Bikash Sahay

Clinical Assistant ProfessorDr. Bikash Sahay

Department of Infectious Diseases & Immunology
Center for Inflammation and Mucosal Immunology
sahayb@ufl.edu

PO Box 110880
2015 SW 16th Ave
Gainesville, FL 32608-0880
352-294-4155
FAX: 352-392-9704

Education

  • PhD, Indian Veterinary Research Institute, Izatnagar, U.P., India, 2005
  • MVSc, Indian Veterinary Research Institute, Izatnagar, U.P., India, 2001
  • BVSc, Bihar Veterinary College, Rajendra Agricultural University, Pusa, Bihar, India, 1999

Research Interests

Borrelia burgdorferi is the causative agent of Lyme disease in humans, and susceptibility to it varies widely within a population, a phenomenon also observed in mice.  Different mouse strains were used to understand the differences and similarities between disease susceptibility and resistance in human populations. The C3H/HeN mouse strain is the most susceptible, whereas the C57BL/6 strain is most resistant to Lyme Borreliosis.  There are several factors associated with the differential disease phenotype, and one of the major determining factors is the IL-10 production between the mice strains. C3H/HeN mice and macrophages (MΦ) isolated from them do not produce adequate IL-10 in response to B. burgdorferi; instead they produce genes belonging to interferon response factors. We found that C3H/HeN MΦ harbored less cAMP in their cytoplasm, and the addition of exogenous cAMP converts their phenotype closer to resistant MΦs isolated from C57/BL6 mice.  Currently, my research focuses on the evaluation of the role of cAMP in modulating epigenetic landscape of disease susceptibility and resistance genes, including IL-10.

Recent Publications

Additional publications here