Donald C. Bolser
Department of Physiological
1333 Center Drive
Gainesville, FL 32610-0144
- BS, Biology, Florida Institute of Technology
- PhD, Physiology, University of South Florida, 1985
Honors and Awards
- Member, American college of Chest Physicians Panel on Evidence-based Clinical Practice Guidelines for Diagnosis and Management of Cough, 2011
- Invited speaker at the Third American Cough Conference in New York, NY, presented “Basic Science Year in Review”., 2011
- Co-Chair, organizer and invited speaker at the 2010 Experimental Biology meeting symposium Airway Protective Behaviors: Cough and Swallow. Presented “Functional organization of brainstem mechanisms controlling cough and swallow”, Anaheim, CA, 2010
- Invited Speaker at the NIH workshop Integrative Neural Systems Underlying Vital Aerodigestive Tract Functions. Presented “Neurogenesis and coordination of cough and pharyngeal swallow in the cat”, Madison, WI, 2010
- Invited speaker at the Interagency Modeling and Analysis Group meeting Impact of Modeling in Biomedical Research, in Bethesda, MD, presented “Computational modeling: A skeptic’s view”, 2009
- Invited speaker at the Second American Cough Conference in New York, NY, presented “Basic science year in review”, 2009
- Pfizer Animal Health Award for Research Excellence, 2008
- Invited speaker at the 4th International Symposium on Respiratory Diseases in Shanghai, China, presented “Centrally-acting antitussives”, 2007
- Invited speaker at the First American Cough Conference in New York, NY, presented “Why do older generation antihistamines make cough better?”, 2007
Brainstem Respiratory Neuron Interactions
9/1/11-8/31/16 Co-I (Bruce Lindsey, PI, University of South Florida), NIH R01 NS019814
Central Mechanisms of Airway Protection
9/1/10-8/31/14 PI and Project Director, NIH R01 HL103415
Neurogenesis of Cough
9/15/08-6/30/12 PI and Project Director, NIH R33 HL89104
Cough is the most common reason why sick patients visit physicians in the US. This defensive reflex is the most common manifestation of tobacco- and non-tobacco-related pulmonary diseases. Furthermore, cough suppressant (also called antitussive) drugs are among the most commonly prescribed in the world. Significant gaps exist in our understanding of how cough is produced and how this defensive reflex is inhibited by antitussive drugs. The long-range goal of research in our laboratory is to delineate the how the nervous system produces and regulates cough. We use antitussive drugs as tools to determine how the cough system is controlled. As such, our work also will expand our knowledge of the mechanisms by which these drugs inhibit cough. Our current approach incorporates the use of multiple extracellular electrode array technology to investigate the behavior of spontaneously active and recruited neurons in the brainstem during cough. Determination of the identity and functional relationships between these neurons will allow modeling of the configuration of the brainstem cough network. Perturbation of the behavior of these neurons with antitussive drugs will allow us to identify the mechanism by which cough suppressants act to inhibit this behavior.
- Central administration of nicotine suppresses tracheobronchial cough in anesthetized cats.
- Peripheral chemoreceptors tune inspiratory drive via tonic expiratory neuron hubs in the medullary ventral respiratory column network.
- Effect of laparotomy on the swallow-breathing relationship in the cat.
- What is chronic cough in children?
Additional publications here