Department of Infectious Diseases & Immunology
PO Box 110880
2015 SW 16th Ave
Gainesville, FL 32608-00881
- BS, Biology/Biochemistry, University of Nebraska, 1999
- PhD, Immunology, University of Florida, Gainesville, 2006
Honors and Awards
- Mentoring Opportunity Scholarship, Graduate Student Council, University of Florida, 2005
- NIDCR Career Development Award “Immune-Pathophysiology of Lymphocytic Foci in Sjögren’s Syndrome” 2009-2014
Primary areas of interest in the Nguyen lab focus on deciphering the autoimmune process of Sjögren’s syndrome using human patients and animal models. Sjögren’s syndrome is a systemic, rheumatic, autoimmune disease primarily targeting the salivary/lacrimal glands resulting in xerostomia/keratoconjunctivitis sicca. It is one of the most prevalent automimmune disorders in the US, affecting approximately four million individuals, predominantly middle-age women (nine out of 10 patients). The precise etiology of the disease is difficult to pinpoint in the human population. Our lab concentrates on the development of animal models to 1) examine the temporal change in the pathophysiological process, utilizing microarray technology, and 2) determine the genetic susceptibility loci, using recombinant animal models. To address the immunological process of the disease, the Nguyen lab investigates the biological function of TH17 cells, their signal transduction in immune system regulation, and their function. This area of research is aimed at identifying potential therapeutic targets for gene therapy. Lastly, the Nguyen lab is adopting the use of a single cell analysis approach, called microengraving technology, to resolve the heterogeneity of the infiltrating cells in the salivary/lacrimal glands and identify novel biomarkers for disease diagnosis.
- What can Sjögren's syndrome-like disease in mice contribute to human Sjögren's syndrome?
- BK viruria and viremia in children with systemic lupus erythematosus.
- Sexual dimorphic function of IL-17 in salivary gland dysfunction of the C57BL/6.NOD-Aec1Aec2 model of Sjögren's syndrome.
- Single-cell antibody nanowells: a novel technology in detecting anti-SSA/Ro60- and anti-SSB/La autoantibody-producing cells in peripheral blood of rheumatic disease patients.
Additional publications here