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Barbie Sheppard

Clinical Associate ProfessorDr. Barbie Sheppard

Department of Infectious Diseases and Pathology
sheppardb@ufl.edu
PO Box 110880
2015 SW 16th Ave
Gainesville, FL 32608-0880
(352) 294-4140
FAX: (352) 392-9704

Education

  • DVM, Veterinary Medicine, North Carolina State University, Raleigh, 1993
  • MS, Physiology, Virginia Polytechnic Institute, Blacksburg, 1989
  • Residency, Anatomic and Surgical Pathology, University of Florida, CVM, 1996
  • PhD, Comparative Medicine, University of Tennessee, Knoxville, 1999
  • Post doctoral Research, Yale University, New Haven, CT, 1999
  • Diplomate, American College of Veterinary Pathologists, 2000

Honors and Awards

  • Phi Kappa Phi, 1988 Phi Zeta Veterinary Honor Society, 1993
  • Resident Research Award Grant, UF, Gainesville, FL, 1995
  • Resident of the Year Award, Ancillary Services, UF, Gainesville, FL, 1996
  • NIEHS Postdoctoral Trainee, Comparative Medicine, U. Tennessee, Knoxville, TN

Research Interests

Our laboratory investigates the potential of brevetoxins, which are the toxins produced by dinoflagellate alga during red tides, to cause DNA mutagenesis, alter cell cycle, and influence apoptosis in normal and neoplastic human lung cells. The action of brevetoxins at sodium channels, cytoplasmic or nuclear targets in lung tumors may result in a loss of normal regulation. However, it is unclear if this will lead to apoptosis and/or mitogenesis, if those responses will be dose-dependent, and if they will have environmental exposure implications or chemotherapeutic applications. Collaborative work on lung cancer with several researchers at the UF Cancer Center includes development and examination of murine cancer models.

I also have a strong interest in the species-dependent environmental/evolutionary relationships resulting in widely disparate levels of toxin sensitivity and resistance in aquatic invertebrates compared to marine mammals. This has led to a subspecialization in aquatic invertebrate histopathology and gastric gland function including protein and genetic expression profiling to identify biomarkers of aquatic invertebrate stress and detoxification mechanisms.

Recent Publications

Additional publications here