biology and Cystic Fibrosis Center, University of Iowa, Iowa City, IA
- 08/2004 – 08/2008: Ph.D, Biomedical Sciences; focus in Neuroscience. University of South Carolina School of Medicine, Columbia, SC
- 02/2000 – 06/2000: Regents Semester Study Abroad Program. University of Newcastle, Newcastle, New South Wales, Australia
- 08/1998 – 08/2002: B.S., Biology. Iowa State University, Ames, IA
Honors and Awards
- 2017: University of South Carolina School of Medicine Distinguished Doctorate Alumni Award
- 2014: K99/R00 Pathway to Independence Grant Recipient
- 2014: University of Iowa 15th Annual Interdisciplinary Research Poster Session Best Poster Award
- 2014: University of Iowa Carver College of Medicine Health Sciences Research Week Cover Art Winner
- 2013: University of Iowa 14th Annual Interdisciplinary Research Poster Session Women in Science and Engineering Award
- 2013: University of Iowa Carver College of Medicine Health Sciences Research Week Outstanding Poster Award in Postdoctoral Fellow and Staff Category
- 2012: University of Iowa Carver College of Medicine Health Sciences Research Week Outstanding Poster Award in Postdoctoral Fellow and Staff Category
- 2010: NIH T32 Institutional NRSA Postdoctoral Fellowship Recipient, Cardiovascular Center, Internal Medicine, University of Iowa
- 2007: International Society of Psychoneuroendocrinology Young Investigator Travel Award
- 2007: Amygdala in Health & Disease Gordon Conference Chair’s Fund Recipient
- 2006: Society for Neuroscience Graduate Student Travel Award
- 2004: Research Assistantship from the Graduate School of University of South Carolina School of Medicine
- 2002: Iowa State University Academic Recognition Scholarship
The research interests of my lab are centered on the interface of the nervous system and the airway. Using multidisciplinary approaches, we aim to answer three big picture questions: 1) Is dysfunction of the nervous system sufficient to induce airway disease? 2) What are the neural substrates that detect airway insults? 3) Can targeting the nervous system prevent airway disease?
To answer these questions, we use models of asthma and cystic fibrosis, with a special emphasis on early stage life. We perform in vitro and in vivo studies in parallel, and utilize numerous techniques ranging from basic molecular biology to microscopy to ion transport studies to whole animal physiology. We are keenly interested in the communication of the sensory nerves with the airway, and the processes governing transmission of that information to target tissues (i.e. epithelia, smooth muscle, submucosal glands, brainstem, etc). The goal of all our efforts is to improve human health and discover new mechanisms of airway disease.
- Meyerholz DK, Reznikov LR. Simple and reproducible approaches for the collection of select porcine ganglia. (2017) Journal of Neuroscience Methods. In press.
- Reznikov LR. Cystic Fibrosis and the Nervous System (2016). Chest. Nov 19. pii: S0012-3692(16)62356-5.
- Reznikov LR, Meyerholz DK, Adam RJ, Abou Alaiwa M, Jaffer O, Michalski AS, Powers LS, Price MP, Stoltz DA, Welsh MJ. Acid -Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice (2016). (2016) PLOS ONE. Nov 7;11(11):e01660.
PLoS One. 2016 Nov 7;11(11):e0166089.
- Shah VS, Meyerholz DK, Tang XX, Reznikov LR, Abou Alaiwa MH, Ernst SE, Karp PK, Wohlford-Lenane CL, Heilmann KP, Leidinger MR, Allen PD, Zabner J, McCray PB, Ostedgaard LS, Stoltz DA, Randak CO, Welsh MJ. Airway Acidification Initiates Host Defense Abnormalities in Cystic Fibrosis Mice. In press. Science. 351(6272):503-7
- Li K, Wohlford-Lenane C, Perlman S, Jewell AK, Gibson-Corley KN, Reznikov LR, Meyerholz DK, McCray PB. Middle east respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4. In press. Journal of Infectious Diseases. 213(5):712-22.
- Cook DP, Rector MV, Bouzek DC, Michalski AP, Gansemer ND, Reznikov LR, Stroik MR, Ostedgaard LS, Abou Alaiwa MH, Thompson MA, Prakash YS, Krishnan R, Meyerholz DK, Seow C, Stoltz DA. CFTR in sarcoplasmic reticulum of airway smooth muscle: implications for airway contractility. In press. American Journal of Respiratory and Critical Care Medicine. 193(4):417-26.
- Meyerholz DK, Lambertz A, Reznikov LR, Ofori-armanfo G, Karp PH, McCray PB, Welsh MJ, Stoltz DA, (2016) Immunohistochemical detection of porcine markers for translational studies of lung diseases.
Additional publications here